Review
Cell Biology
Simon C. de Groot, Magda M. W. Ulrich, Coen G. Gho, Margriet A. Huisman
Summary: Hair disorders and severe burns can negatively impact an individual's social and psychological well-being. Studying human hair follicle development is crucial for wound healing and preventing scar formation, but research is limited and future focus should be on developing human disease-specific models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Vanuchawan Wisuitiprot, Kornkanok Ingkaninan, Panlop Chakkavittumrong, Wudtichai Wisuitiprot, Nitra Neungchamnong, Ruttanaporn Chantakul, Neti Waranuch
Summary: Androgenic alopecia is commonly caused by testosterone metabolism, leading to hair loss. Approved medications like Finasteride and Minoxidil may have side effects, but Acanthus ebracteatus Vahl extract and verbascoside could potentially promote dermal papilla cell growth and have anti-inflammatory effects.
SCIENTIFIC REPORTS
(2022)
Article
Dermatology
Jiyoon Lee, Karl R. Koehler
Summary: Culturing skin cells outside the body has long been essential to dermatological research, but artificial skin equivalents often lack the full complexity of native skin, especially in generating and maintaining skin appendages such as hair follicles and sweat glands.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Ruijun Shi, Shuwei Li, Penggang Liu, Shuhui Zhang, Zhenhui Wu, Tinghui Wu, Shujuan Gong, Yu Wan
Summary: This study analyzed Hetian sheep with different wool densities to assess their wool traits and hair follicle parameters. Transcriptome sequencing analysis was performed on the skins, revealing differentially expressed genes related to hair growth. The study provides valuable resources for enhancing the quality and production of wool in Hetian sheep.
Article
Multidisciplinary Sciences
Carla M. Abreu, Mariana T. Cerqueira, Rogerio P. Pirraco, Luca Gasperini, Rui L. Reis, Alexandra P. Marques
Summary: The conditioned medium from interfollicular keratinocytes (KCs-CM) has been shown to improve the hair inductive ability of DP cells, with significant effects on DP cell growth and restoration of activity. Additionally, DP cells cultured with KCs-CM in spheroids demonstrated superior activity and supported the formation of hair follicle- and sebaceous gland-like structures in mice when co-grafted with human keratinocytes.
JOURNAL OF ADVANCED RESEARCH
(2021)
Editorial Material
Cell Biology
Renzhi Hou, Aliaksandr A. Astrowski, Maksim V. Plikus
Summary: The heightened ability of spiny mice to regenerate after injury is attributed to molecular changes in the Hippo-YAP pathway that protect wound fibroblasts from a persistent contractile state, as revealed in this issue of Developmental Cell.
DEVELOPMENTAL CELL
(2021)
Review
Emergency Medicine
Xiaoxiang Wang, Yinghui Liu, Jia He, Jingru Wang, Xiaodong Chen, Ronghua Yang
Summary: This article reviews the regulation of hair follicles, HFSCs and related signaling pathways, summarizes previous research results, and reveals the regulatory mechanisms of HFSC proliferation and differentiation.
Article
Biochemistry & Molecular Biology
Hailong Yan, Miaohan Jin, Yan Li, Ye Gao, Qiang Ding, Xiaolong Wang, Wenxian Zeng, Yulin Chen
Summary: This study investigates the molecular mechanism of miR-1 in regulating HFSC proliferation and differentiation. The overtranscription of miR-1 inhibits HFSC proliferation but enhances differentiation, providing new insights into HFSC development.
DNA AND CELL BIOLOGY
(2022)
Article
Genetics & Heredity
Yuxin Ding, Yuhong Chen, Xiaoshuang Yang, Piaopiao Xu, Jing Jing, Yujie Miao, Meiqi Mao, Jiali Xu, Xianjie Wu, Zhongfa Lu
Summary: This study investigates the mechanisms of noncoding RNAs and competitive endogenous RNA networks associated with the hair follicle cycle, and identifies new alopecia-related genes such as GSPT1. The study provides valuable insights into the regulation of the hair follicle cycle.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Koya Suzuki, Kosuke Yamaga, Reitaro Tokumasu, Tatsuya Katsuno, Hiroo Tanaka, Shuhei Chiba, Takeshi Yagi, Ichiro Katayama, Atsushi Tamura, Hiroyuki Murota, Sachiko Tsukita
Summary: Hair retention in infant mice is regulated by Claudin (CLDN)-1 and CLDN3, which maintain the appropriate layered architecture of hair follicles. Deficiencies in these proteins can lead to hair loss.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Dermatology
Koji Sugawara, Nora Zakany, Stephan Tiede, Talveen Purba, Matthew Harries, Daisuke Tsuruta, Tamas Biro, Ralf Paus
Summary: Research has shown that selective activation of the cannabinoid receptor-1 pathway significantly increases the number and proliferation of human epithelial stem cells in scalp hair follicles, while also promoting apoptosis in their differentiated progeny. This highlights the crucial role of CB1 signaling in the survival of adult human scalp hair follicle stem cells within their niche.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
Yuting Zhang, Chunya Ni, Yan Huang, Yulong Tang, Kai Yang, Xiangguang Shi, Yue Zhang, Zheng Li, Ji'an Wang, Yifei Zhu, Haiyang Li, Yanyun Ma, Jinran Lin, Jiucun Wang, Qingmei Liu, Wenyu Wu
Summary: Research has shown that resveratrol (RSV) can significantly promote hair growth in mice and delay human hair follicles entering the catagen phase. Additionally, in vitro experiments have demonstrated that RSV promotes the proliferation of human dermal papilla cells and protects them from oxidative damage.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2021)
Article
Dermatology
Yun-Ho Choi, Jae Young Shin, Jaeyoon Kim, Nae-Gyu Kang, Sanghwa Lee
Summary: Niacinamide enhances hair growth by reducing protein expression levels, preventing oxidative stress-induced cell senescence, and premature entry of hair follicles into the catagen phase.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aneta Sciezynska, Krzysztof Luszczynski, Marcin Radziszewski, Michal Komorowski, Marta Soszynska, Natalia Krzesniak, Kateryna Shevchenko, Anna Lutynska, Jacek Malejczyk
Summary: The ABCA4 gene is specifically expressed in the disc of photoreceptor outer segments and mutations in this gene are the main cause of ABCA4-retinopathies. Recent research has found that ABCA4 is expressed in hair follicles and keratinocytes, but its significance remains unknown. A new study investigated the role of ABCA4 gene in human keratinocytes and hair follicle stem cells for the first time and showed that silencing the ABCA4 gene enhances the harmful effects of all-trans-retinal on human hair follicle stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Chinnavuth Vatanashevanopakorn, Thanutchaporn Sartyoungkul
Summary: Hair follicles are involved in a variety of functions and their formation and cycling require interaction between different cell types. Despite extensive research, generating functional human hair follicles for clinical use remains a challenge. Human pluripotent stem cells offer a promising unlimited cell source for generating hair follicle cells. This review discusses hair follicle morphogenesis, different cell sources for regeneration, and potential strategies using induced pluripotent stem cells for hair follicle bioengineering. Challenges and perspectives for using bioengineered hair follicles in treating hair loss disorders are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Dermatology
Talveen S. Purba, Iain S. Haslam, Asim Shahmalak, Ranjit K. Bhogal, Ralf Paus
EXPERIMENTAL DERMATOLOGY
(2015)
Review
Dermatology
Talveen S. Purba, Lars Brunken, Nathan J. Hawkshaw, Michael Peake, Jonathan Hardman, Ralf Paus
EXPERIMENTAL DERMATOLOGY
(2016)
Meeting Abstract
Dermatology
T. Purba, M. Peake, R. Paus
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2016)
Article
Biochemical Research Methods
Talveen S. Purba, Jack Marsh, Kayumba Ng'andu, Svitlana Kurinna, Ralf Paus
Article
Multidisciplinary Sciences
Talveen S. Purba, Michael Peake, Bessam Farjo, Nilofer Farjo, Ranjit K. Bhogal, Gail Jenkins, Ralf Paus
SCIENTIFIC REPORTS
(2017)
Article
Medicine, Research & Experimental
Talveen S. Purba, Kayumba Ng'andu, Lars Brunken, Eleanor Smart, Ellen Mitchell, Nashat Hassan, Aaron O'Brien, Charlotte Mellor, Jennifer Jackson, Asim Shahmalak, Ralf Paus
EMBO MOLECULAR MEDICINE
(2019)
Letter
Dermatology
J. A. Hardman-Smart, T. S. Purba, S. Panicker, B. Farjo, N. Farjo, M. J. Harries, R. Paus
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Letter
Dermatology
Jonathan A. Hardman, Carina Nicu, Charlemagne Tai, Matthew Harries, Aleksandr Mironov, Talveen S. Purba, Ralf Paus
JOURNAL OF DERMATOLOGICAL SCIENCE
(2020)
Article
Cell Biology
Ellen Mitchell, Charlotte E. L. Mellor, Talveen S. Purba
Article
Dermatology
Koji Sugawara, Nora Zakany, Stephan Tiede, Talveen Purba, Matthew Harries, Daisuke Tsuruta, Tamas Biro, Ralf Paus
Summary: Research has shown that selective activation of the cannabinoid receptor-1 pathway significantly increases the number and proliferation of human epithelial stem cells in scalp hair follicles, while also promoting apoptosis in their differentiated progeny. This highlights the crucial role of CB1 signaling in the survival of adult human scalp hair follicle stem cells within their niche.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
Talveen S. Purba, Leila Berriche, Ralf Paus
Summary: Researchers propose that there is the Warburg effect and metabolic compartmentalisation in human scalp hair follicles, with lactate playing a role in regulating cell fate and immune tolerance in different regions.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
Andrea Luengas-Martinez, Jonathan Hardman-Smart, David Rutkowski, Talveen S. Purba, Ralf Paus, Helen S. Young
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2020)
Meeting Abstract
Dermatology
T. Purba, L. Brunken, N. Hawkshaw, M. Peake, J. Hardman, R. Paus
BRITISH JOURNAL OF DERMATOLOGY
(2016)
Meeting Abstract
Dermatology
T. Purba, L. Brunken, L. Ceballos, A. Chaves, E. Poblet, A. Gandarillas, R. Paus
BRITISH JOURNAL OF DERMATOLOGY
(2016)
Article
Cell Biology
Mohamed Kodiha, Nabila Azad, Siwei Chu, Noah Crampton, Ursula Stochaj
Summary: This study reveals that oxidative stress induces the nuclear accumulation of RanBP1 and the signaling pathways mediated by EGFR and PKA play a role in regulating RanBP1 localization during stress. RanBP1 acts as a downstream effector of these signaling routes, positioning it at the intersection of important cellular signaling circuits.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2024)