Safety, pharmacokinetics and pharmacodynamics of single rising doses of BI 655064, an antagonistic anti-CD40 antibody in healthy subjects: a potential novel treatment for autoimmune diseases

THU0407 Preclinical Characterization of a Highly Selective and Potent Antagonistic Anti-CD40 mAb

(2015) K. Ralph et al.   ANNALS OF THE RHEUMATIC DISEASES

First-in-human trial of the safety, pharmacokinetics and immunogenicity of a PEGylated anti-CD40L antibody fragment (CDP7657) in healthy individuals and patients with systemic lupus erythematosus

(2015) A Tocoian et al.   LUPUS

CDP7657, an anti-CD40L antibody lacking an Fc domain, inhibits CD40L-dependent immune responses without thrombotic complications: an in vivo study

(2015) Anthony Shock et al.   ARTHRITIS RESEARCH & THERAPY

Engineering of a Novel Anti-CD40L Domain Antibody for Treatment of Autoimmune Diseases

(2014) J. H. Xie et al.   JOURNAL OF IMMUNOLOGY

A Phase 1, Randomized Ascending Single-Dose Study of Antagonist Anti-Human CD40 ASKP1240 in Healthy Subjects

(2013) R. Goldwater et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Agonistic CD40 Antibodies and Cancer Therapy

(2013) R. H. Vonderheide et al.   CLINICAL CANCER RESEARCH

A phase 1 study of lucatumumab, a fully human anti-CD40 antagonist monoclonal antibody administered intravenously to patients with relapsed or refractory multiple myeloma

(2012) William Bensinger et al.   BRITISH JOURNAL OF HAEMATOLOGY

Anti-CD40L Immune Complexes Potently Activate Platelets In Vitro and Cause Thrombosis in FCGR2A Transgenic Mice

(2010) L. Robles-Carrillo et al.   JOURNAL OF IMMUNOLOGY

Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study

(2009) G. Orozco et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of a single-nucleotide polymorphism inCD40with the rate of joint destruction in rheumatoid arthritis

(2009) Michael P. M. van der Linden et al.   ARTHRITIS AND RHEUMATISM

CD40 and autoimmunity: The dark side of a great activator

(2009) Anna L. Peters et al.   SEMINARS IN IMMUNOLOGY

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

(2008) W Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

When binding is enough: nonactivating antibody formats

(2008) Aran F Labrijn et al.   CURRENT OPINION IN IMMUNOLOGY

Common variants at CD40 and other loci confer risk of rheumatoid arthritis

(2008) Soumya Raychaudhuri et al.   NATURE GENETICS