Article
Medicine, General & Internal
Natalie K. Binder, Teresa M. MacDonald, Sally A. Beard, Natasha de Alwis, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino, Natalie J. Hannan
Summary: Research suggests that beta-blockers can promote the expression of pro-angiogenic factors, reduce secretion of anti-angiogenic factors, decrease inflammation markers, alleviate endothelial dysfunction, and contribute to cytoprotective effects in endothelial cells.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Aida Collado, Elena Domingo, Laura Piqueras, Maria-Jesus Sanz
Summary: Primary hypercholesterolemia is associated with cardiovascular diseases, mainly due to low-density lipoproteins and low-grade systemic inflammation leading to arteriosclerosis. Studying cellular and molecular mechanisms can provide insights into these processes and guide novel therapeutic strategies.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jean Michell Santoyo, Jose Antonio Noguera, Francisco Aviles, Trinidad Hernandez-Caselles, Catalina de Paco-Matallana, Juan Luis Delgado, Santiago Cuevas, M. Teresa Llinas, Isabel Hernandez
Summary: This study aimed to assess the effects of pravastatin on the generation of circulating extracellular vesicles in women at high risk of term preeclampsia. The results showed that pravastatin can reduce the levels of cell-derived membrane vesicles in the circulation of high-risk preeclampsia patients, which may help reduce the characteristics of endothelial dysfunction, inflammation, and other features of the disease.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Michael Poledniczek, Christoph Neumayer, Christoph W. Kopp, Oliver Schlager, Thomas Gremmel, Alicja Jozkowicz, Michael E. Gschwandtner, Renate Koppensteiner, Patricia P. Wadowski
Summary: Inflammation plays a crucial role in the development and progression of atherosclerosis. It negatively affects endothelial barrier properties, glycocalyx, and extracellular matrix composition, leading to vascular remodeling, aneurysm formation, and reduced tissue perfusion. This review discusses the molecular and clinical effects of inflammatory processes on micro- and macrovasculature, with a focus on peripheral artery disease.
Review
Physiology
Ryan Chang, Abrar Mamun, Abishai Dominic, Nhat-Tu Le
Summary: Endothelial cells play a crucial role in SARS-CoV-2 infection and COVID-19 inflammatory pathologies, with dysfunctional endothelial cells contributing to chronic inflammation and diseases like thrombosis and atherosclerosis. Mitochondria in endothelial cells regulate inflammatory pathways through mtROS, which can lead to oxidative stress, senescence, and chronic endothelial dysfunction. This review discusses how SARS-CoV-2 may induce long-term changes in host redox status and endothelial function through mtROS-mediated feedback loops, potentially promoting cardiovascular disease and lung injury post COVID-19 recovery.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Xiaoxuan Ma, Meiming Su, Qingze He, Zhidan Zhang, Fanshun Zhang, Zhenghong Liu, Lu Sun, Jianping Weng, Suowen Xu
Summary: By analyzing human plaque tissue data and conducting experiments on mice, this study identifies PHACTR1 as being associated with endothelial dysfunction, which it regulates through inflammation response and NO production, and finds that its expression can be reduced by certain drugs.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Alexandra A. Melnichenko, Victoria A. Khotina, Alexander N. Orekhov
Summary: Selenium is a vital trace element necessary for metabolic processes, protection against oxidative stress, and cardiovascular system functioning. Deficiency in selenium has been linked to various cardiovascular diseases including Keshan's disease, heart failure, coronary heart disease, myocardial infarction, and atherosclerosis. Through selenoenzymes and selenoproteins, selenium is involved in important processes such as regulation of redox homeostasis, oxidative stress, calcium flux, and thyroid hormone metabolism; an imbalance in selenium supply may disrupt these processes.
Review
Cardiac & Cardiovascular Systems
Yan-li Zheng, Wan-da Wang, Mei-mei Li, Shu Lin, Hui-li Lin
Summary: Cardiovascular disease is the leading cause of death globally, with nicotine-induced endothelial dysfunction playing a significant role in the development of arteriosclerotic cardiovascular disease. Nicotine promotes pathological processes such as oxidative inflammation and thrombosis, and increases the expression of NPY, indicating NPY involvement in nicotine-induced endothelial dysfunction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Spyridon Simantiris, Alexios S. Antonopoulos, Charalampos Papastamos, Georgios Benetos, Nikolaos Koumallos, Konstantinos Tsioufis, Dimitris Tousoulis
Summary: The role of lipoprotein(a) (Lp[a]) as a significant and possibly causal cardiovascular disease (CVD) risk factor has been well established. Many studies have supported inflammation as a mediator of Lp(a)-induced increase in CVD risk. The relationship between Lp(a) and inflammation is bidirectional as Lp(a) levels are regulated by inflammatory stimuli or anti-inflammatory treatment, and reduction of Lp(a) concentration contributes to partial reversion of the Lp(a) related inflammatory profile.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhuqing Li, Qi Li, Li Wang, Chao Li, Mengping Xu, Yajun Duan, Likun Ma, Tingting Li, Qiao Chen, Yilin Wang, Yanxin Wang, Jiaxin Feng, Xuemei Yin, Xiaolin Wang, Jihong Han, Chengzhi Lu
Summary: Chronic sympathetic hyperactivity can lead to oxidative stress and inflammation in endothelial cells, contributing to atherosclerosis development. Renal denervation (RDN) may protect endothelial cells by reducing oxidative stress-induced inflammation, thus reducing atherosclerosis.
Article
Biochemistry & Molecular Biology
Luna Jimenez-Castilla, Lucas Opazo-Rios, Gema Marin-Royo, Macarena Orejudo, Raquel Rodrigues-Diez, Constanza Ballesteros-Martinez, Manuel Soto-Catalan, Teresa Caro-Ordieres, Ines Artaiz, Tatiana Suarez-Cortes, Arturo Zazpe, Gonzalo Hernandez, Marcelino Cortes, Jose Tunon, Ana M. Briones, Jesus Egido, Carmen Gomez-Guerrero
Summary: This study investigates the vasculoprotective effects of the synthetic flavonoid hidrosmin on endothelial dysfunction and atherogenesis in two mouse models of diabetes. The results suggest that hidrosmin can improve vascular function, reduce atherosclerotic plaque size and lipid content, and decrease inflammation and oxidative stress.
Review
Biochemistry & Molecular Biology
Aleksandra Klisic, Dimitrios Patoulias
Summary: Discovered twenty years ago, endocan is still an intriguing biomarker associated with inflammation. It is a soluble dermatan sulphate proteoglycan secreted by endothelial cells and expressed in tissues related to enhanced proliferation. Endocan has been extensively studied in various cardiometabolic disorders, such as type 2 diabetes, hypertension, atherosclerosis, kidney disease, obesity, polycystic ovary syndrome, metabolic syndrome, and fatty liver disease. Understanding the role of endocan in these disorders is important for developing potential therapeutic strategies to delay or prevent related complications.
Article
Biochemistry & Molecular Biology
Sandra Sanchez-Esteban, Mercedes Castro-Pinto, Alberto Cook-Calvete, Paula Reventun, Maria Delgado-Marin, Lucia Benito-Manzanaro, Ignacio Hernandez, Jose Lopez-Menendez, Jose Luis Zamorano, Carlos Zaragoza, Marta Saura
Summary: Calcific aortic valve disease (CAVD) is a common age-related disease. This study found that the expression of integrin-linked kinase (ILK) is downregulated in CAVD patients' aortic valves and is negatively correlated with valve calcification markers. Silencing ILK expression in valve endothelial cells promoted endothelial-to-mesenchymal transition (EndMT) and osteoblastic phenotype switch. Nitric oxide (NO) treatment prevented VEC transdifferentiation and calcification, suggesting the involvement of the ILK-eNOS signaling pathway in valve calcification.
Article
Endocrinology & Metabolism
Hiroko Oda, Takeshi Nagamatsu, Danny J. Schust, Horacio Cabral, Takuya Miyazaki, Takayuki Iriyama, Kei Kawana, Yutaka Osuga, Tomoyuki Fujii
Summary: The novel anticoagulant rTM has shown promising therapeutic potential for treating preeclampsia by inhibiting HMGB1-mediated pathways and ameliorating factors that induce systemic endothelial dysfunction, as confirmed in in vivo and in vitro experiments.
Review
Physiology
Mei Li, Hongmin Wang, Xiao-Jing Zhang, Jingjing Cai, Hongliang Li
Summary: This review summarizes the potential causal relationship between NAFLD and CVD, highlighting the evidence from prospective clinical and Mendelian randomization studies. The mechanisms of NAFLD contributing to the development of CVD and the necessity of addressing CVD risk while managing NAFLD in clinical practice are also discussed.
Article
Peripheral Vascular Disease
Kondababu Kurakula, Quint A. J. Hagdorn, Diederik E. van der Feen, Anton Vonk Noordegraaf, Peter ten Dijke, Rudolf A. de Boer, Harm Jan Bogaard, Marie Jose Goumans, Rolf M. F. Berger
Summary: Pulmonary arterial hypertension (PAH) is a devastating disease characterized by obstructive pulmonary vascular remodeling. Targeting Pin1 could potentially reverse the phenotype of PAH through modulation of TGF-beta/BMP signaling pathways, providing a novel therapeutic option for PAH treatment.
Article
Cardiac & Cardiovascular Systems
Jessie van Wezenbeek, Azar Kianzad, Arno van de Bovenkamp, Jeroen Wessels, Sophia A. Mouratoglou, Natalia J. Braams, Samara M. A. Jansen, Eva Meulblok, Lilian J. Meijboom, J. Tim Marcus, Anton Vonk Noordegraaf, Marie Jose Goumans, Harm Jan Bogaard, M. Louis Handoko, Frances S. de Man
Summary: This study compared cardiac function in HFpEF, HFpEF-PH, and PAH patients and found that despite similar pressure overload, RV/RA function was less compromised in HFpEF-PH compared to PAH. The increased RA pressure and stiffness in HFpEF-PH were explained by left atrial/RA interaction.
CIRCULATION-HEART FAILURE
(2022)
Article
Engineering, Biomedical
Niels Harlaar, Sven O. Dekker, Juan Zhang, Rebecca R. Snabel, Marieke W. Veldkamp, Arie O. Verkerk, Carla Cofino Fabres, Verena Schwach, Lente J. S. Lerink, Mathilde R. Rivaud, Aat A. Mulder, Willem E. Corver, Marie Jose T. H. Goumans, Dobromir Dobrev, Robert J. M. Klautz, Martin J. Schalij, Gert Jan C. Veenstra, Robert Passier, Thomas J. van Brakel, Daniel A. Pijnappels, Antoine A. F. de Vries
Summary: Functional human atrial myocytes can be massively expanded via a conditional cell-immortalization method, and used in in vitro models of atrial fibrillation. This study successfully generated immortalized cell lines with properties resembling primary atrial myocytes, and used them to create in vitro models of atrial fibrillation, displaying fibrillatory activity consistent with clinical manifestations and responding to antiarrhythmic drugs.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Cardiac & Cardiovascular Systems
Alwin de Jong, Vincent Q. Sier, Hendrika A. B. Peters, Natalia K. M. Schilder, J. Wouter Jukema, Marie Jose T. H. Goumans, Paul H. A. Quax, Margreet R. de Vries
Summary: This study investigated the role of ALK1 signaling in vein graft disease, revealing that reduced ALK1 signaling promotes outward remodeling, increases macrophage influx, and promotes an unstable plaque phenotype in murine vein grafts.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Obstetrics & Gynecology
Marlise N. Gunning, Jacob P. Christ, Bas B. van Rijn, Maria P. H. Koster, Gouke J. Bonsel, Joop S. E. Laven, Marinus J. C. Eijkemans, Bart C. J. M. Fauser
Summary: This prospective cohort follow-up study aimed to identify patient features that predict the time to pregnancy leading to term live birth in infertile women diagnosed with polycystic ovary syndrome (PCOS). The results showed that race, smoking, BMI, insulin, total testosterone, and SHBG concentrations were associated with the chance of pregnancy.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Cardiac & Cardiovascular Systems
Carolina C. V. Silva, Susana Santos, Ryan L. Muetzel, Meike W. Vernooij, Bas B. van Rijn, Vincent W. V. Jaddoe, Hanan El Marroun
Summary: The study found that poor maternal cardiovascular health during pregnancy may impact offspring brain development in the long term, with higher maternal diastolic blood pressure in early pregnancy associated with lower offspring white matter mean diffusivity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Genetics & Heredity
Ilse Luyckx, Aline Verstraeten, Marie-Jose Goumans, Bart Loeys
Summary: This article reviews the clinical and genetic similarities of three diseases related to SMAD6, compares mouse models, and discusses the cellular mechanisms of SMAD6 in the development of these diseases. The importance of further research to improve molecular diagnosis, advance therapeutic strategies, and provide counseling for patients and their families is also emphasized.
NPJ GENOMIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sophia M. M. Blaauwendraad, Rama J. J. Wahab, Bas B. B. van Rijn, Berthold Koletzko, Vincent W. V. Jaddoe, Romy Gaillard
Summary: Blood pressure development plays a major role in gestational hypertensive disorders. Metabolomics can identify the underlying metabolic mechanisms and predict gestational hypertensive disorders. Altered early pregnancy serum metabolite profiles, mainly characterized by changes in non-esterified fatty acids and phospholipids, are associated with higher gestational blood pressure throughout pregnancy.
Article
Engineering, Biomedical
Dylan Mostert, Bart Groenen, Leda Klouda, Robert Passier, Marie-Jose Goumans, Nicholas A. A. Kurniawan, Carlijn V. C. Bouten
Summary: In this study, the effect of ECM (dis)organization and cyclic strain on cardiomyocytes and cardiac fibroblasts (cFBs) was investigated in a two-dimensional human in vitro co-culture model of the myocardial microenvironment. The results showed that ECM protein patterning can guide cell orientation, and cFBs exhibit strain avoidance. However, cardiomyocytes only show strain avoidance when co-cultured with at least 30% cFBs via active remodeling of their sarcomeres.
APL BIOENGINEERING
(2022)
Article
Medicine, General & Internal
Camille Souama, Femke Lamers, Yuri Milaneschi, Christiaan H. H. Vinkers, Serena Defina, Linda Garvert, Frederike Stein, Tom Woofenden, Katharina Brosch, Udo Dannlowski, Henrike Galenkamp, Ron de Graaf, Vincent W. V. Jaddoe, Anja Lok, Bas B. B. van Rijn, Henry Volzke, Charlotte A. M. Cecil, Janine F. F. Felix, Hans J. J. Grabe, Tilo Kircher, Karim Lekadir, Margreet ten Have, Esther Walton, Brenda W. J. H. Penninx
Summary: Childhood maltreatment is associated with depression, cardiometabolic disease, and their comorbidity in adulthood. A meta-analysis of 13 international observational studies found that adults with a history of childhood maltreatment have higher odds of depression, cardiometabolic disease, and comorbidity between both conditions. The associations remained significant after adjusting for lifestyle factors.
Article
Cardiac & Cardiovascular Systems
Michelle Spek, Roderick P. Venekamp, Daphne C. A. Erkelens, Maarten van Smeden, Loes T. C. M. Wouters, Hester M. den Ruijter, Frans H. Rutten, Dorien L. Zwart
Summary: Patients with chest discomfort and shortness of breath (SOB) who contact the out-of-hours primary care (OHS-PC) more often receive high urgency allocation, but this association is less significant in men when considering the risk of ACS or other life-threatening diseases.
Article
Engineering, Biomedical
Tom C. L. Bracco Gartner, Ye Wang, Laurynas Leiteris, Iris van Adrichem, Judith Marsman, Marie Jose Goumans, Carlijn V. C. Bouten, Joost P. G. Sluijter, Jaap M. J. den Toonder, Willem J. L. Suyker, Jesper Hjortnaes
Summary: Cardiac fibroblasts in the ever-beating human heart remain quiescent due to the antifibrotic effect of cyclic strain conditions revealed by a novel platform for studying cardiac fibrosis-on-a-chip. This study provides insights into the mechanosensitive pathways and genes involved in the fibrogenic process, which can contribute to the development of new therapies against cardiac fibrosis.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Jens Van Bael, Aline Vandenbulcke, Abdelhakim Ahmed-Belkacem, Jean-Francois Guichou, Jean-Michel Pawlotsky, Jelle Samyn, Arjan D. Barendrecht, Coen Maas, Simon F. De Meyer, Karen Vanhoorelbeke, Claudia Tersteeg
Summary: Inhibiting CypD activity with novel non-immunosuppressive cyclophilin inhibitors (SMCypIs) can effectively reduce procoagulant platelet formation and provide a promising strategy for limiting thrombosis without affecting normal platelet function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Obstetrics & Gynecology
Olivier Schaffers, Catherine Dupont, Diane Van Opstal, Maarten Knapen, Eric Bindels, Joost Gribnau, Bas van Rijn
REPRODUCTIVE SCIENCES
(2022)
Meeting Abstract
Obstetrics & Gynecology
Jasmijn L. Y. Y. Tam, Samuel Ghatan, Fernando Rivadeneira, Jeanine E. Roeters van Lennep, Bas B. van Rijn
REPRODUCTIVE SCIENCES
(2022)