Article
Clinical Neurology
John M. Bernabei, Nishant Sinha, T. Campbell Arnold, Erin Conrad, Ian Ong, Akash R. Pattnaik, Joel M. Stein, Russell T. Shinohara, Timothy H. Lucas, Dani S. Bassett, Kathryn A. Davis, Brian Litt
Summary: Bernabei et al. constructed an atlas of normative interictal intracranial EEG recordings and found that brain regions generating spikes and seizures have different patterns of activity and connectivity compared to the atlas. Comparing EEG recordings to the atlas can reliably identify abnormal regions and guide invasive treatment for epilepsy.
Article
Clinical Neurology
Peter N. Taylor, Christoforos A. Papasavvas, Thomas W. Owen, Gabrielle M. Schroeder, Frances E. Hutchings, Fahmida A. Chowdhury, Beate Diehl, John S. Duncan, Andrew W. McEvoy, Anna Miserocchi, Jane de Tisi, Sjoerd B. Vos, Matthew C. Walker, Yujiang Wang
Summary: This study investigates the detection of interictal abnormalities in intracranial EEG by constructing a normative map of brain dynamics and quantitatively accounting for the range of healthy brain dynamics. The study finds that regions spared by surgery are more abnormal than resected regions, which can differentiate patient outcomes.
Article
Clinical Neurology
Yujiang Wang, Gabrielle M. Schroeder, Jonathan J. Horsley, Mariella Panagiotopoulou, Fahmida A. Chowdhury, Beate Diehl, John S. Duncan, Andrew W. McEvoy, Anna Miserocchi, Jane de Tisi, Peter N. Taylor
Summary: Comparing patient data to a normative map has shown promise in identifying abnormalities on interictal intracranial electroencephalogram (iEEG) for localization of epileptogenic tissue and outcome prediction. However, the temporal stability of these findings has not been established.
Review
Neurosciences
Stanislas Lagarde, Christian-G Benar, Fabrice Wendling, Fabrice Bartolomei
Summary: This article reviews the concept of the epileptogenic network, explains the basic notions of functional connectivity, and reports the current body of published data using intracranial EEG. The data show that there are differential changes in functional connectivity between epileptic and non-epileptic areas even at temporal distance from seizures. These findings may help locate epileptic areas and predict surgical outcomes.
BRAIN CONNECTIVITY
(2022)
Article
Multidisciplinary Sciences
Sakar Rijal, Ludovica Corona, M. Scott Perry, Eleonora Tamilia, Joseph R. Madsen, Scellig S. D. Stone, Jeffrey Bolton, Phillip L. Pearl, Christos Papadelis
Summary: Normal brain functioning relies on complex interactions among different regions forming networks. This study investigates the use of functional connectivity in quantifying epileptogenicity and predicting surgical outcome in children with drug resistant epilepsy (DRE). The findings suggest that functional connectivity can distinguish epileptogenic states and predict outcome in patients with DRE.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Zhaohui Li, Hao Zhang, Shipeng Niu, Yanyu Xing
Summary: A new measure called connectivity high-frequency epileptogenicity index (cHFEI) is proposed to accurately quantify the epileptogenic zone (EZ) in epilepsy surgery. The cHFEI method combines directed connectivity and high-frequency oscillations (HFOs) to distinguish brain regions involved in seizure onset from the propagation network. It outperforms existing detection methods and shows potential for epilepsy therapy.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Article
Medicine, General & Internal
Jonathan J. Horsley, Rhys H. Thomas, FahmidaA. Chowdhury, Beate Diehl, Andrew W. Mcevoy, Anna Miserocchi, Jane de Tisi, Sjoerd B. Vos, Matthew C. Walker, Gavin P. Winston, John S. Duncan, Yujiang Wang, Peter N. Taylor
Summary: Our study investigated the use of structural connectivity abnormalities inferred from dMRI in combination with functional iEEG abnormalities to improve surgical outcomes in patients with epilepsy. Results showed that resection of maximal connectivity and iEEG abnormalities was significantly associated with seizure freedom, and the use of both modalities together correctly identified the surgical outcome for a majority of patients.
Article
Cell Biology
Huifang E. Wang, Marmaduke Woodman, Paul Triebkorn, Jean-Didier Lemarechal, Jayant Jha, Borana Dollomaja, Anirudh Nihalani Vattikonda, Viktor Sip, Samuel Medina Villalon, Meysam Hashemi, Maxime Guye, Julia Makhalova, Fabrice Bartolomei, Viktor Jirsa
Summary: We propose a virtual epileptic patient (VEP) workflow that uses personalized brain models and machine learning methods to estimate epileptogenic zone networks (EZNs) and aid surgical strategies. By sampling and optimizing personalized model parameters using functional stereoelectroencephalography recordings, the VEP accurately determines a patient's EZN. Additionally, the VEP can predict surgical outcomes using virtual surgeries.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Biomedical
Erin C. Conrad, John M. Bernabei, Nishant Sinha, Nina J. Ghosn, Joel M. Stein, Russell T. Shinohara, Brian Litt
Summary: This study investigates the impact of epilepsy on intracranial EEG functional connectivity and its ability to localize the seizure onset zone (SOZ). The results show that functional connectivity is reduced in the SOZ region and interictal data can predict the localization and laterality of SOZ electrodes. However, a predictive model based solely on functional connectivity without interictal spike rates did not significantly outperform a spatial null model.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Clinical Neurology
Huijuan Ma, Zeyu Wang, Chunsheng Li, Jia Chen, Yuping Wang
Summary: In patients with frontal epilepsy, weak and paroxysmal phase-amplitude coupling was observed before and during seizures, with stronger coupling channels predominantly located in the seizure-onset zone and resection region. During seizures, coupling was intense but gradually deviated from the seizure-onset zone. Coupling strength characteristics before and during seizures can accurately locate the epileptogenic zone, with changing preferred coupling phases associated with different stages of seizure activity.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Vasileios Kokkinos, Helweh Hussein, Birgit Frauscher, Mirela Simon, Alexandra Urban, Alan Bush, Anto I. Bagic, R. Mark Richardson
Summary: The study evaluated whether hippocampal spindles and barques are markers of epileptogenicity in epilepsy patients. The results show that both spindles and barques are normal entities in the hippocampal intracranial electroencephalogram and do not indicate epileptogenic properties. Understanding this is crucial for the correct interpretation of epilepsy surgery evaluations and the selection of appropriate surgical treatments.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Yurika Numata-Uematsu, Mitsugu Uematsu, Rie Sakuraba, Masaki Iwasaki, Shinichiro Osawa, Kazutaka Jin, Nobukazu Nakasato, Shigeo Kure
Summary: The study found that determining the onset area of interictal spike-related ripples could facilitate estimation of the epileptogenic zone, leading to better surgical outcomes. This simple method utilizing interictal ECoG may aid in preoperative evaluation and improve epilepsy surgery outcomes.
FRONTIERS IN NEUROLOGY
(2021)
Review
Neurosciences
Xiaonan Li, Herui Zhang, Huanling Lai, Jiaoyang Wang, Wei Wang, Xiaofeng Yang
Summary: Epilepsy is a network disease caused by aberrant neocortical large-scale connectivity. High-frequency oscillations have been identified as a promising biomarker for assessing the severity and susceptibility of epilepsy, but their existence as a network and their relationship with the epileptogenic network are still debated.
CURRENT NEUROPHARMACOLOGY
(2022)
Review
Clinical Neurology
Elma Paredes-Aragon, Norah A. AlKhaldi, Daniel Ballesteros-Herrera, Seyed M. Mirsattari
Summary: Drug-resistant epilepsy affects nearly 30% of patients. Surgical resection of the epileptogenic zone is the most effective treatment for achieving seizure freedom. Stereo-encephalography is a growing field that has made significant advances in the study and treatment of temporal lobe epilepsy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Lucas E. Sainburg, Andrew P. Janson, Graham W. Johnson, Jasmine W. Jiang, Baxter P. Rogers, Catie Chang, Dario J. Englot, Victoria L. Morgan
Summary: Epilepsy surgery involves the resection of the epileptic focus and is used to treat drug-resistant focal epilepsy. However, focal brain lesions can have effects in distant brain regions. This study investigates the effects of focal disconnections in the brain network on function in distant brain regions using epilepsy surgery.
Article
Clinical Neurology
Leslie E. Grayson, Jurriaan M. Peters, Tarrant McPherson, Darcy A. Krueger, Mustafa Sahin, Joyce Y. Wu, Hope A. Northrup, Brenda Porter, Gary R. Cutter, Sarah E. O'Kelley, Jessica Krefting, Scellig S. Stone, Joseph R. Madsen, Aria Fallah, Jeffrey P. Blount, Howard L. Weiner, E. Martina Bebin
PEDIATRIC NEUROLOGY
(2020)
Article
Clinical Neurology
Nadine Madani, Jennifer A. O'Malley, Brenda E. Porter, Fiona M. Baumer
JOURNAL OF CHILD NEUROLOGY
(2020)
Article
Clinical Neurology
Yasunori Nagahama, Thomas M. Zervos, Kristina K. Murata, Lynette Holman, Torin Karsonovich, Jonathon J. Parker, Jia-Shu Chen, H. Westley Phillips, Marytery Fajardo, Hiroki Nariai, Shaun A. Hussain, Brenda E. Porter, Gerald A. Grant, John Ragheb, Shelly Wang, Brent R. O'Neill, Allyson L. Alexander, Robert J. Bollo, Aria Fallah
Summary: This study found that RNS could effectively reduce seizures and was well tolerated in a group of pediatric epilepsy patients. Age did not significantly affect the efficacy and complications of RNS treatment.
Editorial Material
Clinical Neurology
Juliet K. Knowles, Brenda E. Porter
Summary: This viewpoint discusses ways to support MD-PhD graduates in advancing their careers and decreasing the attrition rate among these physician-scientists.
Article
Pharmacology & Pharmacy
Risa Sato, Kotaro Ohmori, Mina Umetsu, Masaki Takao, Mitsutoshi Tano, Gerald Grant, Brenda Porter, Anthony Bet, Tetsuya Terasaki, Yasuo Uchida
Summary: The study quantitatively elucidated the levels of protein expression of anti-epileptic-drug (AED) transporters, metabolizing enzymes, and tight junction molecules at the blood-brain barrier in epilepsy patients, revealing significant changes in the expression levels of various genes in epileptic patients. These findings provide a better understanding of the therapeutic effect of AEDs and molecular mechanisms of AED resistance in epileptic patients.
Article
Biochemistry & Molecular Biology
Tanya L. Brown, Kimberly L. Nye, Brenda E. Porter
Summary: This study characterized the non-neurologic health of patients with autosomal recessive SLC13A5 Citrate Transporter Disorder, finding that in addition to neurologic impairment, there were multiple gastrointestinal and respiratory complaints among the patients, with fewer abnormalities in other organ systems. Early growth parameters were mostly normal, but some adolescent patients showed slower growth. Further data are needed to clarify the impact of adolescence on growth and the development of non-neurologic disorders in adult patients.
Article
Clinical Neurology
Dulcie Lai, Meethila Gade, Edward Yang, Hyun Yong Koh, Jinfeng Lu, Nicole M. Walley, Anne F. Buckley, Tristan T. Sands, Cigdem Akman, Mohamad A. Mikati, Guy M. McKhann, James E. Goldman, Peter Canoll, Allyson L. Alexander, Kristen L. Park, Gretchen K. Von Allmen, Olga Rodziyevska, Meenakshi B. Bhattacharjee, Hart G. W. Lidov, Hannes Vogel, Gerald A. Grant, Brenda E. Porter, Annapurna H. Poduri, Peter B. Crino, Erin L. Heinzen
Summary: Somatic variants in genes involved in brain development have been found to cause malformations associated with epilepsy. These variants have been identified in the PI3K-AKT-mTOR signaling pathway and other genes in patients with hemimegalencephaly and focal cortical dysplasia.
Article
Clinical Neurology
Jonathon J. Parker, Yi Zhang, Parastou Fatemi, Casey H. Halpern, Brenda E. Porter, Gerald A. Grant
Summary: This study analyzed the timing and durability of antiseizure drug reduction after pediatric epilepsy surgery and its impact on healthcare utilization, indicating that achieving an ASD-free period was associated with fewer hospital readmissions within the first year after surgery.
Article
Clinical Neurology
Maaike Nijman, Edward Yang, Camilo Jaimes, Anna K. Prohl, Mustafa Sahin, Darcy A. Krueger, Joyce Y. Wu, Hope Northrup, Scellig S. D. Stone, Joseph R. Madsen, Aria Fallah, Jeffrey P. Blount, Howard L. Weiner, Leslie Grayson, E. Martina Bebin, Brenda E. Porter, Simon K. Warfield, Sanjay P. Prabhu, Jurriaan M. Peters
Summary: The utility of structural MRI features for identifying epileptogenic lesions in young children with TSC is limited, but improves when combined with EEG data.
JOURNAL OF NEUROIMAGING
(2022)
Article
Clinical Neurology
Beatrice S. Goad, Christopher Lee-Messer, Zihuai He, Brenda E. Porter, Fiona M. Baumer
Summary: This study investigated the impact of interictal spikes on brain connectivity in patients with Self-Limited Epilepsy with Centrotemporal Spikes (SeLECTS). The results showed that SeLECTS patients had increased connectivity during sleep, with further elevation during spike and perispike periods. The study is significant in determining whether increased connectivity affects cognition or seizure susceptibility in SeLECTS and more severe epilepsies.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Carmen Barba, Ingmar Blumcke, Melodie R. Winawer, Till Hartlieb, Hoon-Chul Kang, Laura Grisotto, Mathilde Chipaux, Christian G. Bien, Barbora Hermanovska, Brenda E. Porter, Hart G. W. Lidov, Valentina Cetica, Friedrich G. Woermann, Javier A. Lopez-Rivera, Peter D. Canoll, Irina Mader, Ludovico D'Incerti, Sara Baldassari, Edward Yang, Ahmed Gaballa, Hannes Vogel, Barbora Straka, Letizia Macconi, Tilman Polster, Gerald A. Grant, Lenka Krskova, Hui Jin Shin, Ara Ko, Peter B. Crino, Pavel Krsek, Jeong Ho Lee, Dennis Lal, Stephanie Baulac, Annapurna Poduri, Renzo Guerrini
Summary: This study describes the clinical, genetic, neuroimaging, EEG, and histopathologic findings in patients with refractory epilepsy and brain somatic SLC35A2 gene variants. It also assesses possible predictors of postoperative seizure and cognitive outcomes.
Review
Clinical Neurology
Qian-Zhou JoJo Yang, Brenda E. Porter, Erika Axeen
Summary: This study investigated GNAO1-related neurodevelopmental disorder through an online survey and literature review. The survey results showed a high correlation between GNAO1 variants and epilepsy, with varying efficacy of anti-seizure medications. The literature review revealed an epilepsy prevalence of approximately 53% in GNAO1-related cases, with 36% having developmental and epileptic encephalopathy.
EPILEPSY & BEHAVIOR REPORTS
(2023)
Article
Genetics & Heredity
Emily M. Spelbrink, Tanya L. Brown, Elise Brimble, Kirsten A. Blanco, Kimberly L. Nye, Brenda E. Porter
Summary: SLC13A5 citrate transporter disorder is a rare genetic disease that affects the neurologic and clinical laboratory phenotype. Medical records of 15 patients were analyzed to characterize the clinical features and laboratory data.
FRONTIERS IN GENETICS
(2023)
Article
Behavioral Sciences
Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
Summary: The study aimed to evaluate the safety and impact of Dexmedetomidine Hydrochloride (DH) administration during pediatric invasive intracranial electroencephalography (IEEG). The results showed that DH administration was not associated with adverse events and did not significantly affect the frequency of seizures captured on the IEEG and the duration of hospitalization.
EPILEPSY & BEHAVIOR
(2024)
Article
Clinical Neurology
Carmen Barba, Ingmar Blumcke, Melodie R. Winawer, Till Hartlieb, Hoon-Chul Kang, Laura Grisotto, Mathilde Chipaux, Christian G. Bien, Barbora Hermanovska, Brenda E. Porter, Hart G. W. Lidov, Valentina Cetica, Friedrich G. Woermann, Javier A. Lopez-Rivera, Peter D. Canoll, Irina Mader, Ludovico D'Incerti, Sara Baldassari, Edward Yang, Ahmed Gaballa, Hannes Vogel, Barbora Straka, Letizia Macconi, Tilman Polster, Gerald A. Grant, Lenka Krskova, Hui Jin Shin, Ara Ko, Peter B. Crino, Pavel Krsek, Jeong Ho Lee, Dennis Lal, Stephanie Baulac, Annapurna Poduri, Renzo Guerrini
Summary: Brain somatic SLC35A2 gene variants are associated with two main clinical phenotypes, early epileptic encephalopathy (EE) and drug-resistant focal epilepsy (DR-FE). Most patients showed unchanged cognitive performances after surgery, with better postoperative seizure control outcomes seen in cases where postoperative EEG was normal or improved.