Article
Soil Science
Zhen Wu, Yubing Dong, Xi Zhang, Xintong Xu, Zhengqin Xiong
Summary: Biochar application to soil is a promising tool for sequestering carbon, ensuring food security, and mitigating greenhouse gases and emissions of nitrous oxide and nitric oxide. However, limited research has been conducted on the long-term and practical effects of repeatedly amending biochar to soil. A three-year field experiment showed that biochar application significantly decreased methane, nitrous oxide, and nitric oxide emissions without hindering crop yield or mitigation of other greenhouse gases and nitrogen oxides.
Article
Biochemical Research Methods
Zhongyun Jiang, Sidi Liu, Xiang Xiao, Guimei Jiang, Qing Qu, Xingxing Miao, Renfei Wu, Rui Shi, Ruochen Guo, Jian Liu
Summary: In this study, a technique using droplet biosensors for the detection of nitric oxide (NO) secreted by a single macrophage under inflammatory stimuli was reported. The approach allows for studying the interactions between bacteria and macrophages at the single cell level.
Article
Biochemical Research Methods
M. Wilkinson, I White, K. Hamshere, O. Holz, S. Schuchardt, F. G. Bellagambi, T. Lomonaco, D. Biagini, Francesco F. Di, S. J. Fowler
Summary: Exhaled breath contains potentially diagnostic VOCs, and standardizing breath sample analysis can increase confidence in results. This study analyzed peppermint-derived compounds in breath samples to establish benchmark values for TD-GC-MS systems.
JOURNAL OF BREATH RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Eufrasia S. Pereira, Gabriel L. S. Rodrigues, Willian R. Rocha
Summary: NO uptake by the Ru-based anticancer metallodrug NAMI-A takes place at the triplet potential energy surface with a small energy barrier and is thermodynamically favorable, supporting the anti-angiogenesis theory associated with NAMI-A's mode of action.
Article
Nanoscience & Nanotechnology
Li Yang, Guanghao Zheng, Yaoqian Cao, Chuizhou Meng, Yuhang Li, Huadong Ji, Xue Chen, Guangyu Niu, Jiayi Yan, Ye Xue, Huanyu Cheng
Summary: This study presents the design and demonstration of a moisture-resistant, stretchable NOx gas sensor based on laser-induced graphene (LIG). The gas sensor exhibits a large response, an ultralow detection limit, fast response/recovery, and excellent selectivity. It can be stretched by 30% and has been demonstrated to monitor the personal local environment and analyze human breath samples for disease diagnostics.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Physiology
Andrew R. Brotto, Rhys Beaudry, Samira Rowland, Sean van Diepen, Michael K. Stickland
Summary: This study aimed to investigate whether a D-L,D-NO manoeuvre alters pulmonary perfusion pressure. The results suggest that a single D-L,D-NO manoeuvre does not change pulmonary artery systolic pressure (PASP) and therefore would not acutely impact pulmonary capillary blood volume or membrane diffusing capacity.
EXPERIMENTAL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lorenzo Del Sorbo, Vinicius S. Michaelsen, Aadil Ali, Aizhou Wang, Rafaela V. P. Ribeiro, Marcelo Cypel
Summary: Nitric oxide, designated Molecule of the Year in 1992, has shown promising antimicrobial properties when inhaled at high doses. This innovative therapy has demonstrated effectiveness in treating lung infections by killing a broad range of infectious microorganisms.
Article
Biochemistry & Molecular Biology
Bartlomiej Dabrowski, Agnieszka Zuchowska, Artur Kasprzak, Grazyna Zofia Zukowska, Zbigniew Brzozka
Summary: Graphene oxide has potential applications in biomedicine, particularly as a drug carrier, due to its high surface area and functionalization capabilities. However, the internalization of graphene oxide inside mammalian cells is not well understood. Factors such as particle size and surface modifications can affect the cellular uptake of graphene oxide. Additionally, interaction with biological fluids can alter its biological properties. This study investigated the effect of graphene oxide particle size on internalization efficiency and the impact of serum components on its structure and interaction with cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Bianca Maria Rotoli, Rossana Visigalli, Francesca Ferrari, Marianna Ranieri, Grazia Tamma, Valeria Dall'Asta, Amelia Barilli
Summary: This study evaluated the effects of desmopressin on human pulmonary microvascular endothelial cells and found that it had no cytotoxic effect on the endothelium, but significantly stimulated the production of nitric oxide.
Article
Pharmacology & Pharmacy
Felix Javier Jimenez-Jimenez, Blanca G. Agundez, Javier Gomez-Tabales, Hortensia Alonso-Navarro, Laura Turpin-Fenoll, Jorge Millan-Pascual, Monica Diez-Fairen, Ignacio Alvarez, Pau Pastor, Marisol Calleja, Rafael Garcia-Ruiz, Santiago Navarro-Munoz, Marta Recio-Bermejo, Jose Francisco Plaza-Nieto, Esteban Garcia-Albea, Elena Garcia-Martin, Jose A. G. Agundez
Summary: The study investigated the association between variants in the endothelial nitric oxide synthase gene and the risk for idiopathic restless legs syndrome in a Caucasian Spanish population, finding that common NOS3 SNPs were not associated with the risk for RLS. There were weak statistical associations between certain NOS3 SNPs and response to dopamine agonists and clonazepam, but these findings require further confirmation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Physiology
Danilo Cialoni, Andrea Brizzolari, Michele Samaja, Gerardo Bosco, Matteo Paganini, Massimo Pieri, Valentina Lancellotti, Alessandro Marroni
Summary: The study investigated changes in nitrate and nitrite (NOx) concentration, total antioxidant capacity (TAC) and lipid peroxidation (TBARS) before, during, and after repetitive breath-hold dives in healthy volunteers. The results showed a significant increase in NOx at the bottom of dives, a decrease in TAC at the bottom, and no significant difference in TBARS throughout the protocol. The rapid return of NOx and TAC levels to pre-dive values suggested efficient endogenous antioxidant defenses activation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Environmental Sciences
Aqeel Ahmad, Waheed Ullah Khan, Anis Ali Shah, Nasim Ahmad Yasin, Shagufta Naz, Aamir Ali, Arifa Tahir, Aima Iram Batool
Summary: The study demonstrates that NO and Si together can alleviate the detrimental effects of As stress on plants, reducing As uptake. It is recommended to co-apply NO and Si in As-contaminated soils for improving plant growth and stress alleviation.
Editorial Material
Chemistry, Physical
Moumita Ghosh, Jeremy M. Smith
Summary: Scientists have developed mono-dispersed single-atom transition-metal (Fe, Co, and Ni) electrocatalysts, where the metal ion determines product selectivity, to reduce nitric oxide, a major air pollutant associated with environmental problems such as acid rain, smog, and ozone depletion.
Review
Oncology
Hongbin Zhou, Jiuke Li, Zhewen Chen, Ying Chen, Sa Ye
Summary: In this meta-analysis, it was found that FeNO and blood NO levels were significantly higher in lung cancer patients compared to control subjects; NMA model indicated that blood NO levels in all types of lung cancer were higher than those in control patients except SCLC; after therapy, FeNO levels increased and blood NO levels decreased in NSCLC patients.
Article
Multidisciplinary Sciences
Pritam Sukul, Simon Grzegorzewski, Celine Broderius, Phillip Trefz, Thomas Mittlmeier, Dagmar-Christiane Fischer, Wolfram Miekisch, Jochen K. Schubert
Summary: The study analyzed exhaled volatile metabolites data from 204 healthy females to investigate the age-related substance-specific differences and their relationship with endocrine differences, energy homeostasis, microbial diversity, oxidative stress, and lifestyle. The results suggest that breathomics offers a noninvasive approach for understanding aging at a systemic level and personalized monitoring.
Article
Mathematical & Computational Biology
Shu Jiang, Jiguo Cao, Graham A. Colditz, Bernard Rosner
Summary: With mammography as the primary screening strategy for breast cancer, it is important to utilize mammogram imaging data to identify women at different risk levels. This study proposes a supervised functional principal component analysis method for extracting features from mammogram images, which improves prediction accuracy. The method effectively addresses the irregular boundary issue and shows better performance compared to unsupervised methods in simulation studies.
Article
Statistics & Probability
Hua Liu, Jinhong You, Jiguo Cao
Summary: Motivated by recent work on massive functional data, this study proposes a new dynamic interaction semiparametric function-on-scalar (DISeF) model, which is useful to explore the dynamic interaction among a set of covariates and their effects on the functional response. The study develops an efficient estimation procedure to iteratively estimate the bivariate varying-coefficient functions, the index parameters, and the covariance functions of random effects. It also establishes the asymptotic properties of the estimators and develops a test statistic to check the variability of the dynamic interaction.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2023)
Article
Biology
Shu Jiang, Jiguo Cao, Bernard Rosner, Graham A. Colditz
Summary: Screening mammography is a method to detect breast cancer early, and it measures breast density to predict future cancer risk. This article introduces flexible methods, supervised FPCA and functional partial least squares, to extract image-based features associated with failure time while considering right censoring. The proposed methods outperform benchmark models in terms of prediction performance and reveal different risk patterns within mammograms.
Article
Statistics & Probability
Barinder Thind, Kevin Multani, Jiguo Cao
Summary: This article presents a methodology for integrating functional data into deep neural networks. The method not only accurately predicts new data, but also recovers the true underlying relationship between functional covariates and scalar responses. The authors have also developed an R package that enables easy implementation of the approach.
JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS
(2023)
Article
Biology
Matthew R. P. Parker, Laura L. E. Cowen, Jiguo Cao, Lloyd T. Elliott
Summary: This research addresses computational issues in open-population N-mixture models and proposes methods using fast Fourier transform and improved numerical stability. By comparing with standard methods, it demonstrates the advantages of these methods in terms of computational efficiency and precision.
JOURNAL OF AGRICULTURAL BIOLOGICAL AND ENVIRONMENTAL STATISTICS
(2023)
Article
Respiratory System
Frederic Schlemmer, Simon Valentin, Laurent Boyer, Anne Guillaumot, Francois Chabot, Clairelyne Dupin, Pierre Le Guen, Gwenael Lorillon, Anne Bergeron, Damien Basille, Julia Delomez, Claire Andrejak, Valentine Bonnefoy, Helene Goussault, Jean-Baptiste Assie, Pascaline Choinier, Anne-Marie Ruppert, Jacques Cadranel, Maria Chiara Mennitti, Mehdi Roumila, Charlotte Colin, Sven Gunther, Olivier Sanchez, Thomas Gille, Lucile Sese, Yurdagul Uzunhan, Morgane Faure, Maxime Patout, Capucine Morelot-Panzini, Pierantonio Laveneziana, Maeva Zysman, Elodie Blanchard, Chantal Raherison-Semjen, Violaine Giraud, Etienne Giroux-Leprieur, Stefanie Habib, Nicolas Roche, Anh Tuan Dinh-Xuan, Islem Sifaoui, Pierre-Yves Brillet, Camille Jung, Emmanuelle Boutin, Richard Layese, Florence Canoui-Poitrine, Bernard Maitre
Summary: This pragmatic study aimed to describe the clinical follow-up and respiratory recovery trajectories of survivors of severe-to-critical COVID-19, as well as identify factors influencing their health-related quality of life. The results showed that although pulmonary function and radiological abnormalities improved up to 1 year post-acute COVID-19, a high percentage of severe-to-critical disease survivors had significant lung sequelae and residual symptoms, warranting prolonged follow-up.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Hien Thi Thu Nguyen, Vang Le-Quy, Son Van Ho, Jakob Holm Dalsgaard Thomsen, Malene Pontoppidan Stoico, Hoang Van Tong, Nhat-Linh Nguyen, Henrik Bygum Krarup, Son Hong Nguyen, Viet Quoc Tran, Linh Toan Nguyen, Anh Tuan Dinh-Xuan
Summary: This study aims to predict the severity of COVID-19 based on clinical and biological indicators, and identify biomarkers for prognostic assessment. The most important indicators were IL-6, ferritin, and D-dimer. Two different sets of biomarkers can be used for disease severity assessment and prognosis.
Article
Medical Laboratory Technology
Gerald S. Zavorsky, Xander M. R. van Wijk
Summary: The objective of this study was to determine the stability of blood gases under different storage conditions using survival analyses. The results showed that pCO(2) and pH in blood samples remained stable for 60 minutes at room temperature and 3 hours in slushed ice. However, storing samples in slushed ice reduced the stability time for pO(2), especially when the baseline pO(2) was ≥60 mmHg. In conclusion, according to RCPA guidelines, blood gas and CO-oximetry panels can be stored for up to 40 minutes at room temperature.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Letter
Respiratory System
Paul Desbordes, Maarten De Vos, Julie Maes, Frans de Jongh, Karl Sylvester, Claus Franz Vogelmeier, Anh Tuan Dinh-Xuan, Jann Mortensen, Wim Janssens, Marko Topalovic
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Nilakash Das, Sofie Happaerts, Iwein Gyselinck, Michael Staes, Eric Derom, Guy Brusselle, Felip Burgos, Marco Contoli, Anh Tuan Dinh-Xuan, Frits M. E. Franssen, Sherif Gonem, Neil Greening, Christel Haenebalcke, William D-C. Man, Jorge Moises, Rudi Peche, Vitalii Poberezhets, Jennifer K. Quint, Michael C. Steiner, Eef Vanderhelst, Mustafa Abdo, Marko Topalovic, Wim Janssens
Summary: Collaboration between pulmonologists and explainable AI (XAI) is superior in diagnosing pulmonary function tests (PFTs) compared to individual pulmonologists or XAI alone. XAI's suggestions improve accuracy, confidence, and inter-rater agreement of pulmonologists. Therefore, the collaboration between pulmonologists and XAI is crucial for interpreting PFTs.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Rheumatology
Aelle Le Gall, Trieu-Nghi Hoang-Thi, Raphael Porcher, Bertrand Dunogue, Alice Berezne, Loic Guillevin, Veronique Le Guern, Pascal Cohen, Benjamin Chaigne, Jonathan London, Matthieu Groh, Romain Paule, Guillaume Chassagnon, Maria Vakalopoulou, Anh-Tuan Dinh-Xuan, Marie Pierre Revel, Luc Mouthon, Alexis Regent
Summary: A deep-learning-based algorithm for automated quantification of ILD on HRCT can effectively assess the extent of ILD and predict the risk of death in SSc patients.
Article
Health Care Sciences & Services
Nguyen Van Tho, Vu Tran Thien Quan, Do Van Dung, Nguyen Hoang Phu, Anh Tuan Dinh-Xuan, Le Thi Tuyet Lan
Summary: This study evaluated the level of asthma symptoms control and lung function over 5 years of GINA implementation. The results showed that asthma symptoms control and lung function improved after 3 months and the improvement was sustained over 5 years in patients managed according to GINA recommendations.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Nguyen Van Tho, Thu Phuong Phan, Anh Tuan Dinh-Xuan, Quy Chau Ngo, Le Thi Tuyet Lan
Summary: The study aimed to estimate the proportion of COPD patients with asthma features and compare the clinical characteristics and medication use between COPD patients with asthma features and those with COPD alone. A cross-sectional study conducted in Vietnam found that 27.3% of COPD patients had asthma features. These patients were younger, had higher FEV1 values, a higher proportion of positive bronchodilator reversibility tests, higher blood eosinophil count, and were more often treated with ICS/LABA.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Respiratory System
Ana Oliveira, Gaia Fabbri, Thomas Gille, Elena Bargagli, Boris Duchemann, Rachel Evans, Hilary Pinnock, Anne E. Holland, Elisabetta Renzoni, Magnus Ekstrom, Steve Jones, Marlies Wijsenbeek, Anh Tuan Dinh-Xuan, Guido Vagheggini
Summary: This article summarizes the main needs of patients with progressive pulmonary fibrosis (PF) and their caregivers and proposes a supportive care approach. Personalized care, education, emotional and psychological support, specialized treatments, and better access to information and resources are necessary. Treatment should start at diagnosis and be tailored to the patient's needs, including individualized pharmacological and non-pharmacological interventions such as oxygen therapy and pulmonary rehabilitation.
Article
Statistics & Probability
Jianghu (James) Dong, Haolun Shi, Liangliang Wang, Ying Zhang, Jiguo Cao
Summary: Longitudinal biomarkers are commonly used in clinical studies to monitor disease progression. This study develops a joint model that utilizes functional principal component analysis to extract features from longitudinal trajectories and employs a competing risk model to handle multiple time-to-event outcomes.
JOURNAL OF APPLIED STATISTICS
(2023)
