Article
Medicine, General & Internal
Nobuhiko Nagano, Daichi Katayama, Koichiro Hara, Yuki Sato, Satomi Tanabe, Masako Aoki, Ryoji Aoki, Ichiro Morioka
Summary: This study aimed to establish percentile-based reference values of umbilical cord blood IGF-1 levels in Japanese newborns. The results showed that extremely preterm newborns had significantly lower IGF-1 levels compared to other groups, and SGA newborns had lower IGF-1 levels than non-SGA newborns.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Benjamin S. Harris, Anne Z. Steiner, Anne Marie Jukic
Summary: This study investigated the association between biomarkers of ovarian reserve and menstrual cycle length, indicating that higher AMH levels are associated with longer menstrual cycles, independent of age.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Benjamin S. Harris, Anne Z. Steiner, Anne Marie Jukic
Summary: This study analyzed data from 632 women aged 30-44 without infertility history who were attempting to conceive for less than 3 months, and found that increasing AMH levels were associated with longer menstrual cycle lengths.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Obstetrics & Gynecology
Scott M. Nelson, Benjamin J. Ewing, Piotr S. Gromski, Sharon F. Briggs
Summary: This study aimed to compare the effects of different contraceptive methods on the levels of anti-Müllerian hormone (AMH) in reproductive-age women. The study found that different contraceptive methods have varying effects on AMH, with the greatest impact occurring at lower percentiles. However, these differences in contraceptive methods are small compared to the biological variability in ovarian reserve.
FERTILITY AND STERILITY
(2023)
Article
Endocrinology & Metabolism
Yong Han, Huiyu Xu, Guoshuang Feng, Haiyan Wang, Kannan Alpadi, Lixue Chen, Mengqian Zhang, Rong Li
Summary: This study established a model for predicting ovarian reserve using AMH level and age, and demonstrated its effectiveness in predicting poor ovarian response based on external validation data.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Xiangyun Zong, Yang Yu, Wenhu Chen, Weiwei Zong, Hongjian Yang, Xuan Chen
Summary: This study analyzed the changes in anti-Mullerian hormone (AMH) levels and the factors influencing ovarian function in breast cancer patients before and after chemotherapy. The results showed that age, menarche age, baseline AMH level, and GnRHa application are the most important independent factors for the protection and recovery of ovarian reserve in premenopausal women with breast cancer.
Article
Obstetrics & Gynecology
A. La Marca, V Donno, M. Longo, P. Greco, F. Cucinelli, M. T. Varricchio, I Listorti, E. Greco
Summary: This study investigates whether anti-Mullerian hormone (AMH) can predict the number of retrieved oocytes during double stimulation (DuoStim). The results show that serum AMH values can be used as a clinical tool to predict ovarian response in IVF cycles following DuoStim. This is beneficial for patients with poor ovarian response and those undergoing medical fertility preservation.
HUMAN REPRODUCTION
(2023)
Article
Oncology
Ya Xie, Haoran Duan, Dong Wang, Huiqing Li, Jia Jia, Jialin Zhang, Linlin Li
Summary: GnRH agonist co-therapy is effective in preserving ovarian function during platinum-based chemotherapy in patients with ovarian malignancy, reducing the risk of low AMH levels post-chemotherapy and improving menstrual resumption and quality of life. It provides a therapeutic reference for gynecologists, especially in economically and medically underdeveloped areas.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Dodi Suardi, Wiryawan Permadi, Tono Djuwantono, Yudi Mulyana Hidayat, Hartanto Bayuaji, Gusti Putu Edo Gautama
Summary: This study found a significant correlation between serum AMH levels and endometrioma, with levels being lower in the endometrioma group. There was a negative correlation between serum AMH levels and ovarian volume containing endometrioma, although it was not statistically significant.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Review
Obstetrics & Gynecology
Richard A. Anderson, David Cameron, Florian Clatot, Isabelle Demeestere, Matteo Lambertini, Scott M. Nelson, Fedro Peccatori
Summary: Female patients undergoing anticancer treatment are at risk of adverse ovarian outcomes, and AMH can be used as a biomarker to assess ovarian reserve and POI. Chemotherapy or radiotherapy consistently led to reduced/undetectable AMH levels, but partial recovery was observed during follow-up. Oligo/amenorrhea was associated with post-treatment AMH decline, suggesting impending POI. Long-term follow-up of pediatric patients showed significantly lower AMH levels compared to control groups. AMH can identify the damaging effect of cancer treatments on ovarian function, but further studies are needed to determine its diagnostic and predictive value.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Biochemistry & Molecular Biology
Giorgio Maria Baldini, Assunta Catino, Simone Palini, Romualdo Sciorio, Daniele Ferri, Marina Vinciguerra, Domenico Baldini
Summary: This study investigates the possible reasons for a lower than predicted number of cumulus oocyte complexes collected after controlled ovarian stimulation. The study suggests that a single-nucleotide polymorphism (SNP) in the FSH receptor (FSHr), specifically c.2039A > G, resulting in Asn680Ser, may be associated with this deficient ovarian response. The genetic assessment of the FSHr could potentially be used as an accurate and predictive feature for patients undergoing assisted reproductive technology treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Arthur Gavotto, Thibault Mura, Jonathan Rhodes, Suellen Moli Yin, Alfred Hager, Julia Hock, Sophie Guillaumont, Marie Vincenti, Gregoire De La Villeon, Anne Requirand, Marie-Christine Picot, Helena Huguet, Luc Souilla, Johan Moreau, Stefan Matecki, Pascal Amedro
Summary: This study aimed to establish reference Z-score values for paediatric cycloergometer VO2max, applicable to normal and extreme weights, using a logarithmic function of VO2max, height, and BMI. The study found that the mathematical model using natural logarithms of VO2max, height, and BMI was the best fit for the data and more reliable than the existing linear equations.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Geriatrics & Gerontology
Renee M. G. Verdiesen, N. Charlotte Onland-Moret, Carla H. van Gils, Yvonne T. van der Schouw
Summary: Recent research suggests that higher circulating AMH levels in men are associated with lower carotid intima-media thickness (CIMT) and mean carotid aortic plaque burden, indicating a potential link between AMH and local atherosclerosis.
Article
Endocrinology & Metabolism
Laura Melado, Raquel Vitorino, Carol Coughlan, Leyla Depret Bixio, Ana Arnanz, Ibrahim Elkhatib, Neelke De Munck, Human M. Fatemi, Barbara Lawrenz
Summary: This study aimed to describe age-specific serum AMH and AFC values for women native to the Arabian Peninsula. The results showed that AMH and AFC were significantly associated with age, as well as with different styles of head covering among women on the Arabian Peninsula.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Casper P. P. Hagen, Margit Bistrup Fischer, Gylli Mola, Theis Bech Mikkelsen, Line Hartvig Cleemann, Claus Hojbjerg Gravholt, Mette H. H. Viuff, Anders Juul, Anette Tonnes Pedersen, Katharina Maria Main
Summary: Turner syndrome (TS) is a chromosomal disorder characterized by the absence of the second X chromosome, affecting about 1 in 2500 female births. TS is associated with primary ovarian insufficiency (POI), with only a small percentage of women achieving pregnancy without egg donation. This review evaluates the clinical use of ovarian function markers in TS patients and reports on the transition from pediatric to gynecological and adult endocrinological care in a Danish center.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Ralf Weiskirchen
Article
Biochemistry & Molecular Biology
Louis C. Penning, Marina Berenguer, Anna Czlonkowska, Kay L. Double, Petr Dusek, Carmen Espinos, Svetlana Lutsenko, Valentina Medici, Wiebke Papenthin, Wolfgang Stremmel, Jose Willemse, Ralf Weiskirchen
Summary: Wilson disease is a rare inherited metabolic disorder with diverse clinical presentations affecting the liver, neurological system, psychiatric status, and vision, often in combination. Mutations in the ATP7B gene lead to copper accumulation in hepatocytes and/or neurons, making clinical diagnosis challenging. Diagnosis is complicated by mild and non-specific manifestations, mutations with unclear effects on protein function, and ambiguous laboratory tests, particularly concerning serum ceruloplasmin levels. Establishing a global collaboration of researchers, clinicians, and patient advocacy groups is crucial for identifying and addressing the outstanding challenges of Wilson disease.
Review
Nutrition & Dietetics
Bodo C. C. Melnik, Swen Malte John, Pedro Carrera-Bastos, Loren Cordain, Claus Leitzmann, Ralf Weiskirchen, Gerd Schmitz
Summary: This review evaluates the impact of cow milk on breast carcinogenesis by linking recent epidemiological evidence and new insights into the molecular signaling of milk and its constituents in breast cancer pathogenesis. Recent prospective cohort studies support the association between cow's milk consumption and the risk of estrogen receptor-alpha-positive breast cancer. Milk contains various components that can increase systemic insulin-like growth factor 1, insulin, and estrogen signaling, promoting breast cancer. Potential oncogenic components of commercial milk include exosomal microRNAs, bovine meat and milk factors, aflatoxin M1, bisphenol A, pesticides, and micro- and nanoplastics. Individuals with certain gene mutations and genetic polymorphisms may be at increased risk for milk-induced breast cancer.
CURRENT NUTRITION REPORTS
(2023)
Article
Cell Biology
Lilach Barer, Sarah K. Schroeder, Ralf Weiskirchen, Eran Bacharach, Marcelo Ehrlich
Summary: Lipocalin-2 (LCN2) has pleiotropic functions in different types of cancers. This study found that LCN2 can regulate prostate cancer cells by affecting cytoskeleton organization and expression of inflammation mediators. It also showed that LCN2 can modulate prostate cancer cell susceptibility to oncolytic viruses by attenuating PERK activity and increasing interferon and interferon-stimulated gene expression.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Article
Immunology
Sandro Capellmann, Roland Sonntag, Herdit Schueler, Steffen K. Meurer, Lin Gan, Marlies Kauffmann, Katharina Horn, Hiltrud Koenigs-Werner, Ralf Weiskirchen, Christian Liedtke, Michael Huber
Summary: Mast cells (MCs) are heterogeneous immune cells with different protease repertoires and receptor expressions. A new cell line, PMC-306, derived from primary peritoneal MCs, can be used to study PMC function and tumorigenic processes associated with MC leukemia.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Cell Biology
Ralf Weiskirchen
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Erawan Borkham-Kamphorst, Steffen K. Meurer, Ralf Weiskirchen
Summary: The CCN protein family plays important biological functions in cell adhesion, migration, cell cycle progression, and control of extracellular matrix production and degradation. In the liver, CCN proteins are particularly involved in hepatic injury, disease, and remodeling. This study focused on CCN5/WISP2 and found that it is highly expressed in hepatic stellate cells, myofibroblasts, and portal myofibroblasts, while it is absent in hepatocytes. CCN5 upregulation during hepatic fibrosis induces endoplasmic reticulum stress, unfolded protein response, and apoptosis in portal myofibroblasts, potentially acting as a control mechanism against excessive fibrotic responses.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Kiara Gaeberlein, Sarah K. Schroeder, Indrajit Nanda, Claus Steinlein, Thomas Haaf, Eva M. Buhl, Patrick Sauvant, Vincent Sapin, Armand Abergel, Ralf Weiskirchen
Summary: The rat hepatic stellate cell line PAV-1, established two decades ago, is a cellular model for studying hepatic retinoic acid metabolism. Despite being able to store retinyl esters and synthesize retinoic acid, this cell line has been overlooked. Genetically characterized established cell lines, like PAV-1, are valuable for biomedical research as working with in vivo models becomes more complicated.
Review
Cell Biology
Sabine Weiskirchen, Sarah K. K. Schroeder, Eva Miriam Buhl, Ralf Weiskirchen
Summary: The cultivation of cells in a favorable artificial environment has become an essential tool in cellular and molecular biology research. However, cell lines are often affected by misidentification, contamination, and specific biological and chemical hazards. This review offers an introduction to common problems encountered in cell culture laboratories and provides guidelines for preventing and addressing these issues.
Article
Information Science & Library Science
Mahsa Keshavarz-Fathi, Niloufar Yazdanpanah, Sajad Kolahchi, Heliya Ziaei, Gary L. Darmstadt, Tommaso Dorigo, Filip Dochy, Lisa Levin, Visith Thongboonkerd, Shuji Ogino, Wei-Hsin Chen, Matjaz Perc, Mark S. Tremblay, Bolajoko O. Olusanya, Idupulapati M. Rao, Nikos Hatziargyriou, Maziar Moradi-Lakeh, Federico Bella, Laszlo Rosivall, Amir H. Gandomi, Armin Sorooshian, Manoj Gupta, Ciprian Gal, Andres M. Lozano, Connie Weaver, Michael Tanzer, Alessandro Poggi, Sadaf G. Sepanlou, Ralf Weiskirchen, Anet Rezek Jambrak, Pedro J. Torres, Esra Capanoglu, Francisco J. Barba, Chua Kian Jon Ernest, Mariano Sigman, Stefano Pluchino, Gevork B. Gharehpetian, Seyed-Mohammad Fereshtehnejad, Muh-Hwa Yang, Sabu Thomas, Wenju Cai, Elisabetta Comini, Neil J. Scolding, Paul S. Myles, Juan J. Nieto, George Perry, Constantine Sedikides, Nima Rezaeia
Summary: Scientometrics and bibliometrics are subfields of library and information science that study the quantity and quality of research outputs. The h-index is the most well-known scientometric index, but it relies on the count of highly cited publications. To address this limitation, we developed a new index called the Universal Research Index (UR-Index) that considers the impact of every single publication. We incorporated additional variables such as publication type, leading role, co-author count, and source metrics into the UR-Index. However, we recognize that unconscious biases in these variables may disadvantage research from specific groups, and encourage efforts to improve equitable scholarly impact in science and academia.
JOURNAL OF ACADEMIC LIBRARIANSHIP
(2023)
Article
Biochemistry & Molecular Biology
Jan C. Kessel, Ralf Weiskirchen, Sarah K. Schroeder
Summary: Estrogen receptor alpha (ERa) is expressed in reproductive and non-reproductive tissues, and its impact on lipocalin 2 (LCN2) expression varies among tissues. This study found an inverse correlation between ERa and LCN2 expression in reproductive tissues, particularly in Esr1-deficient ovaries. However, no significant differences in LCN2 expression were observed in non-reproductive tissues. These findings provide insight into LCN2 regulation in relation to hormones and health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Sarah K. Schroeder, Natalie Gasterich, Sabine Weiskirchen, Ralf Weiskirchen
Summary: Human 25-kDa Lipocalin 2 (LCN2) was initially thought to be a circulating protein that transports small lipophilic molecules. However, further studies have shown its bacteriostatic properties, involvement in innate immunity, and regulation of various biological processes. The understanding of LCN2 receptors and their mechanisms is still lacking.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ralf Weiskirchen, Sarah K. Schroeder, Sabine Weiskirchen, Eva Miriam Buhl, Bodo Melnik
Summary: Extracellular vesicles, such as exosomes, are small bilayered biovesicles released by cells, enriched with biologically active components. Milk exosomes play a key role in infant growth and development, while exosomes derived from different cell types have regenerative and immunomodulatory properties. Isolation protocols for milk exosomes allow the purification of highly enriched fractions, expressing typical exosomal protein markers.
Article
Biochemistry & Molecular Biology
Marinela Krizanac, Paola Berenice Mass Sanchez, Sarah K. Schroeder, Ralf Weiskirchen, Anastasia Asimakopoulos
Summary: Perilipin 5 (PLIN5) is a lipid droplet coat protein highly expressed in oxidative tissues. It is regulated by peroxisome proliferator-activated receptors (PPARs) and cellular lipid status. Previous research focused on its role in non-alcoholic fatty liver disease (NAFLD) and lipid metabolism regulation. Limited studies connected PLIN5 to hepatocellular carcinoma (HCC), where its expression is upregulated. This study explores the regulation of PLIN5 by cytokines involved in HCC and NAFLD progression, revealing IL-6-induced upregulation mediated by the JAK/STAT3 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Gastroenterology & Hepatology
Ralf Weiskirchen
Article
Obstetrics & Gynecology
Tal Margaliot Kalifa, Hen Y. Sela, Jordanna Joseph, Sorina Grisaru-Granovsky, Fayez Khatib, Misgav Rottenstreich
Summary: Pregnancies following a second trimester uterine evacuation do not have an increased risk of preterm delivery or other adverse perinatal outcomes compared to pregnancies following a first trimester uterine evacuation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Dominique A. Badr, Mieke M. Cannie, Caroline Kadji, Xin Kang, Andrew Carlin, Jacques C. Jani
Summary: The objective of this study was to assess the influence of the test-to-delivery interval on the performance of ultrasound and MRI in predicting birthweight. The results showed that MRI performed best in predicting birthweight greater than gestational age if delivery occurred within two weeks of the examination, with a slight decrease thereafter, while ultrasound performance decreased drastically over time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Corina N. Schoen, Sami Backley, Lauren Orr, Amrita Roy, Tiffany Corlin, Alexander B. Knee
Summary: This retrospective cohort study aimed to evaluate whether induction of labor is associated with a lower risk of cesarean section in patients with isolated polyhydramnios. The study found that planned induction was associated with a lower rate of cesarean delivery compared to expectant management, but the difference was not statistically significant. Additionally, no differences were observed in maternal or fetal secondary outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Ohad Houri, Asaf Romano, Yossi Geron, Gil Zeevi, Eran Hadar, Shiri Barbash-Hazan, Shir Danieli-Gruber
Summary: Women with prior uterine rupture have good maternal and neonatal outcomes in subsequent pregnancies when managed at a tertiary medical center, with planned elective term cesarean delivery, or even earlier, at the onset of spontaneous preterm labor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Correction
Obstetrics & Gynecology
Laura E. Janssen, Marjon A. de Boer, Eline C. E. von Konigslow, Elisa Dal, Martijn A. Oudijk, Danielle Robbers-Visser, Christianne J. M. de Groot
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Review
Obstetrics & Gynecology
Natalia Rzewuska, Jacek Kunicki, Katarzyna Pieniak, Paulina Laskus, Bernadeta Zabielska, Roman Smolarczyk, Michal Kunicki
Summary: This systematic review examined the comorbidity of idiopathic intracranial hypertension (IIH) and polycystic ovarian syndrome (PCOS) and their impact on metabolism, hormone levels, and reproduction. The findings showed a high prevalence of comorbidity between the two conditions, which may have significant clinical implications for patient management.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
