Article
Microbiology
Abbas Karimi, Elham Mohebbi, Sandrine Mckay-Chopin, Hamideh Rashidian, Maryam Hadji, Vahideh Peyghambari, Maryam Marzban, Ahmad Naghibzadeh-Tahami, Mahin Gholipour, Farin Kamangar, Massimo Tommasino, Tarik Gheit, Kazem Zendehdel
Summary: This study analyzed the detection of alpha-, beta-, and gamma-HPVs in oral rinse samples of HNSCC cases and controls in Iran, finding that the contribution of alpha-HPVs to HNSCC in Iran is lower than global prevalence, and high-risk alpha-HPVs or cutaneous beta- and gamma-HPVs were not associated with HNSCC development.
MICROBIOLOGY SPECTRUM
(2022)
Article
Psychology, Developmental
Brittany L. Rosen, Pamina Gorbach, Lili Ding, Courtney Covert, Aaron C. Ermel, Emmanuel Chandler, Talia Malagon, Jessica A. Kahn
Summary: This study aimed to determine individual-and partner-level factors associated with HPV infection in vaccinated and unvaccinated men. The results showed that sexual network variables associated with HPV infection differed based on vaccination status and HPV type. Concurrent sexual relationships and characteristics of sexual partners were consistent risk factors for HPV infection.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Zigui Chen, Filippo Utro, Daniel Platt, Rob DeSalle, Laxmi Parida, Paul K. S. Chan, Robert D. Burk
Summary: A study evaluated the characteristics and differences of Alpha-, Beta- and Gamma-PVs, revealing that Gamma-PVs have the highest genetic diversity and reduced selective pressures. Additionally, a sequence alignment-free trimer phylogeny algorithm grouped most HPV types into a monophyletic clade, providing insights into the relationships among different HPV types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Maria Gonzalez-Cano, Francisco Garrido-Pena, Eugenia Gil-Garcia, Marta Lima-Serrano, Maria Dolores Cano-Caballero
Summary: The study found a lack of communication between adolescents and parents regarding sexual behavior, as well as scarce knowledge about HPV and vaccination in both groups. Parents mistrust vaccination due to a lack of qualified and verified information about its benefits.
Article
Immunology
Rachel L. Winer, John Lin, Troy D. Querec, Elizabeth R. Unger, Joshua E. Stern, Jessica M. Rudd, Matthew R. Golden, Fred Swanson, Lauri E. Markowitz, Elissa Meites
Summary: A study found that among men who have sex with men, those who reported receiving the HPV vaccine before the age of 18 had a lower prevalence of penile HPV infection. This suggests that HPV vaccination is effective in preventing penile HPV infections in young men who have sex with men.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Nelli T. Suominen, Tiina H. Luukkaala, Claudie Laprise, Marjut A. Haataja, Seija E. Grenman, Stina M. Syrjaenen, Karolina Louvanto
Summary: This study aimed to determine whether vertical human papillomavirus (HPV) transmission occurs from parents to their offspring before or during birth. The study included 321 mothers, 134 fathers, and their 321 newborn offspring. The results showed statistically significant genotype-specific HPV concordance between mother-newborn and father-newborn pairs, suggestive for vertical HPV transmission, but transmission from the father to the newborn remains uncertain.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Sara F. Haddad, Anthony Kerbage, Roland Eid, Hampig R. Kourie
Summary: The study revealed a lack of knowledge and low vaccination rate of HPV among Lebanese medical students. Education initiatives are crucial to raise awareness and promote vaccination, especially among medical students, who represent the future healthcare providers and policymakers of the country.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Talia Malagon, Aaron MacCosham, Ann N. Burchell, Mariam El-Zein, Pierre-Paul Tellier, Francois Coutlee, Eduardo L. Franco
Summary: The study shows that transmission rate of HPV from women-to-men is higher than that from men-to-women, and using condoms can reduce the risk of HPV transmission.
Review
Biotechnology & Applied Microbiology
Elissa Meites, Timothy J. Wilkin, Lauri E. Markowitz
Summary: Gay, bisexual, and other MSM and transgender women, especially those living with HIV, are disproportionately affected by HPV. Routine HPV vaccination is recommended for adolescents aged 11-12 and individuals up to age 26 in the United States, with efforts to increase vaccination coverage and monitor health impacts.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Oncology
Marjorie M. A. de Souza, Gunter Hartel, Catherine M. Olsen, David C. Whiteman, Annika Antonsson
Summary: This Australian-based study assessed the prevalence of oral HPV infection in Australian residents and found that the prevalence was 7.2%. The study also found a strong association between oral HPV infection and sexual behaviors, and suggested that HPV vaccination may result in a lower risk of infection with nonavalent HPV types.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Tina M. Rehm, Elke Straub, Thomas Iftner, Frank Stubenrauch
Summary: This study found that the complete beta-HPV49 genome lacks immortalizing activity in normal human keratinocytes unless the E8 gene is inactivated. High-level expression of E6 and E7 is necessary for immortalization.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Annika Antonsson, Marjorie M. A. de Souza, Benedict J. Panizza, David C. Whiteman
Summary: Oropharyngeal cancer is increasingly caused by HPV, possibly due to changing sexual behavior. Sexual intercourse elicits a stronger immune response to HPV compared to oral sex, potentially leading to a weaker immune response in individuals who have their oral sex debut before or at the same time as sexual intercourse, increasing their risk of developing persistent oral HPV infection and oropharyngeal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Immunology
Proma Paul, Anne Hammer, Anne F. Rositch, Anne E. Burke, Raphael P. Viscidi, Michelle Silver, Nicole Campos, Ada O. Youk, Patti E. Gravitt
Summary: Through a prospective cohort study conducted in Baltimore, Maryland, it was found that the newly detected HPV in middle-aged women mainly reflects a recurrence of previously acquired HPV, rather than solely being linked to new sexual partners.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Eva M. Moya, Araceli Garcia, Amy Joyce Ponder, Gabriel Frietze
Summary: The Human Papillomavirus (HPV) is the most common sexually transmitted infection, and healthcare providers and community health workers play a crucial role in promoting the HPV vaccine and educating about HPV. A study identified barriers to HPV knowledge, gaps in self-perceived roles, and opportunities for action in HPV cancer prevention.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Immunology
Yi-Chia Huang, Hsin-Yun Sun, Wang-Huei Sheng, Szu-Min Hsieh, Sung-Hsi Huang, Guan-Jhou Chen, Wang-Da Liu, Sui-Yuan Chang, Yi-Ching Su, Li-Hsin Su, Wen-Chun Liu, Chen-Ching Hung
Summary: Seroprotection of neonatal hepatitis B virus vaccination may wane among people living with HIV, and periodic testing and revaccination should be considered.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Otorhinolaryngology
Martina Bertinazzi, Tarik Gheit, Jerry Polesel, Sandrine McKay-Chopin, Cesare Cutrone, Marianna Sari, Marta Sbaraglia, Angelo Paolo Dei Tos, Piero Nicolai, Massimo Tommasino, Paolo Boscolo-Rizzo
Summary: The study aimed to evaluate the prevalence of different HPV genera in JoRRP and examine the association of viral features with clinical outcomes. Results suggested a correlation between the number of different HPV co-infections and the severity of the disease in JoRRP patients.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Virology
Luisa Galati, Susanna Chiocca, Daria Duca, Marta Tagliabue, Cindy Simoens, Tarik Gheit, Marc Arbyn, Massimo Tommasino
Summary: Head and neck squamous cell carcinoma (HNSCC) is a common cancer with increasing incidence globally. Alcohol consumption, smoking, and HPV infections are major risk factors for HNSCC development. HPV16 is the most frequently associated HPV type. There are currently no screening programs or identifiable pre-malignant lesions for HPV-related HNSCC. Therefore, there is an urgent need for general diagnostic algorithms and HPV biomarkers for early diagnosis, disease progression, and recurrence of HPV-driven HNSCC.
TUMOUR VIRUS RESEARCH
(2022)
Article
Virology
Concetta Saponaro, Luisa Galati, Tarik Gheit, Susanna Anita Pappagallo, Milena Zambetti, Francesco Alfredo Zito, Rosa Angela Cardone, Stephan Joel Reshkin, Massimo Tommasino
Summary: This study found that mucosal HPV types have different impacts on the NHERF-1 protein level in benign and malignant anogenital lesions.
Article
Oncology
Imogen Sharkey Ochoa, Esther O'Regan, Mary Toner, Elaine Kay, Peter Faul, Connor O'Keane, Roisin O'Connor, Dorinda Mullen, Mataz Nur, Eamon O'Murchu, Jacqui Barry-O'Crowley, Niamh Kernan, Prerna Tewari, Helen Keegan, Sharon O'Toole, Robbie Woods, Susan Kennedy, Kenneth Feeley, Linda Sharp, Tarik Gheit, Massimo Tommasino, John J. O'Leary, Cara M. Martin
Summary: HPV infection has been identified as a significant factor in the development of head and neck squamous cell carcinoma (HNSCC). HPV's involvement seems to be associated with better survival and prognosis in patients and suggests the need for different treatment strategies. Limited data on HPV infection in Europe exists, so this study aimed to investigate HPV's impact on HNSCC patient outcomes in the Irish population, providing important findings for further research and treatment pathways for HPV-related HNSCC.
Article
Oncology
Tarik Gheit, Richard Muwonge, Eric Lucas, Luisa Galati, Devasena Anantharaman, Sandrine McKay-Chopin, Sylla G. Malvi, Kasturi Jayant, Smita Joshi, Pulikkottil O. Esmy, M. Radhakrishna Pillai, Partha Basu, Rengaswamy Sankaranarayanan, Massimo Tommasino
Summary: This study compared the prevalence of oral HPV infections in women vaccinated with different doses of HPV vaccine and found that three doses of the vaccine were more effective in preventing oral HPV infection compared to a single dose.
Article
Oncology
Fazlur Rahman Talukdar, David Israel Escobar Marcillo, Ruhina Shirin Laskar, Alexei Novoloaca, Cyrille Cuenin, Paolo Sbraccia, Lorenza Nistico, Valeria Guglielmi, Tarik Gheit, Massimo Tommasino, Eugenia Dogliotti, Paola Fortini, Zdenko Herceg
Summary: This study found that weight loss after bariatric surgery is associated with DNA methylation changes in immune and inflammatory gene pathways. These results were validated in an independent cohort of monozygotic twins. Additionally, bariatric surgery significantly decelerates epigenetic aging. The findings suggest that the effectiveness of weight loss through bariatric surgery may be mediated by epigenetic regulation of genes involved in endothelial and adipose tissue function.
CLINICAL EPIGENETICS
(2022)
Article
Public, Environmental & Occupational Health
Jean-Marc Kutz, Pia Rausche, Tarik Gheit, Dewi Ismajani Puradiredja, Daniela Fusco
Summary: This review synthesizes the factors influencing the successful implementation of HPV vaccination programs in sub-Saharan Africa in order to improve roll-out and coverage. The review provides an overview and contextualizes the barriers and facilitators of HPV vaccination implementation in 12 countries in sub-Saharan Africa. Lessons learned from past experiences of HPV vaccination in sub-Saharan Africa can contribute to more effective national HPV vaccination programs targeted at eliminating cervical cancer and implementing the WHO triple intervention strategy.
Article
Dermatology
Manuelle Viguier, Corine Perals, Beatrice Poirier, Maxime Battistella, Francois Aubin, Herve Bachelez, Jean-Luc Pretet, Tarik Gheit, Massimo Tommasino, Antoine Touze, Marie-Lise Gougeon, Nicolas Fazilleau
Summary: Lichen planus (LP) is a chronic inflammatory disease characterized by CD8(+) T-cell infiltrate, and HPV16-specific CD8(+) T-cells are involved in different clinical forms of LP. Lichen sclerosus et atrophicus (LSA) has a different immune response, with oligoclonal TCRVss6(+) CTL repertoire.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Virology
Luana Lorena Silva Rodrigues, Jose Henrique Pilotto, Katrini Guidolini Martinelli, Alcina F. Nicol, Vanessa Salete De Paula, Tarik Gheit, Nathalia Silva Carlos Oliveira, Carlos Silva-de-Jesus, Vikrant V. Sahasrabuddhe, Diane M. Da Silva, W. Martin Kast, Justin Hardick, Charlotte A. Gaydos, Mariza Goncalves Morgado
Summary: The aim of this study was to classify the diversity of anal HPV and non-HPV sexually transmitted infections (STIs) and compare the concordance between anal and genital infections in HIV-infected and uninfected women living in the Tapajos region, Amazon, Brazil. The overall prevalence of anal HPV infection was high, especially in HIV-infected women. The concordance analysis showed moderate to fair agreement between anal and genital HPV and non-HPV STIs.
Article
Microbiology
Amina Gihbid, Amal El Amrani, Fatima Zahra Mouh, Tarik Gheit, Mustapha Benhessou, Mariam Amrani, Sandrine McKay-Chopin, Selma Mohamed Brahim, Souha Sahraoui, Abdelouaheb Bennani, Mohammed El Mzibri, Meriem Khyatti
Summary: Breast cancer is the most common cancer in women worldwide, accounting for a significant percentage of new cancer cases and deaths. A study in Morocco explored the presence of viral DNA in breast cancer tissues and found a high prevalence of Epstein-Barr virus (EBV), suggesting its potential role in breast cancer development and progression.
Article
Immunology
Walid A. Al-Soneidar, Sam Harper, Francois Coutlee, Tarik Gheit, Massimo Tommasino, Belinda Nicolau
Summary: This study investigated the prevalence of alpha (α), beta (β), and gamma (γ) human papillomaviruses (HPVs) among head and neck cancer (HNC) cases and controls, and their relationship with sociodemographic, behavioral, and oral health factors. The findings showed that the prevalence of α- and γ-HPV was associated with sexual activity, smoking, and drinking habits, while the prevalence of β-HPV was not. Tumor samples mainly included α-HPV, with HPV-16 being the most common genotype.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Nilanjana Chatterjee, Farhin Sultana, Rituparna Roy, Samyadipta Dey, Sukanya Naskar, Aniruddha Dam, Anup K. Bhowmick, Rakiba Begum, Shyam S. Mandal, Ranajit K. Mandal, Jayanta Chakrabarti, Chinmay K. Panda, Massimo Tommasino, Tarik Gheit, Sankhadeep Dutta
Summary: This study investigated the prevalence of novel-HPV 223 and 225 in oral mucosa and keratinized skin epithelium. HPV 223 was found to be present only in the oral mucosal epithelium, while HPV 225 was found in both oral mucosa and skin epithelium.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Taja Lozar, Aysenur Keske, Racheal S. Dube Mandishora, Qiqi Yu, Adam Bailey, Jin Xu, Massimo Tommasino, Stephanie M. Mcgregor, Paul F. Lambert, Tarik Gheit, Megan B. Fitzpatrick
Summary: This study is the first to report the association between p16-negative vulvar squamous intraepithelial lesions and detection of beta-HPVs. These findings expand possible etiologic mechanisms that may contribute to p16-negative lesions of the vulva.
Article
Oncology
Abbas Karimi, Tohid Jafari-Koshki, Mojtaba Zehtabi, Farzaneh Kargar, Tarik Gheit
Summary: Liquid biopsy using HPV ctDNA can predict the rate of relapse or recurrence after treatment, with post-treatment measurement being more effective than baseline assessment. HPV ctDNA could be used as a surrogate or incorporated with other methods for detecting residual disease.
