Book Review
Multidisciplinary Sciences
Alison Abbott
Summary: The neuroscientist, who has won a Nobel Prize, has been studying connections on a larger scale.
News Item
Multidisciplinary Sciences
Davide Castelvecchi, Katharine Sanderson
Summary: Pierre Agostini, Ferenc Krausz, and Anne L'Huillier have been awarded for their research on ultra-short pulses of light, which has made it possible to study electrons in detail.
Article
Chemistry, Medicinal
Hao Zhang, John Ginn, Wenhu Zhan, Annie Leung, Yi J. Liu, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Mayako Michino, Takafumi Yukawa, Sevil Chelebieva, Patrick K. Tumwebaze, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Philip J. Rosenthal, Roland A. Cooper, Nigel Liverton, Michael Foley, Peter T. Meinke, Carl F. Nathan, Laura A. Kirkman, Gang Lin
Summary: Targeting the Plasmodium proteasome is a promising strategy to combat malaria, especially with the increasing reports of resistance to current therapies. In this study, we conducted structure-activity relationship studies on a macrocyclic scaffold and identified compound TDI-8414, which showed potent antiparasitic activity, high selectivity, improved solubility, and enhanced metabolic stability.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Computer Science, Interdisciplinary Applications
Ivan Aranzales, Ho Fai Chan, Benno Torgler
Summary: Understanding the role of emotions in academia is challenging, but studying Nobel Prize winners can provide insights. We hypothesize that Nobel laureates who have waited longer for the award will experience stronger positive emotions upon receiving it. Analyzing banquet speeches, we find a robust positive correlation between waiting time and positive emotions.
Editorial Material
Medicine, Research & Experimental
Katherine E. Uyhazi, Jean Bennett
Summary: The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and Jennifer Doudna for their groundbreaking discovery of the CRISPR/Cas9 genetic scissors, revolutionizing genome editing methods.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Biochemistry & Molecular Biology
Lolita Piersimoni, Marina Abd el Malek, Twinkle Bhatia, Julian Bender, Christin Brankatschk, Jaime Calvo Sanchez, Guy W. Dayhoff, Alessio Di Ianni, Jhonny Oscar Figueroa Parra, Dailen Garcia-Martinez, Julia Hesselbarth, Janett Koeppen, Luca M. Lauth, Laurin Lippik, Lisa Machner, Shubhra Sachan, Lisa Schmidt, Robin Selle, Ioannis Skalidis, Oleksandr Sorokin, Daniele Ubbiali, Bruno Voigt, Alice Wedler, Alan An Jung Wei, Peter Zorn, Alan Keith Dunker, Marcel Koehn, Andrea Sinz, Vladimir N. Uversky
Summary: Intrinsically disordered proteins and regions (IDPs and IDRs) are increasingly recognized in biology, and their importance is demonstrated by their involvement in Nobel Prize-winning discoveries. While the specific molecular functions of IDPs and IDRs are still being determined, their presence in various biological processes highlights their significance in biology.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Computer Science, Information Systems
Chunli Wei, Jiang Li, Dongbo Shi
Summary: To quantify revolutionary discoveries, a two-dimensional metric combining the consolidation-or-destabilization (CD) index with citation count is proposed. Through multivariate linear regression analysis on 164 Nobel prize-winning papers and 9,034 counterparts, significant differences were found between the two groups, with the Nobel prize-winning papers receiving approximately 880 more citations and having an average CD index 0.07 higher than the counterparts. The proposed metric proves to be reliable in measuring revolutionary science.
INFORMATION PROCESSING & MANAGEMENT
(2023)
Article
Multidisciplinary Sciences
Yakub Sebastian, Chaomei Chen
Summary: The study applies the SVA model to investigate Nobel Prize winning papers, finding that they exhibit remarkable boundary-spanning traits and exert significant structural variations on existing intellectual space. SVA not only provides leading indicators for future Nobel Prize winning papers, but also broadens our understanding of prize-winning properties in academic publications.
Article
Microbiology
Maisha Khair Nima, Angana Mukherjee, Saiful Arefeen Sazed, Muhammad Riadul Haque Hossainey, Ching Swe Phru, Fatema Tuj Johora, Innocent Safeukui, Anjan Saha, Afsana Alamgir Khan, Aung Swi Prue Marma, Russell E. Ware, Narla Mohandas, Barbara Calhoun, Rashidul Haque, Wasif Ali Khan, Mohammad Shafiul Alam, Kasturi Haldar
Summary: Emerging resistance to artemisinin drugs threatens malaria elimination. The Chittagong Hill Tracts in Bangladesh have seen an increase in malaria cases, and some patients show resistance to artemisinin combination therapy. The study highlights the importance of comprehensive monitoring of drug resistance.
Article
Microbiology
Maisha Khair Nima, Angana Mukherjee, Saiful Arefeen Sazed, Muhammad Riadul Haque Hossainey, Ching Swe Phru, Fatema Tuj Johora, Innocent Safeukui, Anjan Saha, Afsana Alamgir Khan, Aung Swi Prue Marma, Russell E. Ware, Narla Mohandas, Barbara Calhoun, Rashidul Hague, Wasif Ali Khan, Mohammad Shafiul Alam, Kasturi Halder
Summary: Emerging resistance to artemisinin drugs threatens the elimination of malaria. A study in Bangladesh's Chittagong Hill Tracts (CRTs) found cases of malaria associated with artemisinin resistance, and evaluated the efficacy of artemisinin combination therapy (ACT) in patients. The results showed that ACT effectively cleared parasites, but no mutations associated with resistance were found. In addition, in vitro experiments confirmed the presence of resistance. This study provides important insights into the development of malaria resistance.
Article
Multidisciplinary Sciences
Moses Ocan, Fred Katabazi Ashaba, Savannah Mwesigwa, Kigozi Edgar, Moses R. Kamya, Sam L. Nsobya
Summary: This study investigated the mutations associated with artemisinin resistance in Plasmodium falciparum parasites in Uganda. The results showed a significant increase in the prevalence of pfmdr-2 gene mutations in samples collected from 2005 to 2013, while the prevalence of K13 and arps10 gene mutations did not change significantly. The findings suggest the need for continuous surveillance of molecular markers of artemisinin resistance in malaria-affected regions.
Editorial Material
Toxicology
Edward J. Calabrese
Summary: In his Nobel Prize Lecture, Hermann J. Muller argued for a linear dose-response relationship for radiation-induced germ cell mutations, with no threshold. However, a newly discovered commentary revealed that Curt Stern advised Muller to remove reference to the flawed linear non-threshold (LNT) theory and encouraged him to consider the threshold supportive data of Ernst Caspari. This finding is of historical importance as Muller's Nobel Prize Lecture was influential in shaping the acceptance of the linearity model for radiation and chemical risk assessment.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Immunology
Julia C. Cutts, Katherine O'Flaherty, Sophie G. Zaloumis, Elizabeth A. Ashley, Jo Anne Chan, Marie A. Onyamboko, Caterina Fanello, Arjen M. Dondorp, Nicholas P. Day, Aung Pyae Phyo, Mehul Dhorda, Mallika Imwong, Rick M. Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tran Tinh Hien, Ye Htut, Mayfong Mayxay, M. Abdul Faiz, Eizo Takashima, Takafumi Tsuboi, James G. Beeson, Francois Nosten, Julie A. Simpson, Nicholas J. White, Freya J. Fowkes
Summary: The substantially shorter parasite clearance time observed in African patients compared to Asian patients after artemisinin treatment cannot be explained by differences in P. falciparum antibody responses.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Psychology, Multidisciplinary
Linlin Zheng, Yenchun Jim Wu, Yuyi Li, Di Ye, Wenzhuo Li
Summary: This study explores the relationship between early growth experiences and personality traits of original innovation talents. The findings suggest that factors such as family democracy, family size, family function, and teaching democracy influence the sense of responsibility, extraversion, and openness of these talents. The results have important implications for enhancing the positive effects of early growing-up experiences on personality development.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Jeffrey I. Seeman, Guillermo Restrepo
Summary: The solicitation of nominations has been the first step in the selection process of the Nobel Prizes in Chemistry since its inception in 1901. However, analysis of data from the Nobel Prize Nomination Archives reveals that nominations have not been the decisive factor in selecting the recipients of the award. Instead, nominations have served as a source of information for the committee, guiding future contenders and possibly influencing the selection through personal biases.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Infectious Diseases
Chao-Fu Yang, Cheng-Hsun Tu, Yin-Ping Lo, Chih-Chieh Cheng, Wei-June Chen
PLOS NEGLECTED TROPICAL DISEASES
(2015)
Article
Immunology
Jingshu Zhang, Daniel Man-Yuen Sze, Benjamin Yat-Ming Yung, Petrus Tang, Wei-June Chen, Kwok-Hung Chan, Polly Hang-Mei Leung
Review
Immunology
Tien-Huang Chen, Yi-Jun Wu, Jiun-Nan Hou, Cheng-Hsun Chiu, Wei-June Chen
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2017)
Article
Virology
Jiun-Nan Hou, Tien-Huang Chen, Yi-Hsuan Chiang, Jing-Yun Peng, Tsong-Han Yang, Chih-Chieh Cheng, Eny Sofiyatun, Cheng-Hsun Chiu, Chuan Chiang-Ni, Wei-June Chen
Article
Biotechnology & Applied Microbiology
Tien-Huang Chen, Yi-Hsuan Chiang, Jiun-Nan Hou, Chih-Chieh Cheng, Eny Sofiyatun, Cheng-Hsun Chiu, Wei-June Chen
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Virology
Tien-Huang Chen, Yi-Jun Wu, Jiun-Nan Hou, Yi-Hsuan Chiang, Chih-Chieh Cheng, Eny Sifiyatun, Cheng-Hsun Chiu, Lian-Chen Wang, Wei-June Chen
Article
Parasitology
Chao-Fu Yang, Jion-Nun Hou, Tien-Huang Chen, Wei-June Chen
Article
Biology
Wei-June Chen, Ching-Gi Huang, Mei-Huei Fan-Chiang, Yu-Han Liu, Yi-Feng Lee
JOURNAL OF EXPERIMENTAL BIOLOGY
(2013)
Article
Biotechnology & Applied Microbiology
Ching-Kai Chuang, Tsong-Han Yang, Tien-Huang Chen, Chao-Fu Yang, Wei-June Chen
JOURNAL OF GENERAL VIROLOGY
(2015)
Article
Immunology
Chuen-Mao Yang, Chih-Chung Lin, I-Ta Lee, Yi-Hsin Lin, Caleb M. Yang, Wei-June Chen, Mei-Jie Jou, Li-Der Hsiao
JOURNAL OF NEUROINFLAMMATION
(2012)
Article
Infectious Diseases
Tien-Huang Chen, Yin-Ping Lo, Chao-Fu Yang, Wei-June Chen
PLOS NEGLECTED TROPICAL DISEASES
(2012)
Article
Biotechnology & Applied Microbiology
Chih-Chieh Cheng, Chao-Fu Yang, Yin-Ping Lo, Yi-Hsuan Chiang, Eny Sofiyatun, Lian-Chen Wang, Wei-June Chen
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Zoology
Mauricio E. Alarcon, Chin-Gi Huang, Yi-Shang Tsai, Wei-June Chen, Anil Kumar Dubey, Wen-Jer Wu
ZOOLOGICAL STUDIES
(2011)
Article
Cell Biology
Yu-Fen Tseng, Chien-Chih Wang, Shuen-Kuei Liao, Ching-Kai Chuang, Wei-June Chen
JOURNAL OF BIOMEDICAL SCIENCE
(2011)