Article
Radiology, Nuclear Medicine & Medical Imaging
Bernd M. Erber, Paul Reidler, Sophia S. Goller, Jens Ricke, Hans R. Durr, Alexander Klein, Lars Lindner, Dorit Di Gioia, Tobias Geith, Andrea Baur-Melnyk, Marco Armbruster
Summary: This study evaluated the diagnostic accuracy of quantitative DCE-MRI and DWI in the detection of local recurrence of soft-tissue sarcomas in the limbs. The results showed that rPF was significantly higher in cases of local recurrence, while rMTT was slightly lower. rPF demonstrated higher accuracy and specificity, allowing for differentiation between local recurrence and benign postoperative changes.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
Michal Chodyla, Aydin Demircioglu, Benedikt M. Schaarschmidt, Stefanie Bertram, Janna Morawitz, Sebastian Bauer, Lars Podleska, Christoph Rischpler, Michael Forsting, Ken Herrmann, Lale Umutlu, Johannes Grueneisen
Summary: The study found that the quantification of 18F-FDG PET uptake is useful for evaluating histopathological responses and aggressiveness of high-risk sarcomas, but not correlated with tumor size and ADC values. This suggests that measurements of metabolic activity in untreated soft-tissue sarcomas can provide valuable information for treatment planning and risk stratification in high-risk patients.
Article
Biochemistry & Molecular Biology
William G. J. Kerrison, Alexander T. J. Lee, Khin Thway, Robin L. Jones, Paul H. Huang
Summary: Immunotherapy in soft tissue sarcoma has become a popular and promising therapeutic strategy, with immune checkpoint inhibitors showing effectiveness in certain subtypes. Combination therapies have also shown enhanced response rates.
Review
Medicine, General & Internal
Grace C. Blitzer, Poonam Yadav, Zachary S. Morris
Summary: Soft tissue sarcomas are rare tumors that primarily occur in the extremities, trunk, and retroperitoneum. Surgical resection with clear margins is the main treatment option for localized tumors, while radiation therapy can be used to reduce local recurrence. MRI-guided radiotherapy offers advantages in target delineation and differentiation from normal tissues, particularly for unresectable tumors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Matthew F. Gong, William T. Li, Sumail Bhogal, Brittany Royes, Tanya Heim, Maria Silvaggio, Marcus Malek, Rajeev Dhupar, Stella J. Lee, Richard L. McGough, Kurt R. Weiss
Summary: Soft tissue sarcomas (STS) are rare malignant tumors associated with poor outcomes and high local recurrence rates. Indocyanine green (ICG) has shown efficacy for intraoperative margin assessment in breast and gastrointestinal cancers. This study presents an ongoing clinical study implementing ICG intraoperative margin assessment in patients with STS. ICG margins matched permanent pathology margins in 56% of patients, with 22% sensitivity and 89% specificity. Larger sample sizes are needed to further evaluate the optimal dosage, timing, and impact on different histological subtypes of STS.
Review
Oncology
Zhenyi Chen, Huayi Huang, Siyuan He, Yi Wang, Lin Cai, Yuanlong Xie
Summary: Fluorescence imaging technology can assist surgeons in judging tumor boundaries and improving the accuracy of surgical resection. This technology is simple, safe, and does not require additional time during surgery.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Amani Arthur, Edward W. Johnston, Jessica M. Winfield, Matthew D. Blackledge, Robin L. Jones, Paul H. Huang, Christina Messiou
Summary: The shift towards a data-driven approach in radiology has been made possible by developments in imaging biomarkers and computational science. This has the potential to revolutionize cancer management by providing virtual biopsies. In the case of soft tissue sarcomas, the application of advanced imaging and computational techniques can improve diagnostic accuracy and personalized treatment planning.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Tomoki Nakamura, Akihiro Sudo
Summary: Trabectedin is a safe and effective therapeutic option for patients with advanced STS. While it may be effective as first-line treatment in selected patients, doxorubicin remains the preferred choice for locally advanced or metastatic STS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Lu-Lu Lin, Zi-Zhen Liu, Jing-Zhuo Tian, Xiao Zhang, Yan Zhang, Min Yang, Hou-Cheng Zhong, Wei Fang, Ren-Xiong Wei, Chao Hu
Summary: This study identified 329 differentially expressed RNA-binding proteins (RBPs) in soft tissue sarcoma and found them mainly involved in RNA processes. Nine RBPs were validated as prognosis-related genes in STS patients, and a prognostic model was established to predict patient survival risk effectively. This research provides new insights into the pathogenesis of STS and offers potential candidate biomarkers for prognostic assessment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Sam Sedaghat, Maya Sedaghat, Jens Meschede, Olav Jansen, Marcus Both
Summary: The study evaluated the long-term diagnostic accuracy of MRI for detecting recurrent soft-tissue sarcomas at a multidisciplinary sarcoma center. The results showed that MRI has high sensitivity and specificity in detecting recurrent STS, with a decrease in diagnostic accuracy for subcutaneous lesions and after surgery with radiation therapy compared to intramuscular lesions and surgery alone. Radiologists should pay attention to specific types of recurring lesions and characteristics of primary tumors.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Liu Xiao, Liu Yang, Yueqi Wang, Lin Li
Summary: Angiofibroma of soft tissue is a rare benign neoplasm. We reported a case in a 61-year-old woman, and MRI and PET/CT examinations were used for diagnosis.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Oncology
Andrea Sambri, Emilia Caldari, Andrea Montanari, Michele Fiore, Luca Cevolani, Federico Ponti, Valerio D'Agostino, Giuseppe Bianchi, Marco Miceli, Paolo Spinnato, Massimiliano De Paolis, Davide Maria Donati
Summary: Proximity to major vessels increases the risk of local recurrence in soft tissue sarcomas of the thigh. Vascular resection and bypass reconstruction can offer better local control when major vessels are found to be surrounded by the tumor on preoperative MRI.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Yang, Liyuan Zhang, Ting Wang, Zhiyuan Jiang, Qingqing Li, Yinghua Wu, Zhen Cai, Xi Chen
Summary: This study developed and tested an MRI-based radiomics nomogram for identifying the Ki-67 status of soft tissue sarcomas (STSs). The nomogram showed good performance and clinical utility in determining Ki-67 expression status.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Liu Xiao, Junjun Cheng, Lin Li
Summary: Soft tissue aneurysmal bone cyst is rare, and FDG PET/CT findings can be helpful in diagnosis, but pathology remains crucial for definitive diagnosis.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xin-Yu Ke, Ye Chen, Valarie Yu-Yan Tham, Ruby Yu-Tong Lin, Pushkar Dakle, Kassoum Nacro, Mark Edward Puhaindran, Peter Houghton, Angela Pang, Victor Kwanmin Lee, Ling-Wen Ding, Sigal Gery, Jeffrey Hill, Leilei Chen, Liang Xu, H. Phillip Koeffler
Summary: Depletion of MNK1/2 suppresses growth of soft tissue sarcoma cells, and a novel MNK inhibitor ETC-168 shows significant antiproliferative efficacy. Combination of ETC-168 with MCL1 inhibitor exerts synergistic antiproliferative activity against STS cells. This study highlights the potential clinical translation of MNK inhibitors for the treatment of soft tissue sarcoma.
Article
Mathematics, Applied
Sebastian Burciu
Summary: In this paper, it is shown that integral fusion categories with rational structure constants have a natural group of symmetries, given by the Galois group of their character tables. These symmetries are then used to generalize a well-known result of Burnside in the representation theory of finite groups. The main result establishes that any row in the character table of a weakly integral fusion category, corresponding to a non-invertible object, contains a zero entry.
JOURNAL OF ALGEBRA AND ITS APPLICATIONS
(2023)
Article
Mathematics, Applied
Sebastian Becker, Benjamin Gess, Arnulf Jentzen, Peter E. Kloeden
Summary: This article demonstrates strong convergence rates for fully discrete numerical approximations of space-time white noise driven SPDEs with superlinearly growing nonlinearities, such as the stochastic Allen-Cahn equation with space-time white noise. The obtained strong rates of convergence are essentially sharp.
STOCHASTICS AND PARTIAL DIFFERENTIAL EQUATIONS-ANALYSIS AND COMPUTATIONS
(2023)
Article
Mathematics
S. Baader, P. Feller, L. Ryffel
Summary: This article characterizes the conditions under which a set of simple closed curves forms a bouquet on an orientable surface, based on the relationships between the corresponding Dehn twists.
GLASGOW MATHEMATICAL JOURNAL
(2023)
Article
Oncology
Monika Scheer, Erika Hallmen, Christian Vokuhl, Joerg Fuchs, Per-Ulf Tunn, Marc Muenter, Beate Timmermann, Sebastian Bauer, Anton George Henssen, Bernarda Kazanowska, Felix Niggli, Ruth Ladenstein, Gustaf Ljungman, Angelika Eggert, Thomas Klingebiel, Ewa Koscielniak
Summary: This study evaluated the effects of neoadjuvant or adjuvant radiation therapy and surgery only on long-term outcomes in patients with synovial sarcoma. The results showed that the best local control was achieved when tumors were irradiated pre-operatively and underwent R0 or R1 resection thereafter.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Lazaros Lazaridis, Teresa Schmidt, Christoph Oster, Tobias Blau, Daniela Pierscianek, Jens T. Siveke, Sebastian Bauer, Hans-Ulrich Schildhaus, Ulrich Sure, Kathy Keyvani, Christoph Kleinschnitz, Martin Stuschke, Ken Herrmann, Cornelius Deuschl, Bjorn Scheffler, Sied Kebir, Martin Glas
Summary: The study analyzed the clinical course of 41 patients with relapsed brain cancer and found that molecularly matched targeted therapy can provide longer progression-free survival and overall survival for some patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Clinical Neurology
Yvonne Reiss, Sebastian Bauer, Bastian David, Kavi Devraj, Elif Fidan, Elke Hattingen, Stefan Liebner, Nico Melzer, Sven G. Meuth, Felix Rosenow, Theodor Rueber, Laurent M. Willems, Karl H. Plate
Summary: The blood-brain barrier (BBB) is a crucial physiological barrier that maintains the brain microenvironment necessary for proper neuronal function. Dysfunction of the BBB is a characteristic of neurological diseases including ischemia, brain tumors, neurodegenerative diseases, infections, and autoimmune neuroinflammatory disorders. Additionally, BBB dysfunction is involved in epilepsy, a brain disorder characterized by synchronized neuronal activity and seizures. While antiseizure drugs targeting neuronal hyperexcitability are not always effective, drugs specifically targeting the neurovasculature in epilepsy patients have not been explored. Understanding the mechanism of BBB compromise in epilepsy is important for its therapeutic potential.
Review
Oncology
Silvia Stacchiotti, Hans Roland Duerr, Inga-Marie Schaefer, Klaus Woertler, Rick Haas, Annalisa Trama, Augusto Caraceni, Jyoti Bajpai, Giacomo Giulio Baldi, Nicholas Bernthal, Jean-Yves Blay, Kjetil Boye, Javier-Martin Broto, Wei-Wu Tom Chen, Paolo Angelo Dei Tos, Jayesh Desai, Stephan Emhofer, Mikael Eriksson, Alessandro Gronchi, Hans Gelderblom, Jendrik Hardes, Wolfgang Hartmann, John Healey, Antoine Italiano, Robin L. Jones, Akira Kawai, Andreas Leithner, Herbert Loong, Eric Mascard, Carlo Morosi, Nadine Otten, Emanuela Palmerini, Shreyaskumar R. Patel, Peter Reichardt, Brian Rubin, Piotr Rutkowski, Claudia Sangalli, Kathrin Schuster, Beatrice M. Seddon, Morena Shkcodra, Eric L. Staals, William Tap, Matt van de Rijn, Kirsten van Langevelde, Filip M. M. Vanhoenacker, Andrew Wagner, Lisette Wiltink, Sydney Stern, Michiel Van de Sande, Sebastian Bauer
Summary: Tenosynovial giant cell tumour (TGCT) is a rare, locally aggressive tumor that arises from the joints, bursa, and tendon sheaths. There are two types of TGCT: nodular and diffuse, with the former exhibiting a slow disease course and the latter showing locally aggressive behavior. Although not life-threatening, TGCT can cause chronic pain and negatively impact function and quality of life. CSFR1 inhibitors are effective in treating TGCT but are not widely available. The lack of guidelines and uncertainty in selecting appropriate therapy lead to inconsistent adoption of new treatments and suboptimal outcomes for patients. A global consensus meeting was held in June 2022 to develop evidence-based recommendations for the optimal management of TGCT.
CANCER TREATMENT REVIEWS
(2023)
Article
Oncology
Emanuela Palmerini, John H. Healey, Nicholas M. Bernthal, Sebastian Bauer, Hendrik Schreuder, Andreas Leithner, Javier Martin-Broto, Francois Gouin, Julio Lopez-Bastida, Hans Gelderblom, Eric L. Staals, Florence Mercier, Petra Laeis, Xin Ye, Michiel van de Sande
Summary: This article describes the impact of Tenosynovial giant cell tumor (D-TGCT) on patient-reported outcomes (PROs) based on the Tenosynovial giant cell tumor Observational Platform Project (TOPP) registry. The study found that patients without active treatment strategy had lower pain levels and better quality of life at 1-year and 2-year follow-ups. On the other hand, patients receiving systemic treatment had higher pain levels when they changed treatment strategies. These findings highlight the significant impact of treatment strategies on patient quality of life.
Article
Cardiac & Cardiovascular Systems
Denis Fedorov, Robert Bauernschmitt, Jean-Pilippe Grunebaum, Stefan Bauer, Ralf Sodian, Eberhard von Hodenberg
Summary: This study aimed to evaluate the outcomes of redo-SAVR and TAVI-VIV for degenerated stentless bioprostheses. The results showed outstanding 30-day and 1-year survival rates for both procedures. Isolated redo-SAVR may be preferred in younger patients due to lower pacemaker implantation rates, while TAVI-VIV could be a method of choice for elderly patients with high operative risk.
THORACIC AND CARDIOVASCULAR SURGEON
(2023)
Correction
Multidisciplinary Sciences
Mario Mech, Andre Ehrlich, Andreas Herber, Christof Luepkes, Manfred Wendisch, Sebastian Becker, Yvonne Boose, Dmitry Chechin, Susanne Crewell, Regis Dupuy, Christophe Gourbeyre, Joerg Hartmann, Evelyn Jaekel, Olivier Jourdan, Leif-Leonard Kliesch, Marcus Klingebiel, Birte Solveig Kulla, Guillaume Mioche, Manuel Moser, Nils Risse, Elena Ruiz-Donoso, Michael Schaefer, Johannes Stapf, Christiane Voigt
Editorial Material
Medicine, General & Internal
Stefan Bauer, Lukas Ernstbrunner
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Celina Tretter, Niklas de Andrade Kraetzig, Matteo Pecoraro, Sebastian Lange, Philipp Seifert, Clara von Frankenberg, Johannes Untch, Gabriela Zuleger, Mathias Wilhelm, Daniel P. P. Zolg, Florian S. S. Dreyer, Eva Braeunlein, Thomas Engleitner, Sebastian Uhrig, Melanie Boxberg, Katja Steiger, Julia Slotta-Huspenina, Sebastian Ochsenreither, Nikolas von Bubnoff, Sebastian Bauer, Melanie Boerries, Philipp J. J. Jost, Kristina Schenck, Iska Dresing, Florian Bassermann, Helmut Friess, Daniel Reim, Konrad Gruetzmann, Katrin Pfuetze, Barbara Klink, Evelin Schroeck, Bernhard Haller, Bernhard Kuster, Matthias Mann, Wilko Weichert, Stefan Froehling, Roland Rad, Michael Hiltensperger, Angela M. M. Krackhardt
Summary: RNA variants resulting from cancer-associated RNA editing events can serve as a potential source of neoantigens. The authors use a comprehensive proteogenomic pipeline to identify and validate neoantigen candidates in patients with different tumor types, highlighting the importance of RNA as a significant source of neoantigens. Systemic pan-tumor analyses can provide insights into common features associated with cancer immunogenicity and patient survival.
NATURE COMMUNICATIONS
(2023)
Article
Computer Science, Interdisciplinary Applications
R. Patrick Xian, Vincent Stimper, Marios Zacharias, Maciej Dendzik, Shuo Dong, Samuel Beaulieu, Bernhard Scholkopf, Martin Wolf, Laurenz Rettig, Christian Carbogno, Stefan Bauer, Ralph Ernstorfer
Summary: The electronic band structure and crystal structure are two complementary identifiers of solid-state materials. However, extracting quasiparticle dispersion from photoemission band mapping data is currently limited by available computational methods. In this study, we develop a pipeline that utilizes probabilistic machine learning and associated methods for band-structure reconstruction, showing excellent performance on benchmarks and other materials datasets. This approach uncovers previously inaccessible momentum-space structural information while paving the way for integration with materials science databases.
NATURE COMPUTATIONAL SCIENCE
(2023)
Article
Oncology
Lennart Schardt, Moritz Kaths, Sebastian Bauer
Summary: Summary: Gastrointestinal stromal tumors (GIST) consist of various molecular subtypes with different treatment implications. Genotyping plays a crucial role in treatment decision-making. Adjuvant imatinib treatment is beneficial for patients with KIT exon 11 mutations and high risk of relapse. Evidence for this benefit is weaker for less frequent KIT genotypes, such as exon 9, 13, and 17 mutations. Neoadjuvant treatment is important in imatinib-sensitive subtypes with significant surgery-related morbidity. Multimodal treatment may be considered for metastatic patients with potential complete resection. Next generation inhibitors like ripretinib and avapritinib show promising results in pretreated GIST and GIST with PDGFRA mutations, but the role of multimodal approaches in these settings is yet to be determined.
Article
Oncology
Emanuela Palmerini, John H. Healey, Nicholas M. Bernthal, Sebastian Bauer, Hendrik Schreuder, Andreas Leithner, Javier Martin-Broto, Francois Gouin, Julio Lopez-Bastida, Hans Gelderblom, Eric L. Staals, Florence Mercier, Petra Laeis, Xin Ye, Michiel van de Sande
Summary: This study investigated the impact of diffuse-type Tenosynovial giant cell tumor (D-TGCT) on treatment strategies and quality of life for patients. The results showed that patients who switched to an active treatment strategy had higher scores for pain and interference, while patients who remained off-treatment had lower scores at the 2-year follow-up. These findings are important for guiding the treatment and management of D-TGCT.
