Journal
EUROPEAN POLYMER JOURNAL
Volume 87, Issue -, Pages 478-486Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2016.08.023
Keywords
PIC particles; Polyelectrolyte complexes; Antimicrobials; Drug delivery
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Funding
- University of Birmingham
- Wellcome Trust [177ISSFPP]
- Engineering and Physical Sciences Research Council (EPSRC) [EP/N508755/1]
- John Evans Fellowship
- Centre for Chemical and Materials Analysis in the School of Chemistry at the University of Birmingham
- Advantage West Midlands (AWM)
- European Regional Development fund (ERDF)
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Here, we describe novel polyion complex (PIC) particles for the delivery of Polymyxin B (Pol-B), an antimicrobial peptide currently used in the clinic as a last resort antibiotic against multidrug-resistant gram-negative bacteria. A range of conditions for the controlled assembly of Pol-B with poly(styrene sulphonate) (PSS) has been identified which let us prepare stable colloidal PIC particles. This way, PIC particles containing different Pol-B:PSS ratios have been prepared and their stability under simulated physiological conditions (Le. pH, osmotic pressure and temperature) characterised. Furthermore, preliminary evaluation of the antimicrobial activity of these Pol-B containing PIC particles has been performed, by monitoring their effect on the growth of Pseudomonas aeruginosa, an opportunistic gram-negative bacterium. (C) 2016 The Authors. Published by Elsevier Ltd.
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