Review
Chemistry, Multidisciplinary
Yao Fan, Xiang Li, Lei Zhang, Zhi Zong, Fangwei Wang, Jun Huang, Linghui Zeng, Chong Zhang, Haiyan Yan, Long Zhang, Fangfang Zhou
Summary: SUMOylation, a post-translational modification, plays a crucial role in regulating viral protein function and host antiviral immune response. The review summarizes the regulatory mechanisms of SUMOylation in viral replication and infection, and discusses its potential therapeutic applications in virus-induced diseases.
Review
Biochemistry & Molecular Biology
Li Chen, Limin Yang, Yingyu Li, Tianrun Liu, Bolun Yang, Lei Liu, Rui Wu
Summary: The interaction between autophagy and inflammation plays a crucial role in viral infections, and understanding their regulatory roles can provide insights and theoretical foundations for disease prevention, treatment, and drug development.
Article
Multidisciplinary Sciences
Yining Wang, Pengfei Li, Lei Xu, Annemarie C. de Vries, Robbert J. Rottier, Wenshi Wang, Marie-Rose B. S. Crombag, Maikel P. Peppelenbosch, Denis E. Kainov, Qiuwei Pan
Summary: Indomethacin can inhibit coronavirus infection and activate interferon response, showing potential therapeutic effects against coronavirus infections.
Article
Biochemical Research Methods
Guillaume Lingas, Kyle Rosenke, David Safronetz, Jeremie Guedj
Summary: Lassa fever is caused by Lassa virus and currently has no approved vaccine. Recent findings show that the nucleotide analogue favipiravir has a high antiviral efficacy against Lassa virus, but its mechanism of action is not clear and the lack of pharmacokinetic data hinders the translation of these results to humans.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Audrey Labarde, Lina Jakutyte, Cyrille Billaudeau, Beatrix Fauler, Maria Lopez-Sanz, Prishila Ponien, Eric Jacquet, Thorsten Mielke, Silvia Ayora, Rut Carballido-Lopez, Paulo Tavares
Summary: Infection of Bacillus subtilis by bacteriophage SPP1 leads to the hijacking of host replication proteins to assemble hybrid viral-bacterial replisomes, doubling the cell total DNA content within 15 minutes. The replisomes operate at several independent locations within a single viral DNA focus positioned asymmetrically in the cell. These findings demonstrate that bacteriophages restructure the host cytoplasm to confine the essential processes for their multiplication at different cellular locations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Tong Chen, Shaoyu Tu, Ling Ding, Meilin Jin, Huanchun Chen, Hongbo Zhou
Summary: Autophagy is a cellular process that degrades virus particles and components during a viral infection. However, viruses have evolved various strategies to subvert autophagy and counteract cellular antiviral responses.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Vorrapon Chaikeeratisak, Kanika Khanna, Katrina T. Nguyen, MacKennon E. Egan, Eray Enustun, Emily Armbruster, Jina Lee, Kit Pogliano, Elizabeth Villa, Joe Pogliano
Summary: A unique structure called phage bouquets was discovered, which is formed by viral particles of Pseudomonas nucleus-forming jumbo phage PhiPA3. These particles assemble in a spherical pattern with tails oriented inward and the heads outward at specific subcellular locations. The bouquets maintain the same distance from the phage nucleus, indicating an active mechanism for positioning.
Review
Immunology
Rafael Cardoso Maciel Costa Silva, Jhones Sousa Ribeiro, Gustavo Peixoto Duarte da Silva, Luciana Jesus da Costa, Leonardo Holanda Travassos
Summary: This article discusses the interplay between coronaviruses and autophagy, highlighting the mechanisms by which autophagy restrains inflammatory responses involved in coronavirus pathogenesis. It also explores different autophagy modulators and the rationale for drug repurposing as an attractive adjunctive therapy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Virology
Wei Li, Guangju You, Areayi Haiyilati, Hongnuan Wang, Huixuan Jiao, Yongqiang Wang, Li Gao, Hong Cao, Xiaoqi Li, Shijun J. Zheng
Summary: Hepatitis-pericardial syndrome (HHS) is an acute avian disease caused by fowl adenovirus serotype 4 (FAdV-4) that has caused a widespread epidemic in China. The pathogenesis of the disease and the host responses to infection remain elusive. This study reveals that HPFAdV-4 hexon interacts with the host protein BAG3, promoting autophagy and enhancing viral proliferation.
JOURNAL OF VIROLOGY
(2023)
Article
Biology
Robert LeDesma, Brigitte Heller, Abhishek Biswas, Stephanie Maya, Stefania Gili, John Higgins, Alexander Ploss
Summary: This study reveals that the multifunctional protein ORF1 of Hepatitis E virus (HEV) is crucial for genome replication and is not regulated by proteolytic processing. The essential role of six cysteines in the pPCP domain in viral replication is associated with the coordination of divalent metal ions. Moreover, the pPCP domain can only rescue viral genome replication when expressed in the context of the full-length ORF1 protein.
Article
Chemistry, Multidisciplinary
Margherita M. Botto, Sudarshan Murthy, Meindert H. Lamers
Summary: Exonucleases play a crucial role in removing nucleotides from DNA ends during replication, repair, and maintenance processes. These enzymes are potential targets for novel anticancer and antimicrobial drugs, yet they have been underexploited. In this study, we developed a simple and versatile real-time exonuclease assay using 2-aminopurine, a fluorescent nucleotide that is quenched by neighboring bases in DNA. Our assay effectively works with different eukaryotic and bacterial exonucleases, screening for potential inhibitors on a large scale. Using this assay, we have discovered a novel inhibitor for the Mycobacterium tuberculosis PHP exonuclease, which is involved in DNA replication. Therefore, our assay provides a valuable tool for high-throughput screening of exonuclease inhibitors that may disrupt DNA replication or maintenance.
Review
Microbiology
Chonghui Xu, Jizheng Chen, Xinwen Chen
Summary: Hepatitis viruses are the primary causative agents of hepatitis and pose a major public health issue globally. The host innate immune system acts as the first line of defense against these viruses. However, hepatitis viruses evade host immune surveillance through various strategies, compromising the innate immune response and creating a favorable environment for viral replication.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Roham Parsa, Mariya London, Tiago Bruno Rezende de Castro, Bernardo Reis, Julian Buissant des Amorie, Jason G. Smith, Daniel Mucida
Summary: The intestinal epithelium is the largest surface in the body that is exposed to viruses and houses a large population of intraepithelial T lymphocytes. This study found that newly recruited CD4(+) T cells accumulate in the intestine after infection with certain viruses, and they provide protection against enteric adenovirus. These findings reveal a potential protective role of intraepithelial Ly6A(+)CCR9(+)CD4(+) T cells against enteric adenovirus.
Article
Multidisciplinary Sciences
Aleksandr Ianevski, Rouan Yao, Ronja M. Simonsen, Vegard Myhre, Erlend Ravlo, Gerda D. Kaynova, Eva Zusinaite, Judith M. White, Stephen J. Polyak, Valentyn Oksenych, Marc P. Windisch, Qiuwei Pan, Egle Lastauskiene, Astra Vitkauskiene, Algimantas Matukevicius, Tanel Tenson, Magnar Bjoras, Denis E. Kainov
Summary: This article reviews druggable virus-host interactions, mechanisms of action, immunomodulatory properties, delivery routes, and interactions of broad-spectrum antivirals (BSAs) with other antivirals. It suggests expanding the indications of BSAs and developing new pan- and cross-viral mono- and combinational therapies. The article also introduces a new scoring algorithm to prioritize the development of promising BSAs and BSA-containing drug cocktails (BCCs) during the critical period between the identification of a new virus and the development of specific treatments.
Article
Microbiology
Brooke W. Bullington, Katherine Klemperer, Keith Mages, Andrea Chalem, Humphrey D. Mazigo, John Changalucha, Saidi Kapiga, Peter F. Wright, Maria M. Yazdanbakhsh, Jennifer A. Downs
Summary: Schistosome infections have complex effects on host responses to viruses, potentially increasing susceptibility and virulence for certain viruses, while providing some level of protection in other cases, and impairing immune responses to vaccines. These findings have important implications for the prevention and control of viral infections, as well as for anti-viral vaccination strategies.
Article
Public, Environmental & Occupational Health
A. Ajavon, D. Killian, R. Odom, R. W. Figliozzi, F. Chen, M. Balish, J. Parmar, R. Freeman, J. Snitzer, S. V. Hsia
EPIDEMIOLOGY AND INFECTION
(2015)
Article
Neurosciences
Feng Chen, Robert W. Figliozzi, Gautam Bedadala, Jayavardhana Palem, S. Victor Hsia
JOURNAL OF NEUROVIROLOGY
(2016)
Article
Infectious Diseases
Shao-Chung V. Hsia, Lie Hong Chen, Hung-Fu Tseng
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2017)
Article
Cell Biology
Robert W. Figliozzi, Feng Chen, Shaochung V. Hsia
JOURNAL OF CELL SCIENCE
(2017)
Article
Neurosciences
Qiaojuan Zhang, Shao-Chung Hsia, Miguel Martin-Caraballo
JOURNAL OF NEUROVIROLOGY
(2017)
Article
Biochemistry & Molecular Biology
Jayavardhana R. Palem, Mudit Mudit, Shao-chung V. Hsia, Khalid A. El Sayed
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2017)
Article
Clinical Neurology
Robert W. Figliozzi, Feng Chen, Matthew Balish, Amakoe Ajavon, S. Victor Hsia
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2014)
Article
Multidisciplinary Sciences
Kevin Rochford, Feng Chen, Yan Waguespack, Robert W. Figliozzi, Madan K. Kharel, Qiaojuan Zhang, Miguel Martin-Caraballo, S. Victor Hsia
Article
Biochemistry & Molecular Biology
Qiaojuan Zhang, Shao-Chung Hsia, Miguel Martin-Caraballo
JOURNAL OF NEUROCHEMISTRY
(2019)
Article
Virology
Qiaojuan Zhang, Miguel Martin-Caraballo, S. Victor Hsia
JOURNAL OF VIROLOGY
(2020)
Review
Biochemistry & Molecular Biology
Qiaojuan Zhang, Miguel Martin-Caraballo, Shaochung V. Hsia
CELL AND BIOSCIENCE
(2020)
Article
Immunology
Yu-Chih Chen, Robert W. Figliozzi, Shaochung V. Hsia
Summary: Postherpetic neuralgia (PHN) is a painful neuropathic complication resulting from herpes zoster (HZ), with disrupted immune system signaling and inflammation as potential causes. The study suggests that interferon expression profile (IEP) study could serve as a molecular tool for diagnosing PHN.
Article
Chemistry, Analytical
Faith O. Osinaga, Kenneth Blakeslee, Madan K. Kharel, Yan Waguespack, S. Victor Hsia
Summary: The release of volatile organic compounds (VOCs) triggered by DNA virus infection, especially Herpes Simplex Virus Type-1 (HSV-1), has been studied. As a key intermediate in the pathway for the production of gamma-butyrolactone (GBL), gamma-Hydroxybutyric acid (GHB) plays a crucial role. The development of a sensitive and specific analytical method for the detection and quantification of GHB is essential for further understanding its involvement in the cellular response to HSV-1 infection.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Microbiology
Yu-Chih Chen, Hedong Li, Miguel Martin-Caraballo, Shaochung Victor Hsia
Summary: HSV-1 is a neurotropic pathogen associated with severe encephalitis and other chronic neuropathic complications. It can establish lifelong latency in neurons and reactivate under stressors. MicroRNA may play a role in promoting latency of HSV-1 in human neurons.
