Article
Multidisciplinary Sciences
Caleb R. Matthews, Mackenzie Madison, Lava R. Timsina, Niharika Namburi, Zainab Faiza, Lawrence S. Lee
Summary: The time interval between symptom onset, diagnosis, and surgery for Acute Type A Aortic Dissection has a significant impact on mortality rates. Surgery performed 8-12 hours after diagnosis carries the highest mortality, potentially exacerbated by a longer interval since symptom onset. Time-dependent effects should be taken into consideration, especially in cases where inter-facility transfer is necessary.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Bardia Arabkhani, Jos Verhoef, Anton Tomsic, Thomas J. van Brakel, Jesper Hjortnaes, Robert J. M. Klautz
Summary: The effect of an aggressive approach on the aortic root in acute type A aortic dissection (ATAAD) remains insufficiently explored. The study analyzed a retrospective cohort of ATAAD patients aged 18 years and older between 1992 and 2020. Patients were divided into two groups: aortic root replacement (ARR) and conservative root approach (CRA). The results showed that over the years, ARR increased and was associated with better long-term survival and fewer reinterventions compared to CRA.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Dadi Helgason, Solveig Helgadottir, Anders Ahlsson, Jarmo Gunn, Vibeke Hjortdal, Emma C. Hansson, Anders Jeppsson, Ari Mennander, Shahab Nozohoor, Igor Zindovic, Christian Olsson, Stefan Orri Ragnarsson, Martin Sigurdsson, Arnar Geirsson, Tomas Gudbjartsson
Summary: This study examined the occurrence of AKI in patients undergoing surgery for ATAAD in 8 Nordic centers from 2005 to 2014. AKI was found to be a common complication after ATAAD surgery and independently predicted adverse long-term outcomes, emphasizing the importance of close clinical follow-up for these patients.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Maximilian Luehr, Christopher Gaisendrees, Abdul Kadir Yilmaz, Leila Winderl, Georg Schlachtenberger, Arnaud Van Linden, Thorsten Wahlers, Thomas Walther, Tomas Holubec
Summary: This study evaluated the postoperative outcomes of using the Ascyrus Medical Dissection Stent (AMDS) for the treatment of acute aortic dissection type A (AADA). The study found that AMDS had acceptable 30-day mortality in AADA patients, but careful evaluation of patients' aortic anatomy is necessary to avoid complete central AMDS collapse.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Ashwin Palaniappan, Frank Sellke
Summary: This study analyzes medical malpractice litigations related to aortic dissection, examining trends and predictive factors for verdicts. Plaintiffs commonly cite failure to diagnose, while defendant verdicts are more frequent, indicating that acceptable standards of care are often met.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Markian M. Bojko, Maham Suhail, Joseph E. Bavaria, Alex Bueker, Robert W. Hu, Joey Harmon, Andreas Habertheuer, Rita K. Milewski, Wilson Y. Szeto, Prashanth Vallabhajosyula
Summary: The study found that clinical outcomes after surgery for acute type A aortic dissection were similar in octogenarians and septuagenarians, with no significant differences in quality of life survey responses between the two groups.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
E. Hope Weissler, Oyomoare L. Osazuwa-Peters, Melissa A. Greiner, N. Chantelle Hardy, Panagiotis Kougias, Sean M. O'Brien, Daniel B. Mark, W. Schuyler Jones, Eric A. Secemsky, Andrew M. Vekstein, Sherene Shalhub, Firas F. Mussa, Manesh R. Patel, Sreekanth Vemulapalli
Summary: This study aimed to assess whether initial TEVAR following uTBAD is associated with reduced mortality or morbidity compared with medical therapy alone. The results showed that initial TEVAR was not associated with improved mortality or reduced hospitalizations or aortic interventions over a period of 5 years, but in a sensitivity analysis that included deaths within the first 30 days, initial TEVAR was associated with lower mortality.
Article
Cardiac & Cardiovascular Systems
Jeng-Wei Chen, Nyamsuren Sainbayar, Ron-Bin Hsu
Summary: Emergency surgery for acute type A aortic dissection (AAAD) using a standard conservative approach in octogenarians showed an improved outcome, with the majority of patients alive and well at discharge, indicating a good effect of this method in octogenarians.
JOURNAL OF CARDIAC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Kevin M. Harris, Christoph A. Nienaber, Mark D. Peterson, Elise M. Woznicki, Alan C. Braverman, Santi Trimarchi, Truls Myrmel, Reed Pyeritz, Stuart Hutchison, Craig Strauss, Marek P. Ehrlich, Thomas G. Gleason, Amit Korach, Daniel G. Montgomery, Eric M. Isselbacher, Kim A. Eagle
Summary: This study examined the early mortality rates for patients with TAAAD in the contemporary era and found that the mortality rate for the medical group was 0.5% per hour (23.7% at 48 hours), while for the surgical group, 48-hour mortality decreased to 4.4%.
Article
Multidisciplinary Sciences
Zhigang Wang, Pingping Ge, Lichong Lu, Min Ge, Cheng Chen, Lifang Zhang, Dongjin Wang
Summary: This study investigated the influence of dialysis on early and late outcomes in end-stage renal disease patients who underwent acute type A aortic dissection repair surgery. The results showed no significant difference in early operative variables and complications between dialysis and non-dialysis patients, but dialysis patients had lower survival rates and higher rates of late aortic events compared to non-dialysis patients.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Fausto Biancari, Tatu Juvonen, Antonio Fiore, Andrea Perrotti, Amelie Herve, Joseph Touma, Matteo Pettinari, Sven Peterss, Joscha Buech, Angelo M. Dell'Aquila, Konrad Wisniewski, Andreas Rukosujew, Till Demal, Lenard Conradi, Marek Pol, Petr Kacer, Francesco Onorati, Cecilia Rossetti, Igor Vendramin, Daniela Piani, Mauro Rinaldi, Luisa Ferrante, Eduard Quintana, Robert Pruna-Guillen, Javier Rodriguez Lega, Angel G. Pinto, Metesh Acharya, Zein El-Dean, Mark Field, Amer Harky, Francesco Nappi, Sebastien Gerelli, Dario Di Perna, Giuseppe Gatti, Enzo Mazzaro, Stefano Rosato, Peter Raivio, Mikko Jormalainen, Giovanni Mariscalco
Summary: The aim of this study was to evaluate the outcomes of different surgical strategies for acute TAAD. The study found that replacement of the aortic root and aortic arch did not decrease the risk of aortic reoperation in TAAD patients and should be performed only in the presence of local aortic injury or aneurysm.
Article
Cardiac & Cardiovascular Systems
Daniella Eliathamby, Mariana Gutierrez, Aileen Liu, Maral Ouzounian, Thomas L. Forbes, Kong Teng Tan, Jennifer Chung
Summary: The length of the ascending aorta plays a significant role in discriminating patients with type A aortic dissection, especially after adjusting for diameter, age, and sex. This study highlights the importance of ascending aortic length as a diagnostic marker for aortic dissection.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Yasushi Tashima, Shinichi Iwakoshi, Takeshi Inoue, Noriyuki Nakamura, Taichi Sano, Naoyuki Kimura, Takashi Inoue, Koichi Adachi, Atsushi Yamaguchi
Summary: A higher aortic Agatston score is correlated with larger true lumen area and less distal progression of aortic dissection in patients with acute type A aortic dissection (ATAAD).
Article
Medicine, General & Internal
Lin Li, Wenxian Wu, Na Xu, Qing Zhao, Wanpeng Guo
Summary: This study aimed to analyse the experiences and feelings of patients with TAAD and their families during the medical treatment and referral process, and investigate the needs and problems of the entire process. It was found that patients and their families encountered complex inner experiences, multiple requirements and numerous challenges during this process. The study suggests improving the treatment and referral system for TAAD in China, standardising diagnosis and treatment training, establishing a fast channel for prioritising TAAD treatment, popularising aortic dissection-related knowledge, and improving the funding system.
Article
Cardiac & Cardiovascular Systems
Klaus Kallenbach, Christopher Buesch, Bartosz Rylski, Daniel-Sebastian Dohle, Tobias Krueger, Thomas Holubec, Jens Brickwedel, Jochen Poeling, Thilo Noack, Christian Hagl, Philipp Jawny, Andreas Boening, Khaled Chalabi, Matthias Karck, Rawa Arif
Summary: This study aimed to interpret the strategies of aortic root surgery in German AADA patients. The results showed that supracommissural replacement was the preferred surgical method for elderly and compromised patients. Extended root preservation techniques may be used for selected patients, even in combination with extended aortic arch surgery, with promising early outcomes.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Surgery
Maximilian Luehr, Carolyn Weber, Martin Misfeld, Artur Lichtenberg, Sems-Malte Tugtekin, Mahmoud Diab, Shekhar Saha, Yupeng Li, Klaus Matsche, Torsten Doenst, Michael A. Borger, Thorsten Wahlers, Payam Akhyari, Christian Hagl
Summary: This study aimed to explore the virulence of Staphylococcus species in infectious endocarditis (IE) compared to other commonly causative bacteria in terms of short-term and long-term mortality. The results showed that patients with Staphylococcus IE had significantly higher mortality rates than those with IE caused by other bacteria. It is recommended to make an early diagnosis and refer patients with Staphylococcus infection to specialized centers for surgical treatment to reduce the risk of septic embolism and stroke.
Article
Cardiac & Cardiovascular Systems
Michaela Kluckner, Florian Enzmann, Leonhard Gruber, Sabine Helena Wipper, Nikolaos Bonaros, Thomas Schachner
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2024)
Article
Cardiac & Cardiovascular Systems
Maximilian Luehr, Christopher Gaisendrees, Abdul Kadir Yilmaz, Leila Winderl, Georg Schlachtenberger, Arnaud Van Linden, Thorsten Wahlers, Thomas Walther, Tomas Holubec
Summary: This study evaluated the postoperative outcomes of using the Ascyrus Medical Dissection Stent (AMDS) for the treatment of acute aortic dissection type A (AADA). The study found that AMDS had acceptable 30-day mortality in AADA patients, but careful evaluation of patients' aortic anatomy is necessary to avoid complete central AMDS collapse.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Medicine, General & Internal
Enzo Luesebrink, Clemens Scherer, Leonhard Binzenhoefer, Sabine Hoffmann, Julia Hoepler, Antonia Kellnar, Manuela Thienel, Dominik Joskowiak, Sven Peterss, Tobias Petzold, Simon Deseive, Ralph Hein, Stefan Brunner, Stefan Kaeaeb, Daniel Braun, Hans Theiss, Joerg Hausleiter, Christian Hagl, Steffen Massberg, Martin Orban
Summary: This study aimed to investigate the epidemiology, mortality, diagnosis, and clinical management of HIT occurring in VA-ECMO patients treated with UFH. The prevalence of HIT in VA-ECMO patients was found to be 3.5%, and it was not associated with a higher mortality rate. The functional assay was able to exclude HIT in 75% of VA-ECMO patients with clinical suspicion and positive anti-PF4/heparin antibody test. Argatroban appears to be a suitable and safe therapeutic option for confirmed HIT-positive patients on VA-ECMO support.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Magdalena A. Benda, Hanno Ulmer, Roman Weger, Patrick Reimann, Theresia Lang, Petra Pichler, Thomas Winder, Bernd Hartmann, Irene Strassl, Maria Theresa Krauth, Hermine Agis, Siegfried Sormann, Klaus Podar, Wolfgang Willenbacher, Ella Willenbacher
Summary: In this retrospective study, the attrition rate in the Austrian Myeloma Registry (AMR) was analyzed, and the results showed lower attrition rates compared to previous data, especially in elderly patients and those receiving optimal frontline treatment. The importance of achieving optimal treatment response was highlighted, not only in terms of attrition rates, but also in terms of treatment-free intervals. These promising results support the key role of liberal universal drug access and reimbursement.
Article
Cardiac & Cardiovascular Systems
Clemens Scherer, Hans Theiss, Mario Istrefi, Leonhard Binzenhoefer, Danny Kupka, Thomas Stocker, Enzo Luesebrink, Era Stambollxhiu, Ahmed Alemic, Tobias Petzold, Konstantin Stark, Simon Deseive, Daniel Braun, Dominik Joskowiak, Sven Peterss, Joerg Hausleiter, Christian Hagl, Steffen Massberg, Martin Orban
Summary: In this study, the efficacy and safety of suture-based and plug-based vascular closure devices for VA-ECMO decannulation were compared. The results showed that plug-based devices had a higher rate of technically correct placement and a lower incidence of severe bleeding events during decannulation. Therefore, plug-based vascular closure should be considered as the preferred option for VA-ECMO decannulation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Engineering, Biomedical
Christopher Gaisendrees, Georg Schlachtenberger, Stephen Gerfer, Ihor Krasivskyi, Ilija Djordjevic, Anton Sabashnikov, Marinos Kosmopoulos, Deborah Jaeger, Maximilian Luehr, Elmar Kuhn, Antje-Christin Deppe, Thorsten Wahlers
Summary: In patients undergoing extracorporeal cardiopulmonary resuscitation (eCPR) after cardiac arrest, early administration of levosimendan improves the success rates of ECMO weaning and survival, and reduces the need for mechanical chest compressions.
Article
Cardiac & Cardiovascular Systems
Serdar Akansel, Markus Kofler, Karel M. Van Praet, Simon H. Sundermann, Marian Kukucka, Stephan Jacobs, Volkmar Falk, Joerg Kempfert
Summary: This study investigated the utility of three-dimensional mitral valve (3D-MV) reconstruction models to predict annuloplasty ring size for mitral valve repair. The results showed that commissural width and intertrigonal distance were independent predictors of annuloplasty ring size. Therefore, 3D-MV reconstruction models can assist surgeons in making decisions about annuloplasty ring sizing.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Infectious Diseases
Lisa Seekircher, Zoltan Banki, Janine Kimpel, Annika Roessler, Helena Schaefer, Barbara Falkensammer, David Bante, Lukas Forer, Sebastian Schonherr, Teresa Harthaller, Magdalena Sacher, Cornelia Ower, Lena Tschiderer, Hanno Ulmer, Florian Krammer, Dorothee von Laer, Wegene Borena, Peter Willeit
Summary: This study investigated the associations between antibody and T-cell responses after COVID-19 vaccination and the risk of SARS-CoV-2 breakthrough infection, as well as whether measurement of these responses enhances risk prediction.
Article
Multidisciplinary Sciences
Fausto Biancari, Francesco Nappi, Giuseppe Gatti, Andrea Perrotti, Amelie Herve, Stefano Rosato, Paola D'Errigo, Matteo Pettinari, Sven Peterss, Joscha Buech, Tatu Juvonen, Mikko Jormalainen, Caius Mustonen, Till Demal, Lenard Conradi, Marek Pol, Petr Kacer, Angelo M. Dell'Aquila, Konrad Wisniewski, Igor Vendramin, Daniela Piani, Luisa Ferrante, Timo Makikallio, Eduard Quintana, Robert Pruna-Guillen, Antonio Fiore, Thierry Folliguet, Giovanni Mariscalco, Metesh Acharya, Mark Field, Manoj Kuduvalli, Francesco Onorati, Cecilia Rossetti, Sebastien Gerelli, Dario Di Perna, Enzo Mazzaro, Angel G. Pinto, Javier Rodriguez Lega, Mauro Rinaldi
Summary: This study evaluated the prognostic significance of preoperative arterial lactate concentration on the outcome after surgery for acute type A aortic dissection (TAAD). The results showed that hyperlactatemia significantly increased the risk of mortality after surgery for TAAD and should be considered in the clinical assessment of these critically ill patients.
Article
Cardiac & Cardiovascular Systems
Julia Merkle-Storms, Christopher Gaisendrees, Manuel Feisst, Bartosz Rylski, Daniel-Sebastian Dohle, Christian Hagl, Mario Lescan, Jens Brickwede, Jochen Poeling, Tomas Holubec, Christian D. Etz, Philipp Jawny, Thilo Noack, Rawa Arif, Thorsten Wahlers, Andreas Boening, Maximilian Luehr
Summary: This study analyzed the perioperative data of 3385 patients from the German Registry for Acute Aortic Dissection Type A to investigate the relationship between age and aortic dissection extension length. The results showed that younger patients had more extensive dissection and more organ malperfusion. The postoperative mortality rate remained high regardless of age.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Maximilian Luehr, Murat Yildiz, Wei-Guo Ma, Roland Heck, Andreas Polycarpou, Arminder Jassar, Maximilian Kreibich, Daniel-Sebastian Dohle, Gabriel Weiss, Christian Hagl, Filip Rega, Thomas Schachner, Andreas Martens, Alessandro Della Corte, Hiroaki Osada, Li-Zhong Sun, Konstantinos Tsagakis, Florian Schoenhoff
Summary: This clinical study aims to determine the prevalence and potential causes of acute aortic dissection type A (AADA) in surgically treated patients <= 30 years and evaluate their postoperative outcomes. The study found that the overall prevalence of AADA in patients = 30 years was 1.8%, with connective tissue disease (CTD) being a common factor. The postoperative mortality rate was 8.6%, and the 10-year survival rate was 80%.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Medicine, General & Internal
Julia von der Linden, Florian Herrmann, Sergey Belyaev, Gerd Juchem, Sven Peterss, Christian Hagl, Alexey Dashkevich
Summary: This study analyzed the feasibility of using RD SAVR to treat BAV. It was found that annular symmetry can be restored through precise prosthesis sizing and placement, and comparable clinical outcomes were observed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Becker, Jan Stana, Carlota F. Prendes, Nikolaos Konstantinou, Tugce Oez, Maximilian Pichlmaier, Sven Peterss, Nikolaos Tsilimparis
Summary: The study investigated the outcomes of using custom-made double or triple inner-branched arch endograft for repairing anastomotic aneurysms in patients after open surgical repair of the ascending aorta or proximal arch. The results showed that endovascular arch repair is technically feasible and a promising alternative for patients unfit for surgery.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Leonard Pitts, Markus Kofler, Matteo Montagner, Roland Heck, Stephan D. Kurz, Semih Buz, Volkmar Falk, Joerg Kempfert
Summary: The aim of this study was to investigate the outcome of elderly patients with surgically treated acute type A aortic dissection (ATAAD) complicated by malperfusion. The results showed that elderly patients with multilevel malperfusion had poor surgical outcomes, therefore surgical decision for these patients should be cautious.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
