Review
Environmental Sciences
Naima Hamid, Muhammad Junaid, De-Sheng Pei
Summary: The review highlights the importance of combined toxicological assessment in evaluating the hazard of chemical cocktails in the environment. It focuses on the mixture toxicity of endocrine-disrupting chemicals (EDCs) and their effects on various physiological axes. The study emphasizes the significance of experimental design and concentration selection in mixture toxicity research, while presenting the impacts of EDC mixtures on different biological pathways.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Agriculture, Multidisciplinary
Jia Yu, Haoyang Zou, Tiehua Zhang, Jie Zhang
Summary: This review examines the molecular mechanisms by which non-phthalate plasticizers modulate nuclear receptor activity, emphasizing the importance of evaluating their endocrine-disrupting effects and laying the foundation for the development of safer alternatives within the plastic industry.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Changhwan Ahn, Eui-Bae Jeung
Summary: Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, especially by disrupting hormone balance, affecting reproductive, neurological, and metabolic development and function, and even stimulating tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates, have been identified as risk factors for reproductive, neural, metabolic diseases, and cancers. Endocrine disruption has spread to wildlife and species connected to the food chains. Dietary uptake is an important source of EDC exposure. The relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and disease endpoints associated with endocrine disruption to better understand the EDC-disease relationship, and explores the development of new prevention/treatment opportunities and screening methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Minghui Li, Tian Yang, Lixiong Gao, Haiwei Xu
Summary: Endocrine disrupting chemicals (EDCs) can disrupt hormone balance and lead to physiological abnormalities, affecting ocular diseases. Despite EDCs passing through the blood-retinal barrier and accumulating in the neural retina, research on their impact remains limited.
Review
Plant Sciences
Eui-Man Jung, Seung Hyun Lee, Geun-Shik Lee
Summary: With the progress of industrialization, a variety of chemicals have been developed, including endocrine-disrupting chemicals (EDCs) that are crucial for plastic production as plasticizers and flame retardants. Plastics have become essential in modern life, leading to increased exposure to EDCs and their associated adverse effects on human reproductive function, cancer, and neurological abnormalities by disrupting the endocrine system. EDCs are classified as dangerous substances and are toxic to various organs despite their continued use. Therefore, it is necessary to review the contamination status of EDCs, select potentially hazardous substances for management, and monitor safety standards. In addition, finding substances that protect against EDC toxicity and conducting active research on their protective effects is crucial. Recent research has shown that Korean Red Ginseng (KRG) exhibits protective effects against various toxicities caused by EDCs in humans. This review discusses the effects of EDCs on the human body and the role of KRG in protecting against EDC toxicity.
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Environmental Sciences
Ruiqiu Zhang, Bailun Wang, Ling Li, Shengjie Li, Huizhu Guo, Pei Zhang, Yuqing Hua, Xueyan Cui, Yan Li, Yan Mu, Xin Huang, Xiao Li
Summary: In this study, a series of artificial intelligence models targeting endocrine-disrupting chemicals (EDCs) receptors, including the androgen receptor (AR), estrogen receptor (ER), and pregnane X receptor (PXR), were developed. The consensus models achieved good predictive results for validation sets with balanced accuracy values of 87.37%, 90.13%, and 79.21% for AR, ER, and PXR binding assays, respectively. Analysis of the physical-chemical properties suggested significant differences between EDCs and non-EDCs. Structural alerts that can indicate an EDC were identified and integrated into the web server SApredictor. These models and structural characteristics can provide useful tools and information in the discrimination and mechanistic understanding of EDCs in drug discovery and environmental risk assessment.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Jonny Beyer, You Song, Adam Lillicrap, Simon Rodriguez-Satizabal, Marios Chatzigeorgiou
Summary: In this article, the potential of tunicates, particularly solitary ascidians, as bioindicator organisms for endocrine disrupting pollutants is discussed. The biological characteristics of solitary ascidians, such as rapid development, short lifespan, and ease of cultivation, make them ideal model organisms for studying the effects of contaminants.
MARINE ENVIRONMENTAL RESEARCH
(2023)
Review
Environmental Sciences
Wenxin Hu, Peng Gao, Lei Wang, Jianying Hu
Summary: This article reviewed the endocrine disrupting toxicity and metabolic disrupting toxicity of aryl OPEs (AOPEs) as well as their underlying molecular mechanisms via various signaling pathways.
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sophie Fouyet, Elodie Olivier, Pascale Leproux, Melody Dutot, Patrice Rat
Summary: This study aimed to explore and compare the placental toxicity and endocrine disrupting effects of various essential oils (EOs) and their key compounds. The results showed that the EOs and their key components disrupted at least one of the studied hormones in placental cells, but did not activate the cell death receptor. Therefore, these tested EOs appear to act as hormonal modulators rather than endocrine disrupting compounds in human placental cells.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Vinay Kumar, Neha Sharma, Preeti Sharma, Ritu Pasrija, Komalpreet Kaur, Mridul Umesh, Basheer Thazeem
Summary: Endocrine disrupting compounds mimic natural hormones and activate signaling cycles, leading to uncontrolled growth. Pesticides are endocrine disruptors that cause cancer, birth defects, and reproductive defects in non-target organisms. However, there is a lack of critical analysis on pesticide toxicity and its role as an endocrine disruptor. This review aims to understand the role of pesticides as endocrine disruptors and discusses their effects on non-target organisms, including neurological disruption, genotoxicity, and ROS-induced toxicity.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Environmental Sciences
Aris Ismanto, Tony Hadibarata, Risky Ayu Kristanti, Lilik Maslukah, Novia Safinatunnajah, Wulan Kusumastuti
Summary: Endocrine disrupting chemicals (EDCs) have adverse impacts on human and environmental well-being, being associated with diseases such as cancer, cardiovascular risk, behavioral disorders, autoimmune defects, and reproductive diseases. Conventional treatment methods are insufficient to fully remove EDCs from water, necessitating the use of advanced psychochemical and biological treatments. The lack of laws regarding acute concentration limits of EDCs in various water sources contributes to the intensified concerns about these mixed contaminants. Further data is needed to address the risks associated with the presence of EDCs in the environment.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Dania Elisa C. Mazzeo, Andrea Dombrowski, Flavio Andrade Oliveira, Carlos Emilio Levy, Jorg Oehlmann, Mary Rosa R. Marchi
Summary: Sewage sludge has high agronomic potential but requires additional detoxification to eliminate toxic substances. This study developed a low-cost technology combining microorganisms and biostimulating agents to remove endocrine-disrupting chemicals from sewage sludge. The results showed significant reduction in endocrine-disrupting activity after the detoxification process, indicating the effectiveness of the technology in eliminating receptor-mediated toxicity.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Ecology
Ewa Liwarska-Bizukojc, Christian V. Stevens, Elisabeth I. P. Delbeke, Kevin M. Van Geem
Summary: A new class of biosurfactants, quaternary ammonium sophorolipids (SQAS), were tested for their estrogenic and androgenic potency as well as their toxicity towards yeasts and bacteria. Acetylation of the hydroxyl group of the carbohydrate head of SQAS was found to decrease their toxicity towards yeasts and endocrine disrupting potency. SQAS1 and SQAS2 showed weak antiestrogenic and antiandrogenic effects, while SQAS3 exhibited inhibitory activity towards male hormones. Cytotoxicity of some SQAS interfered with endocrine disruption activity.
Review
Nutrition & Dietetics
Aneta Sokal, Sara Jarmakiewicz-Czaja, Jacek Tabarkiewicz, Rafal Filip
Summary: Environmental pollution is a serious global issue, with endocrine disrupting chemicals (EDCs) having a significant impact on thyroid function. Strengthening food safety policies and reducing waste production, while using biodegradable packaging, are important actions to protect the ecosystem and improve food health.
Review
Environmental Sciences
Eve Pellerin, Christophe Caneparo, Stephane Chabaud, Stephane Bolduc, Martin Pelletier
Summary: Bisphenols are endocrine-disrupting chemicals that have been linked to cancer progression, particularly prostate cancer. They are found in the urine of the vast majority of the population and could potentially impact the normal physiology and cancer development of the bladder.
ENVIRONMENTAL RESEARCH
(2021)
Article
Energy & Fuels
Gabriel D. Reske, Bruno C. da Rosa, Luiz J. Visioli, Guilherme L. Dotto, Fernanda De Castilhos
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
(2020)
Article
Food Science & Technology
Mariana Pereira Martins, Joao Luiz Andreotti Dagostin, Talita Szlapak Franco, Graciela Ines Bolzon de Muniz, Maria Lucia Masson
Article
Agricultural Engineering
Julia B. Barbieri, Caroline Goltz, Flavia Batistao Cavalheiro, Aline Theodoro Toci, Luciana Igarashi-Mafra, Marcos R. Mafra
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Article
Food Science & Technology
Danielle Carpine, Joao Luiz Andreotti Dagostin, Elisa Mazon, Rafaela Cristina Turola Barbi, Fillemon Edillyn da Silva Bambirra Alves, Francisco Paulo Chaimsohn, Rosemary Hoffmann Ribani
JOURNAL OF FOOD SCIENCE
(2020)
Article
Chemistry, Applied
Felipe Ketzer, Dian Celante, Fernanda de Castilhos
MICROPOROUS AND MESOPOROUS MATERIALS
(2020)
Article
Green & Sustainable Science & Technology
S. S. Simoes, J. S. Ribeiro, D. Celante, L. N. Brondani, F. Castilhos
Article
Engineering, Chemical
Cristina Angelica T. Toro, Joao Luiz A. Dagostin, Erika de Castro Vasques, Michele R. Spier, Luciana Igarashi-Mafra, Tirzha L. P. Dantas
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
(2020)
Article
Engineering, Chemical
Fabiane Oliveira Farias, Karina Mayumi Ueda, Carlos Itsuo Yamamoto, Luciana Igarashi-Mafra, Marcos R. Mafra
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2020)
Article
Food Science & Technology
Elaine Kaspchak, Joana Lea Meira Silveira, Luciana Igarashi-Mafra, Marcos R. Mafra
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2020)
Article
Food Science & Technology
Tais Cardoso, Mariana Carolina Gipiela Correa Dias, Joao Luiz Andreotti Dagostin, Maria Lucia Masson
Summary: The study applied LBA/lactic acid as a food additive in the production of requeijao cremoso model, showing antioxidant and antimicrobial properties. Results indicated the potential of LBA for microbial inhibition in food products.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)
Correction
Agricultural Engineering
Caroline Goltz, Suelen Avila, Julia Bortoluzzi Barbieri, Luciana Igarashi-Mafra, Marcos R. Mafra
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Correction
Agricultural Engineering
Julia B. Barbieri, Caroline Goltz, Flavia Batistao Cavalheiro, Aline Theodoro Toci, Luciana Igarashi-Mafra, Marcos R. Mafra
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Article
Engineering, Chemical
Jose Pedro Wojeicchowski, Caroline Marques, Luciana Igarashi-Mafra, Joao A. P. Coutinho, Marcos R. Mafra
Summary: In this study, deep eutectic solvents (DES) based on choline chloride were used to extract phenolics from rosemary leaves, resulting in a compound with good antioxidant and antimicrobial activities. The optimized extract showed high antioxidant activity and significant antimicrobial effects against tested bacteria.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Food Science & Technology
Mariana Pereira Martins, Romaildo Santos de Sousa, Joao Luiz Andreotti Dagostin, Talita Szlapak Franco, Graciela Ines Bolzon de Muniz, Maria Lucia Masson
Summary: The effects of incorporating clove essential oil and potassium sorbate on the functional properties of starch/nanofibril films were investigated. The active films showed antibacterial activities and the antimicrobial agents influenced all the physical characteristics of the films. These active films have potential application as packaging materials to protect food from light.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)