Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2017, Issue 32, Pages 4859-4863Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201700791
Keywords
Palladium; Asymmetric catalysis; Carbonylation; Hydroesterification; Hydroxycarbonylation
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Funding
- Engineering and Physical Sciences Research Council (EPSRC) [EP/MC038868/1]
- Doctoral Training Grant (DTG)
- EPSRC [EP/M003868/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/M003868/1, 1398296] Funding Source: researchfish
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A highly enantioselective synthesis of (S)-flurbiprofen methyl ester in two steps from commercially available 4-bromo-2-fluoro-1,1-biphenyl is shown. [PdCl2((S)-xylyl-phanephos)] catalyst is used to accomplish both Grignard cross-coupling and the highly enantioselective intermolecular methoxycarbonylation reaction.
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