Review
Oncology
Agnese Barnabei, Lidia Strigari, Andrea Corsello, Rosa Maria Paragliola, Luca Falzone, Roberto Salvatori, Salvatore Maria Corsello, Francesco Torino
Summary: Immune checkpoint inhibitors may cause central diabetes insipidus, but there are inconsistencies and a lack of specific guidelines in its diagnosis and management. Endocrinological consultation can assist medical oncologists in treating this side effect, but they are still responsible for early diagnosis and drug management.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Takahiro Asada, Shintaro Takenoshita, Mayuko Senda, Koichiro Yamamoto, Ryo Sasaki, Fumio Otsuka, Seishi Terada, Norihito Yamada
Summary: Autoimmune hypothalamitis is a rare neuroendocrine disorder that may be associated with autoimmune hypophysitis, but it is uncertain if they are consecutive diseases. This case presents the development of autoimmune hypothalamitis after central diabetes insipidus, with partial improvement through treatment.
Article
Endocrinology & Metabolism
Felix Amereller, Anna-Maria Kuppers, Katharina Schilbach, Jochen Schopohl, Sylvere Stormann
Summary: Clinical data on primary hypophysitis, especially in non-surgical cases, are limited. This study analyzed 60 patients with primary hypophysitis, showing a female predominance, common symptoms like fatigue and headache, and frequent concomitant autoimmune diseases. MRI findings typically included infundibular thickening and space occupying lesions, with pituitary size often initially enlarged. Male patients tended to have more affected hormone axes, with the gonadotropic axis being most frequently impaired. The cohort of clinically diagnosed patients did not differ significantly from those histopathologically diagnosed, indicating that clinical criteria can be effective in diagnosing primary hypophysitis.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2021)
Article
Oncology
Sidi Xie, Yunxiao Zhang, Tao Peng, Jinglin Guo, Yongfu Cao, Jing Guo, Xiaofeng Shi, Yaqin Li, Yawei Liu, Songtao Qi, Hai Wang
Summary: Our study found that TMEFF2 expression is lower in glioma tumor tissues, and its DNA methylation might be associated with tumor progression, serving as a valuable prognostic marker for adult diffuse gliomas.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Hsiao-Chen Huang, Yun-Ti Chen, Han-Huei Lin, Zhi-Qin Li, Jinn-Moon Yang, Shey-Cherng Tzou
Summary: IRAK1 is upregulated in autoimmune hypophysitis (AH) and treatment with the specific inhibitor rosoxacin can effectively treat AH. Rosoxacin reduces production of autoantigen-specific antibodies, downregulates cytokines and chemokines involved in T cell differentiation or recruitment, and decreases class II major histocompatibility complex expression on antigen-presenting cells, suggesting a potential pathogenic role of IRAK1 dysregulation in AH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Mengxia Yu, Lirong Liu, Pengfei Shi, Hong Zhou, Shenxian Qian, Kuang Chen
Summary: Modulating PD-1 expression can control tumor growth, but it may lead to rare complications like central diabetes insipidus. This case report highlights the immediate-onset central diabetes insipidus caused by anti-PD-1 treatment, which was successfully resolved with glucocorticoids and desmopressin acetate. Further studies are needed to understand the potential risks associated with anti-PD-1 therapy in Hodgkin lymphoma patients.
Article
Cell Biology
Hao Wu, Jinrui Zhang, Yi Bai, Sai Zhang, Zhixin Zhang, Wen Tong, Pinsheng Han, Bing Fu, Yamin Zhang, Zhongyang Shen
Summary: Long non-coding RNAs (lncRNAs) and enhancer RNAs (eRNAs) have been shown to play important roles in tumor development, with DCP1A being identified as a potential novel biomarker for hepatocellular carcinoma (HCC) patients. High expression of DCP1A is associated with poor overall survival and advanced tumor characteristics in HCC patients, indicating its potential as a therapeutic target. Further functional analysis revealed the involvement of DCP1A in multiple tumor-related signaling pathways, suggesting its potential as a therapeutic target for HCC patients.
Review
Medicine, General & Internal
F. de Vries, W. R. van Furth, N. R. Biermasz, A. M. Pereira
Summary: Hypophysitis is characterized by inflammation of the pituitary gland, which can originate from different parts and pathophysiological processes. It often presents with endocrine deficiencies and can also have mass effects. Significant progress has been made in understanding this disease in recent years, including recognizing new forms, developing new diagnostics, and proposing specific treatments.
Review
Endocrinology & Metabolism
Brijesh Krishnappa, Ravikumar Shah, Saba Samad Memon, Chakra Diwaker, Anurag R. Lila, Virendra A. Patil, Nalini S. Shah, Tushar R. Bandgar
Summary: High-dose glucocorticoids, particularly when administered intravenously and for a longer duration, lead to better outcomes in patients with primary autoimmune hypophysitis (PAH). In severe cases, intravenous administration and very high-dose steroids are associated with higher rates of visual field and corticotroph axis recovery.
ENDOCRINE CONNECTIONS
(2023)
Article
Medicine, General & Internal
Shih-Lun Chang, Ching-Chieh Yang, Hong-Yue Lai, Hsin-Hwa Tsai, Cheng-Fa Yeh, Sung-Wei Lee, Yu-Hsuan Kuo, Nai-Wen Kang, Wen-Bin Wu, Tzu-Ju Chen
Summary: This study found that SYNPO2 expression was significantly higher in patients with nasopharyngeal carcinoma (NPC) and was associated with advanced disease stage and poor prognosis. Therefore, SYNPO2 may serve as a potential prognostic biomarker for NPC patients.
Article
Endocrinology & Metabolism
Avraham Ishay, Elena Chertok Shacham
Summary: A rare case of central diabetes insipidus potentially associated with SARS-CoV-2 mRNA vaccination is reported. The patient, a 59-year-old female with a history of Crohn's disease, developed polyuria eight weeks after vaccination. Laboratory evaluation confirmed central diabetes insipidus and MRI showed involvement of the pituitary. Further studies are needed to understand the mechanisms behind the development of autoimmune endocrinopathies in the context of COVID-19 infection and SARS-CoV-2 vaccination.
BMC ENDOCRINE DISORDERS
(2023)
Article
Endocrinology & Metabolism
JiaQi Chen, Ting Lu, ChenXiao Liu, Yun Zhao, AiJie Huang, XingNa Hu, Min Li, Rong Xiang, Min Feng, HongHong Lu
Summary: This case report describes a 20-year-old male diagnosed with APS-1 and presenting with symptoms of diabetes insipidus. Through whole-exome sequencing (WES), a novel compound heterozygous mutation in the AIRE gene was identified, expanding the understanding of mutations associated with APS-1.
BMC ENDOCRINE DISORDERS
(2021)
Article
Oncology
Haiwei Wang, Xinrui Wang, Liangpu Xu, Yingying Lin, Ji Zhang, Hua Cao
Summary: This study identified that low expression of CDHR1 in glioma is an independent unfavorable prognostic factor and is associated with various clinical prognostic factors.
Article
Endocrinology & Metabolism
Yohei Kume, Hiroko Sakuma, Hitomi Sekine, Makoto Sumikoshi, Yoshihisa Sugimura, Mitsuaki Hosoya
Summary: Childhood-onset lymphocytic infundibuloneurohypophysitis (LINH) is rare, and definitive diagnosis requires pituitary biopsy. This case of a 10-year-old boy with LINH suggests that anti-rabphilin-3A antibody may be a useful diagnostic marker in children. Treatment includes desmopressin replacement and other hormone replacement therapies.
CLINICAL PEDIATRIC ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Chia-Lin Chou, Tzu-Ju Chen, Yu-Feng Tian, Ti-Chun Chan, Cheng-Fa Yeh, Wan-Shan Li, Hsin-Hwa Tsai, Chien-Feng Li, Hong-Yue Lai
Summary: In this study, upregulated MUC2 immunoexpression in rectal cancer patients undergoing CCRT was found to be significantly associated with treatment resistance and worse prognosis, suggesting its potential as a prognostic marker.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Claudio Urbani, Alessandro Mattiello, Gianmarco Ferri, Francesco Raggi, Dania Russo, Giulia Marconcini, Daniele Cappellani, Luca Manetti, Claudio Marcocci, Francesco Cardarelli, Fausto Bogazzi
Summary: This study demonstrated that PCB153 reduces apoptosis in pituitary cells through activation of the PI3K/Akt-mediated NF-κB pathway, while also inhibiting the expression of pro-apoptotic proteins like p38-MAPK, P53, and P21.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Daniele Cappellani, Giuseppina De Marco, Eleonora Ferrarini, Liborio Torregrossa, Agostino Maria Di Certo, Giada Cosentino, Claudio Urbani, Giulia Marconcini, Alessandro Mattiello, Luca Manetti, Patrizia Agretti, Fulvio Basolo, Massimo Tonacchera, Luigi Bartalena, Fausto Bogazzi
Summary: The study found that in AIT patients, having TRAb-positive does not necessarily mean having GD and AIT1, with approximately 60% of TRAb-positive patients exhibiting destructive thyroiditis. The response to methimazole and glucocorticoids also varied among TRAb1 and TRAb2 patients.
Review
Endocrinology & Metabolism
Daniele Cappellani, Alessandro Brancatella, Riccardo Morganti, Simona Borsari, Fulvia Baldinotti, Maria Adelaide Caligo, Martin Kaufmann, Glenville Jones, Claudio Marcocci, Filomena Cetani
Summary: CYP24A1 variants can cause vitamin D-dependent hypercalcemia with clinical heterogeneity and age-dependent phenotype. Pregnancy may exacerbate the symptoms of the disease. Monoallelic carriers have an increased risk of calcium-related conditions. There is currently no consensus on the preferred therapeutic regime for this disease.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Manuel Cappellari, Valentina Saia, Giovanni Procucci, Fainardi Enrico, Arturo Consoli, Sergio Nappini, Lucio Castellon, Sandra Bracco, Mauro Bergui, Mirco Cosottini, Alessandra Briatico Vangosa, Sergio Vinci, Maria Ruggiero, Edoardo Puglielli, Luigi Chiumarulo, Giacomo Cester, Chiara Comelli, Umberto Silvagni, Daniele Morosetti, Valentina Caldiera, Nicola Cavasin, Valeria Ledda, Giuseppina Sanfilippo, Andrea Saletti, Pietro Filauri, Ivan Gallesio, Nunzio Paolo Nuzzi, Pitero Amista, Cecilia Zivelonghi, Mauro Plebani, Marco Pavia, Daniele Romano, Francesco Biraschi, Roberto Menozzi, Roberto M. Gasparotti, Andrea Giorgianni, Andrea Zini, Domenico Inzitari, Danilo Toni, Salvatore Mangiafico
Summary: The Careggi Collateral Score (CCS) is a helpful tool for predicting outcomes in stroke patients undergoing thrombectomy for middle cerebral artery occlusion. A higher CCS score is associated with better prognosis, with CCS >= 3 being the optimal threshold for predicting excellent outcomes and CCS >= 1 for predicting survival.
JOURNAL OF NEUROLOGY
(2022)
Correction
Clinical Neurology
Manuel Cappellari, Valentina Saia, Giovanni Pracucci, Enrico Fainardi, Arturo Consoli, Sergio Nappini, Lucio Castellan, Sandra Bracco, Mauro Bergui, Mirco Cosottini, Alessandra Briatico Vangosa, Sergio Vinci, Maria Ruggiero, Edoardo Puglielli, Luigi Chiumarulo, Giacomo Cester, Chiara Comelli, Umberto Silvagni, Daniele Morosetti, Valentina Caldiera, Nicola Cavasin, Valeria Ledda, Giuseppina Sanfilippo, Andrea Saletti, Pietro Filauri, Ivan Gallesio, Nunzio Paolo Nuzzi, Pitero Amista, Cecilia Zivelonghi, Mauro Plebani, Marco Pavia, Daniele Romano, Francesco Biraschi, Roberto Menozzi, Roberto Gasparotti, Andrea Giorgianni, Andrea Zini, Domenico Inzitari, Danilo Toni, Salvatore Mangiafico
JOURNAL OF NEUROLOGY
(2022)
Meeting Abstract
Clinical Neurology
Chiara Milano, Silvia Canovetti, Enrico Tagliaferri, Francesco Turco, Stefano Verdenelli, Lorenzo Nesti, Marta Franchi, Enrica Bonanni, Francesco Menichetti, Duccio Volterrani, Mirco Cosottini, Gabriele Siciliano, Chiara Pizzanelli
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Andrea Maria Alexandre, Iacopo Valente, Alessandro Pedicelli, Angelo Maria Pezzullo, Francesca Colo, Luca Scarcia, Andrea Romi, Mariangela Piano, Antonio Macera, Joseph Domenico Gabrieli, Giacomo Cester, Antonio Armando Caragliano, Sergio Lucio Vinci, Maria Ruggiero, Christian Commodaro, Andrea Saletti, Guido Andrea Lazzarotti, Mirco Cosottini, Valerio Da Ros, Luigi Bellini, Emilio Lozupone, Adriana Paladini, Valerio Brunetti, Roberta Morosetti, Giovanni Frisullo, Paolo Calabresi, Giacomo Della Marca, Aldobrando Broccolini
Summary: This study evaluated the effectiveness of mechanical thrombectomy in patients with acute ischemic stroke due to large vessel occlusion and baseline mild neurological symptoms. After propensity score matching, patients who received immediate mechanical thrombectomy had a higher chance of excellent outcome at 90 days compared to those who received best medical management/rescue mechanical thrombectomy, with a similar risk of death.
NEUROLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Alessandro Brancatella, Daniele Cappellani, Martin Kaufmann, Antonella Semeraro, Simona Borsari, Chiara Sardella, Fulvia Baldinotti, Maria Adelaide Caligo, Glenville Jones, Claudio Marcocci, Filomena Cetani
Summary: Rifampin may be an effective choice for stably reducing calcium levels in patients with HCINF1, with a good safety profile.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Surgery
Sohail Bakkar, Daniele Cappellani, Francesco Forfori, Claudio Di Salvo, Sonia Catarsi, Carlo Enrico Ambrosini, Paolo Miccoli, Fausto Bogazzi, Gabriele Materazzi, Piermarco Papini
Summary: This study retrospectively analyzed 53 patients who underwent thyroidectomy for amiodarone-induced thyrotoxicosis (AIT), showing that total thyroidectomy can be safely performed, improves cardiac function, and increases survival rates.
UPDATES IN SURGERY
(2022)
Article
Endocrinology & Metabolism
Rosario Pivonello, Renata Simona Auriemma, Alessandra Delli Veneri, Francesca Dassie, Riccardina Lorusso, Marta Ragonese, Marco Liotta, Elisa Sala, Barbara Zarino, Elisa Lai, Claudio Urbani, Fausto Bogazzi, Giovanna Mantovani, Salvatore Cannavo, Pietro Maffei, Paolo Chiodini, Annamaria Colao
Summary: Acromegaly is associated with significant impairments in psychological profile, sleep quality, sexual function, cognitive functions, and quality of life. Female patients experience more discomfort in body image, while both male and female patients experience worsened sexual function. These psychopathological conditions are mainly determined by disease duration, patient's age, and gender.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Daniele Cappellani, Giulia Marconcini, Luca Manetti, Luigi Bartalena, Fausto Bogazzi
Summary: The first-line medical therapy for patients with amiodarone-induced thyrotoxicosis (AIT) affects the outcome of AIT patients, with appropriate therapy reducing the risk of cardiovascular events and hospitalizations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
N. Viola, C. Urbani, M. Cosottini, A. Abruzzese, L. Manetti, G. Cosentino, G. Marconcini, C. Marcocci, F. Bogazzi, I Lupi
Summary: Pituitary apoplexy is a complex medical emergency that is difficult to diagnose and manage. This study presents a case of pituitary apoplexy in a 63-year-old male with atrial fibrillation treated with oral anticoagulant therapy. The patient presented with asthenia and severe headache that did not respond to common analgesics. Further evaluation revealed a haemorrhagic pituitary macroadenoma compressing the optic chiasm. Treatment with intravenous fluids and high-dose hydrocortisone resulted in rapid improvement of the patient's health and visual field abnormalities.
ENDOCRINOLOGY DIABETES & METABOLISM
(2022)
Letter
Endocrinology & Metabolism
Daniele Cappellani, Liborio Torregrossa, Piermarco Papini, Anello Marcello Poma, Enrico Ambrosini, Luigi De Napoli, Gabriele Materazzi, Fulvio Basolo, Fausto Bogazzi
Article
Clinical Neurology
Andrea Quattrone, Angelo Antonini, David E. Vaillancourt, Klaus Seppi, Roberto Ceravolo, Antonio P. Strafella, Maurizio Morelli, Salvatore Nigro, Basilio Vescio, Maria G. Bianco, Roberta Vasta, Pier Paolo Arcuri, Luca Weis, Eleonora Fiorenzato, Roberta Biundo, Roxana G. Burciu, Florian Krismer, Nikolaus R. McFarland, Christoph Mueller, Elke R. Gizewski, Mirco Cosottini, Eleonora Del Prete, Sonia Mazzucchi, Aldo Quattrone
Summary: The measurement of third ventricle width can distinguish Parkinson's disease (PD) from progressive supranuclear palsy (PSP).
MOVEMENT DISORDERS
(2021)