Article
Pharmacology & Pharmacy
Carla Perpetuo, Ana Placido, Daniela Rodrigues, Jorge Aperta, Maria Pineiro-Lamas, Adolfo Figueiras, Maria Teresa Herdeiro, Fatima Roque
Summary: The study included 616 older patients with a median age of 85 years. The prevalence of potentially inappropriate medication use was found to be high, with poor concordance among the EU(7)-PIM list, 2019 Beers criteria, and STOPP v2 criteria. Association between PIM and prescribed medicines, as well as specific diseases and days of hospitalization, was observed.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Ferhan Demirer Aydemir, Seyma Oncu, Nuri M. Yakar, Gokalp A. Utkugun, Necati Gokmen, Bilgin Comert, Reyhan Ucku, Ayse Gelal
Summary: The prevalence of Potentially Inappropriate Medication (PIM) was found to be higher in elderly patients in ICU. Reducing the number of drugs administered may be the first step to decrease PIMs in this population and to maintain treatment safety. The 2019 Beers Criteria seemed to be more effective in detecting PIMs and determining prognosis in ICU patients.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Public, Environmental & Occupational Health
Tzvetan Krustev, Petya Milushewa, Konstantin Tachkov, Konstantin Mitov, Guenka Petrova
Summary: This study evaluates the use of STOPP/START criteria in identifying potentially inappropriate medication and potential prescribing omissions in older patients with cardiovascular diseases in Bulgaria. The study finds a high percentage of potentially inappropriate medication among older patients receiving polypharmacy.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Agnieszka Lisowska, Edyta Czepielewska, Martyna Rydz, Anna Dworakowska, Magdalena Makarewicz-Wujec, Malgorzata Kozlowska-Wojciechowska
Summary: Potentially inappropriate prescribing is a major risk factor for adverse drug events in elderly patients. This study assessed the appropriateness of pharmacotherapy in elderly patients and identified potential instances of inappropriate prescribing based on pharmacist-led medication reviews.
Article
Medicine, General & Internal
Raquel Diez, Raquel Cadenas, Julen Susperregui, Ana M. Sahagun, Nelida Fernandez, Juan J. Garcia, Matilde Sierra, Cristina Lopez
Summary: Inappropriate prescribing in the elderly is a risk factor for adverse drug reactions, hospitalization, and mortality. This study aimed to examine and compare the prevalence of potentially inappropriate medications in nursing home residents and determine the prevalence of potential prescribing omissions. The results showed that benzodiazepines and proton pump inhibitors were the most frequent inappropriate medications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Denis O'Mahony, Antonio Cherubini, Anna Renom Guiteras, Michael Denkinger, Jean-Baptiste Beuscart, Graziano Onder, Adalsteinn Gudmundsson, Alfonso J. Cruz-Jentoft, Wilma Knol, Guelistan Bahat, Nathalie van der Velde, Mirko Petrovic, Denis Curtin
Summary: This study updated and validated the STOPP/START criteria for potentially inappropriate prescribing. The third version of the criteria has been expanded and validated by an international panel of experts. It aims to optimize medication use and minimize adverse events in older people, especially those with multiple conditions and medications.
EUROPEAN GERIATRIC MEDICINE
(2023)
Article
Geriatrics & Gerontology
Marisa Bare, Marina Lleal, Sara Ortonobes, Maria Queralt Gorgas, Daniel Sevilla-Sanchez, Nuria Carballo, Elisabet De Jaime, Susana Herranz
Summary: The objectives of this study were to estimate the frequency of potentially inappropriate prescribing (PIP) at admission according to STOPP/START criteria in older patients hospitalized due to chronic disease exacerbation, and to identify risk factors associated with the most frequent inappropriate medications (PIMs). The study found that PIPs were highly prevalent in these patients, especially those involving proton pump inhibitors (PPIs) and benzodiazepines (BZDs).
Article
Medicine, General & Internal
Eirin Guldsten Robinson, Khedidja Hedna, Katja M. Hakkarainen, Hanna Gyllensten
Summary: This study found that inappropriate prescribing and adverse drug reactions among older adults are associated with higher healthcare costs. The costs are particularly high when adverse drug reactions are caused by inappropriate prescribing. Preventing these occurrences may lead to potential savings that can partially offset the additional costs.
Article
Multidisciplinary Sciences
Esra'a Samara, Zaher Nazzal, Shayma Naghnaghia, Rowa' AL-Ramahi
Summary: This study investigated the prevalence of potentially inappropriate medication (PIM) and its associated factors among elderly patients attending primary health care clinics in the West Bank. The results showed that over one-third of the participants were using PIM, with polypharmacy and diabetes being the main predicting variables.
Article
Pharmacology & Pharmacy
Ying Zhang, Zhaoyan Chen, Fangyuan Tian
Summary: The study found a high prevalence of potentially inappropriate medications among older Chinese outpatients, with the Chinese criteria having a higher detection rate than the Beers criteria. The main risk factors for potentially inappropriate medication use in older patients include age, number of diseases, and number of medications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Fangyuan Tian, Zhaoyan Chen, Ya Zeng, Qiyi Feng, Xi Chen
Summary: This systematic review and meta-analysis found that the use of potentially inappropriate medications (PIMs) is prevalent among older outpatients and has increased in the past two decades. These findings emphasize the need for healthcare reforms and improvements in drug safety for outpatients worldwide.
Review
Public, Environmental & Occupational Health
Bastiaan T. G. M. Sallevelt, Toine C. G. Egberts, Corlina J. A. Huibers, Jimmy Ietswaart, A. Clara Drenth-van Maanen, Emma Jennings, Cian O'Mahony, Katharina Tabea Jungo, Martin Feller, Nicolas Rodondi, Francois-Xavier Sibille, Anne Spinewine, Eugene P. van Puijenbroek, Ingeborg Wilting, Wilma Knol
Summary: The study aimed to assess the detectability of medication errors (MEs) with a STOPP/START-based in-hospital medication review in older people with polypharmacy and multimorbidity prior to a potentially preventable drug-related hospital admission (DRA). The results showed that a significant portion of MEs were not detectable during the medication review, and the recommendations made during the review were not implemented.
Article
Geriatrics & Gerontology
Marina Azab, Alessio Novella, Aladar Ianes, Luca Pasina
Summary: This study investigated the challenges physicians face in selecting appropriate medications for older adults with multiple comorbidities, and found that the use of potentially inappropriate psychotropic drugs is widespread among nursing home residents. Different criteria for appropriate drug prescription identified different percentages of patients exposed to potentially inappropriate psychotropic drugs.
Article
Pharmacology & Pharmacy
Monika Pury Oktora, Sofa Dewi Alfian, H. Jens Bos, Catharina Carolina Maria Schuiling-Veninga, Katja Taxis, Eelko Hak, Petra Denig
Summary: The study found that polypharmacy increased significantly in older and middle-aged people with diabetes between 2012 and 2016, with a decrease in the prevalence of potentially inappropriate medication use in patients aged 65 and older, but an increase in those aged 45-64. Common potentially inappropriate medications included long-term high-dose proton pump inhibitors, benzodiazepines, and strong opioids.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Catarina Candeias, Jorge Gama, Marcio Rodrigues, Amilcar Falcao, Gilberto Alves
Summary: In a study of geriatric Portuguese patients receiving post-acute and long-term care, high prevalence of PIMs and PPOs were found, with predictors of PIMs including female gender, hospital provenience, and number of medications, while predictors of PPOs were Charlson Comorbidity Index and history of recent fractures.STOPP/START criteria may be effective in improving prescribing quality and clinical outcomes in frail elderly patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Katarina Fehir Sola, Iva Mucalo, Andrea Brajkovic, Ivona Jukic, Donatella Verbanac, Sanda Vladimir Knezevic
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2020)
Article
Environmental Sciences
Andrea Brajkovic, Lorena Bosnar, Mariana Martins Gonzaga do Nascimento, Ingrid Prkacin, Antonija Balenovic, Djenane Ramalho de Oliveira, Iva Mucalo
Summary: This study evaluated the impact of comprehensive medication management (CMM) services on healthcare utilization and cardiovascular risk factors in older patients with established cardiovascular diseases (CVDs). The findings demonstrated that pharmacists providing CMM services significantly improved clinical parameters and reduced healthcare utilization, potentially leading to cost savings in healthcare.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Pharmacology & Pharmacy
Lucija Lesnjakovic, Lana Ganoci, Ivan Bilic, Livija Simicevic, Iva Mucalo, Stjepko Plestina, Nada Bozina
Summary: FPs are widely used antineoplastic drugs for solid tumors treatment, but they can cause severe toxicity, especially in patients with reduced DPD activity. European agencies recommend pre-treatment DPD deficiency screening, but American ones do not. Current guidelines recommend testing four DPD gene risk variants, but new evidence on additional common DPYD polymorphisms and rare DPYD variants may help address the missing heritability of DPD deficiency and FP-related toxicity.
Article
Pharmacology & Pharmacy
Andrea Brajkovic, Lucija Ana Bicanic, Marija Strgacic, Helena Orehovacki, Djenane Ramalho-de-Oliveira, Iva Mucalo
Summary: The aim of this research was to assess the impact of comprehensive medication management (CMM) services on the health-related quality of life and frequency of adverse drug reactions in older patients with cardiovascular diseases. The study found that CMM services significantly improved self-care and usual activities dimensions of patients' quality of life, while also reducing the rate of adverse drug reactions.
Article
Health Care Sciences & Services
Iva Mucalo, Andrea Brajkovic, Marija Strgacic, Djenane Ramalho-de-Oliveira, Elizabeta Ribaric, Ana Bobinac
Summary: The paper aims to identify and measure the costs and savings associated with the delivery of Comprehensive Medication Management (CMM) services in Croatia, showing that CMM has the potential to reduce healthcare costs significantly.
Article
Horticulture
Kristina Bljajic, Andrea Brajkovic, Ana Cacic, Lovorka Vujic, Jasna Jablan, Isabel Saraiva de Carvalho, Marijana Zovko Koncic
Summary: This study evaluated the chemical composition, antioxidant, and alpha-glucosidase inhibiting activity of seven traditional antidiabetic plants from Croatian ethnomedicine. Ethanol extracts rich in phenolic compounds showed superior efficacy in antioxidant and enzyme inhibiting properties, while aqueous extracts were more active in other assays. The plants contained significant amounts of minerals useful in managing T2D, with negligible levels of heavy metals making them safe for human consumption.
Article
Pharmacology & Pharmacy
Andrea Braikovic, Iva Mucalo, Toni Vidovic, Mariana Martins Gonzaga, Do Nascimento, Antonija Balenovic, Ino Protrka, Dienane Ramalho De Oliveira
ACTA PHARMACEUTICA
(2019)
