Article
Oncology
Jingjing Miao, Lin Wang, Sze Huey Tan, Jin-Gao Li, Junlin Yi, Enya H. W. Ong, Laura L. Y. Tan, Ye Zhang, Xiaochang Gong, Qiuyan Chen, Yan-Qun Xiang, Ming-Yuan Chen, Ying Guo, Xing Lv, Wei-Xiong Xia, Linquan Tang, Xiaowu Deng, Xiang Guo, Fei Han, Hai-Qiang Mai, Melvin L. K. Chua, Chong Zhao
Summary: In this randomized clinical trial, adjuvant capecitabine at the full dose following CCRT was well tolerated and improved failure-free survival among patients with LA-NPC and high-risk factors. Further investigations assessing optimal dose and duration are warranted.
Article
Oncology
Fen Xue, Dan Ou, Xiaomin Ou, Xin Zhou, Chaosu Hu, Xiayun He
Summary: A dose and volume de-escalated IMRT based on response to IC was associated with high progression-free survival and mild late neurological toxicities. Further exploration of de-escalation strategies in appropriate patients is needed.
Article
Medicine, General & Internal
Nancy Y. Lee, Jonathan Harris, John Kim, Adam Garden, James Mechalakos, David G. Pfister, Anthony T. C. Chan, Kenneth Hu, A. Dimitrios Colevas, Steven Frank, George Shenouda, Voichita Bar-Ad, John N. Waldron, Paul M. Harari, Adam Raben, Pedro Torres-Saavedra, Quynh-Thu Le
Summary: The study aimed to assess the long-term toxic effects and clinical outcomes associated with adding bevacizumab, a vascular endothelial growth factor inhibitor, to standard chemoradiation for patients with nasopharyngeal carcinoma (NPC). The results showed favorable long-term outcomes and no severe adverse events when using bevacizumab in combination with chemoradiation. Further investigation may be warranted.
Article
Medicine, General & Internal
Yu-Pei Chen, Xu Liu, Qin Zhou, Kun-Yu Yang, Feng Jin, Xiao-Dong Zhu, Mei Shi, Guo-Qing Hu, Wei-Han Hu, Yan Sun, Hong-Fen Wu, Hui Wu, Qin Lin, Hui Wang, Ye Tian, Ning Zhang, Xi-Cheng Wang, Liang-Fang Shen, Zheng-Zheng Liu, Jing Huang, Xiu-Ling Luo, Ling Li, Jian Zang, Qi Mei, Bao-Min Zheng, Dan Yue, Jing Xu, San-Gang Wu, Yan-Xia Shi, Yan-Ping Mao, Lei Chen, Wen-Fei Li, Guan-Qun Zhou, Rui Sun, Rui Guo, Yuan Zhang, Cheng Xu, Jia-Wei Lv, Ying Guo, Hui-Xia Feng, Ling-Long Tang, Fang-Yun Xie, Ying Sun, Jun Ma
Summary: This study found that adding oral metronomic capecitabine as adjuvant chemotherapy significantly improved failure-free survival in patients with high-risk locoregionally advanced nasopharyngeal carcinoma, with a good safety profile. These results support the potential role of metronomic chemotherapy as an adjuvant therapy in the treatment of nasopharyngeal carcinoma.
Article
Oncology
Rui Zou, Jing-Jing Yuan, Qiang Li, Jian-Wu Ding, Bing Liao, Zi-Wei Tu, Rong-Huan Hu, Dan Gong, Jia-Li Hu, Lei Zeng
Summary: The study analyzed the outcomes and toxicities of ICT followed by CCRT plus ACT in LA-NPC patients, and found that this treatment approach did not significantly improve DFS and OS compared to adding ICT to CCRT, with more acute adverse events. Longer-term clinical studies are needed to evaluate treatment outcomes and late toxicities.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Qi Yang, Le Xia, Mei Lin, Meng-Xia Zhang, Chong-Yang Duan, You-Ping Liu, Yu-Long Xie, Zhi-Qiang Wang, Rui You, Xiong Zou, Yi-Jun Hua, Pei-Yu Huang, Rui Sun, Ming-Huang Hong, Ming-Yuan Chen
Summary: This study confirmed that induction chemotherapy (IC) followed by concurrent chemo-radiotherapy (CCRT) had better long-term quality of life outcomes compared with CCRT alone in patients with locoregionally advanced nasopharyngeal carcinoma. The IC followed by CCRT group showed significantly improved results in role functioning, cognitive functioning, social functioning, fatigue, pain, and constipation, while showing poorer results in senses problems.
Article
Oncology
Joaquim Bellmunt, Maha Hussain, Jurgen E. Gschwend, Peter Albers, Stephane Oudard, Daniel Castellano, Siamak Daneshmand, Hiroyuki Nishiyama, Martin Majchrowicz, Viraj Degaonkar, Yi Shi, Sanjeev Mariathasan, Petros Grivas, Alexandra Drakaki, Peter H. O'Donnell, Jonathan E. Rosenberg, Daniel M. Geynisman, Daniel P. Petrylak, Jean Hoffman-Censits, Jens Bedke, Arash Rezazadeh Kalebasty, Yousef Zakharia, Michiel S. van der Heijden, Cora N. Sternberg, Nicole N. Davarpanah, Thomas Powles
Summary: IMvigor010 is the largest adjuvant study evaluating a checkpoint inhibitor in muscle-invasive urothelial carcinoma. The trial did not show improved disease-free survival with atezolizumab compared to observation. Atezolizumab was generally well tolerated, but higher rates of adverse events leading to discontinuation were reported compared to previous studies on metastatic urothelial carcinoma.
Article
Oncology
Longjiang She, Kun Tian, Jiaqi Han, Weihan Zuo, Zhu Wang, Ning Zhang
Summary: Adding metronomic capecitabine to concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma patients has been shown to be a cost-effective strategy, resulting in additional quality-adjusted life years and a favorable incremental cost-effective ratio at a willingness-to-pay threshold of $33,585 per QALY.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Lin Su, Lei She, Liangfang Shen
Summary: Nasopharyngeal carcinoma is a common malignant tumor of the head and neck, originating from the mucous epithelium of the nasopharynx. Symptoms are often missed, with majority of patients presenting with locally advanced disease. Concurrent radiation therapy with chemotherapy can improve regional control, but distant metastasis remains a challenge. Adjuvant chemotherapy's role in treating locally advanced NPC is still unclear and associated with increased toxicity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Otorhinolaryngology
Raymond K. Tsang, Walter C. P. Chan, Floyd Christopher Holsinger, Joseph C. K. Chung, Velda L. Y. Chow, Jimmy Y. W. Chan, Wai-Kuen Ho, William Wei
Summary: This study presents the experience of 33 cases of robotic-assisted nasopharyngectomy, with a focus on local recurrent nasopharyngeal carcinoma. The study shows a high local control rate of 85.1% and a median follow-up period of 38 months.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Trisha M. Wise-Draper, Shuchi Gulati, Sarah Palackdharry, Benjamin H. Hinrichs, Francis P. Worden, Matthew O. Old, Neal E. Dunlap, John M. Kaczmar, Yash Patil, Muhammed Kashif Riaz, Alice Tang, Jonathan Mark, Chad Zender, Ann M. Gillenwater, Diana Bell, Nicky Kurtzweil, Maria Mathews, Casey L. Allen, Michelle L. Mierzwa, Keith Casper, Roman Jandarov, Mario Medvedovic, J. Jack Lee, Nusrat Harun, Vinita Takiar, Maura Gillison
Summary: The study investigates the clinical activity and survival impact of neoadjuvant pembrolizumab in patients with head and neck squamous cell carcinoma. The results show a significant improvement in one-year disease-free survival rate for intermediate-risk patients, while no significant improvement was observed for high-risk patients.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Lingling Meng, Feng Teng, Qiteng Liu, Lei Du, Boning Cai, Chuanbin Xie, Hanshun Gong, Xinxin Zhang, Lin Ma
Summary: A retrospective analysis was conducted on 190 newly diagnosed non-metastatic NPC patients treated with helical tomotherapy, showing excellent long-term outcomes and mild treatment-related toxicities. Further studies are needed to confirm the role of anti-EGFR monoclonal antibody treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Shi-Ping Yang, Ming-Yue Rao, Qing-Shuang Chen, Ping Zhou, Chen-Lu Lian, San-Gang Wu
Summary: This study assessed the causes of death and long-term survival after nasopharyngeal carcinoma (NPC) diagnosis. The results showed that primary NPC remains a significant cause of death even 15 years after diagnosis, while death due to cardiac disease and other causes increased over time. Age, race, and diagnosis time were identified as important factors affecting NPC-specific survival.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Yu-Jing Liang, Qiu-Yan Chen, Jing-Xiao Xu, Xiu-Feng Liu, Jian-Chuan Xia, Li-Ting Liu, Shan-Shan Guo, Bin Song, Pan Wang, Ji-Bin Li, Qing Liu, Hao-Yuan Mo, Ling Guo, Rui Sun, Dong-Hua Luo, Jia He, Yi-Na Liu, Cai-Ping Nie, Lin-Quan Tang, Jiang Li, Hai-Qiang Mai
Summary: The phase I study evaluated the safety and clinical responses of adjuvant autologous TILs after CCRT in NPC patients. No significant difference was observed in the 3-year PFS rate between the CCRT plus TIL infusion group and the CCRT alone group. TIL infusion was safe and the high-grade adverse effects were associated with myelosuppression caused by CCRT.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Li Xiang, Jin-Feng Rong, Xiao-Yue Li, Yun Zheng, Pei-Rong Ren, Sheng Lin, Qing-Lian Wen, Li-Jia He, Jian-Wen Zhang, Chang-Ling Shang, Hong-Ru Yang, Juan Fan, Hao-Wen Pang, Jing Zhang, Bang-Xian Tan, Ling Zhang, Xiao-Bo Du, Shi-Min Wen, Liang Jiang, Gang Qin, Jing-Bo Wu
Summary: The purpose of this study was to evaluate the long-term survival, late toxicity profile, and quality of life of patients with advanced nasopharyngeal carcinoma who received combined induction chemotherapy and concurrent chemoradiotherapy. The results showed that reducing the target volumes of intensity modulated radiation therapy after induction chemotherapy did not increase the risk of locoregional relapse and may improve quality of life and reduce late toxicity.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Lilong Sun, Zhijia Liu, Houkuan Tian, Zhicheng Le, Lixin Liu, Kam W. Leong, Hai-Quan Mao, Yongming Chen
Article
Chemistry, Physical
Boyuan Chen, Zhitao Hu, Haoqi Li, Zhiyong Li, Qiong Li, Yongming Chen
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2019)
Review
Oncology
Run-Cong Nie, Fo-Ping Chen, Shu-Qiang Yuan, Ying-Shan Luo, Shi Chen, Yong-Ming Chen, Xiao-Jiang Chen, Ying-Bo Chen, Yuan-Fang Li, Zhi-Wei Zhou
EUROPEAN JOURNAL OF CANCER
(2019)
Article
Oncology
Wen-Fei Li, Nian-Yong Chen, Ning Zhang, Guo-Qing Hu, Fang-Yun Xie, Yan Sun, Xiao-Zhong Chen, Jin-Gao Li, Xiao-Dong Zhu, Chao-Su Hu, Xiang-Ying Xu, Yuan-Yuan Chen, Wei-Han Hu, Ling Guo, Hao-Yuan Mo, Lei Chen, Yan-Ping Mao, Rui Sun, Ping Ai, Shao-Bo Liang, Guo-Xian Long, Bao-Min Zheng, Xing-Lai Feng, Xiao-Chang Gone, Ling Li, Chun-Ying Shen, Jian-Yu Xu, Ying Guo, Yu-Ming Chen, Fan Zhang, Li Lin, Ling-Long Tang, Meng-Zhong Liu, Jun Ma, Ying Sun
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Polymer Science
Jing Wang, Yan Lu, Yongming Chen
Article
Oncology
Shao-Bo Liang, Ning Zhang, Dan-Ming Chen, Xing-Li Yang, Bin-Hong Chen, Hai Zhao, Rui-Liang Lu, Yong Chen, Li-Wu Fu
RADIOTHERAPY AND ONCOLOGY
(2019)
Article
Engineering, Biomedical
Zhipeng Zeng, Cong Dong, Pengfei Zhao, Zhijia Liu, Lixin Liu, Hai-Quan Mao, Kam W. Leong, Xiaohu Gao, Yongming Chen
ADVANCED HEALTHCARE MATERIALS
(2019)
Article
Oncology
Ruiwan Chen, Yu Zhou, Yujie Yuan, Qun Zhang, Shasha He, Yong Chen, Yufeng Ren
FRONTIERS IN ONCOLOGY
(2019)
Article
Oncology
Min Luo, Cheng Wu, Ergang Guo, Shan Peng, Linli Zhang, Wei Sun, Dongbo Liu, Guangyuan Hu, Guoqing Hu
Article
Medicine, General & Internal
Yuan Zhang, Lei Chen, Guo-Qing Hu, Ning Zhang, Xiao-Dong Zhu, Kun-Yu Yang, Feng Jin, Mei Shi, Yu-Pei Chen, Wei-Han Hu, Zhi-Bin Cheng, Si-Yang Wang, Ye Tian, Xi-Cheng Wang, Yan Sun, Jin-Gao Li, Wen-Fei Li, Yu-Hong Li, Ling-Long Tang, Yan-Ping Mao, Guan-Qun Zhou, Rui Sun, Xu Liu, Rui Guo, Guo-Xian Long, Shao-Qiang Liang, Ling Li, Jing Huang, Jin-Hua Long, Jian Zang, Qiao-Dan Liu, Li Zou, Qiong-Fei Su, Bao-Min Zheng, Yun Xiao, Ying Guo, Fei Han, Hao-Yuan Mo, Jia-Wei Lv, Xiao-Jing Du, Cheng Xu, Na Liu, Ying-Qin Li, Melvin L. K. Chua, Fang-Yun Xie, Ying Sun, Jun Ma
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Article
Oncology
Cheng Wu, Ergang Guo, Jun Ming, Wei Sun, Xin Nie, Lu Sun, Shan Peng, Min Luo, Dongbo Liu, Linli Zhang, Qi Mei, Guoxian Long, Guangyuan Hu, Guoqing Hu
MOLECULAR THERAPY-ONCOLYTICS
(2020)
Article
Medicine, General & Internal
Yu-Pei Chen, Xu Liu, Qin Zhou, Kun-Yu Yang, Feng Jin, Xiao-Dong Zhu, Mei Shi, Guo-Qing Hu, Wei-Han Hu, Yan Sun, Hong-Fen Wu, Hui Wu, Qin Lin, Hui Wang, Ye Tian, Ning Zhang, Xi-Cheng Wang, Liang-Fang Shen, Zheng-Zheng Liu, Jing Huang, Xiu-Ling Luo, Ling Li, Jian Zang, Qi Mei, Bao-Min Zheng, Dan Yue, Jing Xu, San-Gang Wu, Yan-Xia Shi, Yan-Ping Mao, Lei Chen, Wen-Fei Li, Guan-Qun Zhou, Rui Sun, Rui Guo, Yuan Zhang, Cheng Xu, Jia-Wei Lv, Ying Guo, Hui-Xia Feng, Ling-Long Tang, Fang-Yun Xie, Ying Sun, Jun Ma
Summary: This study found that adding oral metronomic capecitabine as adjuvant chemotherapy significantly improved failure-free survival in patients with high-risk locoregionally advanced nasopharyngeal carcinoma, with a good safety profile. These results support the potential role of metronomic chemotherapy as an adjuvant therapy in the treatment of nasopharyngeal carcinoma.
Article
Polymer Science
Yongwei Wu, Zhitao Hu, Huahua Huang, Yongming Chen
Article
Oncology
Jing Guo, Yongming Chen, Zhimin Liu, Yuanxiang Guan, Wei Wang, Xiaowei Sun, Wei Li, Dazhi Xu
Article
Polymer Science
Houbo Zhou, Christopher M. Plummer, Huaan Li, Huahua Huang, Pengfei Ma, Le Li, Lixin Liu, Yongming Chen
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)