Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2017, Issue 32, Pages 4753-4757Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201700794
Keywords
C-H activation; Amination; Regioselectivity; Azodicarboxylates; Fluorine
Categories
Funding
- Chinese Scholarship Council
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An effective, mild, and clean method for the C-H amination of free anilines with azodicarboxylates in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) without the need for any additional catalysts or reagents was developed. The reaction was found to be highly regioselective and provided a series of p-aminophenylhydrazine derivatives in excellent yields. Moreover, compatibility with a free amino group makes this protocol an attractive strategy in synthetic chemistry.
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