Journal
ADIPOCYTE
Volume 5, Issue 2, Pages 130-135Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21623945.2016.1140708
Keywords
brown fat; beige fat; morphogens; cytoskeleton dynamics; cell shape
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Funding
- NIDDK NIH HHS [T32 DK007201] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [T32DK007201] Funding Source: NIH RePORTER
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Brown and beige (or brite) fat cells are capable of evoking non-shivering thermogenesis in response to cold and beta-adrenergic stimulation. By metabolizing lipids and carbohydrate via uncoupled respiration these cells directly convert energy to heat. The discovery of brown and brown-like adipocytes in adult humans has reinvigorated interest in stimulating brown and beige fat development to combat the obesity epidemic. This review focuses on the role that cytoskeleton dynamics play in the regulation of adipocyte biology, specifically beige and brown fat development and how newly discovered adipogenic morphogens affect these processes.
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