Article
Geriatrics & Gerontology
Anne-Maree Kelly, Gerben Keijzers, Sharon Klim, Simon Craig, Win Sen Kuan, Anna Holdgate, Colin A. Graham, Peter Jones, Said Laribi
Summary: This study describes the epidemiology and outcomes of non-traumatic dyspnoea in patients aged 75 years or older presenting to emergency departments in the Asia-Pacific region. The results show that older patients with dyspnoea make up a small proportion of ED presentations, with common diagnoses including heart failure, lower respiratory tract infection, and chronic obstructive pulmonary disease. Older patients with dyspnoea have a high admission rate and significant mortality.
Article
Critical Care Medicine
Thomas Lafon, Arthur Baisse, Henry Hani Karam, Alexandre Organista, Marion Boury, Marcela Otranto, Aloise Blanchet, Thomas Daix, Bruno Francois, Philippe Vignon
Summary: The implementation of a new pathway dedicated to septic patients in the emergency department significantly improved early management, organ dysfunction, and outcomes. This improvement was achieved through educational programs, the incorporation of a sepsis alert in the professional software, adherence to severity scores and Surviving Sepsis Campaign bundle reminders, and the dedication of specific rooms for septic patients. Compliance with SSC bundles, organ dysfunction, and short-term mortality rates all showed significant improvement.
Article
Medicine, General & Internal
Oliver S. Mueller, Katharina M. Rentsch, Christian H. Nickel, Roland Bingisser
Summary: The study aimed to develop a TRIAL risk score based on routinely collected baseline and laboratory data to provide prognostic information for disposition decisions in the emergency department. Results showed that patients in the high-risk group had significantly higher mortality rates compared to those in the intermediate and low-risk groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Marco La Salvia, Emanuele Torti, Gianmarco Secco, Carlo Bellazzi, Francesco Salinaro, Paolo Lago, Giovanni Danese, Stefano Perlini, Francesco Leporati
Summary: This study developed two diagnostic tools for COVID-19 detection and oxygen therapy prediction, achieving promising classification results with F1 score levels meeting 92%. The research demonstrated machine learning models as a potential screening methodology during contingency times.
APPLIED SCIENCES-BASEL
(2022)
Article
Medicine, General & Internal
Paolo Bima, Emanuele Pivetta, Denise Baricocchi, Jacopo Davide Giamello, Francesca Risi, Matteo Vesan, Michela Chiarlo, Giuliano De Stefano, Enrico Ferreri, Giuseppe Lauria, Stefano Podio, Peiman Nazerian, Franco Apra, Enrico Lupia, Fulvio Morello
Summary: This study assessed the utility of lung ultrasound (LUS) in the Emergency Department (ED) for prognostic stratification of COVID-19 patients. The findings showed that LUS had good performance in predicting hospitalization or death as the primary outcome. The integration of LUS with a clinical score further improved sensitivity. LUS can improve prognostic stratification and support standardized disposition decisions for unvaccinated COVID-19 patients in the ED.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Paul M. E. L. van Dam, Noortje Zelis, Sander M. J. van Kuijk, Aimee E. M. J. H. Linkens, Renee A. G. Bruggemann, Bart Spaetgens, Iwan C. C. van der Horst, Patricia M. Stassen
Summary: This study evaluated the value of various prediction models in COVID-19 patients in the emergency department and found that the RISE UP score and 4 C mortality score had the best discriminatory performance for predicting 30-day mortality.
ANNALS OF MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Maria I. Donoso-Calero, Ancor Sanz-Garcia, Begona Polonio-Lopez, Clara Maestre Miquel, Carlos Durantez Fernandez, Laura Mordillo-Mateos, Alicia Mohedano-Moriano, Rosa Conty-Serrano, Martin Otero-Agra, Cristina Jorge-Soto, Jose L. Martin-Conty, Francisco Martin-Rodriguez
Summary: This study compared the predictive ability of the Sequential Organ Failure Assessment (SOFA) score and modified SOFA (mSOFA) score in patients with acute neurological pathology. The results showed that the mSOFA score was better at predicting 2-day mortality, while the SOFA score was better at predicting 28-day mortality and ICU admission. Therefore, the mSOFA score is a better predictor for short-term mortality, while the SOFA score is a better predictor for medium-term mortality and ICU admission.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Paul M. E. L. van Dam, Sien Lievens, Noortje Zelis, William P. T. M. van Doorn, Steven J. R. Meex, Jochen W. L. Cals, Patricia M. Stassen
Summary: This retrospective study compared the performance of different prediction models in identifying high-risk emergency department patients. The RISE UP and COPE scores were found to have the best discriminatory performance for predicting 31-day mortality.
ANNALS OF MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simone Schiaffino, Domenico Albano, Andrea Cozzi, Carmelo Messina, Roberto Arioli, Claudio Bna, Antonio Bruno, Luca A. Carbonaro, Alessandro Carriero, Serena Carriero, Pietro S. C. Danna, Elisa D'Ascoli, Claudia De Berardinis, Gianmarco Della Pepa, Zeno Falaschi, Salvatore Gitto, Alexis E. Malavazos, Giovanni Mauri, Lorenzo Monfardini, Alessio Pasche, Roberto Rizzati, Francesco Secchi, Angelo Vanzulli, Valeria Tombini, Ilaria Vicentin, Domenico Zagaria, Francesco Sardanelli, Luca M. Sconfienza
Summary: This study found that lower muscle mass on CT images was independently associated with intensive care unit admission and in-hospital mortality in patients with COVID-19.
Article
Emergency Medicine
Thomas Tschoellitsch, Philipp Seidl, Carl Bock, Alexander Maletzky, Philipp Moser, Stefan Thumfart, Michael Giretzlehner, Sepp Hochreiter, Jens Meier
Summary: This study aims to provide prediction models for discharge versus admission for ward observation or intensive care, and 30 day-mortality for patients triaged with the Manchester Triage System. Machine learning models were used to predict the outcomes, and the results showed that machine learning can effectively predict the admission decisions and mortality risk for patients in the emergency department.
EUROPEAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Review
Medicine, General & Internal
Kevin J. Karlic, Ellen K. Hummel, Nathan Houchens, Jennifer Meddings
Summary: Refractory dyspnoea is a challenging symptom, and access to palliative care specialists may be limited. Opioids are a safe and recommended pharmacological intervention, despite concerns about regulation and adverse effects. Current evidence suggests low rates of severe adverse effects when opioids are used for refractory dyspnoea, making them a valuable option for palliation, particularly in a hospital setting.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Henos Kiflom Zewde
Summary: This study evaluates the association between various process and timeliness indicators of comprehensive emergency obstetric care (CEmOC) and adverse maternal outcome in Keren Hospital. The study found that failure to provide necessary medication for postpartum hemorrhage, failure to administer prophylactic antibiotics, and delayed treatment for uterine rupture were significantly associated with adverse maternal outcomes. Delays in referral, triaging, seeing an obstetrician, and receiving definitive treatment were also strongly associated with adverse outcomes. Factors contributing to delay included erroneous diagnosis, inappropriate management, multiple referrals, unavailability of a senior obstetrician, and poor communication during referral. The study concludes that improving the referral system, upgrading the skills of health professionals, ensuring availability of life-saving drugs and equipment, and implementing standard management protocols are vital in reducing adverse maternal outcomes in Keren Hospital.
SCIENTIFIC REPORTS
(2022)
Article
Emergency Medicine
Ibrahim Toker, Aysin Kilinc Toker, Ayse Turung Ozdemir, Ilhami Celik, Oguzhan Bol, Emre Bulbul
Summary: This study investigated the characteristics and mortality rates among hospitalized patients with moderate and severe COVID-19 based on their vaccination status. The results showed that individuals aged 65 and above, unvaccinated individuals, and those with comorbidities had higher mortality rates, while vaccination status, age, and comorbidities were associated with mortality. The study did not evaluate vaccine efficacy, but lower mortality rates were observed among those vaccinated with Coronavac and Pfizer-BioNTech vaccines.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Pediatrics
Xiaoxia Li, Shu-Jun Hong, Hui Hong, Zhi-Qun Zhang, Jing Li
Summary: Neonatal hypertrophic cardiomyopathy is a rare and difficult-to-diagnose heart disease that can progress to sudden death. Echocardiography plays a crucial role in early detection and treatment. Family history investigation helps identify mildly affected individuals and gene carriers for timely intervention and treatment.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, General & Internal
Feng Xie, Marcus Eng Hock Ong, Johannes Nathaniel Min Hui Liew, Kenneth Boon Kiat Tan, Andrew Fu Wah Ho, Gayathri Devi Nadarajan, Lian Leng Low, Yu Heng Kwan, Benjamin Alan Goldstein, David Bruce Matchar, Bibhas Chakraborty, Nan Liu
Summary: This cohort study developed an interpretable machine learning tool to estimate mortality risk in individuals admitted to the hospital from the emergency department. The tool, named Score for Emergency Risk Prediction, showed promise in accurately identifying patients at risk of death within 2, 7, or 30 days of admission. The machine learning tool outperformed several benchmark clinical scores, indicating its potential for widespread application and validation in different healthcare settings.
Article
Multidisciplinary Sciences
Fabrizia Schmid, Alexandra Malinovska, Karin Weigel, Tito Bosia, Christian H. Nickel, Roland Bingisser
Article
Critical Care Medicine
Christian H. Nickel, John Kellett, Ricardo Nieves Ortega, Le Lyngholm, Lucien Wasingya-Kasereka, Mikkel Brabrand
Article
Emergency Medicine
Ricardo Nieves Ortega, Christiane Rosin, Roland Bingisser, Christian H. Nickel
JOURNAL OF EMERGENCY MEDICINE
(2019)
Article
Medicine, General & Internal
Christian H. Nickel, John Kellett, Ricardo Nieves Ortega, Le Lyngholm, Stine Hanson, Tim Cooksley, Roland Bingisser, Mikkel Brabrand
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2020)
Article
Medicine, General & Internal
Roland Bingisser, Severin Manuel Baerlocher, Tobias Kuster, Ricardo Nieves Ortega, Christian H. Nickel
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Medicine, General & Internal
Isabelle Osterwalder, Merve Ozkan, Alexandra Malinovska, Christian H. Nickel, Roland Bingisser
JOURNAL OF CLINICAL MEDICINE
(2020)
Letter
Anesthesiology
Alexandra Malinovska, Ketina Arslani, Nuria Zellweger, Catherine Gebhard, William Beaubien-Souligny, Alexander Calderone, Martin Siegemund, Markus Aschwanden, Andre Denault, Caroline E. Gebhard
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2021)
Article
Emergency Medicine
Ricardo Nieves-Ortega, Mikkel Brabrand, Gilles Dutilh, John Kellett, Roland Bingisser, Christian H. Nickel
Summary: Assessing patient's mobility at triage can improve ESI's prediction of adverse outcomes. Patients with impaired mobility had lower 30-day survival rates in ESI levels 1-3, while patients with normal mobility had similar survival rates regardless of their ESI level.
EUROPEAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Medicine, General & Internal
Alexandra Malinovska, Liliana Malinovska, Christian H. Nickel, Roland Bingisser
Summary: Research has found that there can be discrepancies between symptoms and abnormal body temperature in emergency department patients, which may be associated with an increased risk of acute morbidity and hospitalization.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Oluwakemi Badaki-Makun, Scott Levin, Arnaud Debraine, Benjamin Hernried, Alexandra Malinovska, Aria Smith, Matthew Toerper, Katherine Z. J. Fenstermacher, Taylor Cottle, Malgorzata Latallo, Richard E. Rothman, Jeremiah S. Hinson
Summary: Monocyte Distribution Width (MDW) can serve as an indicator for screening SARS-CoV-2 and influenza infections, with high sensitivity and negative predictive values.
SCIENTIFIC REPORTS
(2022)
Article
Emergency Medicine
Alexandra Malinovska, Jeremiah S. Hinson, Oluwakemi Badaki-Makun, Benjamin Hernried, Aria Smith, Arnaud Debraine, Matthew Toerper, Richard E. Rothman, Thomas Kickler, Scott Levin
Summary: This study evaluated the performance of monocyte distribution width (MDW) alone and in combination with other routine CBC parameters as a screen for sepsis and septic shock in ED patients. The results showed that MDW, when used alone or in combination with white blood count (WBC) and neutrophil-to-lymphocyte ratio (NLR), can effectively detect infections and septic shock in a broad ED population. This suggests that MDW has pragmatic value as a rapid screening method.
JOURNAL OF THE AMERICAN COLLEGE OF EMERGENCY PHYSICIANS OPEN
(2022)
Article
Multidisciplinary Sciences
Stefan M. Herzog, Mirjam A. Jenny, Christian H. Nickel, Ricardo Nieves Ortega, Roland Bingisser
Article
Medicine, General & Internal
Ammann Stefan, Schoell Eckehart, Ortega Ricardo Nieves, Bingisser Roland
SWISS MEDICAL WEEKLY
(2020)
Article
Emergency Medicine
Alexandra Malinovska, Laurentia Pitasch, Nicolas Geigy, Christian H. Nickel, Roland Bingisser
WESTERN JOURNAL OF EMERGENCY MEDICINE
(2019)
Article
Oncology
Marcus Vetter, Julia Landin, Barbara Maria Szczerba, Francesc Castro-Giner, Sofia Gkountela, Cinzia Donato, Ilona Krol, Ramona Scherrer, Catharina Balmelli, Alexandra Malinovska, Alfred Zippelius, Christian Kurzeder, Viola Heinzelmann-Schwarz, Walter Paul Weber, Christoph Rochlitz, Nicola Aceto
BREAST CANCER RESEARCH
(2018)