Journal
EUROPEAN JOURNAL OF CLINICAL NUTRITION
Volume 71, Issue 4, Pages 512-518Publisher
SPRINGERNATURE
DOI: 10.1038/ejcn.2016.271
Keywords
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Funding
- Sir Halley Stewart Trust
- Crohn's and Colitis UK
- NHS Executive Eastern Region
- European Commission (DG-SANCO)
- International Agency for Research on Cancer
- Danish Cancer Society (Denmark)
- Ligue contre le Cancer (France)
- German Cancer Aid (Germany)
- Hellenic Health Foundation (Greece)
- Italian Association for Research on Cancer (Italy)
- World Cancer Research Fund (WCRF)
- Statistics Netherlands (The Netherlands)
- Swedish Cancer Society (Sweden)
- Cancer Research UK
- Medical Research Council (UK)
- European Commission - BIOCAPS project (FP-7) [FP7316265]
- Institut Gustave Roussy (France)
- Mutuelle Generale de I'Education Nationale (France)
- Institut National de la Sante et de la Recherche Medicale (INSERM) (France)
- Federal Ministry of Education and Research (Germany)
- Compagnia San Paolo (Italy)
- Swedish Scientific Council (Sweden)
- Regional Government of Skane (Sweden)
- Vaterbotten (Sweden)
- Dutch Ministry of Health, Welfare and Sports
- Dutch Prevention Funds
- LK Research Funds
- Dutch ZON (Zorg Onderzoek Nederland)
- MRC [MR/N003284/1] Funding Source: UKRI
- Cancer Research UK [14136] Funding Source: researchfish
- Medical Research Council [G1000143, MR/N003284/1, G0401527] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10114] Funding Source: researchfish
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BACKGROUND/OBJECTIVES: The role of long- term alcohol consumption for the risk of developing ulcerative colitis (UC) and Crohn's disease (CD) is unclear. For the first time, to prospectively assess the role of pre-disease alcohol consumption on the risk of developing UC or CD. SUBJECTS/METHODS: Nested within the European Prospective Investigation into Cancer and Nutrition (EPIC- IBD), incident UC and CD cases and matched controls where included. At recruitment, participants completed validated food frequency and lifestyle questionnaires. Alcohol consumption was classified as either: non-use, former, light (<= 0.5 and 1 drink per week), below the recommended limits (BRL) (<= 1 and 2 drinks per day), moderate (<= 2.5 and 5 drinks per day), or heavy use (42.5 and 45 drinks per day) for women and men, respectively; and was expressed as consumption at enrolment and during lifetime. Conditional logistic regression was applied adjusting for smoking and education, taking light users as the reference. RESULTS: Out of 262 451 participants in six countries, 198 UC incident cases/792 controls and 84 CD cases/336 controls were included. At enrolment, 8%/27%/32%/23%/11% UC cases and 7%/29%/40%/19%/5% CD cases were: non- users, light, BRL, moderate and heavy users, respectively. The corresponding figures for lifetime non- use, former, light, BRL, moderate and heavy use were: 3%/5%/23%/44%/19%/6% and 5%/2%/25%/44%/23%/1% for UC and CD cases, respectively. There were no associations between any categories of alcohol consumption and risk of UC or CD in the unadjusted and adjusted odds ratios. CONCLUSION: There was no evidence of associations between alcohol use and the odds of developing either UC or CD.
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