Article
Clinical Neurology
Peter N. Taylor, Christoforos A. Papasavvas, Thomas W. Owen, Gabrielle M. Schroeder, Frances E. Hutchings, Fahmida A. Chowdhury, Beate Diehl, John S. Duncan, Andrew W. McEvoy, Anna Miserocchi, Jane de Tisi, Sjoerd B. Vos, Matthew C. Walker, Yujiang Wang
Summary: This study investigates the detection of interictal abnormalities in intracranial EEG by constructing a normative map of brain dynamics and quantitatively accounting for the range of healthy brain dynamics. The study finds that regions spared by surgery are more abnormal than resected regions, which can differentiate patient outcomes.
Article
Computer Science, Artificial Intelligence
Chenchen Cheng, Yuanfeng Zhou, Bo You, Yan Liu, Gao Fei, Liling Yang, Yakang Dai
Summary: This study developed a novel multiview feature fusion representation (MVFFR) method to detect EEG signals with/without interictal epileptiform spikes (IES). The experimental results showed that MVFFR achieved the optimal detection performance compared with other feature ranking methods, and the MVFFR-related methods were complementary and indispensable. Additionally, MVFFR maintained excellent generalization capacity in an independent test.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2022)
Article
Clinical Neurology
Nino Epitashvili, Victoria San Antonio-Arce, Armin Brandt, Andreas Schulze-Bonhage
Summary: By analyzing 33 patients, it was found that scalp small sharp spikes (SSS) have cortical correlates with intracranial discharges, and intrahippocampal spikes or polyspikes occur concurrently with SSS. Additionally, in 45% of cases, intracranial spikes accompanying SSS were located within the seizure onset zone.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Rui Sun, Wenbo Zhang, Anto Bagic, Bin He
Summary: Electromagnetic source imaging (ESI) offers unique capability of imaging brain dynamics and aiding the clinical management of brain disorders. By combining generative models and deep learning, more accurate and realistic source modeling can be achieved, providing an alternative approach to ESI beyond equivalent physical source models.
Article
Clinical Neurology
John M. Bernabei, Nishant Sinha, T. Campbell Arnold, Erin Conrad, Ian Ong, Akash R. Pattnaik, Joel M. Stein, Russell T. Shinohara, Timothy H. Lucas, Dani S. Bassett, Kathryn A. Davis, Brian Litt
Summary: Bernabei et al. constructed an atlas of normative interictal intracranial EEG recordings and found that brain regions generating spikes and seizures have different patterns of activity and connectivity compared to the atlas. Comparing EEG recordings to the atlas can reliably identify abnormal regions and guide invasive treatment for epilepsy.
Article
Clinical Neurology
Barbora Sklenarova, Eva Zatloukalova, Jan Cimbalnik, Petr Klimes, Irena Dolezalova, Martin Pail, Jitka Kocvarova, Michal Hendrych, Marketa Hermanova, Jean Gotman, Francois Dubeau, Jeffery Hall, Raluca Pana, Birgit Frauscher, Milan Brazdil
Summary: This study investigated the differences in interictal spikes, high-frequency oscillations (HFOs), and functional connectivity among different epileptogenic pathologies. The results showed significant variations in these measures, with the highest values observed in hippocampal sclerosis and nonspecific gliosis/normal tissue. A predictive model based on these measures achieved high accuracy in determining the underlying brain lesion type before surgery.
Article
Clinical Neurology
Tim A. Guth, Lukas Kunz, Armin Brandt, Matthias Duempelmann, Kerstin A. Klotz, Peter C. Reinacher, Andreas Schulze-Bonhage, Julia Jacobs, Jan Schoenberger
Summary: The study shows that HFO-IEDs and non-HFO-IEDs have different single-unit correlates. Single-unit firing rates are higher in HFO-IEDs compared to non-HFO-IEDs, with a pronounced pre-peak increase in firing in HFO-IEDs. Moreover, most cells exhibit higher rates during HFO-IEDs, suggesting a distinct subset of neurons prefer this IED subtype.
Article
Clinical Neurology
Yujiang Wang, Gabrielle M. Schroeder, Jonathan J. Horsley, Mariella Panagiotopoulou, Fahmida A. Chowdhury, Beate Diehl, John S. Duncan, Andrew W. McEvoy, Anna Miserocchi, Jane de Tisi, Peter N. Taylor
Summary: Comparing patient data to a normative map has shown promise in identifying abnormalities on interictal intracranial electroencephalogram (iEEG) for localization of epileptogenic tissue and outcome prediction. However, the temporal stability of these findings has not been established.
Review
Clinical Neurology
Isabelle Lambert, Eve Tramoni-Negre, Stanislas Lagarde, Francesca Pizzo, Agnes Trebuchon-Da Fonseca, Fabrice Bartolomei, Olivier Felician
Summary: Accelerated long-term forgetting (ALF) is a specific form of amnesia commonly seen in patients with focal epilepsy, especially temporal lobe epilepsy. Researchers have proposed a pathophysiological model of ALF that integrates the role of interictal spikes to explain the mechanisms of ALF occurring at different time scales.
Article
Multidisciplinary Sciences
Zhengxiang Cai, Abbas Sohrabpour, Haiteng Jiang, Shuai Ye, Boney Joseph, Benjamin H. Brinkmann, Gregory A. Worrell, Bin He
Summary: High-frequency oscillations (HFOs) serve as a promising biomarker for localizing epileptogenic brain and guiding successful neurosurgery. The consistent concurrence of HFOs with epileptiform spikes (pHFOs) offers a tractable means to automatically identify pathological HFOs, enhancing presurgical diagnosis and postsurgical evaluation. This method shows significant improvements in localization of epileptogenic tissue and surgical outcomes, particularly in patients with multitype spikes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
I. Rigoni, J. Rue Queralt, K. Glomb, M. G. Preti, N. Roehri, S. Tourbier, L. Spinelli, M. Seeck, D. Van De Ville, P. Hagmann, S. Vulliemoz
Summary: This study investigated the structure-function coupling during interictal epileptic discharges (IEDs) in temporal lobe epilepsy (TLE) using graph signal processing. The results showed that integrative mechanisms prevail during the IED at the whole-brain level, with increased reliance on long-range couplings in the mesial temporal regions. This study is significant for understanding the structure-function relationship in brain disorders.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Thea Giacomini, Gianvittorio Luria, Vanessa D'Amario, Carolina Croci, Matteo Cataldi, Maria Piai, Giulia Nobile, Oliviero Bruni, Alessandro Consales, Maria Margherita Mancardi, Lino Nobili
Summary: The study shows that phasic REM sleep (PREM) has a greater suppressive effect on epileptic activity compared to tonic REM sleep (TREM). Even in the extreme condition of Electrical Status Epilepticus during Sleep (ESES), PREM still significantly reduces epileptic activity.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Robert J. Quon, Stephen Meisenhelter, Edward J. Camp, Markus E. Testorf, Yinchen Song, Qingyuan Song, George W. Culler, Payam Moein, Barbara C. Jobst
Summary: The study utilized an automated method combining template-matching algorithm and CNN to successfully detect intracranial IEDs with high F1 score and AUC. On the external test set, it was able to identify 100% of high-amplitude IED complexes, 96.23% of high amplitude isolated IEDs, and 66.15% of IEDs with atypical morphology.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Liliana Camarillo-Rodriguez, Iwin Leenen, Zachary Waldman, Mijail Serruya, Paul A. Wanda, Nora A. Herweg, Michael J. Kahana, Daniel Rubinstein, Iren Orosz, Bradley Lega, Irina Podkorytova, Robert E. Gross, Gregory Worrell, Kathryn A. Davis, Barbara C. Jobst, Sameer A. Sheth, Shennan A. Weiss, Michael R. Sperling
Summary: The study found that IS in the medial and lateral temporal cortex contribute to transient memory decline during verbal episodic memory.
Article
Mathematical & Computational Biology
Giulia Varotto, Gianluca Susi, Laura Tassi, Francesca Gozzo, Silvana Franceschetti, Ferruccio Panzica
Summary: This study compared the performances of different resampling procedures for imbalanced data in patients with focal epilepsies using SEEG recordings. Both oversampling and undersampling approaches showed improved performances compared to the original dataset. Among the different classifiers, oversampling was found to be more sensitive to the type of classification method used, while Random Undersampling exhibited the best performance despite being a simple method.
FRONTIERS IN NEUROINFORMATICS
(2021)
Article
Psychology, Biological
Oscar Woolnough, Cristian Donos, Patrick S. Rollo, Kiefer J. Forseth, Yair Lakretz, Nathan E. Crone, Simon Fischer-Baum, Stanislas Dehaene, Nitin Tandon
Summary: Through direct intra-cranial recordings, researchers identified the mid-fusiform cortex as the first brain region sensitive to lexicality, driven by natural language statistics; information regarding lexicality and word frequency propagates backward from this region to visual word form regions and earlier visual cortex, impacting reading efficiency.
NATURE HUMAN BEHAVIOUR
(2021)
Article
Neurosciences
Giridhar P. Kalamangalam, Mircea Chelaru
Summary: The study investigates the relationship between brain dynamics and brain networks, revealing a rostrocaudal topography in the EEG presentation over the lateral frontal lobe, consistent with the structural and functional parcellation of the human frontal lobe.
BRAIN CONNECTIVITY
(2021)
Article
Clinical Neurology
Antonio Dono, Azim Z. Pothiawala, Cole T. Lewis, Meenakshi B. Bhattacharjee, Leomar Y. Ballester, Nitin Tandon
Summary: The study evaluated molecular alterations in Meningioangiomatosis (MA) and found that some MAs may arise from meningiomas rather than transform into meningiomas. Although known oncogenic drivers were not detected in the 3 cases of pure MA, MA-meningiomas exhibit a neoplastic nature.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Oscar Woolnough, Cihan M. Kadipasaoglu, Christopher R. Conner, Kiefer J. Forseth, Patrick S. Rollo, Matthew J. Rollo, Vatche G. Baboyan, Nitin Tandon
Summary: This study utilized high spatiotemporal resolution direct intracranial recordings to investigate the network dynamics involved in visual scene recognition. A dataset containing recordings from a large cohort of humans identifying images of famous landmarks was provided, along with behavioral metrics and electrode localization. This rich dataset allows for further exploration of the spatiotemporal progression of neural processes involved in visual processing, scene recognition, and cued memory recall.
Article
Neurosciences
Elliot Murphy, Oscar Woolnough, Patrick S. Rollo, Zachary J. Roccaforte, Katrien Segaert, Peter Hagoort, Nitin Tandon
Summary: The ability to understand phrases is an important function of the brain. This study investigated the neural processes involved in transitioning from single-word processing to minimal compositional schemes. The findings suggest that the posterior superior temporal sulcus (pSTS) is a specialized region in the brain that encodes both lower and higher level linguistic features, forming the basis for hierarchically organized linguistic structures.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Meredith J. McCarty, Oscar Woolnough, John C. Mosher, John Seymour, Nitin Tandon
Summary: Intracranial electroencephalographic (icEEG) recordings provide valuable insights into neural dynamics in humans. The study quantified the listening zone of icEEG recordings and explored the influence of array design, spectral bands, and referencing schema on local field potential recordings and source localization.
Article
Neurosciences
Oscar Woolnough, Cristian Donos, Aidan Curtis, Patrick S. Rollo, Zachary J. Roccaforte, Stanislas Dehaene, Simon Fischer-Baum, Nitin Tandon
Summary: Reading words aloud is a fundamental aspect of literacy. The study found that lexicality is encoded earliest in the mid-fusiform cortex and precentral sulcus, while word frequency is first represented in the mid-fusiform cortex and later in the inferior frontal gyrus and inferior parietal sulcus. Orthographic neighborhood sensitivity resides solely in the inferior parietal sulcus.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Amada M. Abrego, Wasif Khan, Christopher E. Wright, M. Rabiul Islam, Mohammad H. Ghajar, Xiaokang Bai, Nitin Tandon, John P. Seymour
Summary: Researchers have developed a novel device, called the directional and scalable (DISC) array, which combines a stereo-electroencephalographic electrode with radially distributed microelectrodes to record local field potentials (LFPs) with different resolutions simultaneously. The DISC array demonstrated improved signal-to-noise ratio, directional sensitivity, and decoding accuracy in rat barrel cortex recordings during whisker stimulation. The results suggest that the directional sensitivity of LFPs can significantly enhance brain-computer interfaces and various diagnostic procedures.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Clinical Neurology
Cihan M. Kadipasaoglu, Cale Morse, Kevin Pham, Cristian Donos, Nitin Tandon
Summary: The SAMCOR approach is a novel method for co-registration of CT and MR brain imaging that addresses the inherent differences between the modalities and overcomes registration failures.
INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT
(2022)
Article
Clinical Neurology
Kathryn M. M. Snyder, Kiefer J. J. Forseth, Cristian Donos, Patrick S. S. Rollo, Simon Fischer-Baum, Joshua Breier, Nitin Tandon
Summary: Researchers found that surgical resections in the ventral temporal cortex were associated with a decline in naming ability, highlighting the important role of this region in postoperative language deficits.
Article
Oncology
Philipp Karschnia, Antonio Dono, Jacob S. Young, Stephanie T. Juenger, Nico Teske, Levin Haeni, Tommaso Sciortino, Christine Y. Mau, Francesco Bruno, Luis Nunez, Ramin A. Morshed, Alexander F. Haddad, Michael Weller, Martin van den Bent, Juergen Beck, Shawn Hervey-Jumper, Annette M. Molinaro, Nitin Tandon, Roberta Ruda, Michael A. Vogelbaum, Lorenzo Bello, Oliver Schnell, Stefan J. Grau, Susan M. Chang, Mitchel S. Berger, Yoshua Esquenazi, Joerg-Christian Tonn
Summary: This study retrospectively analyzed 681 patients with first recurrence of IDH wild-type glioblastomas. It found that re-resection could prolong the survival time of patients, and residual contrast-enhancing tumor of 1 cm³ or less had longer survival than non-surgical management. Complete resection according to the RANO resect classification had a better prognosis. Patients without postoperative deficits who received (radio-)chemotherapy had enhanced survival associations with smaller residual contrast-enhancing tumors. However, resection of non-contrast-enhancing tumor did not prolong survival.
Article
Multidisciplinary Sciences
Oscar Woolnough, Cristian Donos, Elliot Murphy, Patrick S. Rollo, Zachary J. Roccaforte, Stanislas Dehaene, Nitin Tandon Abf
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Clinical Neurology
Yash Shashank Vakilna, Ganne Chaitanya, Muhammad Ubaid Hafeez, Adeel Ilyas, Manojkumar Saranathan, Jay Gavvala, Nitin Tandon, Sandipan Pati
Summary: Deep brain stimulation (DBS) is a promising treatment for drug-refractory epilepsies (DRE) when targeting the anterior nuclei of thalamus (ANT). In addition, targeting other thalamic nuclei, such as the pulvinar, shows therapeutic promise. Our case study demonstrates the application of ambulatory seizure monitoring using spectral fingerprinting recorded through Medtronic Percept DBS implanted bilaterally in the medial pulvinar thalami. This technology provides unprecedented opportunities for real-time monitoring of seizure burden and thalamocortical network modulation for effective seizure reduction in patients with bilateral mesial temporal and temporal plus epilepsies that are not suitable for resection.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Oncology
Philipp Karschnia, Jorg Dietrich, Francesco Bruno, Antonio Dono, Stephanie T. Juenger, Nico Teske, Jacob S. Young, Tommaso Sciortino, Levin Haeni, Martin van den Bent, Michael Weller, Michael A. Vogelbaum, Ramin A. Morshed, Alexander F. Haddad, Annette M. Molinaro, Nitin Tandon, Juergen Beck, Oliver Schnell, Lorenzo Bello, Shawn Hervey-Jumper, Niklas Thon, Stefan J. Grau, Yoshua Esquenazi, Roberta Ruda, Susan M. Chang, Mitchel S. Berger, Daniel P. Cahill, Joerg-Christian Tonn
Summary: The absence of contrast enhancement in glioblastomas characterizes a less aggressive clinical phenotype, with smaller postoperative tumor volumes associated with more favorable outcomes. Maximal resection of non-CE tumors has prognostic implications and leads to a better outcome compared to lesion biopsy. Patients with non-CE glioblastoma have a more favorable clinical profile and superior outcome when compared to those with CE glioblastoma.
Article
Multidisciplinary Sciences
Arun Parajuli, Diego Gutnisky, Nitin Tandon, Valentin Dragoi
Summary: The state of cortical activity can have both facilitatory and suppressive effects on perceptual performance, depending on the type of task. Contrary to previous beliefs, this study shows that synchronized activity can enhance performance in a detection task but impair it in a discrimination task. These findings suggest that the brain adapts to utilize endogenous fluctuations in neural populations to selectively enhance different sensory processing modes during perception.
NATURE COMMUNICATIONS
(2023)