Microcystin-LR disrupts insulin signaling by hyperphosphorylating insulin receptor substrate 1 and glycogen synthase

Microcystin-LR promotes cell proliferation in the mice liver by activating Akt and p38/ERK/JNK cascades

(2016) Jinghui Liu et al.   CHEMOSPHERE

Microcystin-LR promotes proliferation by activating Akt/S6K1 pathway and disordering apoptosis and cell cycle associated proteins phosphorylation in HL7702 cells

(2016) Jinghui Liu et al.   TOXICOLOGY LETTERS

PP2A inhibition results in hepatic insulin resistance despite Akt2 activation

(2016) Thomas Galbo et al.   Aging-US

Microcystin-LR induced thyroid dysfunction and metabolic disorders in mice

(2015) Yanyan Zhao et al.   TOXICOLOGY

MCLR-induced PP2A inhibition and subsequent Rac1 inactivation and hyperphosphorylation of cytoskeleton-associated proteins are involved in cytoskeleton rearrangement in SMMC-7721 human liver cancer cell line

(2014) Hao Wang et al.   CHEMOSPHERE

Selectivity and Potency of Microcystin Congeners against OATP1B1 and OATP1B3 Expressing Cancer Cells

(2014) Timo H. J. Niedermeyer et al.   PLoS One

Glucose-6-Phosphate-Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis

(2013) A. von Wilamowitz-Moellendorff et al.   DIABETES

Microcystin-LR-Caused ROS generation involved in p38 activation and tau hyperphosphorylation in neuroendocrine (PC12) cells

(2013) Guanmin Meng et al.   ENVIRONMENTAL TOXICOLOGY

Deficiency of a Glycogen Synthase-associated Protein, Epm2aip1, Causes Decreased Glycogen Synthesis and Hepatic Insulin Resistance

(2013) Julie Turnbull et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Effects of microcystin-containing cyanobacterial extract on hematological and biochemical parameters of common carp (Cyprinus carpio L.)

(2012) Anna Sieroslawska et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

Microcystin-LR Induces Ceramide to Regulate PP2A and Destabilize Cytoskeleton in HEK293 Cells

(2012) Tan Li et al.   TOXICOLOGICAL SCIENCES

Fasting-Induced Protein Phosphatase 1 Regulatory Subunit Contributes to Postprandial Blood Glucose Homeostasis via Regulation of Hepatic Glycogenesis

(2011) X. Luo et al.   DIABETES

Microcystin-LR induces cytoskeleton system reorganization through hyperphosphorylation of tau and HSP27 via PP2A inhibition and subsequent activation of the p38 MAPK signaling pathway in neuroendocrine (PC12) cells

(2011) Guanmin Meng et al.   TOXICOLOGY

Regulation of heat shock protein 27 phosphorylation during microcystin-LR-induced cytoskeletal reorganization in a human liver cell line

(2011) Yu Sun et al.   TOXICOLOGY LETTERS

Irs1 Serine 307 Promotes Insulin Sensitivity in Mice

(2010) Kyle D. Copps et al.   Cell Metabolism

Allosteric Regulation of Glycogen Synthase Controls Glycogen Synthesis in Muscle

(2010) Michale Bouskila et al.   Cell Metabolism

p53 Plays an Important Role in Cell Fate Determination after Exposure to Microcystin-LR

(2010) Shota Takumi et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Impaired Glucose Tolerance and Predisposition to the Fasted State in Liver Glycogen Synthase Knock-out Mice

(2010) Jose M. Irimia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycogen synthase kinase 3β mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1

(2010) Sanhua Leng et al.   JOURNAL OF ENDOCRINOLOGY

Molecular Aspects of Microcystin-induced Hepatotoxicity and Hepatocarcinogenesis

(2010) Z. Svirčev et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Control of Liver Glycogen Synthase Activity and Intracellular Distribution by Phosphorylation

(2009) Susana Ros et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of muscle glycogen synthase phosphorylation and kinetic properties by insulin, exercise, adrenaline and role in insulin resistance

(2009) Jørgen Jensen et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Four grams of glucose

(2008) David H. Wasserman   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Insulin action and signalling in fat and muscle from dexamethasone-treated rats

(2008) J. Burén et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2

(2008) Jin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY