Potential Applications of Gliclazide in Treating Type 1 Diabetes Mellitus: Formulation with Bile Acids and Probiotics

High-Loading Dose of Microencapsulated Gliclazide Formulation Exerted a Hypoglycaemic Effect on Type 1 Diabetic Rats and Incorporation of a Primary Deconjugated Bile Acid, Diminished the Hypoglycaemic Antidiabetic Effect

(2017) Svetlana Golocorbin-Kon et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Insulin analogues in type 1 diabetes mellitus: getting better all the time

(2017) Chantal Mathieu et al.   Nature Reviews Endocrinology

Sulfonylurea challenge test in subjects diagnosed with type 1 diabetes mellitus

(2017) Maria S. Remedi et al.   PEDIATRIC DIABETES

Incidence of type 1 diabetes in age groups above 15 years: facts, hypothesis and prospects for future epidemiologic research

(2016) G. Bruno et al.   ACTA DIABETOLOGICA

The role of the intestinal microbiota in type 1 diabetes mellitus

(2016) Mikael Knip et al.   Nature Reviews Endocrinology

Diabetes mellitus and oxidative stress—A concise review

(2016) Ullah Asmat et al.   SAUDI PHARMACEUTICAL JOURNAL

The Gut Microbiota in Immune-Mediated Inflammatory Diseases

(2016) Jessica D. Forbes et al.   Frontiers in Microbiology

Is gliclazide a sulfonylurea with difference? A review in 2016

(2016) Awadhesh Kumar Singh et al.   Expert Review of Clinical Pharmacology

The Impact of Farnesoid X Receptor Activation on Intestinal Permeability in Inflammatory Bowel Disease

(2016) Maja Stojancevic et al.   CANADIAN JOURNAL OF GASTROENTEROLOGY

State of the art paper Sulfonylureas and their use in clinical practice

(2015) Daniele Sola et al.   Archives of Medical Science

A comprehensive study of novel microcapsules incorporating gliclazide and a permeation enhancing bile acid: hypoglycemic effect in an animal model of Type-1 diabetes

(2015) Sangeetha Mathavan et al.   DRUG DELIVERY

Bile acid signaling through farnesoid X and TGR5 receptors in hepatobiliary and intestinal diseases

(2015) Bojan Stanimirov et al.   Hepatobiliary & Pancreatic Diseases International

The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity

(2015) Ningwen Tai et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Mortality risk among sulfonylureas: a systematic review and network meta-analysis

(2015) Scot H Simpson et al.   Lancet Diabetes & Endocrinology

The bile acid TGR5 membrane receptor: From basic research to clinical application

(2014) Henri Duboc et al.   DIGESTIVE AND LIVER DISEASE

Release and swelling studies of an innovative antidiabetic-bile acid microencapsulated formulation, as a novel targeted therapy for diabetes treatment

(2014) Armin Mooranian et al.   JOURNAL OF MICROENCAPSULATION

Beyond intestinal soap—bile acids in metabolic control

(2014) Folkert Kuipers et al.   Nature Reviews Endocrinology

An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations

(2014) Armin Mooranian et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Neural integration of satiation and food reward: Role of GLP-1 and orexin pathways

(2014) Diana L. Williams   PHYSIOLOGY & BEHAVIOR

Stability and Release Kinetics of an Advanced Gliclazide-Cholic Acid Formulation: The Use of Artificial-Cell Microencapsulation in Slow Release Targeted Oral Delivery of Antidiabetics

(2014) Armin Mooranian et al.   Journal of Pharmaceutical Innovation

Application of bile acids in drug formulation and delivery

(2014) Maja Stojančević et al.   Frontiers in Life Science

Human Intestinal Microbiota and Type 1 Diabetes

(2013) Outi Vaarala   Current Diabetes Reports

Glucagon and GLP-1 inhibit food intake and increase c-fos expression in similar appetite regulating centres in the brainstem and amygdala

(2013) J A Parker et al.   INTERNATIONAL JOURNAL OF OBESITY

Effects of Taurocholic Acid on Glycemic, Glucagon-like Peptide-1, and Insulin Responses to Small Intestinal Glucose Infusion in Healthy Humans

(2013) Tongzhi Wu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The bile acid membrane receptor TGR5: a novel pharmacological target in metabolic, inflammatory and neoplastic disorders

(2013) Vanesa Stepanov et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

The many faces of diabetes: a disease with increasing heterogeneity

(2013) Tiinamaija Tuomi et al.   LANCET

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

Differences in the gut microbiota of healthy children and those with type 1 diabetes

(2013) Erdogan Soyucen et al.   PEDIATRICS INTERNATIONAL

Deoxycholic Acid as a Modifier of the Permeation of Gliclazide through the Blood Brain Barrier of a Rat

(2013) Mladena Lalić-Popović et al.   Journal of Diabetes Research

Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells

(2012) Divya P. Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The use of animal models in diabetes research

(2012) Aileen JF King   BRITISH JOURNAL OF PHARMACOLOGY

Effect of ketocholate derivatives on methotrexate uptake in Caco-2 cell monolayers

(2012) Gong Chen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Bile Acid Metabolism and the Pathogenesis of Type 2 Diabetes

(2011) Janne Prawitt et al.   Current Diabetes Reports

Etiological Approach to Characterization of Diabetes Type: The SEARCH for Diabetes in Youth Study

(2011) D. Dabelea et al.   DIABETES CARE

Treating diabetes today: a matter of selectivity of sulphonylureas

(2011) S. Seino et al.   DIABETES OBESITY & METABOLISM

Probiotics decreased the bioavailability of the bile acid analog, monoketocholic acid, when coadministered with gliclazide, in healthy but not diabetic rats

(2011) Hani Al-Salami et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Intestinal microbiota in human health and disease: the impact of probiotics

(2011) Jacoline Gerritsen et al.   Genes and Nutrition

Research Highlights

(2011) Jonathan F Lovell et al.   Nanomedicine

Channeling dysglycemia: ion-channel variations perturbing glucose homeostasis

(2011) Jerod Scott Denton et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Gut Microbiota, Immunity, and Disease: A Complex Relationship

(2011) Michele M. Kosiewicz et al.   Frontiers in Microbiology

The bile acid sensor FXR regulates insulin transcription and secretion

(2010) Barbara Renga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Bile Acid Sequestrants for Lipid and Glucose Control

(2010) Bart Staels et al.   Current Diabetes Reports

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

(2010) Marleen Kars et al.   DIABETES

Bile Acids as Regulators of Hepatic Lipid and Glucose Metabolism

(2010) Michael Trauner et al.   DIGESTIVE DISEASES

Probiotic treatment reduces blood glucose levels and increases systemic absorption of gliclazide in diabetic rats

(2010) Hani Al-Salami et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

The influence of 3α,7α-dihydroxy-12-keto-5β-cholanate on gliclazide pharmacokinetics and glucose levels in a rat model of diabetes

(2010) Momir Mikov et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Toward defining the autoimmune microbiome for type 1 diabetes

(2010) Adriana Giongo et al.   ISME Journal

Persistently autoantibody negative (PAN) type 1 diabetes mellitus in children

(2010) Shihab Hameed et al.   PEDIATRIC DIABETES

Diabetes mellitus: new challenges and innovative therapies

(2010) Cristina M. Sena et al.   EPMA Journal

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Secondary Consequences of β Cell Inexcitability: Identification and Prevention in a Murine Model of KATP-Induced Neonatal Diabetes Mellitus

(2009) Maria Sara Remedi et al.   Cell Metabolism

Effects of exposure of human islet beta-cells to normal and high glucose levels with or without gliclazide or glibenclamide

(2009) S. Del Guerra et al.   DIABETES & METABOLISM

Diagnosis and Classification of Diabetes Mellitus

(2009)   DIABETES CARE

Bile Acids and Metabolic Regulation: Mechanisms and clinical responses to bile acid sequestration

(2009) B. Staels et al.   DIABETES CARE

FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats

(2009) Sabrina Cipriani et al.   JOURNAL OF LIPID RESEARCH

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Influence of the semisynthetic bile acid MKC on the ileal permeation of gliclazide in vitro in healthy and diabetic rats treated with probiotics

(2009) H. Al-Salami et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Physicochemical and Biological Characterization of Monoketocholic Acid, a Novel Permeability Enhancer

(2009) Lin Yang et al.   MOLECULAR PHARMACEUTICS

Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders

(2009) Stefano Fiorucci et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Bile-acid-induced cell injury and protection

(2009) Maria J Perez et al.   WORLD JOURNAL OF GASTROENTEROLOGY