Article
Medicine, General & Internal
Jiayin Qin, Kai Li, Xijuan Wang, Yongzhen Bao
Summary: This study aimed to investigate the differences in visual impairment caused by functioning and non-functioning pituitary adenomas. It was found that patients with functioning pituitary adenomas had better corrected visual acuity and lighter visual field defects compared to those with non-functioning pituitary adenomas. Additionally, tumor volume was correlated with visual field defects in both groups.
Article
Clinical Neurology
Yinxing Huang, Meina Wang, Jianwu Wu, Kunzhe Lin, Shousen Wang, Fangfang Zhang
Summary: The aim of this study was to assess the factors influencing the occurrence of delayed hyponatremia after transsphenoidal surgery (TSS) in patients with a non-functional pituitary adenoma (NFPA). The results showed that delayed postoperative hyponatremia was independently associated with larger craniocaudal dimension, preoperative hyperprolactinemia, and larger preoperative pituitary stalk deviation angle.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Carlos Perez-Lopez, Cristina Alvarez-Escola, Alberto Isla Guerrero
Summary: The treatment of non-functioning pituitary adenomas depends on symptoms, contact with the optic tract, and growth on imaging tests. Medical treatment is used after surgical and radiotherapy options are exhausted.
Article
Endocrinology & Metabolism
Ross Hamblin, Athanasios Fountas, Kirstie Lithgow, Paul Benjamin Loughrey, Efstathios Bonanos, Shah Khalid Shinwari, Kirsten Mitchell, Syed Shah, Lydia Grixti, Mike Matheou, Kristina Isand, David S. McLaren, Ashutosh Surya, Hafiz Zubair Ullah, Katarina Klaucane, Anuradha Jayasuriya, Sumbal Bhatti, Akash Mavilakandy, Masato Ahsan, Susan Mathew, Ziad Hussein, Thijs Jansz, Wunna Wunna, James MacFarlane, John Ayuk, Prakash Abraham, William M. Drake, Mark Gurnell, Antonia Brooke, Stephanie E. Baldeweg, Amir H. Sam, Niamh Martin, Claire Higham, Narendra Reddy, Miles J. Levy, Rupa Ahluwalia, John Newell-Price, Joannis Vamvakopoulos, Amutha Krishnan, Andrew Lansdown, Robert D. Murray, Aparna Pal, Karin Bradley, Yaasir Mamoojee, Tejpal Purewal, Janki Panicker, E. Marie Freel, Faisal Hasan, Mohit Kumar, Biju Jose, Steven J. Hunter, Niki Karavitaki
Summary: This study provides evidence on the natural history of non-functioning pituitary microadenomas (micro-NFPAs) and suggests that the probability of micro-NFPA growth is low, and the development of new hypopituitarism is rare. Delaying the first follow-up MRI to 3 years and avoiding hormonal re-evaluation in the absence of tumor growth or clinical manifestations is a safe approach for micro-NFPA surveillance.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Friso de Vries, Daniel J. Lobatto, Marco J. T. Verstegen, Pieter J. Schutte, Irene C. Notting, Mark C. Kruit, S. Faisal Ahmed, Alberto M. Pereira, Wouter R. van Furth, Nienke R. Biermasz
Summary: Transsphenoidal surgery is the standard treatment for hormone-secreting pituitary adenomas. This study proposes a novel way to classify and report surgical outcomes by integrating efficacy and safety at the patient level. The results show that surgical interventions can be presented in four categories, incorporating both efficacy and safety.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Friso de Vries, Daniel J. Lobatto, Marco J. T. Verstegen, Pieter J. Schutte, Irene C. Notting, Mark C. Kruit, S. Faisal Ahmed, Alberto M. Pereira, Wouter R. van Furth, Nienke R. Biermasz
Summary: This study proposed a novel way to classify and report surgical outcomes, integrating efficacy and safety at the patient level. By presenting results in four outcome groups ranging from good to poor, the study highlights the importance of balancing efficacy and complications in surgical interventions.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Clinical Neurology
Andrew S. Little, Varun R. Kshettry, Marc R. Rosen, Ryan M. Rehl, Timothy W. Haegen, Mindy R. Rabinowitz, Gurston G. Nyquist, Pablo F. Recinos, Raj Sindwani, Troy D. Woodard, Christopher J. Farrell, Griffin D. Santarelli, John Milligan, James J. Evans
Summary: The study found that postoperative prophylactic oral antibiotics did not result in superior sinonasal quality of life compared with placebo among patients who underwent standard endoscopic transsphenoidal surgery.
Article
Oncology
Soudeh Ghafouri-Fard, Arash Safarzadeh, Mehdi Akhavan-Bahabadi, Bashdar Mahmud Hussen, Mohammad Taheri, Nader Akbari Dilmaghani
Summary: This study identified differentially expressed genes (DEGs), including long non-coding RNAs (DElncRNAs) and microRNAs (DEmiRNAs), in non-functioning pituitary adenomas (NFPA) compared to normal samples. The study also assessed the relationship between these genes and important signaling pathways. The findings revealed dysregulated pathways and differential expression of several genes in NFPA.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Alexander Micko, Matthew S. Agam, Andrew Brunswick, Ben A. Strickland, Martin J. Rutkowski, John D. Carmichael, Mark S. Shiroishi, Gabriel Zada, Engelbert Knosp, Stefan Wolfsberger
Summary: The aim of this study is to assess the treatment strategies and outcomes of giant pituitary adenomas (GPAs) in the era of endoscopic transsphenoidal surgery (ETS). The study found that the extent of resection is dependent on the morphology of the GPA. Treatment strategies for residual pituitary adenoma include early transcranial reoperation, delayed endoscopic transsphenoidal/transcranial reoperation, and adjuvant radiosurgery.
JOURNAL OF NEUROSURGERY
(2022)
Review
Clinical Neurology
Shengfu Guo, Zidong Wang, Xiaokui Kang, Wenqiang Xin, Xin Li
Summary: The study found that endoscopic surgery had higher rates of gross-total resection in NFPA patients, while ETSS in FPA patients was associated with higher rates of visual improvement and gross-total resection, as well as lower rates of meningitis.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Yasuyuki Kinoshita, Akira Taguchi, Atsushi Tominaga, Kazunori Arita, Fumiyuki Yamasaki
Summary: There were no significant differences in perioperative complication rates between elderly and younger patients undergoing TSS for NFPA. Pseudocapsular resection did not increase surgical risks in either age group, but younger patients showed significant improvement in sGHD. Older age, rather than pseudocapsular resection, was the only factor predicting new development of sGHD post-TSS.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Genetics & Heredity
Jing Guo, Qiuyue Fang, Yulou Liu, Weiyan Xie, Chuzhong Li, Yazhuo Zhang
Summary: This study aimed to identify microenvironment-related genes in NFPAs and evaluate their prognostic value. Analysis of 73 NFPA tumor samples revealed a correlation between immune/stromal scores and cavernous sinus invasion, as well as a significant association between high immune score group and poor recurrence-free survival. The study identified critical genes involved in the tumor microenvironment, suggesting new therapeutic targets for NFPA.
FRONTIERS IN GENETICS
(2021)
Article
Neurosciences
Domenico Solari, Luigi Maria Cavallo, Chiara Graziadio, Sergio Corvino, Ilaria Bove, Felice Esposito, Paolo Cappabianca
Summary: Giant pituitary adenomas present a surgical challenge due to their growth patterns and locations. There is no consensus on the optimal surgical strategy, but transcranial or transsphenoidal approaches are commonly used. Endoscopic endonasal approach is preferred, but transcranial approach is more suitable when the tumor has significant intracranial extension. Accurate preoperative evaluation and individualized treatment plans are crucial for long-term effectiveness.
Article
Clinical Neurology
Robert C. Osorio, Matheus P. Pereira, Rushikesh S. Joshi, Kevin C. Donohue, Patricia Sneed, Steve Braunstein, Philip Theodosopoulos, Ivan H. El-Sayed, Jose Gurrola, Sandeep Kunwar, Lewis S. Blevins, Manish K. Aghi
Summary: This study examined the influence of socioeconomic status (SES) on the clinical presentations and outcomes of nonfunctional pituitary adenoma (NFPA) resections. The presence of a primary care provider (PCP) was found to be the most important factor, affecting hospital lengths of stay, readmission rates, follow-up adherence, and tumor recurrence.
JOURNAL OF NEUROSURGERY
(2022)
Review
Endocrinology & Metabolism
Mathias Brown Pedersen, Stefan Dukanovic, Jacob Bertram Springborg, Mikkel Andreassen, Jesper Krogh
Summary: The effects of transsphenoidal surgery on pituitary endocrine function in patients with NFPAs are uncertain. The chance of recovery and the risk of pituitary failure and hypopituitarism are unclear. Further systematic data collection is needed for a better understanding.
NEUROENDOCRINOLOGY
(2022)
Article
Agronomy
Pedro Monteiro, Micael F. M. Goncalves, Gloria Pinto, Beatriz Silva, Jorge Martin-Garcia, Julio Javier Diez, Artur Alves
Summary: Novel fungal species were discovered in pine trees, potentially contributing to the symptoms of red band and brown spot needle blight diseases. While the pathogenicity of these fungi needs further confirmation, the study highlights a high complexity in fungal species associated with these diseases.
EUROPEAN JOURNAL OF PLANT PATHOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Cristina Zamora-Ballesteros, Jorge Martin-Garcia, Aroa Suarez-Vega, Julio Javier Diez
Summary: This study conducted the first comprehensive genome-wide analysis of P. radiata lncRNAs, revealing their important regulatory role in response to Fusarium circinatum infection and potential involvement in regulating defense mechanisms such as cell wall reinforcement.
Article
Ecology
Carmen Romeralo, Jorge Martin-Garcia, Pablo Martinez-Alvarez, E. Jordan Munoz-Adalia, Danilo Reis Goncalves, Esteban Torres, Johanna Witzell, Julio Javier Diez
Summary: The composition and abundance of fungal communities in trees are influenced by the host species, as well as the presence of a fungal pathogen. There are distinct core and satellite fungal communities, and the presence of the pathogen does not co-occur with a specific fungal community. Host species play an important role in shaping microbiome assembly in common environments.
Article
Multidisciplinary Sciences
Iva Franic, Simone Prospero, Kalev Adamson, Eric Allan, Fabio Attorre, Marie Anne Auger-Rozenberg, Sylvie Augustin, Dimitrios Avtzis, Wim Baert, Marek Barta, Kenneth Bauters, Amani Bellahirech, Piotr Boron, Helena Braganca, Tereza Brestovanska, May Bente Brurberg, Treena Burgess, Daiva Burokiene, Michelle Cleary, Juan Corley, David R. Coyle, Gyorgy Csoka, Karel Cerny, Kateryna Davydenko, Maarten de Groot, Julio Javier Diez, H. Tugba Dogmus Lehtijarvi, Rein Drenkhan, Jacqueline Edwards, Mohammed Elsafy, Csaba Bela Eotvos, Roman Falko, Jianting Fan, Nina Feddern, Agnes Furjes-Miko, Martin M. Gossner, Bartlomiej Grad, Martin Hartmann, Ludmila Havrdova, Miriam Kadasi Horakova, Marketa Hrabetova, Mathias Just Justesen, Magdalena Kacprzyk, Marc Kenis, Natalia Kirichenko, Marta Kovac, Volodymyr Kramarets, Nikola Lackovic, Maria Victoria Lantschner, Jelena Lazarevic, Marianna Leskiv, Hongmei Li, Corrie Lynne Madsen, Chris Malumphy, Dinka Matosevic, Iryna Matsiakh, Tom W. May, Johan Meffert, Duccio Migliorini, Christo Nikolov, Richard O'Hanlon, Funda Oskay, Trudy Paap, Taras Parpan, Barbara Piskur, Hans Peter Ravn, John Richard, Anne Ronse, Alain Roques, Beat Ruffner, Karolis Sivickis, Carolina Soliani, Venche Talgo, Maria Tomoshevich, Anne Uimari, Michael Ulyshen, Anna Maria Vettraino, Caterina Villari, Yongjun Wang, Johanna Witzell, Milica Zlatkovic, Rene Eschen
Summary: International trade and climate change are major factors contributing to the spread of damaging tree pests. This study presents a large-scale assessment of tree-associated fungi and insects, revealing the diversity of these taxa across different geographic and climatic gradients. The dataset generated will facilitate further research on the distribution of fungal endophytes and insects in trees.
Article
Forestry
Steve Woodward, J. Asdrubel Flores-Pacheco, E. Jordan Munoz-Adalia, Pablo Martinez-Alvarez, Jorge Martin-Garcia, Julio J. Diez
Summary: This study examined the effect of inoculation with Fusarium circinatum on the survival of seed and seedlings of 19 populations of Pinus sylvestris. Results showed that spore density significantly affected germination and the survival of seedlings. Different populations of P. sylvestris exhibited varying levels of susceptibility to F. circinatum. These findings can be used in future breeding programs to reduce the pathogen's impact in Europe and Eurasia.
Review
Biochemistry & Molecular Biology
Irene Teresa Bocos-Asenjo, Jonatan Nino-Sanchez, Mireille Ginesy, Julio Javier Diez
Summary: RNA-based strategies, including mycoviruses and RNAi, offer a promising alternative to agrochemicals for plant disease management, with the potential to overcome research gaps and limitations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Hong Guo, Chenyang Lou, Junru Pang, Victoria Bellomo, Natalie Mantegna, Patricia Iglesias
Summary: A series of protic ionic liquids (PILs) derived from linear alkyl-benzenesulfonic acids with different alkyl chain length were synthesized in the laboratory and studied as additives to improve the frictional performance of mineral oil. The results showed that all PILs significantly enhanced the lubricity of mineral oil at low concentrations.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Entomology
Eva Sanchez-Hernandez, Pablo Martin-Ramos, Jonatan Nino-Sanchez, Sergio Diez-Hermano, Flor Alvarez-Taboada, Rodrigo Perez-Garcia, Alberto Santiago-Aliste, Jesus Martin-Gil, Julio Javier Diez-Casero
Summary: This study investigated the chemical components of the egg glue used by the Western Conifer Seed Bug to agglutinate eggs and adhere to pine needles. The adhesive secretion contains plasticizers, thermoplastic elastomer resins, and proteins in an oily matrix. Understanding the composition of the egg glue can help develop new control strategies for this pest insect to reduce the economic impact on pine nut production.
Article
Agriculture, Multidisciplinary
Jaime Olaizola, Oscar Santamaria, Julio J. Diez
Summary: Ectomycorrhizal fungi play a crucial role in forest ecosystem development and plant protection against pathogens. The study evaluated the impact of soil pH on the growth of nine species of edible ectomycorrhizal fungi in vitro. Results showed that A. rubescens and S. luteus exhibited the highest growth at high pH levels (6.5-8.5), while X. ferrugineus thrived at low pH (3.5-6.5). Furthermore, all strains acidified the growth medium after eight weeks of incubation.
Article
Endocrinology & Metabolism
Cristina Lamas, Rosa Camara, Carmen Fajardo, Pablo Remon-Ruiz, Betina Biagetti, Fernando Guerrero-Perez, Marta Araujo-Castro, Mireia Mora, Felicia Hanzu, Pedro Iglesias, Rogelio Garcia-Centeno, Alfonso Soto
Summary: In this retrospective study, temozolomide was found to be an effective medical treatment for aggressive pituitary neuroendocrine tumors and pituitary carcinomas, but may sometimes lead to tumor progression. Co-administration with radiotherapy may increase progression-free survival.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Carlos Garcia Gomez, Elena Navarro, Victoria Alcazar, Antonio Lopez-Guzman, Francisco Arrieta, Emma Anda, Betina Biagetti, Fernando Guerrero-Perez, Carles Villabona, Andres Ruiz de Assin Valverde, Cristina Lamas, Beatriz Lecumberri, Jose Antonio Rosado Sierra, Julia Sastre, Juan Jose Diez, Pedro Iglesias
Summary: Antithyroid drug-induced agranulocytosis is a rare but serious complication in the treatment of hyperthyroidism. This retrospective study in Spain analyzed 29 adult patients with AIA, finding that it usually occurs around 6 weeks after starting medication and presents with fever and odynophagia. Multiple drugs are needed to control hyperthyroidism and some patients may spontaneously recover.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Pedro Iglesias, Javier Arias, Guillermo Lopez, Iago Romero, Juan J. Diez
Summary: This study used artificial intelligence tools to evaluate the association between primary hyperparathyroidism (PHPT) and cardiovascular diseases (CVDs). The study found that patients with PHPT had a higher prevalence of hypertension, dyslipidemia, diabetes mellitus, and smoking habit compared to patients without a diagnosis of PHPT. Moreover, PHPT patients had a higher incidence of stroke, ischemic heart disease, atrial fibrillation, deep vein thrombosis, and pulmonary embolism compared to patients without a diagnosis of PHPT.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Pedro Iglesias, Ramona A. Silvestre, Maria Jose Fernandez-Reyes, Juan J. Diez
Summary: This review summarizes the clinical significance and potential therapeutic implications of copeptin as a surrogate marker for AVP concentrations in different kidney diseases and renal replacement therapy.
Article
Ecology
Sergio Diez-Hermano, Farooq Ahmad, Jonatan Nino-Sanchez, Alvaro Benito, Elena Hidalgo, Laura Morejon Escudero, Wilson Acosta Morel, Julio Javier Diez
Summary: This study describes and compares the fungal communities of declined and healthy specimens of keystone Mediterranean tree species, revealing differential abundance of certain genera between healthy and declined samples. The study emphasizes the importance of Mediterranean forests as biodiversity refuges and highlights the value of above-ground tissues as a valid approach to assess shifts in forests' microbiome diversity.
FRONTIERS IN FORESTS AND GLOBAL CHANGE
(2022)
Article
Engineering, Mechanical
Akshay Gaikwad, Juan Manuel Vazquez-Martinez, Jorge Salguero, Patricia Iglesias
Summary: The loss of energy due to friction is a major challenge in industries today, impacting both mechanical efficiency and the environment. Surface texturing, especially through laser texturing, has shown great potential in reducing friction and wear. This study focuses on the effect of laser texturing on the tribological properties of Ti6Al4V in contact with a ceramic ball. Results show that high dimple densities lead to significant reductions in friction and wear, while intermediate densities initially reduce friction, but eventually wear out and result in similar friction levels as untextured surfaces.
