Article
Pharmacology & Pharmacy
H. K. Ucar, E. Arhan, K. Aydin, T. Hirfanoglu, A. Serdaroglu
Summary: The study aims to evaluate epilepsy classification in children before and after monitoring, comparing the ILAE and SSC systems. The results show that parents can generally describe seizures well, and both systems can be applied in daily practice.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Markus Breu, Chiara Haefele, Petra Trimmel-Schwahofer, Wolfgang M. Schmidt, Franco Laconne, Julia Vodopiutz, Christoph Male, Anastasia Dressler
Summary: The study investigates the effectiveness and safety of the ketogenic diet (KD) in drug-resistant epilepsy in children, based on the 2017 ILAE classification of etiology. Results show that KD is most effective in genetic and unknown etiology, with a decrease in seizure freedom in known etiology over time. Further research with larger numbers of patients in infectious and immune-mediated etiology groups is needed to confirm the results.
Article
Clinical Neurology
Isaac J. Egesa, Charles R. J. C. Newton, Symon M. Kariuki
Summary: The study found that the two ILAE classification schemes are broadly consistent, but the introduction of the combined onset seizure category in ILAE-2017 significantly reduces the proportion of mutually exclusive focal and generalized seizures. The comprehensive classification of etiology categories in ILAE-2017 will facilitate appropriate treatment and improve prognosis.
Article
Medicine, General & Internal
Nahla L. Faizo, Amani A. Alrehaili
Summary: This study aimed to assess the prevalence of epilepsy among neurological patients of different age groups and genders in the Taif region, and identify the most common brain lesion in epilepsy patients in the Taif city using MRI. The study found that epilepsy was generally more common in males than females in the Taif city, and the occurrence of seizures varied across different age groups. White matter lesions were identified as the most common brain lesion among epilepsy patients in the Taif city.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2023)
Article
Computer Science, Artificial Intelligence
Guangyu Jia, Hak-Keung Lam, Kaspar Althoefer
Summary: Recent advances in deep learning have shown promising results in medical diagnosis and signal processing. The proposed variable weight convolutional neural networks (VWCNNs) outperform traditional CNNs in terms of classification accuracy, generalization capability, and robustness. VWCNNs show potential as a useful tool for medical diagnosis, particularly in classifying seizure phases and types.
PATTERN RECOGNITION
(2022)
Review
Behavioral Sciences
Grant Turek, Karen Skjei
Summary: In the field of epilepsy research, the term semiology is crucial for describing the clinical characteristics of seizures for pre-surgical evaluation. Studies focus on the correlation between seizure semiology and activation of specific cortical regions, as well as distinguishing between seizure onset and symptomogenic zones. The 2017 ILAE classification heavily relies on seizure semiology for operational classification of seizure types, with advancements in understanding coming from both scalp EEG studies and recent stereo-electroencephalography discoveries.
EPILEPSY & BEHAVIOR
(2022)
Article
Medicine, General & Internal
Chingiz Nurimanov, Aisha Babi, Karashash Menlibayeva, Yerbol Makhambetov, Assylbek Kaliyev, Elena Zholdybayeva, Serik Akshulakov
Summary: This study evaluated the effect of curative embolization on seizure presentation in brain arteriovenous malformation (AVM) patients. The results showed that embolization had a positive effect on seizure outcomes and a relatively low prevalence of complications. However, inadequate antiepileptic drug treatment received by the patients obscured the results, highlighting the need for further prospective studies on this topic.
Article
Clinical Neurology
Louise Linka, Benedikt Magnus, Lena Habermehl, Panagiota-Eleni Tsalouchidou, Felix Zahnert, Leona Moeeller, Kristina Krause, Susanne Knake, Katja Menzler
Summary: This study evaluated the impact of the new definition of epilepsy on treatment decisions, seizure recurrence rates, and risk factors associated with epilepsy. The results showed that the new definition led to an increase in the use of antiseizure medication, but did not reduce the recurrence rates. The study also confirmed the relationship between seizure recurrence and interictal epileptiform discharges, as well as the protective effect of antiseizure medication, but could not confirm the impact of imaging findings on the new definition of epilepsy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Pediatrics
Ali M. El-Shafie, Wael A. Bahbah, Sameh A. Abd El Naby, Zein A. Omar, Elsayedamr M. Basma, Aya A. A. Hegazy, Heba M. S. El Zefzaf
Summary: This study evaluated the short- and long-term efficacy, safety, and tolerability of classic KD and modified Atkins diet (MAD) in childhood drug-resistant epilepsy (DRE), and investigated the effect of KD on EEG features. Both classic KD and MAD were effective in seizure control and had a positive impact on growth and EEG.
PEDIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Gemma Poke, James Stanley, Ingrid E. Scheffer, Lynette G. Sadleir
Summary: The study aimed to determine the population-based cumulative incidence and prevalence of developmental and epileptic encephalopathies (DEEs) and intellectual disability and epilepsy (ID+E) in children. The findings showed that 1 in 340 children under the age of 16 has epilepsy and developmental impairment, with 1 in 590 having a DEE and 1 in 800 having ID+E.
Article
Clinical Neurology
Sharika Raga, Farida Essajee, Regan Solomons, Ronald Van Toorn, Jo M. Wilmshurst
Summary: This retrospective analysis studied infants with epileptic spasms in South Africa and found that structural causes were most common and failure to recognize preceding developmental delay was common. Hormonal therapy was found to be safe and effective in this setting.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenxi Yu, Corrine E. Smolen, Sophie F. Hill, Miriam H. Meisler
Summary: Somatic mutations of neuronal sodium channels may not contribute to the increased incidence of epilepsy in the elderly population, but they could increase susceptibility to other seizure stimuli.
HUMAN MOLECULAR GENETICS
(2021)
Review
Medicine, General & Internal
Doaa Alqaidy
Summary: This article discusses the naming, classification, and staging of thymomas, which are one of the most common types of mediastinal epithelial tumors. There is controversy over the significance of thymoma histologic classifications, and the challenges that diagnostic surgical pathologists may face in evaluating the histopathology of these tumors and staging them are presented. The clinical characteristics and current management strategy of these distinct tumors are also briefly reviewed.
Article
Integrative & Complementary Medicine
Haiqiong Lv, Xiaoying Zhao, Jian Yu
Summary: Levetiracetam is more effective than sodium valproate in controlling seizures and improving maternal and infant outcomes in women with epilepsy during pregnancy. It can effectively regulate neurological and cognitive functions and reduce serum inflammation factor levels.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Clinical Neurology
Hire Hersi, Jukka T. Saarinen, Jani Raitanen, Jukka Peltola
Summary: This study found that after failing the first ASM, about 60% of patients responded positively to subsequent ASM regimens, supporting the feasibility and applicability of the ILAE concept of defining DRE as failure of two ASMs.
FRONTIERS IN NEUROLOGY
(2022)
Article
Behavioral Sciences
Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
Summary: The study aimed to evaluate the safety and impact of Dexmedetomidine Hydrochloride (DH) administration during pediatric invasive intracranial electroencephalography (IEEG). The results showed that DH administration was not associated with adverse events and did not significantly affect the frequency of seizures captured on the IEEG and the duration of hospitalization.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Sabra Zaraa, H. Steve White, Andy Stergachis, Edward Novotny Jr, Chris Protos, Grant Simic, Jennifer L. Bacci
Summary: This study used design thinking to develop a community pharmacist-led intervention for people living with epilepsy. Four features - pharmacist-patient consultations, care plan development, regular check-ins, and care coordination with other health care providers - were identified as desirable, feasible, and viable for the intervention. The study highlights the importance of involving pharmacists in epilepsy care and provides evidence-based features for such interventions.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Bofei Tan, Qiang Liu, Yameng Qin, Qiuyan Chen, Rong Chen, Yanzi Jin, Mengyun Li, Xiaodan Jia, Xianrui Xu, Qing Zhang
Summary: The purpose of this study was to identify factors associated with insomnia in patients with epilepsy. The results showed that nocturnal seizures and anxiety were independently associated with insomnia in these patients. Patients with epilepsy and insomnia were more likely to experience depression and excessive daytime sleepiness.
EPILEPSY & BEHAVIOR
(2024)
