Review
Medicine, General & Internal
Ana Carolina Pereira Nunes Pinto, Aline Rocha, Luciano F. Drager, Geraldo Lorenzi-Filho, Daniela Pachito
Summary: The study aimed to evaluate the effectiveness and safety of non-invasive positive pressure ventilation (NIPV) for the treatment of adults with central sleep apnoea (CSA). The results showed that CPAP plus best supportive care may reduce central AHI in people with CSA associated with chronic heart failure compared to best supportive care alone. Further high-quality trials focusing on patient-centered outcomes are needed to determine the best treatment for different groups of CSA patients.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Satomi Imanari, Yasuhiro Tomita, Satoshi Kasagi, Fusae Kawana, Yuka Kimura, Sugao Ishiwata, Koji Narui, Takatoshi Kasai
Summary: The study found a modest correlation between AHI determined by the ASV device AutoSet CS (ASC) and that calculated by polysomnography (PSG) in patients with HF and SDB. However, the ASC device tended to overestimate AHI and showed moderate agreement with PSG results.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Jingting Wang, Naima Covassin, Tianxin Dai, Zhengyang Fan, Patiguli Yisilamu, Dance Sun, Fei Li, Jiang Xie
Summary: The effectiveness of ASV therapy in reducing cardiovascular and all-cause mortality in CSA patients remains debatable. However, ASV treatment can significantly reduce the risk of MACEs in patients with nadir nocturnal saturation <= 80%. For heart failure patients, those with LVEF > 33% or NYHA I/II classification benefit from ASV therapy in lowering MACEs risk compared to usual care.
Article
Cardiac & Cardiovascular Systems
Christoph Fisser, Lara Gall, Jannis Bureck, Victoria Vaas, Joerg Priefert, Sabine Fredersdorf, Florian Zeman, Dominik Linz, Holger Woehrle, Renaud Tamisier, Helmut Teschler, Martin R. R. Cowie, Michael Arzt
Summary: This study aimed to evaluate the effects of ASV on nocturnal ventricular arrhythmias in patients with CSA and HFrEF. The results showed that adding ASV to guideline-based medical management did not significantly affect nocturnal ventricular ectopy or tachyarrhythmia over a period of 12 months.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Clinical Neurology
Renaud Tamisier, Jean-Louis Pepin, Martin R. Cowie, Karl Wegscheider, Eik Vettorazzi, Anna Suling, Christiane Angermann, Marie-Pia D'Ortho, Erland Erdmann, Anita K. Simonds, Virend K. Somers, Helmut Teschler, Patrick Levy, Holger Woehrle
Summary: This sub study analyzed the effectiveness of adaptive servo ventilation (ASV) in treating central sleep apnea (CSA) in heart failure patients. The results showed that after 12 months, the ASV group had better respiratory measures compared to the control group. However, the differences in sleep measures were unlikely to be clinically significant. ASV therapy also led to an increase in periodic leg movements during sleep (PLMS), which may be associated with increased cardiovascular risk.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Clinical Neurology
Dominik Linz, Maximilian Valentin Malfertheiner, Nils Werner, Christoph Lerzer, Florian Gfuellner, Benedikt Linz, Florian Zeman, R. Doug McEvoy, Michael Arzt, Mathias Baumert
Summary: ASV treatment reduced AHI in all patient groups, but nocturnal hypoxemic burden remained high due to a non-specific component of T90 not related to episodic desaturation. Further study is warranted to explore whether adjunct risk factor management, such as weight-loss, can further reduce T90.
Review
Medicine, General & Internal
Aline Rocha, Ana Carolina Pereira Nunes Pinto, Daniela Pachito, Luciano F. Drager, Geraldo Lorenzi-Filho, Alvaro N. Atallah
Summary: Central sleep apnoea (CSA) is a condition characterized by impaired breathing during sleep, and pharmacological treatment has shown some benefit in improving the symptoms and quality of life in patients with CSA. However, the available evidence is uncertain and further research is needed to establish the effectiveness and safety of pharmacological agents for CSA.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Article
Clinical Neurology
Sandeep Raut, Gaurav Gupta, Rajiv Narang, Animesh Ray, R. M. Pandey, Atul Malhotra, Sanjeev Sinha
Summary: The study found a significant association between OSA severity and ventricular function as well as cardiac injury assessed by hs-cTnI. There was a marginal positive correlation between AHI events and mitral E/e' ratio. The circulating levels of hs-cTnI were significantly associated with different severity grades of OSA.
Article
Respiratory System
Patrick Levy, Matthew T. Naughton, Renaud Tamisier, Martin R. Cowie, T. Douglas Bradley
Summary: Heart failure and sleep disordered breathing often coexist and can lead to myocardial damage and worse prognosis in patients.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Mathias Baumert, Dominik Linz, Michael Pfeifer, Maria Tafelmeier, Philippe Felfeli, Michael Arzt, Sobhan S. Shahrbabaki
Summary: This study confirmed the effectiveness of adaptive servo-ventilation (ASV) in reducing hypoxaemic burden related to sleep apnoea in heart failure patients. However, a significant hypoxaemic burden remained, which was related to the severity of heart failure and may have negative implications for long-term cardiovascular outcomes.
Article
Respiratory System
Christoph Fisser, Jannis Bureck, Lara Gall, Victoria Vaas, Jorg Priefert, Sabine Fredersdorf, Florian Zeman, Dominik Linz, Holger Wohrle, Renaud Tamisier, Helmut Teschler, Martin R. Cowie, Michael Arzt
Summary: Cheyne-Stokes respiration (CSR) may trigger ventricular arrhythmia in patients with heart failure with reduced ejection fraction (HFrEF) and central sleep apnoea (CSA). This study found a high nocturnal ventricular arrhythmia burden in HFrEF and CSA patients, with significant associations with male sex, lower systolic blood pressure, non-use of antiarrhythmic medication, and a specific level of CSR. Ventricular arrhythmias occurred more frequently during sleep stages with CSR compared to those without.
Article
Medicine, Research & Experimental
Simone B. Duss, Anne-Kathrin Brill, Sebastien Baillieul, Thomas Horvath, Frederic Zubler, Dominique Fluegel, Georg Kaegi, Gabriel Benz, Corrado Bernasconi, Sebastian R. Ott, Lyudmila Korostovtseva, Yurii Sviryaev, Farid Salih, Matthias Endres, Renaud Tamisier, Haralampos Gouveris, Yaroslav Winter, Niklaus Denier, Roland Wiest, Marcel Arnold, Markus H. Schmidt, Jean-Louis Pepin, Claudio L. A. Bassetti
Summary: This study aims to investigate the feasibility and efficacy of ASV treatment in patients with acute stroke and SDB, as well as assess the impact of SDB on stroke outcomes.
Article
Clinical Neurology
Paulina Sun, Kyle Porter, Winfried Randerath, David Jarjoura, Rami Khayat
Summary: This study analyzed the mortality risk of patients with heart failure and central sleep apnea who used different types of adaptive servo-ventilation (ASV) devices. The results showed that patients who used the ASV device for more than 3 hours had a lower mortality rate compared to those who used it for less than 3 hours. Furthermore, there were differential effects on patient survival between ASVpf devices with automatically adjusting end-expiratory pressure (EPAP) and ASVmv devices with fixed EPAP.
SLEEP AND BREATHING
(2023)
Article
Clinical Neurology
Mahssa Karimi, Jan Hedner, Ludger Grote
Summary: Adaptive Servo Ventilation (ASV) treatment improves sleep quality, neurocognition, and daytime performance in patients with chronic heart failure (CHF) and Cheyne-Stokes respiration (CSR).
Article
Cardiac & Cardiovascular Systems
Muthiah Vaduganathan, Naveed Sattar, Jialin Xu, Javed Butler, Kenneth W. Mahaffey, Bruce Neal, Wayne Shaw, Norman Rosenthal, Michael Pfeifer, Michael K. Hansen, James L. Januzzi
Summary: This study found that canagliflozin, an SGLT2 inhibitor, delays the increase of hs-cTnT and sST2 and reduces the occurrence of heart failure and kidney events. High levels of hs-cTnT and sST2, along with other cardiovascular biomarkers, can predict cardiovascular and kidney outcomes and may influence the treatment effects of canagliflozin.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Respiratory System
Renaud Tamisier, Jean-Louis Pepin, Holger Woehrle, Muriel Salvat, Gilles Barone-Rochette, Cecile Rocca, Eik Vettorazzi, Helmut Teschler, Martin Cowie, Patrick Levy
Summary: This study investigated the effect of ASV on sympathetic tone in patients with HFrEF and CSA. The results showed that ASV did not effectively suppress sympathetic activation in heart failure patients and was associated with increased cardiovascular mortality.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Edith L. Posada-Martinez, Zachary L. Cox, Mariana M. Cano-Nieto, Nikein D. Ibarra-Marquez, Julieta Moreno-Villagomez, Pedro Gudino-Bravo, Jose A. Arias-Godinez, Salvador Lopez-Gil, Magdalena Madero, Veena S. Rao, Alexandre Mebazaa, Daniel Burkhoff, Martin R. Cowie, Marat Fudim, Kevin Damman, Barry A. Borlaug, Jeffrey M. Testani, Juan B. Ivey-Miranda
Summary: In this study, we compared changes in inferior vena cava diameter (IVCD) with venous pressure during ultrafiltration in patients with cardiac dysfunction. The results showed that IVCD tracked changes in volume status and hemoconcentration better than venous pressure, suggesting that IVCD is a more accurate indicator for monitoring the management of heart failure patients.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Transplantation
Xinting Cai, Barbara Thorand, Simon Hohenester, Wolfgang Koenig, Wolfgang Rathmann, Annette Peters, Jana Nano
Summary: This German cohort study aimed to evaluate the relationship between fatty liver and kidney function/chronic kidney disease (CKD). The study found that fatty liver is associated with kidney function and CKD, and this association is partially mediated by metabolic factors such as inflammation, diabetes, and hypertension.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Respiratory System
Patrick Levy, Sophia Schiza
EUROPEAN RESPIRATORY JOURNAL
(2023)
Letter
Hematology
Jordan M. Kraaijenhof, Tjerk S. J. Opstal, Jan H. Cornel, Dipender Gill, G. Kees Hovingh, Alberico L. Catapano, Wolfgang Koenig, Paul M. Ridker, Erik S. G. Stroes, Nick S. Nurmohamed
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Nick S. Nurmohamed, Jordan M. Kraaijenhof, Manuel Mayr, Stephen J. Nicholls, Wolfgang Koenig, Alberico L. Catapano, Erik S. G. Stroes
Summary: Given the limited accuracy of clinically used risk scores, novel risk algorithms based on proteomics and lipidomics data could provide more reliable ASCVD risk prediction. Retrospective studies have consistently shown the additive prognostic value of these panels over traditional risk scores, and prospective studies are needed to determine their clinical utility.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Ewa A. Jankowska, Peter P. Liu, Martin R. Cowie, Max Groenhart, Kelly D. Cobey, Jonathan Howlett, Michel Komajda, Lars H. Lund, Jose Antonio Magana Serrano, Ricardo Mourilhe-Rocha, Giuseppe M. C. Rosano, Clara Saldarriaga, Pedro V. Schwartzmann, Faiez Zannad, Jian Zhang, Yuhui Zhang, Andrew J. S. Coats
Summary: As part of the REWOLUTION HF programme, two international surveys were conducted to assess the educational needs of healthcare professionals (HCPs) and patients' perspectives on the care of heart failure (HF). The surveys revealed that most HCPs prioritize rapid initiation of guideline-mandated medications and discuss treatment goals with patients. There was good agreement between HCPs and patients on key treatment goals, although HCPs placed greater emphasis on reducing hospitalizations. Patients expressed a desire for more information about HF and its consequences, prognosis, and treatments.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Letter
Respiratory System
Renaud Tamisier, Jean-Louis Pepin, Patrick Levy
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Health Care Sciences & Services
Arvind Singhal, Jillian P. Riley, Martin R. Cowie
Summary: Prior to the Covid-19 pandemic, heart failure (HF) disease management programmes were predominantly in-person, but the pandemic necessitated a shift to teleconsultations. Telemedicine consultations were found to be more convenient for patients, saved them time, and were generally acceptable to clinicians. However, it also brought changes to workflows, consultation dynamics, and clinical assessment methods.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Wolfgang Koenig, Elke S. Lorenz, Lea Beier, Ioanna Gouni-Berthold
Summary: This study investigated the real-world persistence and adherence to lipid-lowering therapies in German patients with cardiovascular disease. The findings showed low persistence and adherence rates, especially in women. The study also found that patients who discontinued treatment had a relatively short average treatment duration, and only about 10% of patients persisted in medication for more than 300 days. Overall, the persistence rates with lipid-lowering therapies were low at 36 months.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Philip Moons, Tone M. Norekval, Elena Arbelo, Britt Borregaard, Barbara Casadei, Bernard Cosyns, Martin R. Cowie, Donna Fitzsimons, Alan G. Fraser, Tiny Jaarsma, Paulus Kirchhof, Josepa Mauri, Richard Mindham, Julie Sanders, Francois Schiele, Aleksandra Torbica, Ann Dorthe Zwisler
Summary: Patient-reported outcomes (PROs) play a crucial role in understanding patients' perspectives on their health and medical conditions. Their use can lead to improvements in healthcare quality and informed clinical decisions. This article provides an overview of PROs for cardiovascular populations, including disease-specific and domain-specific measures, as well as international standards and guidelines for their selection. Collaboration and evaluation of PROs are needed to guide decision-making in regulatory contexts and to monitor care quality and resource allocation. New sources, such as wearable devices and electronic health records, offer opportunities for collecting PROs.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Amr Abdin, Stefan D. Anker, Martin R. Cowie, Gerasimos S. Filippatos, Piotr Ponikowski, Luigi Tavazzi, Jakob Schoepe, Stefan Wagenpfeil, Michel Komajda, Michael Boehm
Summary: This study evaluated the associations between baseline resting heart rate and systolic blood pressure with outcomes and treatment patterns in heart failure patients. The results showed that high resting heart rate and low systolic blood pressure were associated with worse cardiovascular outcomes, but were not the only reasons for suboptimal treatment in patients.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Vasileios Kouranos, Rajdeep S. Khattar, Joseph Okafor, Raheel Ahmed, Alessia Azzu, John Arun Baksi, Kshama Wechalekar, Martin R. Cowie, Athol Umfrey Wells, Thomas F. Luscher, Rakesh Sharma
Summary: This study describes the baseline characteristics of a sizable and deeply phenotyped contemporary cohort of cardiac sarcoidosis (CS) patients and investigates the predictors of poor outcomes. The study found that CS is associated with significant morbidity and mortality, particularly in those with cardiac involvement as the first manifestation. Serum brain natriuretic peptide levels, left ventricular ejection fraction, and myocardial inflammation were identified as independent predictors of outcomes.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Liesl Zuhlke, Jennifer Franke, Martin R. Cowie
Article
Cardiac & Cardiovascular Systems
Julia Karady, Thomas Mayrhofer, James L. Januzzi, James E. Udelson, Jerome L. Fleg, Bela Merkely, Michael T. Lu, William F. Peacock, John T. Nagurney, Wolfgang Koenig, Maros Ferencik, Udo Hoffmann
Summary: This study aimed to determine the concordance of different high-sensitivity cardiac troponin (hs-cTn) assays in risk stratification for cardiovascular disease and compare the differences in patient management, cost, and predicted quality of care.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)