Article
Cardiac & Cardiovascular Systems
Caroline Espersen, Daniel Modin, Elke Platz, Gorm Boje Jensen, Peter Schnohr, Eva Prescott, Gunnar Gislason, Rasmus Mogelvang, Tor Biering-Sorensen
Summary: This study aimed to investigate the prognostic importance of Wall Motion Score Index (WMSI) for the development of heart failure (HF). The study found that wall motion abnormalities in any regional left ventricular wall and global WMSI were associated with incident HF, independent of baseline clinical data, left ventricular ejection fraction, and E/A.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alia S. Alhakak, Morten Sengelov, Peter G. Jorgensen, Niels E. Bruun, Cecilie Johnsen, Ulrik Abildgaard, Allan Z. Iversen, Thomas F. Hansen, John R. Teerlink, Fady I. Malik, Scott D. Solomon, Gunnar Gislason, Tor Biering-Sorensen
Summary: In patients with HFrEF, SET provides independent and incremental prognostic information regarding all-cause mortality. MPI is a significant predictor in an unadjusted model, but the association does not remain significant after multivariable adjustment. No significant associations between IVCT or IVRT and mortality were found.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Medicine, General & Internal
Banafsheh Arshi, Sven Geurts, Martijn J. Tilly, Marten van den Berg, Jan A. Kors, Dimitris Rizopoulos, M. Arfan Ikram, Maryam Kavousi
Summary: HRV indices are associated with worse systolic function in men and improvement in left atrial size in women. Higher HRV is associated with a higher risk of new-onset HF in men.
Article
Cardiac & Cardiovascular Systems
Katja Vu, Brian L. Claggett, Jenine E. John, Hicham Skali, Scott D. Solomon, Thomas H. Mosley, Janice E. Williams, Anna Kucharska-Newton, Tor Biering-Sorensen, Amil M. Shah
Summary: Depressive symptoms are associated with incident HFpEF in late life, independent of common comorbidities, cardiac structure and function, and prognostic biomarkers.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Ruth Tamrat, Yu Kang, Marielle Scherrer-Crosbie, Lisa D. Levine, Zoltan Arany, Jennifer Lewey
Summary: In a study on peripartum cardiomyopathy (PPCM), it was found that women typically have normal left ventricular ejection fraction and size during gestation before developing PPCM, but there is a trend towards abnormal global longitudinal and circumferential strain. This indicates that strain imaging could potentially serve as a screening method for high-risk PPCM populations.
Article
Cardiac & Cardiovascular Systems
Renato A. Hortegal, Renata Valeri, Mariana Grizante, Renato Cancellier, Carlos Gun, Jorge Assef, Henrique Moriya, Romeu Meneghelo, Fausto Feres, Kleber G. Franchini
Summary: The study aimed to improve the low sensitivity of HFpEF detection through provocative maneuvers. The findings revealed a significant decrease in peak strain during acute pressure overload in patients with HFpEF.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Amir A. Mahabadi, Viktoria Anapliotis, Iryna Dykun, Stefanie Hendricks, Fadi Al-Rashid, Peter Luedike, Matthias Totzeck, Tienush Rassaf
Summary: This study aimed to investigate the association between epicardial adipose tissue (EAT) and the development of heart failure with preserved ejection fraction (HFpEF) in patients with coronary artery disease. The results showed that EAT index (EATi) at baseline and its change over time were both associated with the development of HFpEF. This finding supports the need for further research on regulating EAT as a treatment target for HFpEF.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Harpreet S. Bhatia, Marin Nishimura, Armando Martinez, Sai Vanam, Andrew M. Kahn, Anthony DeMaria, Isac C. Thomas
Summary: This study evaluated the occult systolic dysfunction and the effect of methamphetamine cessation in patients with both methamphetamine use and heart failure with preserved ejection fraction. The results showed that methamphetamine cessation led to an improvement in global longitudinal strain and a reduction in the risk of heart failure admissions.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Shiro Hoshida, Shungo Hikoso, Yukinori Shinoda, Koichi Tachibana, Tomoko Minamisaka, Tamaki Shunsuke, Masamichi Yano, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Takahisa Yamada, Yoshio Yasumura, Daisaku Nakatani, Yasushi Sakata
Summary: This study aimed to investigate the association between changes in the afterload-integrated diastolic index (Ed/Ea) and prognosis in patients with heart failure with preserved ejection fraction (HFpEF). The results showed that high Ed/Ea was significantly associated with increased mortality and re-admission for heart failure during the second year after discharge. This finding suggests that Ed/Ea has time-sensitive prognostic performance in older patients with HFpEF.
Review
Cardiac & Cardiovascular Systems
Brian P. Halliday, Roxy Senior, Dudley J. Pennell
Summary: The measurement of left ventricular ejection fraction (LVEF) has been a key component in imaging studies for cardiac patients, but its utility as a prognostic indicator has diminished in certain populations such as heart failure patients with preserved ejection fraction (HF-PEF) and those with valvular heart disease. Assessing myocardial strain, particularly global longitudinal strain (GLS), holds promise in improving risk stratification and therapy selection for these patients. Additional studies are needed to fully integrate GLS into routine clinical practice and improve patient outcomes.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Brian P. Halliday, Roxy Senior, Dudley J. Pennell
Summary: Traditional methods of assessing cardiac function like LVEF are no longer accurate in predicting prognosis for heart failure patients, highlighting the need for better indicators such as GLS to improve risk stratification and accuracy of disease assessment. For patients with heart failure and valvular heart disease, GLS may be a superior option to consider.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Yook Chin Chia, Lyanne M. Kieneker, Gaston van Hassel, S. Heleen Binnenmars, Ilja M. Nolte, Jelmer J. van Zanden, Peter van der Meer, Gerjan Navis, Adriaan A. Voors, Stephan J. L. Bakker, Martin H. De Borst, Michele F. Eisenga
Summary: The study found that IL-6 levels are associated with new-onset HFpEF in community-dwelling individuals, independent of potential confounders.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Ditte Madsen Andersen, Morten Sengelov, Flemming Javier Olsen, Jacob Louis Marott, Gorm Boje Jensen, Peter Schnohr, Elke Platz, Morten Schou, Rasmus Mogelvang, Tor Biering-Sorensen
Summary: In a large community cohort study, left atrial parameters measured on transthoracic echocardiography were found to be predictors of incident heart failure. Among participants without atrial fibrillation or significant valve disease, LAVImin was identified as an independent predictor of incident heart failure, whereas LAVImax was not.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Review
Cardiac & Cardiovascular Systems
Sherif F. Nagueh
Summary: HFpEF is a prevalent form of heart failure with various cardiac and non-cardiac manifestations, diagnosis of which relies on multiple measurements. Despite increasing understanding of its pathophysiology, specific treatment for HFpEF patients remains elusive.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Sungwoo Choi, Sangun Nah, Young Soon Cho, Inki Moon, Jae Wook Lee, Choung Ah Lee, Ji Eun Moon, Sangsoo Han
Summary: This study aimed to confirm the effect of augmented reality (AR) glasses on echocardiographic interpretation in patients with heart failure (HF). The results showed that the use of AR glasses improved the consistency of left ventricular ejection fraction (LVEF) measurements, especially for less experienced physicians.
Article
Cardiac & Cardiovascular Systems
Daniel Molager Christensen, Sidsel Marie Bernt Jorgensen, Mohamad El-Chouli, Matthew Phelps, Anne-Marie Schjerning, Thomas S. G. Sehested, Thomas Gerds, Caroline Sindet-Pedersen, Tor Biering-Sorensen, Christian Torp-Pedersen, Morten Schou, Gunnar Gislason
Summary: Influenza vaccine uptake among patients with cardiovascular disease in a universal-access healthcare system is suboptimal, especially among young patients.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Letter
Cardiac & Cardiovascular Systems
Emilie K. Frimodt-Moller, John S. Gottdiener, Elsayed Z. Soliman, Jorge R. Kizer, Eric Vittinghoff, Bruce M. Psaty, Tor Biering-Sorensen, Gregory M. Marcus
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Psychiatry
Valdemar Romer, Pradeesh Sivapalan, Josefin Ekloef, Susanne D. Nielsen, Zitta B. Harboe, Tor Biering-Sorensen, Theis Itenov, Jens-Ulrik S. Jensen
Summary: This study found that SARS-CoV-2 infection was not associated with an increased risk of psychiatric admissions in the general population of Denmark. However, there was an increased risk of de novo prescription of psychoactive medication among infected individuals.
EUROPEAN PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Tor Biering-Sorensen, Mats C. Hojbjerg Lassen, Amil Shah, Brian Claggett, Michael Zile, Burkert Pieske, Elisabeth Pieske-Kraigher, Adriaan Voors, Victor Shi, Martin Lefkowitz, Milton Packer, John J. V. Mcmurray, Scott D. Solomon
Summary: This study aimed to assess whether treating patients with heart failure with preserved ejection fraction with sacu-bitril/valsartan would significantly improve global longitudinal strain (GLS) and global circumferential strain (GCS) compared with valsartan alone. The results showed that GCS was significantly improved in the sacubitril/valsartan group, while GLS did not show significant improvement.
JOURNAL OF CARDIAC FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Mats Christian Hojbjerg Lassen, Jannie Norgaard Lind, Morten Sengelov, Kristoffer Grundtvig Skaarup, Niklas Dyrby Johansen, Atif N. Qasim, Magnus T. Jensen, Gorm Boje Jensen, Peter Schnohr, Rasmus Mogelvang, Tor Biering-Sorensen
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Medicine, General & Internal
Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Daniel Modin, Brian L. Claggett, Erica L. Dueger, Sandrine Samson, Matthew M. Loiacono, Lars Kober, Scott Solomon, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Cyril Jean-Marie Martel, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: This study investigated whether behavioural nudges delivered via a governmental electronic letter system could increase influenza vaccination uptake among older adults in Denmark. The results showed that sending an electronic letter highlighting potential cardiovascular benefits of vaccination or sending repeated letters at randomisation and at day 14 significantly improved vaccination rates.
Article
Immunology
Jorge Jacob, Tor Biering-Sorensen, Lars Holger Ehlers, Christina H. Edwards, Kristin Greve-Isdahl Mohn, Anna Nilsson, Jonas Hjelmgren, Wenkang Ma, Yuvraj Sharma, Emanuele Ciglia, Joaquin Mould-Quevedo
Summary: This study evaluated the cost-effectiveness of the MF59 (R)-adjuvanted quadrivalent influenza vaccine (aQIV) compared to the traditional standard-dose quadrivalent influenza vaccine (SD-QIV) and the high-dose quadrivalent influenza vaccine (HD-QIV) for adults aged 65 years and above in Denmark, Norway, and Sweden. The results showed that vaccination with aQIV could prevent a significant number of influenza infections, hospitalizations, and deaths compared to SD-QIV. From a healthcare payer perspective, aQIV was cost-effective in all three countries and was cost saving compared to HD-QIV.
Review
Medicine, General & Internal
Caroline Lokke Bjerregaard, Kristoffer Grundtvig Skaarup, Mats Christian Hojbjerg Lassen, Tor Biering-Sorensen, Flemming Javier Olsen
Summary: Ventricular arrhythmia is a main cause of sudden cardiac death and identifying patients at risk is important but challenging. Left ventricular ejection fraction (LVEF) is used to determine the need for an implantable cardioverter defibrillator (ICD), but it has limitations. Strain imaging, specifically speckle-tracking echocardiography, has potential as a sensitive technique to identify systolic dysfunction and predict ventricular arrhythmias. Different strain measures, such as global longitudinal strain, regional strain, and mechanical dispersion, have been proposed as markers for ventricular arrhythmias.
Review
Cardiac & Cardiovascular Systems
Shreeya Sharma, Mats Christian Hojbjerg Lassen, Anne Bjerg Nielsen, Kristoffer Grundtvig Skaarup, Tor Biering-Sorensen
Summary: Longitudinal layer specific strain (LSS) is a novel non-invasive imaging technique that can accurately diagnose and predict adverse cardiac events. This systematic review and meta-analysis found that longitudinal LSS is a significant diagnostic marker for coronary artery disease (CAD) in patients with ischemic heart disease (IHD), with epicardial LSS being the strongest diagnostic marker for CAD in stable angina pectoris (SAP) patients and endocardial LSS being the strongest diagnostic marker for CAD in non-ST elevation acute coronary syndrome (NSTE-ACS) patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Helena Zander Wodschow, Filip Soskov Davidovski, Jacob Christensen, Mats Christian Hojbjerg Lassen, Kristoffer Grundtvig Skaarup, Hanne Nygaard, Niels Moller, Jorgen Rungby, Tor Biering-Sorensen, Peter Rossing, Nicole Jacqueline Jensen, Jens Christian Laursen
Summary: Ketone esters did not show significant effects on left ventricular ejection fraction, cardiac output, or blood oxygen saturation in COVID-19 patients, but acutely improved absolute global longitudinal strain.
FRONTIERS IN NUTRITION
(2023)
Article
Respiratory System
Sarah Altaraihi, Peter Kamstrup, Josefin Eklof, Niklas Dyrby Johansen, Tor Biering-Sorensen, Pradeesh Sivapalan, Jens-Ulrik Jensen
Summary: This study aimed to evaluate whether the use of prophylactic oral anticoagulation prior to COVID-19 infection could reduce the risk of all-cause mortality, hospital admission, and ICU admission in COVID-19 patients. The results showed that the use of oral anticoagulants did not provide any prophylactic benefits in terms of reducing the risk of all-cause mortality, but slightly increased the risk of hospital admission.
Article
Cardiac & Cardiovascular Systems
Alia Saed Alhakak, Flemming Javier Olsen, Kristoffer Grundtvig Skaarup, Mats Christian Hojbjerg Lassen, Niklas Dyrby Johansen, Caroline Espersen, Ulrik Abildgaard, Gorm Boje Jensen, Peter Schnohr, Jacob Louis Marott, Peter Sogaard, Rasmus Mogelvang, Tor Biering-Sorensen
Summary: This study found that cardiac time intervals change over time and are accelerated by certain clinical factors. An increase in IVRT is associated with an increased risk of future heart failure in younger participants.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Urology & Nephrology
Katja Vu Bartholdy, Niklas Dyrby Johansen, Nino Landler, Kristoffer Grundtvig Skaarup, Jesper Jensen, Iain Bressendorff, Morten Schou, Jacob Christensen, Bo Feldt-Rasmussen, Muthiah Vaduganathan, Scott Solomon, Richard Haynes, Frederik Persson, Peter Rossing, Lars Kober, Faiez Zannad, Ditte Hansen, Tor Biering-Sorensen
Summary: This study aims to evaluate the effects of SGLT2 inhibitors on cardiac structure and function in patients with CKD. The results will provide insights into the cardioprotective mechanisms of SGLT2 inhibitors in patients with CKD.
Article
Health Care Sciences & Services
Saba Manzoor, Mike Colacci, Jason Moggridge, Michelle Gyenes, Tor Biering-Sorensen, Mats Hojbjerg C. Lassen, Fahad Razak, Amol Verma, Shohinee Sarma, Michael Fralick
Summary: Hyperglycemia in hospitalized patients does not always indicate diabetes, and overtreatment can lead to potential harm.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Philip Brainin, Laura Cordeiro Gomes, Anna E. Holm, Luan O. Matos, Alma Wegener, Karine O. Lima, Molly D. Kaagaard, Isabelle V. M. Vieira, Rodrigo Medeiros de Souza, Flemming Javier Olsen, Claudio Romero Farias Marinho, Tor Biering-Sorensen, Odilson M. Silvestre
Summary: Adults with uncomplicated malaria have lower left ventricular contractile function compared to the general population, and this improves after antimalarial treatment.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)