Article
Veterinary Sciences
Kaiqiang Fu, Hao Chen, Zezhi Wang, Rongfeng Cao
Summary: Andrographolide exhibits significant anti-inflammatory effects in the LPS-induced inflammatory response of bEECs by reducing the production of inflammatory factors through the activation of Nrf2.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Immunology
Luying Cui, Jing Guo, Zhihao Wang, Jiaqi Zhang, Wenjie Li, Junsheng Dong, Kangjun Liu, Long Guo, Jun Li, Heng Wang, Jianji Li
Summary: Meloxicam has anti-inflammatory and antioxidant effects on uterine inflammation and oxidative stress in dairy cows.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Haranatha R. Potteti, Lalith K. Venkareddy, Patrick M. Noone, Aparna Ankireddy, Chandramohan R. Tamatam, Dolly Mehta, Chinnaswamy Tiruppathi, Sekhar P. Reddy
Summary: This study demonstrates the crucial role of Nrf2 in optimal A20 transcriptional induction in macrophages in response to endotoxin, and shows that this regulation occurs in a contextual manner.
Article
Immunology
Lu Wang, Xiaohui Wang, Lina Kong, Shuyuan Wang, Kai Huang, Jingjing Wu, Changyuan Wang, Huijun Sun, Kexin Liu, Qiang Meng
Summary: Isoliquiritigenin (ISL) improves acute liver failure by ameliorating liver histopathological changes, enhancing anti-oxidative stress ability, reducing inflammation, apoptosis, and inhibiting NLRP3 inflammasome through activating the PGC-1 alpha/Nrf2 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Fang -Fang Guo, Fan -Ge Meng, Xiu-Ning Zhang, Tao Zeng
Summary: The study found that spermidine can suppress the activation of macrophages induced by LPS, possibly by activating Nrf-2 in macrophages. In addition, spermidine also blunted LPS-induced proinflammatory response.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Cell Biology
Yuling Feng, Ramesh Bhandari, Chunmeng Li, Pengfei Shu, Imran Ibrahim Shaikh
Summary: The study reveals the potential beneficial effects of pectolinarigenin (PEC) in macrophage cells and DSS-induced colitis model. PEC pretreatment inhibits NF-kappa B activation and increases Nrf2 protein expression. Moreover, PEC regulates the NF-kappa B/Nrf2 pathway, reducing inflammation and pathological damages in the colon. PEC may be a promising therapeutic agent for the treatment of inflammatory bowel disease.
Article
Biochemistry & Molecular Biology
Tao Qin, Danni Feng, Bangyue Zhou, Lirong Bai, Yinyan Yin
Summary: Melatonin, a natural compound with powerful antioxidant and anti-inflammatory properties, was found to suppress oxidative stress in dendritic cells (DCs) in an acute lung injury (ALI) model. The inhibition of oxidative stress was achieved through the regulation of antioxidant enzymes and the Nrf2/HO-1 axis. These findings suggest that melatonin could be a promising strategy for ALI treatment.
Article
Biochemistry & Molecular Biology
Ji Cao, Qian Li, Xuehuai Shen, Yao Yao, Longlong Li, Haitian Ma
Summary: DHEA suppresses inflammatory responses through the activation of Nrf2 and inhibition of NF-kappa B in LPS-stimulated macrophages.
MOLECULAR IMMUNOLOGY
(2021)
Article
Environmental Sciences
Upkardeep Pandher, Shelley Kirychuk, David Schneberger, Brooke Thompson, Gurpreet Aulakh, R. S. Sethi, Baljit Singh
Summary: The combined exposure of LPS and glyphosate resulted in more severe inflammatory responses in the respiratory system of mice compared to individual exposure, but the inflammation decreased after 10 days, with leukocyte infiltration persisting. Glyphosate exposure modified LPS-induced inflammatory responses, and TLR-2 might play a crucial role in modulating the inflammatory response.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sara Salman, Cyprien Guermonprez, Laurent Peno-Mazzarino, Elian Lati, Audrey Rousseaud, Lieve Declercq, Saadia Kerdine-Romer
Summary: Photobiomodulation (PBM) is a valuable tool in dermatology for treating inflammatory skin conditions using low levels of light, but the physiological pathways responsible for its anti-inflammatory effect have not been well defined. This study found that PBM activated the Nrf2 pathway to control inflammation and played a key role in reducing inflammatory response. The findings support the role of PBM in skin immunomodulation and suggest it as a promising alternative or complementary therapeutic approach for skin-related inflammatory diseases.
Article
Nutrition & Dietetics
Gabriele Serreli, Micaela Rita Naitza, Sonia Zodio, Vera Piera Leoni, Martina Spada, Maria Paola Melis, Anna Boronat, Monica Deiana
Summary: Ferulic acid and its metabolites show efficacy in combating inflammation by limiting the expression and activity of proinflammatory enzymes, reducing NF-κB translocation, and promoting Nrf2 expression.
Article
Immunology
Yanhao He, Guangde Yang, Lijing Sun, Hongqian Gao, Feng Yao, Zhen Jin, Zihan Zheng, Lifang Chen, Weirong Wang, Nanbo Zheng, Rong Lin
Summary: SIRT6 protects against vascular inflammation through its deacetylase activity and the NRF2-dependent signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Neurosciences
Mohamed H. Yousef, Mohamed Salama, Hassan A. N. El-Fawal, Anwar Abdelnaser
Summary: This study aims to explore the therapeutic utility of GSK3 inhibition in multimodal disease modification and emphasizes the difference in therapeutic value between selective isoform inhibition. The results reveal that GSK3 beta-selective inhibition has superior anti-inflammatory and anti-oxidative efficacy compared to GSK3 alpha-selective and non-selective pan-inhibition.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Yongjie Cai, Ruiqing Yu, Yiping Kong, Zhihui Feng, Qiong Xu
Summary: This study found that METTL3 depletion increases the expression of proinflammatory cytokines in macrophages and promotes LPS-induced inflammatory response. This effect may be achieved by increasing the expression and stability of the NOD1 pathway, which is regulated by YTHDF1 and YTHDF2.
CELLULAR SIGNALLING
(2022)
Article
Chemistry, Medicinal
Eui-Jeong Han, Thilina U. Jayawardena, Jae-Hyuk Jang, Ilekuttige Priyan Shanura Fernando, Youngheun Jee, You-Jin Jeon, Dae-Sung Lee, Jeong-Min Lee, Mi-Jin Yim, Lei Wang, Hyun-Soo Kim, Ginnae Ahn
Summary: The study isolated sargachromenol (SC) from Sargassum horneri and demonstrated its anti-inflammatory effect on LPS-stimulated RAW 264.7 macrophages. SC increased cell viability by reducing NO and ROS production, decreased inflammatory cytokines and mediators, suppressed NF kappa B and MAPK signaling, and activated Nrf2/HO-1 signaling. The antioxidant capacity of SC contributes to its anti-inflammatory effect, suggesting its potential application in nutraceutical and pharmaceutical sectors.
