Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2017, Issue 34, Pages 5131-5134Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201701094
Keywords
1-Aryl-3; 4-dihydroisoquinolines; Asymmetric synthesis; Hydrogenation; Iridium; Phosphoric acid
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Funding
- Czech Science Foundation [GA15-08992S]
- MSMT [20-SVV/2017]
- Operational Programme Prague - Competitiveness [CZ.2.16/3.1.00/24501]
- National Program of Sustainability [NPU I LO1613, MSMT-43760/2015]
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We report herein a simple alternative method for the asymmetric transfer hydrogenation (ATH) of 1-aryl-3,4-dihydroisoquinolines (1-Ar-DHIQs) that are known to be challenging substrates owing to their poor reactivity. The hydrogenation protocol employs the readily available Cp*Ir(TsDPEN) {where Cp* = pentamethylcyclopentadienyl and TsDPEN = (S,S)-HNCHPhCHPhNTs2-} catalytic complex, 2-propanol and HCOOH/triethylamine mixture as the solvent and hydrogen donor, and anhydrous phosphoric acid as an inexpensive additive. The series of examined substrates shows a favorable tolerance to various functional groups. Unlike 1-alkyl-DHIQs, where the enantiomeric excess (ee) starkly changes during the course of hydrogenation, 1-Ar-DHIQs exhibit a constant ee value, which makes the method practical and useful for the production of fine chemicals containing the 1,2,3,4-tetrahydroisoquinoline motif.
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