Article
Environmental Sciences
Peiwei Xu, Shiming Lai, Lizhi Wu, Weizhong Chen, Yuan Chen, Dandan Xu, Jie Xiang, Ping Cheng, Zhijian Chen, Xiaofeng Wang, Xiaoming Lou, Jun Tang
Summary: A cross-sectional study conducted in Zhejiang Province, China in 2016 found that populations living near electroplating industries had high body burdens of metals and metalloids associated with renal dysfunction. The study also showed that the exposure group had higher levels of abnormal nasal symptoms, as well as elevated blood and urinary levels of certain metals and metalloids. Moreover, the exposure group demonstrated higher levels of renal dysfunction biomarkers compared to the control group.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, General & Internal
Xiaoqi Shen, Jun Cheng, Guizhen Yu, Xiayu Li, Heng Li, Jianghua Chen
Summary: This study retrospectively investigated 2,153 patients with IgA nephropathy and found that higher levels of urine beta 2-microglobulin and retinol-binding protein were associated with worse renal outcomes. Urine beta 2-MG and RBP were identified as independent risk factors for renal disease progression in IgAN.
FRONTIERS IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Jia-Jia Song, Xiao-Fang Han, Jian-Feng Chen, Ke-Mei Liu
Summary: This study investigated the correlation between glycated hemoglobin A1c (HbA1c), urinary microalbumin (U-mALB), urinary creatinine (U-CR), mALB/U-CR ratio, beta 2 microglobulin (beta 2MG), retinol binding protein (RBP) and diabetic retinopathy (DR). The results showed that HbA1c, mALB, mALB/U-CR, U-CR, beta 2MG and RBP can reflect the development of DR and are risk factors affecting proliferative DR (PDR).
WORLD JOURNAL OF DIABETES
(2023)
Article
Environmental Sciences
JingJing Quan, Yan Li, Minxue Shen, Yao Lu, Hong Yuan, Bin Yi, Xiang Chen, Zhijun Huang
Summary: This study aimed to explore the relationship between multimetal coexposure and renal tubular damage in adults living in heavy metal-polluted rural regions of China. The results showed that exposure to high levels of multimetal mixtures increases the risk of renal tubular damage. Selenium was positively associated, while iron was negatively associated with renal tubular damage risk or its biological indicators under the conditions of multimetal exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Hong Zhu, Wenwen Chu, Shuai Han, Bihu Gao, Xin Wang
Summary: By analyzing urine proteins and performing bioinformatics analysis, we found differences in the proteome of CI-AKI patients compared to non-CI-AKI patients, with a focus on immune response and inflammation.
Article
Environmental Sciences
Supabhorn Yimthiang, Phisit Pouyfung, Tanaporn Khamphaya, David A. Vesey, Glenda C. Gobe, Soisungwan Satarug
Summary: The most common causes of chronic kidney disease, diabetes, and hypertension are significant public health issues worldwide. Exposure to cadmium, a heavy metal pollutant, has been associated with kidney damage and increased blood pressure, especially in diabetics. This study found that increased blood cadmium levels were significantly associated with higher blood pressure in diabetics, suggesting a potential link between cadmium exposure, kidney damage, and hypertension in diabetics.
Article
Hematology
Laila Elsherif, Praghalathan Kanthakumar, Jeremiah Afolabi, Ashley F. F. Stratton, Ugochi Ogu, Marquita Nelson, Ayesha Mukhopadhyay, Matthew P. P. Smeltzer, Adebowale Adebiyi, Kenneth I. I. Ataga
Summary: This study explored the association between novel urinary biomarkers and albumin-creatinine ratio (ACR) in adults with sickle cell anaemia. Among the participants, 13 (35.2%) had persistent albuminuria (PA). Urinary levels of clusterin, retinol-binding protein 4, alpha-1 microglobulin, and angiotensinogen were significantly higher in participants with PA compared to those without PA. Multivariable analysis revealed that urinary angiotensinogen was associated with ACR, suggesting its potential in identifying sickle cell anaemia patients at risk for kidney disease.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Environmental Sciences
Xian Liang Sun, Hoang Duc Phuc, Rie Okamoto, Teruhiko Kido, Nguyen Thi Phuong Oanh, Ho Dung Manh, Le Thai Anh, Akie Ichimori, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa
Summary: Cadmium is an environmental pollutant that can have adverse health effects on humans. A study found that three decades after cadmium exposure ceased, age had a stronger association with renal function than cadmium. Additionally, renal tubular dysfunction caused by cadmium exposure is irreversible and more pronounced in females.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Brianna D. Young, Kristen M. Varney, Paul T. Wilder, Brianna K. Costabile, Edwin Pozharski, Mary E. Cook, Raquel Godoy-Ruiz, Oliver B. Clarke, Filippo Mancia, David J. Weber
Summary: The interaction between calmodulin (CaM) and the retinol uptake receptor STRA6 involves binding of a peptide derived from BP2 to the C-lobe of CaM in low free Ca2+ concentrations. As free Ca2+ levels increase, BP2 also interacts with the N-lobe of CaM. This structural rearrangement could be relevant to vitamin A transport by the full-length (CaM)-Ca-Ca-STRA6 complex as intracellular Ca2+ concentrations approach those typical of a Ca2+-signaling event.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Nutrition & Dietetics
Hiroko Moriya, Yuki Yokobori, Taichi Furukawa, Taku Kato, Ryota Sato, Asako Takenaka
Summary: This study found that there are sex-dependent differences in blood retinol and RBP concentrations, which are associated with sex hormones. The expression of hepatic Rbp4 mRNA is higher in male rats, but there is no difference in castrated and control rats. Ovariectomy leads to increased Rbp4 mRNA and blood RBP4 concentrations in adipose tissue, which may contribute to insulin resistance in ovariectomized rats and postmenopausal women.
JOURNAL OF NUTRITION
(2023)
Article
Pediatrics
Douglas John Stewart, Nadeesha Lakmal Mudalige, Mae Johnson, Rukshana Shroff, Pascale du Pre, Jelena Stojanovic
Summary: This study evaluated the incidence of acute kidney injury and risk factors in PIMS-TS, finding that hypotension/hypoperfusion was associated with almost all cases, and higher levels of triglycerides and C-reactive protein were linked to an increased risk of AKI.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Materials Science, Biomaterials
Minjun Zhang, Xinjie Liu, Xiaofan Li, Wan Zhou, Huibin Yu, Shenqi Wang, Lei Zhou
Summary: In this study, a novel TNTA-based hemoperfusion adsorbent was designed and developed for the removal of β2m, which demonstrated good biocompatibility, selectivity, and reusability. The results indicate that TNTAs with a pore size matching the size of β2m exhibit higher adsorption capacity while also having lower adsorption capacity for albumin, showing the importance of pore size on the selectivity of adsorbents. Additionally, green regeneration of TNTAs is achieved via the photocatalytic activity originating from TiO2.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Environmental Sciences
Soisungwan Satarug, Supabhorn Yimthiang, Phisit Pouyfung, Tanaporn Khamphaya, David A. Vesey
Summary: The global prevalence of diabetes and its major complication, diabetic nephropathy, is at an epidemic level. Cadmium exposure can induce kidney damage, but little is known about its nephrotoxicity in the diabetic population. A study compared cadmium exposure, kidney function, and tubular dysfunction in diabetics and non-diabetics in Thailand. The results showed that diabetics had a higher risk of tubular dysfunction and reduced kidney function compared to non-diabetics. Cadmium exposure and beta(2)-microglobulin excretion were associated with kidney damage. Tubular dysfunction was more severe in diabetics even after adjusting for other factors.
Article
Biochemistry & Molecular Biology
Xian Liang Sun, Rie Okamoto, Hoang Duc Phuc, Teruhiko Kido, Nguyen Thi Phuong Oanh, Akie Nakada, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa, Masaru Sakurai
Summary: Cadmium pollution is a concerning environmental problem that has adverse effects on human health. Despite the removal of cadmium-polluted paddy soil, the concentration of urinary cadmium in residents has increased, along with the concentration of urinary beta(2)-microglobulin, an early sign of cadmium-induced renal dysfunction. Age shows a significant correlation with blood cadmium, urinary cadmium, and beta(2)-microglobulin.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Environmental Sciences
Supabhorn Yimthiang, David A. Vesey, Glenda C. Gobe, Phisit Pouyfung, Tanaporn Khamphaya, Soisungwan Satarug
Summary: The study investigated the relationship between cadmium exposure and renal pathologies in residents of Cd-polluted and non-polluted regions in Thailand. It was found that chronic cadmium exposure was associated with tubulopathy and a reduced estimated glomerular filtration rate (eGFR), particularly in women. The study also revealed that cadmium-induced impairment in protein reabsorption and nephron loss contributed to the increase in tubulopathy.