Article
Biochemistry & Molecular Biology
Jeyce Kelle Ferreira de Andrade, Alexandre Jose da Silva Goes, Vanessa Xavier Barbosa, Mariza Severina de Lima Silva, Mariana Aragao Matos Donato, Christina Alves Peixoto, Gardenia Carmen Gadelha Militao, Teresinha Goncalves da Silva
Summary: Thiosemicarbazones derived from beta-lapachone showed potent cytotoxic effects on leukemia cells, with BV3 being the most selective compound, exhibiting high toxicity to tumor cells and low toxicity to normal cells. These compounds have the potential to be promising candidates for anticancer drugs.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Medicinal
Zhang-Xu He, Jin-Ling Huo, Yun-Peng Gong, Qi An, Xin Zhang, Hui Qiao, Fei-Fei Yang, Xin-Hui Zhang, Le-Min Jiao, Hong-Min Liu, Li-Ying Ma, Wen Zhao
Summary: Novel thiosemicarbazone-indole analogues were designed and synthesized based on lead compound 4, with compound 16f showing strong anticancer activity and selectivity towards PC3 cells. Its mechanism of action may involve inducing G1/S cycle arrest and apoptosis to inhibit cancer cell growth.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Marwa F. Ahmed, Atiah H. Almalki
Summary: New thiosemicarbazone derivatives were synthesized and evaluated for their anticancer activity, with compounds IIIa, IIIe, and IIIh showing promising results. Compound IIIa exhibited potent inhibitory activity against ribonucleotide reductase and induced apoptosis through activating the intrinsic apoptotic pathway.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Chengfeng Bai, Shuangjie Wu, Shengnan Ren, Meiqi Zhu, Guoshun Luo, Hua Xiang
Summary: The novel hecogenin derivative 4c showed potent inhibitory effects on the proliferation of various cancer cells at low concentrations, inducing apoptosis of MDA-MB-231 cells by arresting the cell cycle. Additionally, 4c notably suppressed the migration and invasion of MDA-MB-231 cells compared to its parent hecogenin at an equal concentration.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Jakeb S. S. M. Petersen, Sarah K. Baird
Summary: The study compared the efficacy of anthelmintic drugs mebendazole and albendazole in breast and colon cancer cell lines, revealing their selective cancer cell killing ability through classical apoptosis and cell cycle arrest involving microtubule destabilization.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Chemistry, Applied
Nithya Balakrishnan, Jebiti Haribabu, Mahendiran Dharmasivam, Srividya Swaminathan, Ramasamy Karvembu
Summary: Denticity of ligands plays a significant role in the cytotoxicity of metal complexes. This study evaluated the impact of ligand denticity in the Ru(II)-DMSO complexes on the cytotoxicity of cancer cells. Results showed that the complex with a tridentate chromone ligand exhibited better anticancer activity compared to the one with a bidentate chromene ligand. The stable nature of the tridentate system and the higher reactivity of the chloride ligand in the tridentate species were attributed to the observed differences in cytotoxicity. The complex demonstrated selective cytotoxicity against breast cancer cells and lower toxicity against normal cells, indicating its effective anticancer potential.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Emanuelle Fraga da Silva, Paulo Roberto dos Santos, Krist Helen Antunes, Caroline Marinho Franceschina, Deise Nascimento de Freitas, Priscila Konrad, Rafael Fernandes Zanin, Pablo Machado, Sidnei Moura, Ana Paula Duarte de Souza
Summary: Valproate-Zn+2 complexes exhibit potential anti-tumoral activity in lung cancer cells, with complex 2 showing higher selectivity. The results suggest these complexes could serve as prototypes for new drugs.
Article
Biochemistry & Molecular Biology
Melyssa L. Grieve, Patrick R. W. J. Davey, Craig M. Forsyth, Brett M. Paterson
Summary: A new variant of 1,4,7,10-tetraazacyclododecane (cyclen) with two thiosemicarbazone pendant groups was prepared and successfully formed complexes with Mn2+, Co2+, and Zn2+. X-ray crystallography revealed a six-coordinate environment provided by the ligand for the metal ions, with different diastereomers observed in the solid state for each metal complex. Density functional theory calculations indicated that the diastereomers had similar relative energies.
Review
Plant Sciences
Rosa Tundis, Jayanta Kumar Patra, Marco Bonesi, Subrata Das, Rajat Nath, Anupam Das Talukdar, Gitishree Das, Monica Rosa Loizzo
Summary: Despite advancements in treatment strategies, cancer remains a leading cause of death globally. Therefore, the main focus should be on early cancer diagnosis, optimal therapeutic strategies, and the search for more effective molecules. This review comprehensively summarizes the potential anti-cancer properties of andrographolide, highlighting its mechanisms of action, pharmacokinetics, and potential side effects, while discussing future perspectives, challenges, and limitations of use.
Article
Cell Biology
Qiong Liu, Lingying Chen, Wenjun Yin, Yuehua Nie, Penghui Zeng, Xin Yang
Summary: The study demonstrated that ginkgetin has an anti-tumor effect on human hepatocellular carcinoma cell lines by inducing apoptosis through affecting the balance between cell proliferation and apoptosis.
Article
Biochemistry & Molecular Biology
Belay Zeleke Sibuh, Piyush Kumar Gupta, Pankaj Taneja, Sonia Khanna, Paratpar Sarkar, Sanya Pachisia, Abrar Ali Khan, Niraj Kumar Jha, Kamal Dua, Sachin Kumar Singh, Sadanand Pandey, Petr Slama, Kavindra Kumar Kesari, Shubhadeep Roychoudhury
Summary: Thiosemicarbazones, namely 3-MBTSc and 4-NBTSc, were synthesized and characterized, showing comparable anticancer activities with Doxorubicin. In vitro assays revealed growth inhibition in treated cells, along with gene expression changes in tumor suppressor and oncogenes. Molecular docking indicated potential binding to TGF-beta 1, with favorable ADMET and drug-likeness properties, suggesting both compounds as multitargeting drug candidates for further study, with 3-MBTSc exhibiting better activity.
Article
Medicine, Research & Experimental
Jinxiao Li, Luorui Shang, Fangyuan Zhou, Shuhan Wang, Na Liu, Minfeng Zhou, Qifeng Lin, Mengqi Zhang, Yuju Cai, Guo Chen, Shenglan Yang
Summary: This study investigated the potential mechanisms of Herba Patriniae (HP) and its primary component Isovitexin against colorectal cancer (CRC) using network pharmacology analysis and in vitro and in vivo experiments. The study identified nine bioactive compounds of HP and predicted 3460 CRC-related targets. Ten hub genes, including CDK4, CDK2, CDK1, CCND1, CCNB1, CCNA2, MYC, E2F1, CHEK1, and CDKN1A, were identified as core target genes. The study also found that HP activated the p53 signaling pathway, promoting apoptosis and suppressing cell proliferation. This study provides valuable insights into the underlying mechanisms of HP and its component Isovitexin against CRC, supporting further experimental verification of their clinical application.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Inorganic & Nuclear
Azadeh Mirzaahmadi, Seyed Abolfazl Hosseini-Yazdi, Majid Mahdavi, Michal Dusek, Valcav. Eigner, Morgane Poupon
Summary: New water-soluble Zn(II) and Ni(II) complexes, synthesized and characterized in this study, exhibit good solubility and stability in aqueous media. These complexes show potential anticancer activity in cell experiments.
Article
Biochemistry & Molecular Biology
Ming Jiang, Shanhe Li, Junmiao Wu, Wenjuan Li, Xiao-An Wen, Hong Liang, Feng Yang
Summary: The research team designed and synthesized two ruthenium thiosemicarbazone compounds and successfully constructed active Biotin-HSA nanoparticles for anticancer treatment. These nanoparticles not only exhibited stronger killing and inhibiting abilities, but also acted against MCF-7 cells through multiple mechanisms.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Amani A. Mahbub, Akhmed Aslam, Mohamed E. Elzubier, Mohamed El-Boshy, Abdelghany H. Abdelghany, Jawwad Ahmad, Shakir Idris, Riyad Almaimani, Aiman Alsaegh, Mahmoud Zaki El-Readi, Mohammed A. Baghdadi, Bassem Refaat
Summary: The study found that the individual use of E2 and P4 can inhibit the development of colorectal cancer, showing good anti-tumor effects in male mice and cell experiments. The combination of the two shows a stronger anti-cancer effect.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Thermodynamics
Qi Liu, Bin Zhou, Jianyong Zhang, Ruixue Cheng, Minglu Dai, Xuhao Zhao, Yihong Wang
Summary: Acoustic thermometry and velocimetry are effective methods for in situ measurement of gas temperature and velocity. This paper proposes a novel TOF estimation method based on the DLF technique, which improves the linearity of the time-frequency series and the accuracy of the TOF using linear fitting. Experimental studies show that the DLF method performs well in terms of accuracy and robustness in a strong noise environment.
EXPERIMENTAL THERMAL AND FLUID SCIENCE
(2023)
Article
Chemistry, Inorganic & Nuclear
Xiao-Min Yang, Ai-Rong Wang, Juan Li, Pei-Lian Huang, Zhen-Feng Lu, Shu-Yan Li, Jia-Ming Li
Summary: Two zinc(II)-based one-dimensional homologous coordination polymers were successfully synthesized and characterized. Both polymers have the same zigzag infinite chain framework and are further connected into three-dimensional supramolecular structures through hydrogen bonds and stacking interactions. The thermal stability and solid-state fluorescence properties of the polymers were investigated.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
(2023)
Article
Thermodynamics
Rong Zhao, Bin Zhou, Jianyong Zhang, Ruixue Cheng, Qi Liu, Minglu Dai, Bubin Wang, Yihong Wang
Summary: A novel stable laser absorption spectroscopy (LAS) tomographic sensor with enhanced stability and spatial resolution is developed and applied to complex combustion flame diagnosis. The sensor reduces the need for laser collimation and alignment even in extremely harsh environments and improves the stability of the received laser signal. Furthermore, a new miniaturized laser emission module was designed to achieve multi-degree of freedom adjustment, allowing for improved spatial resolution and reduced equipment cost.
CASE STUDIES IN THERMAL ENGINEERING
(2023)
Article
Optics
Yu Wang, Yihong Wang, Tong Liu, Xiubao Sui, Guohua Gu, Qian Chen
Summary: This paper introduces a novel variational model for nonuniformity correction (NUC) that leverages single-frame and inter-frame structural similarity (SISB) to effectively solve the intensity nonuniformity in infrared images.
Article
Chemistry, Applied
Lai Wei, Xiangdong He, Xinyue Shang, Martha Kandawa-Shultz, Guoqiang Shao, Yihong Wang
Summary: This study investigated the application of three newly designed biotin-modified cyclometalated Ir(III) complexes for cancer treatment. The results showed that these complexes had good photocatalytic activity and selective targeting of tumor cells. Among them, Ir3 demonstrated effective inhibition of tumor growth and could induce cell apoptosis through ROS-mediated mitochondrial signaling pathways.
Article
Thermodynamics
Rong Zhao, Bin Zhou, Jianyong Zhang, Ruixue Cheng, Qi Liu, Minglu Dai, Bubin Wang, Yihong Wang
Summary: Laser absorption spectroscopy tomography is widely used to measure the two-dimensional distribution information in complex combustion flow fields. In this paper, a novel method is introduced with wavelength modulation spectroscopy (WMS) for obtaining the integrated absorption area (IA), which is applied in the reconstruction of temperature and species concentrations distributions of non-uniform complex combustion flames. This method eliminates the need for traditional time-consuming line-shape fitting process and instead obtains the IA through simple algebraic operations, significantly improving computational efficiency.
EXPERIMENTAL THERMAL AND FLUID SCIENCE
(2023)
Article
Chemistry, Physical
Xinyue Shang, Mingwei Fu, Zhuoer Cai, Lai Wei, Shuwang Ge, Min Ge, Yihong Wang
Summary: In this study, one important drug salt and two solvates were synthesized, and their crystal structure, stability, thermal properties, and solubility were investigated using various analytical techniques. Crystal structure analyses showed that salt 1 formed a two-dimensional layered network through coordination with K+ and solvate 2 formed a three-dimensional framework through hydrogen bonds network and pi-pi stacking. Hirshfeld surface and 2D fingerprint plots were obtained to further study the weak interaction between molecules. All crystals exhibited significantly enhanced aqueous solubility compared to REB and had potential in clinical applications.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Analytical
Liang Tian, Jiyuan Zhang, Yanci Zhang, Huiling Fan, Chun Liu, Yihong Wang, Jiansheng Cui
Summary: A dual-model photoelectrochemical biosensor based on label-free trimetallic nanoprobe and Mg2+ dependent DNAzyme driven DNA walker was developed for ultrasensitive detection of microRNA-155 in serum at the early stage of cancer. The biosensor exhibited a low limit of detection (1.2 fM), excellent stability, and superior performance in complex human serum samples and tumor cell lysates, showing great potential for early-stage clinical diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Engineering, Electrical & Electronic
Bo Wang, Yihong Wang, Xiubao Sui, Yuan Liu, Qian Chen
Summary: This paper proposes a new algorithm that accurately identifies the edges of an image using gradient information and distinguishes flat areas from edge areas using weighted information. It effectively reduces halo artifacts and improves image denoising and detail enhancement.
SIGNAL IMAGE AND VIDEO PROCESSING
(2023)
Article
Thermodynamics
Qi Liu, Bin Zhou, Ruixue Cheng, Jianyong Zhang, Rong Zhao, Minglu Dai, Xuhao Zhao, Yihong Wang
Summary: This paper presents a novel technique using frequency division multiplexing (FDM) to improve the temporal resolution of the currently existing acoustic tomography (AT) system. The method allows for concurrent transmissions of acoustic signals in different frequency bands, resulting in more efficient channel utilization and better temporal uniformity of multipath acoustic signals. The effectiveness of this technique has been verified through theoretical analysis and experiments, showing significant improvement in the temporal resolution of the AT system while maintaining accuracy and robustness of the reconstruction.
CASE STUDIES IN THERMAL ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Dihai Gu, Min Liu, Hongshuai Wu, Jiannan Mao, Jinzhong Hu, Xu Zhi, Zhaohan Wang, Xinyue Shang, Xiongwei Deng, Yihong Wang
Summary: A versatile core-shell nanoparticle system was designed and synthesized for reactive oxygen-primed and autophagy inhibition-sensitized ferroptosis. The system caused the inactivation of glutathione peroxidase 4 (GPX4) and reinforced intracellular oxidative stress through the generation of highly toxic reactive oxygen species. Additionally, the autophagy inhibitor loaded in the system enhanced the sensitivity of ferroptosis, while the CuS core triggered an excellent photothermal therapy effect. In vivo and in vitro experiments demonstrated the excellent anticancer effect of the system in a human breast cancer model, indicating the promising potential of the ferroptosis/photothermal dual-inductive strategy in combating malignant tumors.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Xiangdong He, Lai Wei, Jun Chen, Shuwang Ge, Martha Kandawa-Shultz, Guoqiang Shao, Yihong Wang
Summary: Interest in targeted cancer therapies with fewer side effects has increased. Photodynamic therapy (PDT) selectively kills cancer cells using photosensitizers (PSs) and light, generating reactive oxygen species (ROS). A water-soluble iridium metal complex (Ir-PEG-Fn) with folate-targeting characteristics has been synthesized. The combination of ferroptosis and PDT has demonstrated excellent anti-cancer efficacy in tumor models.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Xiangdong He, Jun Chen, Martha Kandawa-Shultz, Guoqiang Shao, Yihong Wang
Summary: A series of half-sandwich ruthenium complexes with quinoline derivative ligands were synthesized, exhibiting excellent antitumor toxicity and lysosome targeting. The damage to lysosomes promoted the release of cathepsin B and initiated downstream apoptotic signals. The increase in reactive oxygen species (ROS) due to decreased mitochondrial membrane potential (Delta psi(m)) synergistically intensified lysosome damage. Moreover, the complex inhibited cell transfer and clone formation. In vivo experiments demonstrated outstanding biological effects, with minimal change in mouse body weight and significantly reduced tumor volume compared to the control group.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Physical
Hong Yang, Wenli Li, Yihong Wang, Haibo Zhu, Zhanggao Le, Zongbo Xie
Summary: A method for synthesizing 2-substituted quinazoline derivatives from 2-aminobenzylamines and benzylamines using visible light and organoselenium catalysts was established. The process achieved a high yield without the use of other oxidants and was tolerant to various substrates.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Multidisciplinary
Xiangdong He, Mengke Xu, Xicheng Liu, Yihong Wang
Summary: Two organo-bimetallic complexes of ferrocene and organotin were synthesized and evaluated as potential anticancer drugs. The complexes showed excellent antitumor activity and the ability to induce immunogenic cell death. The promising results provide hope for the development of new anticancer drugs.
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
