Article
Surgery
Elisabeth Dupont, Theodore Tsangaris, Carlos Garcia-Cantu, Marissa Howard-McNatt, Akiko Chiba, Adam C. Berger, Edward A. Levine, Jennifer S. Gass, Kristalyn Gallagher, Sharon S. Lum, Ricardo D. Martinez, Alliric Willis, Sonali Pandya, Eric A. Brown, Andrew Fenton, Amanda Mendiola, Mary Murray, Naveenraj L. Solomon, Maheswari Senthil, David W. Ollila, David Edmonson, Melissa Lazar, Jukes P. Namm, Fangyong Li, Meghan Butler, Noreen E. McGowan, Maria E. Herrera, Yoana P. Avitan, Brian Yoder, Laura L. Walters, Tara McPartland, Anees B. Chagpar
Summary: This study demonstrates that resection of cavity shave margins (CSM) significantly reduces positive margin and re-excision rates in breast cancer patients undergoing partial mastectomy (PM).
Article
Oncology
Joshua Kong, Sudeshna Bandyopadhyay, Wei Chen, Faisal Al-Mufarrej, Lydia Choi, Mary A. Kosir
Summary: Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer with a poor survival rate. Intraoperative frozen section analysis (FSA) can decrease the number of positive margins in IBC patients undergoing modified radical mastectomy (MRM), potentially reducing the need for re-operation, allowing immediate wound closure, and preventing delays in adjuvant radiation therapy.
Article
Oncology
Aviad Hoffman, Itamar Ashkenazi
Summary: This study evaluated the application of Margin Probe in patients undergoing lumpectomy for breast cancer and found that it has a relatively low sensitivity in detecting positive margins and a high false-positive rate, resulting in unnecessary margin shavings.
Article
Oncology
Tamaki Tamanuki, Maki Namura, Tomoyoshi Aoyagi, Sinichirou Shimizu, Tomoko Suwa, Hiroshi Matsuzaki
Summary: The combination of imprint cytology followed by frozen section for intraoperative margin assessment significantly reduces the positive margin rate. The false-positive rate decreased from 13.4% with imprint cytology alone to 2.5% when frozen section was added. The overall positive margin rate based on permanent sections was 2.9%.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Zhiqiang Chen, Bingran Yu, Jiaping Bai, Qiong Li, Bowen Xu, Zhaoru Dong, Xuting Zhi, Tao Li
Summary: The benefits of intraoperative frozen section (FS) for obtaining a secondary R0 resection in distal cholangiocarcinoma (dCCA) patients are controversial. The study showed no significant difference in survival between FS and non-FS groups, but patients in the R0 group had better survival outcomes compared to the R1 group.
FRONTIERS IN ONCOLOGY
(2021)
Review
Multidisciplinary Sciences
Mila Trementosa Garcia, Bruna Salani Mota, Natalia Cardoso, Ana Luiza Cabrera Martimbianco, Marcos Desiderio Ricci, Filomena Marino Carvalho, Rodrigo Goncalves, Jose Maria Soares Junior, Jose Roberto Filassi
Summary: Frozen section is a reliable procedure with high accuracy, sensitivity, and specificity in intraoperative margin assessment of breast-conserving surgery. It can be useful in reducing reoperation rates and local recurrence.
Article
Oncology
Anna Kubo, Tomonori Tanei, Ambara R. Pradipta, Koji Morimoto, Motoko Fujii, Yoshiaki Sota, Tomohiro Miyake, Naofumi Kagara, Masafumi Shimoda, Yasuto Naoi, Yuichi Motoyama, Eiichi Morii, Katsunori Tanaka, Kenzo Shimazu
Summary: The CTS assay demonstrates comparable accuracy to FS analysis in examining simulated surgical margins in breast cancer patients, suggesting its potential to replace FS analysis due to its efficiency and time-saving advantages.
Article
Oncology
Jeongeun Do, Jinah Chu, Jaeyoung Ahn, Go Eun Bae, Sang Hwa Lee, Hyun-Soo Kim, Sung -Im Do
Summary: An accurate evaluation of resection margin (RM) is critical in breast-conserving surgery (BCS) for successful local control. We compared gross and microscopic methods for RM evaluation and analyzed their concordances. Results showed higher sensitivity and specificity in microscopic methods, but there were discordant results with gross methods.
ANTICANCER RESEARCH
(2022)
Article
Surgery
Biqi Zhang, Grace C. Lee, Motaz Qadan, Zhi Ven Fong, Mari Mino-Kenudson, Vikram Desphande, Giuseppe Malleo, Laura Maggino, Giovanni Marchegiani, Roberto Salvia, Aldo Scarpa, Claudio Luchini, Lucia De Gregorio, Cristina R. Ferrone, Andrew L. Warshaw, Keith D. Lillemoe, Claudio Bassi, Carlos Fernandez-del Castillo
Summary: Complete, tumor-free resection at the pancreatic neck, achieved either en-bloc or non-en-bloc, is associated with improved survival in pancreatic ductal adenocarcinoma patients, without increased perioperative morbidity or mortality.
Article
Medical Laboratory Technology
Rebecca Czaja, Ruizhe Wu, Julie M. Jorns
Summary: In recent years, there has been a trend towards less aggressive surgical management of axillary lymph nodes in breast cancer. This study evaluated the effectiveness of evaluating axillary sentinel lymph nodes and found that serial sectioning at 2-mm intervals reduced false negatives due to macrometastatic disease. Discordant cases were mostly false negatives detected on the first permanent section level due to sampling errors.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Oncology
Seiji Asoda, Hidetaka Miyashita, Tomoya Soma, Kanako Munakata, Yuka Yamada, Yuta Yasui, Yoko Kudo, Shin Usuda, Toshihiro Hasegawa, Taneaki Nakagawa, Hiromasa Kawana
Summary: The study demonstrated that e-IFSA combined with iodine staining is valuable for achieving complete resection of superficial SCC of the tongue.
Article
Surgery
Jian Guo Shen, Lin Bo Wang, Zi Nong Jiang, Xiao Ming Yuan, Wen He Zhao, Jun Shen
Summary: Intraoperative frozen section analysis of lumpectomy margins can decrease reoperation rates in breast cancer patients undergoing breast-conserving surgery. However, routine intraoperative frozen margin evaluation may have limited value in analyzing re-excised margins in these patients.
INDIAN JOURNAL OF SURGERY
(2022)
Article
Oncology
Tae-Kyung Yoo, Young-Joon Kang, Joon Jeong, Jeong-Yoon Song, Sun Hee Kang, Hye Yoon Lee, Eui Tae Kim, Onvox Yi, Han-Byoel Lee, Soojeong Choi, Hyung Seok Park, Geumhee Gwak, Jae Il Kim, Min Kyoon Kim, Jeeyeon Lee, Hee Joon Kang, Byung Joo Chae
Summary: This study is a phase III, randomized controlled, parallel-group, multicenter non-inferiority clinical trial aimed at determining if omitting frozen section biopsy for intraoperative margin evaluation in selected patients is not inferior to performing frozen section biopsy in terms of resection margin positivity rate.
JOURNAL OF BREAST CANCER
(2021)
Article
Oncology
Cindy Cen, Jennifer Chun, Elianna Kaplowitz, Deborah Axelrod, Richard Shapiro, Amber Guth, Freya Schnabel
Summary: This study investigated the clinicopathologic characteristics, margin status, and re-excision rates for NAC+BCS patients with and without the use of MarginProbe. Patients with a larger residual tumor burden and ER-positive disease had a greater risk for inadequate margins at surgery. MarginProbe use was associated with a lower re-excision rate, supporting the use of BCS after NAC.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Katharina Nentwig, Tobias Unterhuber, Klaus-Dietrich Wolff, Lucas M. Ritschl, Markus Nieberler
Summary: The study evaluated the diagnostic value of intraoperative frozen section analysis in patients with oral squamous cell carcinoma and found that achieving instant R0 status is crucial in reducing disease recurrence and improving patient survival. While IFSA has sensitivity and specificity, it falls short in ensuring secure definite surgical margins.Improved intraoperative diagnostic information on OSCC location and extent could support patient treatment.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Surgery
Kortney A. Robinson, Cornelius A. Thiels, Sean Stokes, Sarah Duncan, Mario Feranil, Aaron Fleishman, Charles H. Cook, Larry A. Nathanson, Lyen C. Huang, Elizabeth B. Habermann, Gabriel A. Brat
Summary: This study compares consensus recommendations for surgical procedures with actual patient consumption data and points out the issue of overprescription in consensus guidance.
Article
Surgery
Maria E. Linnaus, Matthew R. Neville, Elizabeth B. Habermann, Richard J. Gray
Summary: Patients tend to use fewer opioids postoperatively than prescribed, leading to a majority having leftover pills. Satisfaction with pain control regimens is not significantly related to the amount of opioids taken.
Article
Surgery
Kristen M. Jogerst, Yu-Hui H. Chang, David A. Etzioni, Amit K. Mathur, Elizabeth B. Habermann, Nabil Wasif
Summary: This study analyzed data from the National Cancer Database and found that there were differential improvements in 30-day mortality at low and medium-volume hospitals, leading to similar 30-day mortality odds at medium and high-volume hospitals in pancreatic surgery.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Orthopedics
Rebecca L. Johnson, Ryan D. Frank, Matthew P. Abdel, Elizabeth B. Habermann, Alanna M. Chamberlain, Carlos B. Mantilla
Summary: This study found that frailty levels improved in vulnerable and frail patients 1 year after TJA, while preoperative frailty status can be modified through TJA. Preoperative frailty measurement is crucial for identifying patients who will benefit most from TJA, as well as for postoperative frailty surveillance.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Surgery
Alaa Sada, Amy E. Glasgow, Melanie L. Lyden, Benzon M. Dy, Trenton R. Foster, Elizabeth B. Habermann, Irina Bancos, Travis J. McKenzie
Summary: The anatomical boundaries of lymphadenectomy for adrenocortical carcinoma (ACC) are not defined. Further studies are necessary to determine the boundaries of lymphadenectomy in ACC resection.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Surgery
Steven B. Porter, Amy E. Glasgow, Elizabeth B. Habermann
Article
Surgery
Alaa Sada, William S. Harmsen, Travis J. McKenzie, Todd A. Kellogg, Omar Ghanem, Michael L. Kendrick, Elizabeth B. Habermann
Summary: This study found that video postoperative follow-up visits are acceptable among bariatric surgery patients, with the majority of patients expressing a preference for video visits. Among those who received video visits, 82% felt that their visit was better or as good as an in-person visit.
Article
Oncology
Simone Garzon, Andrea Mariani, Courtney N. Day, Elizabeth B. Habermann, Carrie Langstraat, Gretchen Glaser, Amanika Kumar, Jvan Casarin, Stefano Uccella, Fabio Ghezzi, Alyssa Larish
Summary: In patients with endometrial cancer, there was no significant difference in overall survival between those who underwent sentinel node biopsy alone, sentinel node biopsy followed by lymphadenectomy, or lymphadenectomy alone. This observation held true regardless of lymph node status, histotype, and extent of lymphadenectomy.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Urology & Nephrology
Kevin J. Hebert, Brian J. Linder, Matthew T. Gettman, Daniel Ubl, Elizabeth B. Habermann, Timothy D. Lyon, Matthew J. Ziegelmann, Boyd R. Viers
Summary: The study analyzed data from a national surgical outcomes registry to compare the 30-day morbidity of upper and lower ureteral reconstruction surgery using open and minimally invasive approaches. The findings suggest that open surgery was associated with increased 30-day complications across multiple postoperative outcome measures, highlighting the potential benefits of considering a minimally invasive approach for these procedures.
JOURNAL OF ENDOUROLOGY
(2022)
Article
Surgery
Nicholas P. McKenna, Amy E. Glasgow, Omair A. Shariq, David W. Larson, Omar M. Ghanem, Travis J. McKenzie, Elizabeth B. Habermann
Summary: This study investigated the frequency and clinical value of routine postoperative day 1 laboratory tests after bariatric operations. The findings showed that the abnormality rate of these tests was very low, and only a small percentage of abnormal results required intervention. The study suggests that postoperative day 1 laboratory tests should be ordered based on specific patient comorbidities and clinical criteria.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Orthopedics
Elizabeth B. Habermann, Alex H. S. Harris, Nicholas J. Giori
Summary: Direct data abstraction from patient charts has been the gold standard for quality and accuracy in medical research. This article reviews two programs that circumvent the high personnel costs by utilizing trained abstractors. These programs provide important benchmarks for big data efforts.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Orthopedics
Michael P. Bolognesi, Elizabeth B. Habermann
Summary: Individual or pooled commercial claims data sources provide valuable information for orthopaedic studies on short-term complications, costs, and utilization. These data sources contain deidentified data on demographic characteristics, enrollment start and end dates, procedures and medical diagnoses, and dispensed medications.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Editorial Material
Surgery
Elizabeth B. Habermann
Article
Surgery
Matthew Aizpuru, Amy E. Glasgow, Marita Salame, Omer Ul Hassan, Maria L. Collazo-Clavell, Todd A. Kellogg, Elizabeth B. Habermann, Karen Grothe, Omar M. Ghanem
Summary: This study aimed to explore the outcomes of bariatric surgery in patients with bipolar/schizoaffective disorder (BSD). The results showed that BSD patients had slightly improved weight loss compared to the control group over 24 months, with similar remission rates of obesity-related diseases. The rates of perioperative complications were similar, except for a higher risk of deep venous thrombosis in BSD patients. Additionally, BSD patients had increased alcohol use after bariatric surgery, highlighting the importance of psychological care in this population before and after surgery.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Surgery
Nicholas P. McKenna, Katherine A. Bews, Kathleen J. Yost, Robert R. Cima, Elizabeth B. Habermann
Summary: This study found that major low anterior resection syndrome (LARS) following low anterior resection surgery significantly impacts the quality of life. However, there is a lack of awareness among clinicians and patients regarding LARS, and treatment rates for LARS are low. This highlights the importance of long-term follow-up, improved education, and ongoing symptom assessment to enhance the treatment of major LARS.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)