Article
Medicine, General & Internal
Jonathan H. Chung, Ayodeji Adegunsoye, Brenna Cannon, Rekha Vij, Justin M. Oldham, Christopher King, Steven M. Montner, Prahasit Thirkateh, Scott Barnett, Ronald Karwoski, Brian J. Bartholmai, Mary Strek, Steven D. Nathan
Summary: A study comparing quantitative imaging data between IPF and CTD-ILD in a UIP setting found that VRS was higher in IPF patients. VRS showed an inverse correlation with DLCO%, while the total volume of normal lung was associated with both DLCO% and FVC% in multivariable analysis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sarah C. Scharm, Jens Vogel-Claussen, Cornelia Schaefer-Prokop, Sabine Dettmer, Lars Knudsen, Danny Jonigk, Jan Fuge, Rosa-Marie Apel, Tobias Welte, Frank Wacker, Antje Prasse, Hoen-oh Shin
Summary: The study found that CT-derived functional parameters of regional ventilation and parenchymal late enhancement may serve as early imaging markers for idiopathic pulmonary fibrosis progression.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ju Gang Nam, Yunhee Choi, Sang-Min Lee, Soon Ho Yoon, Jin Mo Goo, Hyungjin Kim
Summary: The prognostic value of DL-driven CT fibrosis quantification in IPF was investigated. CT-Norm% and CT-Fib% showed significant correlations with FVC and D-LCO. Both CT-Norm% and CT-Fib% were independent prognostic factors for overall survival in IPF when adjusted for various variables. Substituting CT-Norm% for D-LCO showed comparable discrimination to the original GAP index.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haishuang Sun, Xiaoyan Yang, Xuebiao Sun, Xiapei Meng, Han Kang, Rongguo Zhang, Haoyue Zhang, Min Liu, Huaping Dai, Chen Wang
Summary: The elastic registration technique can assess the morphological deterioration of lung shrinkage in idiopathic pulmonary fibrosis (IPF), and the log_jac values are significantly correlated with pulmonary function tests (PFTs).
EUROPEAN RADIOLOGY
(2023)
Article
Respiratory System
Noriyuki Enomoto, Sakae Homma, Naohiko Inase, Yasuhiro Kondoh, Takeshi Saraya, Hajime Takizawa, Yoshikazu Inoue, Hiroshi Ishii, Yoshio Taguchi, Shinyu Izumi, Yasuhiko Yamano, Yoshinori Tanino, Yasuhiko Nishioka, Mikio Toyoshima, Koshi Yokomura, Shiro Imokawa, Naoki Koshimizu, Takehisa Sano, Taisuke Akamatsu, Hiroshi Mukae, Motoyasu Kato, Naoki Hamada, Hirofumi Chiba, Shinobu Akagawa, Shigeo Muro, Hironori Uruga, Hiroyuki Matsuda, Yusuke Kaida, Miho Kanai, Kazutaka Mori, Masafumi Masuda, Hironao Hozumi, Tomoyuki Fujisawa, Yutaro Nakamura, Noriyoshi Ogawa, Takafumi Suda
Summary: This nationwide multicentre study prospectively evaluated 376 patients with IIP, finding that 18.6% of them met the IPAF criteria. Patients with IPAF were more likely to develop systemic autoimmune diseases, had fewer acute exacerbations of IIP, and showed better survival outcomes. Cluster analysis identified a subgroup with more autoimmune features, predominantly female, and with a better prognosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hye Jeon Hwang, Joon Beom Seo, Sang Min Lee, Eun Young Kim, Beomhee Park, Hyun-Jin Bae, Namkug Kim
Summary: The CBIR system showed good performance in retrieving chest CTs displaying similar patterns for DILD, with higher retrieval rates in UIP compared to NSIP and COP. Radiologists evaluated 71.3%-73.0% of retrieved CTs as having a similarity score of 4 or 5.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Review
Cell Biology
Shengnan Yang, Peipei Liu, Yale Jiang, Zai Wang, Huaping Dai, Chen Wang
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with unknown causes, and currently the only medications that can slow down the progression of the disease and improve survival rate are pirfenidone and nintedanib. The use of mesenchymal stem cells (MSCs) provides a new hope for treating interstitial lung disease, but optimal treatment protocols are still lacking.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Roxana-Elena Cirjaliu, Mariana Deacu, Ioana Gherghisan, Angela Stefania Marghescu, Manuela Enciu, Gabriela Izabela Baltatescu, Antonela Anca Nicolau, Doina-Ecaterina Tofolean, Oana Cristina Arghir, Ariadna-Petronela Fildan
Summary: This review provides a comprehensive analysis of the risk factors, clinical, radiologic, and histological features of both post-COVID-19 pulmonary fibrosis (PCPF) and idiopathic pulmonary fibrosis (IPF). It highlights the similarities and differences between these two diseases by gathering relevant articles published in English up until October 2022 using multiple databases. This review aims to assist clinicians, pathologists, and researchers in making accurate diagnoses and selecting patients for anti-fibrotic therapies and future therapeutic perspectives.
Review
Biochemistry & Molecular Biology
Sheiphali Gandhi, Roberto Tonelli, Margaret Murray, Anna Valeria Samarelli, Paolo Spagnolo
Summary: Idiopathic pulmonary fibrosis (IPF) is a common and severe disease that primarily affects middle-aged and elderly males. In addition to aging, occupational and environmental exposures, as well as lifestyle factors such as smoking and diet, have been associated with an increased risk of IPF. Trigger factors may also lead to acute exacerbations and poor prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
Takahito Suzuki, Masato Karayama, Yoichiro Aoshima, Kazutaka Mori, Nobuko Yoshizawa, Shintaro Ichikawa, Shinpei Kato, Koshi Yokomura, Masato Kono, Dai Hashimoto, Yusuke Inoue, Hideki Yasui, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Satoshi Goshima, Naoki Inui, Takafumi Suda
Summary: The lung immune prognostic index (LIPI) has been found to be a predictive factor for the survival of patients with idiopathic pulmonary fibrosis (IPF), aiding in the management of IPF.
Article
Respiratory System
Kazuya Tsubouchi, Naoki Hamada, Shoji Tokunaga, Katsuyuki Ichiki, Shohei Takata, Hiroshi Ishii, Yasuhiko Kitasato, Masaki Okamoto, Satoru Kawakami, Kazuhiro Yatera, Masayuki Kawasaki, Masaki Fujita, Makoto Yoshida, Takashige Maeyama, Taishi Harada, Hiroshi Wataya, Ryo Torii, Masashi Komori, Yuichi Mizuta, Kazunori Tobino, Eiji Harada, Hidetake Yabuuchi, Yoichi Nakanishi, Isamu Okamoto
Summary: This study aimed to evaluate disease progression and cause of death in patients with non-idiopathic pulmonary fibrosis (non-IPF) of idiopathic interstitial pneumonia (IIP) and IPF. The results showed that there was not a significant difference in survival rate and incidence of acute exacerbation between the two groups. Chronic respiratory failure was the main cause of death in both groups. Closer monitoring of disease progression and palliative care interventions after acute exacerbation are important for both non-IPF IIP and IPF patients.
BMJ OPEN RESPIRATORY RESEARCH
(2023)
Article
Respiratory System
Yoichiro Aoshima, Masato Karayama, Yasuoki Horiike, Kazutaka Mori, Hideki Yasui, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Takafumi Suda
Summary: Cluster analysis identified four clinical phenotypes of IIPs, which may be useful for predicting the risk of acute exacerbation and overall survival.
BMC PULMONARY MEDICINE
(2021)
Article
Respiratory System
Nicholas D. Weatherley, James A. Eaden, Paul J. C. Hughes, Matthew Austin, Laurie Smith, Jody Bray, Helen Marshall, Stephen Renshaw, Stephen M. Bianchi, Jim M. Wild
Summary: The study found correlations between DCE-MRI first pass perfusion and existing physiological gas exchange metrics in IPF patients, suggesting that capillary perfusion deficit may contribute to gas exchange limitation. The FWHMmean metric showed a significant increase over a 6-month period and may serve as a quantitative biomarker for pulmonary vascular disease progression in IPF.
Article
Respiratory System
Toru Arai, Hiroto Matsuoka, Masaki Hirose, Hiroshi Kida, Suguru Yamamoto, Yoshitaka Ogata, Masahide Mori, Kazuyoshi Hatsuda, Chikatoshi Sugimoto, Kazunobu Tachibana, Masanori Akira, Yoshikazu Inoue
Summary: The study found that an increase in serum RANTES level at the time of diagnosis of acute exacerbation in idiopathic interstitial pneumonias predicted a good survival outcome, whereas elevated serum IL-10 level on day 8 predicted a poor survival outcome.
BMJ OPEN RESPIRATORY RESEARCH
(2021)
Review
Respiratory System
Tyler Pitre, Jasmine Mah, Wryan Helmeczi, Muhammad Faran Khalid, Sonya Cui, Melanie Zhang, Renata Husnudinov, Johnny Su, Laura Banfield, Brent Guy, Jade Coyne, Ciaran Scallan, Martin R. J. Kolb, Aaron Jones, Dena Zeraatkar
Summary: Through the evaluation of 48 eligible studies, it was found that nintedanib, pirfenidone, and sildenafil may reduce the mortality of IPF patients; nintedanib, nintedanib+sildenafil, pirfenidone, pamrevlumab, and pentraxin may reduce the decline in lung capacity in IPF patients; sildenafil may reduce the likelihood of acute exacerbation and hospitalizations; while corticosteroids+azathioprine+N-acetylcysteine increased the risk of serious adverse events compared to placebo.
Review
Radiology, Nuclear Medicine & Medical Imaging
Takahiko Nakazono, Ken Yamaguchi, Ryoko Egashira, Yukari Takase, Junichi Nojiri, Masanobu Mizuguchi, Hiroyuki Irie
JAPANESE JOURNAL OF RADIOLOGY
(2019)
Letter
Hematology
Keisuke Kidoguchi, Mariko Yoshimura, Kensuke Kojima, Hiroshi Ureshino, Ryoko Egashira, Masako Yokoo, Keita Kai, Yoshiaki Egashira, Koichi Ohshima, Toshihiko Ando, Shinya Kimura
ANNALS OF HEMATOLOGY
(2019)
Editorial Material
Oncology
Miki Yukimoto, Ken Yamaguchi, Takahiko Nakazono, Ryoko Egashira, Jun Nakamura, Yasue Matsumoto, Hiromi Kimura, Mihoko Yamamoto, Hiroyuki Irie
Article
Radiology, Nuclear Medicine & Medical Imaging
Ken Yamaguchi, Yukiko Hara, Isao Kitano, Takahiro Hamamoto, Kazumitsu Kiyomatsu, Fumio Yamasaki, Ryoko Egashira, Takahiko Nakazono, Hiroyuki Irie
BRITISH JOURNAL OF RADIOLOGY
(2019)
Article
Multidisciplinary Sciences
Noriyuki Enomoto, Ryoko Egashira, Kazuhiro Tabata, Mikiko Hashisako, Masashi Kitani, Yuko Waseda, Tamotsu Ishizuka, Satoshi Watanabe, Kazuo Kasahara, Shinyu Izumi, Akira Shiraki, Atsushi Miyamoto, Kazuma Kishi, Tomoo Kishaba, Chikatosi Sugimoto, Yoshikazu Inoue, Kensuke Kataoka, Yasuhiro Kondoh, Yutaka Tsuchiya, Tomohisa Baba, Hiroaki Sugiura, Tomonori Tanaka, Hiromitsu Sumikawa, Takafumi Suda
SCIENTIFIC REPORTS
(2019)
Review
Radiology, Nuclear Medicine & Medical Imaging
Takahiko Nakazono, Ken Yamaguchi, Ryoko Egashira, Masanobu Mizuguchi, Hiroyuki Irie
Summary: This article reviews the CT and MRI features of anterior mediastinal lesions and highlights the importance of understanding the pathological features for differential diagnosis.
JAPANESE JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ken Yamaguchi, Takahiko Nakazono, Ryoko Egashira, Shuichi Fukui, Koichi Baba, Takahiro Hamamoto, Hiroyuki Irie
Summary: The study found a significant association between the maximum slope (MS) of breast cancer lesions and prognostic factors of breast cancer, with higher MS in invasive cancer compared to ductal carcinoma in situ, higher MS in invasive cancer with axillary lymph node metastasis compared to those without, and a significant increase in MS with increasing ki-67 levels.
JAPANESE JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shuichi Fukui, Ryoko Egashira, Ken Yamaguchi, Takahiko Nakazono, Ryota Sakurai, Miho Asahi, Hiroyuki Irie
JOURNAL OF THORACIC IMAGING
(2020)
Article
Oncology
Ken Yamaguchi, Yukiko Hara, Isao Kitano, Takahiro Hamamoto, Kazumitsu Kiyomatsu, Fumio Yamasaki, Rin Yamaguchi, Takahiko Nakazono, Ryoko Egashira, Takeshi Imaizumi, Hiroyuki Irie
Summary: The study aimed to assess the relationship between MRI findings and invasive breast cancer with cancer-associated fibroblasts (CAFs) that are positive for podoplanin. Results indicated that IBCs with podoplanin(+) CAFs tended to have a more malignant pathological status and showed higher L/M ratio in STIR images. In dynamic study, the podoplanin(+) group had a significantly higher percentage of the washout pattern.
Editorial Material
Respiratory System
Ryoko Egashira, Ganesh Raghu
Editorial Material
Respiratory System
Ryoko Egashira, Ganesh Raghu
EUROPEAN RESPIRATORY JOURNAL
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ryoko Egashira, Mizuki Nishino
Article
Radiology, Nuclear Medicine & Medical Imaging
Makiko Murota, Takeshi Johkoh, Kyung Soo Lee, Tomas Franquet, Yasuhiro Kondoh, Yoshihiro Nishiyama, Tomonori Tanaka, Hiromitsu Sumikawa, Ryoko Egashira, Norihiko Yamaguchi, Kiminori Fujimoto, Junya Fukuoka
EUROPEAN JOURNAL OF RADIOLOGY OPEN
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hiromitsu Sumikawa, Takeshi Johkoh, Ryoko Egashira, Hiroaki Sugiura, Yasuhiko Yamano, Kensuke Kataoka, Yasuhiro Kondoh, Hiroaki Arakawa, Masahisa Nakamura, Akihiro Kuriu, Katsuyuki Nakanishi, Noriyuki Tomiyama
EUROPEAN JOURNAL OF RADIOLOGY OPEN
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ryoko Egashira, Ken Yamaguchi, Tetsuya Kondo, Takahiko Nakazono, Shuichi Fukui, Hiroyuki Irie
EUROPEAN JOURNAL OF RADIOLOGY OPEN
(2020)