Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus

Safety and tolerability of adjunctive brivaracetam as intravenous infusion or bolus in patients with epilepsy

(2016) Pavel Klein et al.   EPILEPSIA

Time to onset of sustained ≥50% responder status in patients with focal (partial-onset) seizures in three phase III studies of adjunctive brivaracetam treatment

(2016) Pavel Klein et al.   EPILEPSIA

Evidence for a differential interaction of brivaracetam and levetiracetam with the synaptic vesicle 2A protein

(2016) Martyn D. Wood et al.   EPILEPSIA

Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment

(2016) Henrik Klitgaard et al.   EPILEPSIA

Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society

(2016) Tracy Glauser et al.   Epilepsy Currents

Status Epilepticus: Epidemiology and Public Health Needs

(2016) Sebastián Sánchez et al.   Journal of Clinical Medicine

Pharmacotherapy for Status Epilepticus

(2015) Eugen Trinka et al.   DRUGS

A randomized, double-blind, placebo-controlled, multicenter, parallel-group study to evaluate the efficacy and safety of adjunctive brivaracetam in adult patients with uncontrolled partial-onset seizures

(2015) Pavel Klein et al.   EPILEPSIA

Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action

(2015) Jean-Marie Nicolas et al.   EPILEPSIA

Brivaracetam Single and Multiple Rising Oral Dose Study in Healthy Japanese Participants: Influence of CYP2C19 Genotype

(2014) Armel Stockis et al.   Drug Metabolism and Pharmacokinetics

Brivaracetam as adjunctive treatment for uncontrolled partial epilepsy in adults: A phase III randomized, double-blind, placebo-controlled trial

(2013) Victor Biton et al.   EPILEPSIA

Adjunctive brivaracetam in adults with uncontrolled focal epilepsy: Results from a double-blind, randomized, placebo-controlled trial

(2013) Philippe Ryvlin et al.   EPILEPSIA

Guidelines for the Evaluation and Management of Status Epilepticus

(2012) Gretchen M. Brophy et al.   Neurocritical Care

Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus

(2012) Robert Silbergleit et al.   NEW ENGLAND JOURNAL OF MEDICINE

The acute and chronic effects of the novel anticonvulsant lacosamide in an experimental model of status epilepticus

(2011) Claude G. Wasterlain et al.   EPILEPSY RESEARCH

Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: Relationship to anti-convulsant properties

(2011) Michel Gillard et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A

(2008) A Matagne et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL