Article
Cardiac & Cardiovascular Systems
Meng Wang, Derick R. R. Peterson, Eleonora Pagan, Vincenzo Bagnardi, Andrea Mazzanti, Scott McNitt, David Q. Q. Rich, Christopher L. L. Seplaki, Valentina Kutyifa, Bronislava Polonsky, Alon Barsheshet, Deni Kukavica, Spencer Rosero, Ilan Goldenberg, Silvia Priori, Wojciech Zareba
Summary: This study developed two risk prediction algorithms for assessing the 5-year absolute risk of life-threatening arrhythmic events in LQTS patients, aiding in clinical decision making.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Janos Borbas, Mate Vamos, Lidia Hategan, Lilla Hanak, Nelli Farkas, Zsolt Szakacs, Dezso Csupor, Balint Tel, Peter Kupo, Beata Csanyi, Viktoria Nagy, Andras Komocsi, Tamas Habon, Peter Hegyi, Robert Sepp
Summary: Mutations in the CACNA1C gene can result in various clinical manifestations. Timothy syndrome is associated with the most severe clinical phenotype and the highest risk of morbidity and mortality. However, our data does not support distinguishing subtypes of TS.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Genetics & Heredity
Alexis Hermida, Guillaume Jedraszak, Maciej Kubala, Amel Mathiron, Pascal Berna, Youssef Bennis, Jean-Sylvain Hermida
Summary: This case study reports a detailed case of type 2 long QT syndrome caused by a p.(Gly402Ser) mutation in the CACNA1C gene, with severe cardiac phenotypes and developmental delays. The patient experienced a resuscitated cardiac arrest and multiple appropriate shocks, and the addition of mexiletine to nadolol showed some improvement.
Article
Cardiac & Cardiovascular Systems
Meng Wang, Derick R. Peterson, Spencer Rosero, Scott McNitt, David Q. Rich, Christopher L. Seplaki, Bronislava Polonsky, Ilan Goldenberg, Wojciech Zareba
Summary: The study indicates that implantable cardioverter-defibrillators can reduce the risk of all-cause mortality, all-cause mortality before age 50 years, and sudden cardiac death in patients with long QT syndrome.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Critical Care Medicine
Roi Bar Cohen, Matthew Dai, Anthony Aizer, Chirag Barbhaiya, Connor Peterson, Scott Bernstein, David S. Park, Michael Spinelli, Larry A. Chinitz, Lior Jankelson
Summary: The QTc/JTc interval is significantly and independently prolonged after sudden cardiac arrest, regardless of known QT prolonging triggers. Normalization of the QTc is expected only after day 6 of hospitalization. Assessment of the QTc for determining the etiology of arrest or monitoring the effect of QT prolonging medications may be unreliable.
Review
Pharmacology & Pharmacy
Tibor Hornyik, Marina Rieder, Alessandro Castiglione, Peter Major, Istvan Baczko, Michael Brunner, Gideon Koren, Katja E. Odening
Summary: To study human cardiac diseases and develop treatment strategies, complex interactions of cardiac cells on multiple levels need to be considered. While mice are commonly used in cardiac research, differences in function and composition limit their translatability; rabbits, with closer resemblance to human hearts, are suitable as models. Different methodological approaches for generating transgenic rabbits and their utility in understanding disease mechanisms and treatment options are discussed.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Maria E. Frazier, Stephanie R. Brown, Amanda O'Halloran, Tia Raymond, Richard Hanna, Dana E. Niles, Monica Kleinman, Robert M. Sutton, Joan Roberts, Ken Tegtmeyer, Heather A. Wolfe, Vinay Nadkarni, Maya Dewan
Summary: This study aimed to describe the risk factors and outcomes for paediatric recurrent in-hospital cardiac arrest (IHCA). The results showed that patients with recurrent IHCA had shorter duration of cardiopulmonary resuscitation and worse survival outcomes compared to those with a single IHCA. Event and patient factors were found to be associated with the risk for recurrent IHCA.
Article
Cardiac & Cardiovascular Systems
Dae-Young Kim, Jae-Sun Uhm, Min Kim, In-Soo Kim, Moo-Nyun Jin, Hee Tae Yu, Tae-Hoon Kim, Jong-Youn Kim, Boyoung Joung, Hui-Nam Pak, Moon-Hyoung Lee
Summary: In a subset of the Korean population, patients with SQTI were found to have higher prevalence of early repolarization, tall T wave, and U wave, wider QT dispersion, slower heart rate, and significantly increased risk of atrial fibrillation and ventricular arrhythmia/sudden cardiac arrest compared to those without SQTI.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Christina Y. Miyake, Erica J. Lay, Cheyenne M. Beach, Scott R. Ceresnak, Caridad M. Delauz, Taylor S. Howard, Christopher M. Janson, Kate Jardine, Prince J. Kannankeril, Maina Kava, Jeffrey J. Kim, Leonardo Liberman, Scott L. Macicek, Tam Dam Pham, Terry Robertson, Santiago O. Valdes, Gregory Webster, Sara B. Stephens, Diana M. Milewicz, Mahshid Azamian, Saad A. Ehsan, Kimberly M. Houck, Claudia Soler-Alfonso, Kevin E. Glinton, Mustafa Tosur, Na Li, Weiyi Xu, Seema R. Lalani, Lilei Zhang
Summary: Cardiac crises associated with TDD are characterized by a high risk of arrhythmias, cardiomyopathy, cardiac arrest, and death. Early recognition and appropriate treatment are critical. Intravenous magnesium, isoproterenol, atrial pacing, and ECMO as a last resort appear to be the best current treatment options for controlling arrhythmias.
Article
Cardiac & Cardiovascular Systems
Sami Viskin, Ehud Chorin, Arie Lorin Schwartz, Piotr Kukla, Raphael Rosso
Summary: Cardiac memory is an interesting electrocardiographic phenomenon where T waves become abnormal in the opposite direction of wide QRS complex, and normalize at a later stage. Reduction of repolarizing potassium currents during cardiac memory may lead to prolonged QT syndrome and ventricular arrhythmias.
Letter
Medicine, General & Internal
Sofia Schierbeck, Leif Svensson, Andreas Claesson
Summary: This case report discusses the use of a drone to deliver an automated external defibrillator for defibrillation in a patient who experienced an out-of-hospital cardiac arrest in Sweden.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
William A. Agudelo, Sebastian Ramiro Gil-Quinones, Alejandra Fonseca, Alvaro Arenas, Laura Castro, Diana Carolina Sierra-Diaz, Manuel A. Patarroyo, Paul Laissue, Carlos F. Suarez, Rodrigo Cabrera
Summary: Congenital long QT syndrome (LQTS) is a cardiac channelopathy characterized by prolonged QT interval and T-wave abnormalities, often caused by mutations in genes such as KCNQ1, KCNH2, and SCN5A. This study aimed to investigate the structural impact of compound mutations on potassium channels in severe LQTS phenotypes using molecular dynamic simulations. The findings suggest that mutant channels show moderate changes in energy and mobility, potentially influencing K+ ion flow and differentiating from wild-type channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Jamal Chu, K. H. Benjamin Leung, Paul Snobelen, Gordon Nevils, Ian R. Drennan, Sheldon Cheskes, Timothy C. Y. Chan
Summary: The study found that machine learning-based dispatch rules can effectively reduce response time for drone-delivered defibrillators, decrease the number of flights, and achieve comparable results to universally dispatching drones.
Article
Critical Care Medicine
Lindsay N. Shepard, Ron W. Reeder, Amanda O'Halloran, Martha Kienzle, Jameson Dowling, Kathryn Graham, Garrett P. Keim, Alexis A. Topjian, Nadir Yehya, Robert M. Sutton, Ryan W. Morgan
Summary: The aim of this study was to characterize respiratory failure prior to pediatric in-hospital cardiac arrest (IHCA) and to associate pre-arrest respiratory failure characteristics with survival outcomes. The study found substantial heterogeneity in respiratory failure characteristics and ventilatory requirements pre-arrest, and higher pre-arrest oxygen requirement and greater degree of oxygenation failure were associated with worse survival outcomes.
Article
Cardiac & Cardiovascular Systems
Andrea Mazzanti, Alessandro Trancuccio, Deni Kukavica, Eleonora Pagan, Meng Wang, Muhammed Mohsin, Derick Peterson, Vincenzo Bagnardi, Wojciech Zareba, Silvia G. Priori
Summary: This study validated a novel risk score model for patients with long QT syndrome (LQTS) in a geographically diverse cohort from the USA and demonstrated its clinical implications. The validated model can aid clinicians in identifying high-risk LQTS patients who could benefit from an implantable cardioverter-defibrillator (ICD) and avoid unnecessary implants.
Article
Medicine, General & Internal
Michael Mullen, Xu Yu Jin, Anne Child, A. Graham Stuart, Matthew Dodd, Jose Antonio Aragon-Martin, David Gaze, Anatoli Kiotsekoglou, Li Yuan, Jiangting Hu, Claire Foley, Laura Van Dyck, Rosemary Knight, Tim Clayton, Lorna Swan, John D. R. Thomson, Guliz Erdem, David Crossman, Marcus Flather
Review
Cardiac & Cardiovascular Systems
Guido E. Pieles, A. Graham Stuart
CLINICAL CARDIOLOGY
(2020)
Letter
Cardiac & Cardiovascular Systems
Graham Stuart
Article
Cardiac & Cardiovascular Systems
Werner Budts, Guido E. Pieles, Jolien W. Roos-Hesselink, Maria Sanz de la Garza, Flavio D'Ascenzi, George Giannakoulas, Jan Mueller, Renate Oberhoffer, Doris Ehringer-Schetitska, Vesna Herceg-Cavrak, Harald Gabriel, Domenico Corrado, Frank van Buuren, Josef Niebauer, Mats Borjesson, Stefano Caselli, Peter Fritsch, Antonio Pelliccia, Hein Heidbuchel, Sanjay Sharma, A. Graham Stuart, Michael Papadakis
EUROPEAN HEART JOURNAL
(2020)
Review
Cardiac & Cardiovascular Systems
Antonio Pelliccia, Sanjay Sharma, Sabiha Gati, Maria Back, Mats Borjesson, Stefano Caselli, Jean-Philippe Collet, Domenico Corrado, Jonathan A. Drezner, Martin Halle, Dominique Hansen, Hein Heidbuchel, Jonathan Myers, Josef Niebauer, Michael Papadakis, Massimo Francesco Piepoli, Eva Prescott, Jolien W. Roos-Hesselink, A. Graham Stuart, Rod S. Taylor, Paul D. Thompson, Monica Tiberi, Luc Vanhees, Matthias Wilhelm
EUROPEAN HEART JOURNAL
(2021)
Article
Physiology
Guido E. Pieles, Lucy Gowing, Diane Ryding, Dave Perry, Steven R. McNally, A. Graham Stuart, Craig A. Williams
Summary: This study investigated LV myocardial mechanics and reserve during dynamic exercise in adolescent athletes using 2-D strain deformation imaging. It found significant differences between LV longitudinal and circumferential myocardial mechanics during exercise, with circumferential strain being the dominant mechanism of exercise LV contractility increase. The study provides reference values for LV myocardial strain and strain rate during exercise in adolescent footballers, offering a methodology to quantify LV function and cardiac reserve during exercise.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Curtis A. Wadey, Guido Pieles, Graham Stuart, Rod Taylor, Linda Long, Craig A. Williams
Review
Medicine, General & Internal
Dan M. Dorobantu, Curtis A. Wadey, Nurul H. Amir, A. Graham Stuart, Craig A. Williams, Guido E. Pieles
Summary: The study systematically evaluated the role of STE in pediatric inherited cardiomyopathies, finding that longitudinal and circumferential strains were the most commonly reported STE measurements, showing higher abnormal rates in DCM and LVNC, while not necessarily abnormal in HCM. Abnormal STE parameters were reported even in cohorts with normal cardiac function.
Review
Pediatrics
Nurul Hidayah Amir, Dan M. Dorobantu, Curtis A. Wadey, Massimo Caputo, A. Graham Stuart, Guido E. Pieles, Craig A. Williams
Summary: Exercise and physical activity are effective for children with CHD, but are not commonly used as interventions. Understanding safe exercise participation can increase PA engagement and reduce inactivity-related diseases.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Sport Sciences
Harvey Johnson, Nuno Duarte, Diane Ryding, Dave Perry, Steve McNally, A. Graham Stuart, Craig Anthony Williams, Guido Pieles
Summary: This study evaluated the parameter accuracy of CardioSecur's 22-lead ECG compared to the standard 12-lead ECG in elite adolescent footballers. The results showed clinically acceptable agreement in most parameters, but unsatisfactory agreement in certain aspects. CardioSecur's 22-lead ECG provides immediate pitch- or track-side analysis for adolescent footballers with consistent results in rhythm, durations, and T-wave determination.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Curtis A. Wadey, Max E. Weston, Dan Mihai Dorobantu, Guido E. Pieles, Graham Stuart, Alan R. Barker, Rod S. Taylor, Craig A. Williams
Summary: This study conducted a systematic review and meta-analysis to investigate the associations between cardiopulmonary exercise testing parameters and major adverse cardiovascular events (MACE) in patients with congenital heart disease. The results showed consistent evidence that improved cardiopulmonary exercise testing measures are associated with a reduced risk of MACE.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Graham Stuart, Lynsey Forsythe
Article
Pediatrics
Gabrielle Norrish, Thomas Rance, Elena Montanes, Ella Field, Elspeth Brown, Vinay Bhole, Graham Stuart, Orhan Uzun, Karen A. McLeod, Maria Ilina, Satish Adwani, Piers Daubeney, Grazia Delle Donne, Katie Linter, Caroline B. Jones, Tara Bharucha, Elena Cervi, Juan Pablo Kaski
Summary: This study describes the clinical characteristics of children with Friedreich's ataxia and hypertrophic cardiomyopathy, revealing a high prevalence of atrial arrhythmias and systolic impairment in childhood, suggesting early progression to end-stage disease. The overall mortality rate is similar to non-syndromic childhood HCM, but sudden cardiac death did not occur in this cohort.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Review
Sport Sciences
Nathan R. Riding, Dan-Mihai Dorobantu, Craig A. Williams, Graham Stuart, Peter Fritsch, Mathew G. Wilson, Elias Mossialos, Guido Pieles
Summary: This article systematically reviews and evaluates the quality of cardiovascular screening policies for athletes in the context of pediatric population. It finds that there is a lack of specific recommendations for pediatric athletes and the overall quality of the policies is moderate.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Curtis A. Wadey, Alan R. Barker, Graham Stuart, Derek L. Tran, Karina Laohachai, Julian Ayer, Rachael Cordina, Craig A. Williams
Summary: The traditional method of ratio-scaling peak V?O2 to body mass is invalid in people with a Fontan circulation. However, scaling to measures of body composition (fat-free mass, lean mass, and appendicular lean mass) and using allometric techniques can produce size-independent expressions of peak V?O2 in this population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)