Journal
EUROPEAN JOURNAL OF CANCER
Volume 86, Issue -, Pages 178-185Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2017.09.007
Keywords
Electronic health record; Population-based registry; Randomised clinical trial; Evidence-based medicine; Haematology; Oncology
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Randomised clinical trials (RCTs) are considered the basis of evidence-based medicine. It is recognised more and more that application of RCT results in daily practice of clinical decision-making is limited because the RCT world does not correspond with the clinical real world. Recent strategies aiming at substitution of RCT databases by improved population-based registries (PBRs) or by improved electronic health record (EHR) systems to provide significant data for clinical science are discussed. A novel approach exemplified by the HemoBase haemato-oncology project is presented. In this approach, a PBR is combined with an advanced EHR, providing high-quality data for observational studies and support of best practice development. This PBR + EHR approach opens a perspective on randomised registry trials. (C) 2017 Elsevier Ltd. All rights reserved.
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