Article
Oncology
Riccardo Laudicella, Albert Comelli, Virginia Liberini, Antonio Vento, Alessandro Stefano, Alessandro Spataro, Ludovica Croce, Sara Baldari, Michelangelo Bambaci, Desiree Deandreis, Demetrio Arico', Massimo Ippolito, Michele Gaeta, Pierpaolo Alongi, Fabio Minutoli, Irene A. Burger, Sergio Baldari
Summary: Machine learning techniques offer new opportunities for radiomics analysis to predict treatment response in patients with neuroendocrine tumors.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Nabeel Mansour, Kasturi Rangan, Reinhold Tiling, Johannes Ruebenthaler, Matthias P. Fabritius
Summary: We report a unique case of a 74-year-old woman with a suspected neuroendocrine tumor (NET) in the pancreatic head, in which Ga-68-DOTATOC PET/CT imaging revealed a solitary SSTR-expressing lesion. Fine-needle aspiration confirmed that the lesion was a metastasis from a previous clear cell renal cell carcinoma (ccRCC). This case highlights the importance of recognizing that RCC metastases can mimic well-differentiated neuroendocrine tumors in Ga-68-DOTATOC PET/CT.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Filippo Lococo, Vittoria Rufini, Angelina Filice, Massimiliano Paci, Guido Rindi
Summary: SFTPs are rare mesenchymal tumors with difficult preoperative diagnosis. Ga-68-DOTATOC PET/CT imaging can aid in diagnosing SFTP and potentially offer new treatment options in unresectable or metastatic disease.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
Sarah Boughdad, Sofiya Latifyan, Craig Fenwick, Hasna Bouchaab, Madeleine Suffiotti, Javid J. Moslehi, Joe-Elie Salem, Niklaus Schaefer, Marie Nicod-Lalonde, Julien Costes, Matthieu Perreau, Olivier Michielin, Solange Peters, John O. Prior, Michel Obeid
Summary: This study aimed to evaluate the value of Ga-68-DOTATOC PET/CT for the early detection and diagnosis of ICI-related myocarditis. The research found that Ga-68-DOTATOC PET/CT is a highly sensitive method that can effectively detect early myocardial inflammation, especially useful for patients with concomitant myositis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Peipei Wang, Shuai Liu, Xiaojie Li, Xing Liu, Shaowu Li, Zhen Wu, Xin Cheng
Summary: This study evaluated the diagnostic performance of [(68) Ga]Ga-DOTA-JR11 PET/CT in detecting meningiomas and found it to be superior in tumor uptake compared to other tumors. The study also found that [(68) Ga]Ga-DOTA-JR11 PET/CT had a higher diagnostic value in initial diagnosis. In specific cases, PET provided more accurate determination of pituitary involvement and bone involvement compared to MRI.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexis Slama, Benedikt M. Schaarschmidt, Oezlem Okumus, Ken Herrmann, Clemens Aigner, Stephane Collaud, Hubertus Hautzel
Summary: This experiment demonstrates the feasibility and benefits of using ILP combined with PET/CT imaging. The results show that ILP can preserve near physiologic gas exchange and glucose metabolism. The peripheral area of the carcinoid exhibits delayed but high somatostatin receptor agonist uptake compared to the surrounding parenchyma and the intrapulmonary artery, while the central area of the carcinoid shows very low uptake.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexis Slama, Benedikt M. Schaarschmidt, Oezlem Okumus, Ken Herrmann, Clemens Aigner, Stephane Collaud, Hubertus Hautzel
Summary: This experiment demonstrates the potential and benefits of using isolated lung perfusion (ILP) combined with positron emission tomography-computed tomography (PET/CT) imaging for real-time visualization of tumors in ventilated and perfused lung tissue. The experiment involved a 49-year-old male patient who underwent lung surgery, and the results showed that ILP combined with PET/CT imaging can provide important insights into tumor physiology and molecular imaging.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Oncology
Rexhep Durmo, Angelina Filice, Federica Fioroni, Veronica Cervati, Domenico Finocchiaro, Chiara Coruzzi, Giulia Besutti, Silvia Fanello, Andrea Frasoldati, Annibale Versari
Summary: This study aimed to identify biomarkers derived from 68Ga-DOTATOC PET/CT in patients undergoing PRRT. The results showed that high baseline total tumor volume (bTV) is a negative predictor for PRRT response and is associated with worse overall survival rates. Integrating bTV as an imaging biomarker in the initial assessment of NET patients could improve risk stratification and contribute to a tailored therapy approach.
Article
Oncology
Freba Grawe, Natalie Rosenberger, Maria Ingenerf, Leonie Beyer, Ralf Eschbach, Andrei Todica, Ricarda Seidensticker, Christine Schmid-Tannwald, Clemens C. Cyran, Jens Ricke, Peter Bartenstein, Christoph. J. Auernhammer, Johannes Ruebenthaler, Matthias P. Fabritius
Summary: This retrospective study aimed to compare the diagnostic accuracy of SSR-PET/CT and liver MRI in evaluating hepatic involvement in neuroendocrine tumors. The results showed that SSR-PET/CT has high sensitivity and specificity in identifying hepatic involvement, but potential pitfalls should be considered when evaluating neuroendocrine liver metastases using a single imaging method.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Wei Liu, Xiao Yang, Liming Chen, Yue Chen, Tingting Xu
Summary: A 28-year-old woman presented with a 2-month history of chest wall swelling and pain. Chest CT revealed an irregular soft tissue mass in the chest wall and mediastinum. F-18-FDG PET/CT showed significant FDG uptake in the mass. Subsequently, the patient participated in a Ga-68-DOTA-FAPI-04 PET/CT tumor clinical trial, which also showed elevated tracer uptake in the mass. Biopsy confirmed a diagnosis of myeloid sarcoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Capucine Richard, Jerome Cros, Romain-David Seban, Laurence Champion, Segolene Hescot
Summary: A 73-year-old woman with a grade 2 pancreatic neuroendocrine tumor underwent Ga-68-DOTATOC PET/CT staging, revealing primary pancreatic tumor, liver and pleural metastases, and high uptake in a triceps muscle mass. Previous F-18-FDG PET/CT and In-111-pentetreotide scans showed low and high uptake in the triceps mass, respectively. The histopathological analysis identified a solitary fibrous tumor with no staining for SSTR-2 and SSTR-5, indicating overexpression of another somatostatin receptor. This case highlights a potential pitfall in Ga-68-DOTATOC PET/CT.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Hiba Jawlakh, Irina Velikyan, Staffan Welin, Anders Sundin
Summary: This study compared multiple imaging technologies for neuroendocrine tumor imaging. The combination of Ga-68-DOTATOC-PET/MRI and C-11-5-HTP-PET/MRI showed higher detection rates and reader's confidence compared to Ga-68-DOTATOC-PET/CT. MRI alone was the best for liver metastasis imaging, while contrast-enhanced Ga-68-DOTATOC-PET/MRI and C-11-5-HTP-PET/MRI outperformed PET/CT.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Oncology
Stefan Prado-Wohlwend, Monica Ballesta-Moratalla, Irene Torres-Espallardo, Maria Isabel del Olmo-Garcia, Pilar Bello-Arques, Consuelo Olivas-Arroyo, Juan Francisco Merino-Torres
Summary: The aim of this study was to validate the diagnostic performance of [(68) Ga]Ga-DOTA-TOC PET/MRI compared to PET/CT in advanced disease paragangliomas and pheochromocytomas (PGGLs) and to assess in which clinical settings PET/MRI may have a greater diagnostic yield. The results showed that PET/MRI had a higher diagnostic accuracy than PET/CT in bone and liver locations, with an increase of 14.6%. PET/MRI also revealed a higher overall lesion uptake and an upward elevation of the Krenning Score in a significant number of patients. PET/MRI modified clinical management in 12% of patients.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Anne-Claire Dupont, Fanny Borrelly, Thierry Lecomte, Serge Maia, Maria-Joao Santiago Ribeiro
Summary: In this case, Ga-68-DOTATOC PET/CT imaging revealed abnormal biodistribution of the tracer with vascular binding and very low fixation on known lesions, possibly due to a high intake of turmeric inhibiting hepatic uptake process.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
M. P. Fabritius, V. Soltani, C. C. Cyran, J. Ricke, P. Bartenstein, C. J. Auernhammer, C. Spitzweg, M. L. Schnitzer, R. Ebner, S. Mansournia, A. Hinterberger, A. Lohse, G. T. Sheikh, M. Winkelmann, T. Knoesel, M. Ingenerf, C. Schmid-Tannwald, W. G. Kunz, J. Ruebenthaler, Freba Grawe
Summary: SSR-PET/CT is a highly accurate imaging modality for diagnosing liver metastases in patients with proven NETs. However, around 4-5% of NETs, particularly in G2 NETs, are SSR-negative and may require additional imaging with [18F]FDG PET/CT due to tumor heterogeneity.