Article
Pharmacology & Pharmacy
Xiaofang Cai, S. J. Jiang, Jiana Chen, Xiujuan Cai, W. L. Wang, J. D. Huang, J. H. Zhang
Summary: The objective of this study is to compare the safety and efficacy of clopidogrel and ticagrelor among patients with cytochrome P450 2C19*2 and *3 mutations and assess the necessity of pharmacogenetic testing. It is a two-center retrospective, observational cohort study of 425 patients. The study found that there were no significant differences between the two groups in terms of rehospitalization incidence and duration due to the primary disease, recurrent myocardial infarction, revascularization, stent thrombosis, and ischemic stroke. However, ticagrelor-treated patients experienced a higher incidence of dyspnea events compared to those treated with clopidogrel.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Anh B. Nguyen, Larisa H. Cavallari, Joseph S. Rossi, George A. Stouffer, Craig R. Lee
Summary: The article highlights the importance of dual antiplatelet therapy for patients undergoing PCI, as well as the impact of CYP2C19 genotype on the efficacy of clopidogrel. Racial and ethnic disparities in genotype-guided antiplatelet therapy should receive more attention.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Health Care Sciences & Services
Jiaming Liu, Yulong Zhao, He Chen, Fangyu Yang, Ligang Chen, Guangzhi Hao, Xu Gao
Summary: This study found that hypertension, stroke history, carriers, and high platelet reactivity are independent risk factors for recurrent ischemic events in cerebrovascular disease. CYP2C19 gene polymorphism and high platelet reactivity can be used as effective predictors of recurrent ischemic events in clinical cerebrovascular disease.
ANNALS OF PALLIATIVE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Seung-Jun Lee, Jung-Joon Cha, Young-Hoon Jeong, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Hyung Joon Loo, Kiyuk Chang, Yongwhi Park, Young Bin Song, Sung Gyun Ahn, Jung-Won Suh, Sang Yup Lee, Jung Rae Cho, Ae-Young Her, Hyo-Soo Kim, Moo Hyun Kim, Eun-Seok Shin, Do-Sun Lim, Byeong-Keuk Kim
Summary: The long-term prognostic implications of platelet reactivity after percutaneous coronary intervention (PCI) are important. High PRU is significantly associated with the occurrence of major adverse cardiac and cerebrovascular events (MACCE), all-cause death, and net adverse clinical events (NACE).
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Nutrition & Dietetics
Vanessa Rosa Retamoso, Fernanda Barbisan, Graziele Meira Moro, Patricia Maurer, Debora Vasquez Rubio, Lauren Flores Viera dos Santos, Lyana Berro Feijoo, Matias Nunes Frizzo, Ivana Beatrice Manica da Cruz, Vanusa Manfredini, Ana Leticia Vargas Barcelos, Jacqueline da Costa Escobar Piccoli
Summary: This study evaluates the effect of the BsmI single nucleotide polymorphism (SNP) of the VDR gene on the expression of VDR, SOD2, and CYP24A1 genes in individuals with low serum vitamin D levels. The results show that the BsmI SNP of the VDR gene leads to overexpression of the CYP24A1 gene and low expression of the SOD2 gene. Therefore, the BsmI SNP of the VDR gene can modulate gene expression without interfering with serum vitamin D levels.
Review
Chemistry, Medicinal
Yeo-Jung Kwon, Sangyun Shin, Young-Jin Chun
Summary: Human cytochrome P450 enzymes of the CYP1 family are critical in the metabolism of various substrates related to cancer pathogenesis and the pathogenesis of several human diseases, particularly in the activation and inactivation of therapeutic drugs. Their role in diseases and drug metabolism has attracted significant interest in the scientific community for the development of novel therapeutic strategies.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Engineering, Environmental
Hang Yu, Meiqi Song, Keqi Hu, Yujian Wang, Ruifang Fan, Zongying Yang, Hansruedi Glatt, Albert Braeuning, Yungang Liu
Summary: Bisphenol compounds may increase the genotoxic effects of metabolically activated carcinogens by modulating the expression of nuclear receptors and xenobiotic-metabolizing enzymes in human liver cancer cells, potentially aggravating chromosome damage caused by impactful carcinogens in human cells.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shiori Takeji, Mai Okada, Shu Hayashi, Kengo Kanamaru, Yuichi Uno, Hiromasa Imaishi, Tomohide Uno
Summary: CYP2C19 gene polymorphisms contribute to significant variation in enzyme levels and activity, resulting in different substrate specificities for testosterone and progesterone.
BIOPHARMACEUTICS & DRUG DISPOSITION
(2023)
Article
Chemistry, Medicinal
Natthaporn Kuendee, Alisa Naladta, Thitianan Kulsirirat, Thunyatorn Yimsoo, Werayut Yingmema, Kanoktip Pansuksan, Korbtham Sathirakul, Sophida Sukprasert
Summary: This study investigated the effects of Lysiphyllum strychnifolium extracts on the gene expression of drug-metabolizing enzymes in rats. The results showed that different doses of the extracts can modulate the mRNA expression levels of clinically relevant CYP genes, and gender also plays a role in gene expression. These findings provide valuable information for the practical use of Lysiphyllum strychnifolium extracts in humans.
Article
Pharmacology & Pharmacy
Fabio Bachmann, Urs Duthaler, Stephan Krahenbuhl
Summary: This study investigated the effect of deglucuronidation on the plasma concentration of the constituents of the Basel phenotyping cocktail. The results showed that deglucuronidation of plasma samples improves the stability of phenotyping results and is necessary to reliably detect CYP induction.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ragini D. D. Singh, Avadhesh Avadhesh, Gaurav Sharma, Sagar Dholariya, Rima B. B. Shah, Bela Goyal, Subash Chandra Gupta
Summary: Targeted cancer therapy using CYP as drug target has shown promise, but there are still challenges including drug resistance and limited therapeutic index. Recent advances in molecular tools and structure-activity relationship understanding have helped in the development of CYP-based drugs with better efficacy. Future directions involve the development of more selective tools to understand molecular alterations and develop specific CYP inhibitors/inducers.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Multidisciplinary Sciences
Xueyao Jiang, Jing Wu, Boyu Tan, Sulan Yan, Nan Deng, Hongyan Wei
Summary: This study found that chronic unpredictable mild stress (CUMS)-induced depression alters the pharmacokinetics of clopidogrel, and the changes in CYP450 activity and expression in the livers of depressed rats may contribute to the disturbance of clopidogrel pharmacokinetics.
Article
Engineering, Environmental
Hang Yu, Yungang Liu
Summary: Bisphenol compounds are significant environmental pollutants and disruptors of the endocrine system. This study suggests that combined and extended exposure to these compounds can enhance their genotoxicity, specifically promoting the formation of aneuploid chromosomes.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Toxicology
Slobodan P. Rendic, F. Peter Guengerich
Summary: This overview discusses the metabolic activation of various compounds by cytochrome P450 enzymes, with a focus on bioactivation reactions. The study identifies a higher level of activation for general chemicals, drugs, and natural products compared to physiological compounds. Enzymes such as P450 3A4, 1A2, 2E1, and 1A1 are highlighted for their roles in catalyzing the formation of activated metabolites from different compound groups.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ji Woong Roh, Seung-Jun Lee, Byeong-Keuk Kim, Sung-Jin Hong, Hee-Yeol Kim, Chul-Min Ahn, Deok-Kyu Cho, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
Summary: The effects of ticagrelor-based dual antiplatelet therapy on ACS patients with CKD varied according to CKD stage. Among CKD patients without ESRD, ticagrelor-based DAPT reduced MACCE risk without increasing bleeding risks compared with clopidogrel-based DAPT.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)