Article
Environmental Sciences
Alberto Romero-Blanco, Adrian Remon-Elola, Alvaro Alonso
Summary: Microplastics are widely spread in aquatic ecosystems, impacting the behavior of aquatic organisms such as the New Zealand mud snail P. antipodarum. This study found that while microplastics did not significantly affect mortality and reproduction in P. antipodarum, they did lead to a notable increase in reaction time, especially at environmental concentrations.
WATER AIR AND SOIL POLLUTION
(2021)
Article
Environmental Sciences
Luigi Margiotta-Casaluci, Stewart F. Owen, Matthew J. Winter
Summary: The extrapolation of biological data across species is essential for biomedical research and drug development. The use of comparative biology enables researchers to understand human diseases and develop safe and effective medicines. However, the presence of pharmaceuticals in the environment and the need to assess their impact on wildlife have led to increased interest in extrapolating pharmacological and toxicological data across different species. This article discusses the theoretical and experimental advancements in this field over the past decade and calls for further research on the conservation of drug targets and the quantitative relationship between target modulation and adverse effects, as well as the use of high-throughput experimental and computational approaches to predict internal exposure dynamics.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Review
Environmental Sciences
Dan Li, Hongxing Chen, Hongsong Liu, Daniel Schlenk, Jingli Mu, Silvia Lacorte, Guang-Guo Ying, Lingtian Xie
Summary: Anticancer drugs are commonly detected in aquatic ecosystems, with potential toxic effects on aquatic organisms, particularly crustaceans. More research is needed to identify appropriate chronic endpoints for risk assessment thresholds, better understand the mechanisms of action, potential multigenerational toxicity, and trophic transfer in ecosystems.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Claudia Rivetti, Jade Houghton, Danilo Basili, Geoff Hodges, Bruno Campos
Summary: Over the past two decades, there has been a strong trend towards integrating cell-based and computational approaches in safety assessments, leading to a shift in global regulatory paradigms towards reducing and replacing animal use in toxicity tests. The understanding of molecular targets and pathways conservation allows for extrapolation of effects across species and determination of the applicability of assays and biological effects. A novel pipeline, G2P-SCAN, has been developed to support cross-species extrapolation of biological processes by extracting and structuring data from various databases, such as gene orthologs, protein families, entities, and reactions. The use of G2P-SCAN enables the analysis of orthology and functional families to identify conservation and susceptibility at the pathway level. Five case studies are discussed to demonstrate the validity and potential use of this pipeline in supporting species extrapolation for research and safety decisions. Environ Toxicol Chem 2023;00:1-15. (c) 2023 UNILEVER GLOBAL IP LTD. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Review
Environmental Sciences
Lena Barascou, Jean-Luc Brunet, Luc Belzunces, Axel Decourtye, Mickael Henry, Julie Fourrier, Yves Le Conte, Cedric Alaux
Summary: The gap between new evidence of pesticide toxicity in honeybees and conventional toxicological assays has led to the need for a combination of lethal and sublethal endpoints. Behavioral and reproductive performances have gained interest since the 2000s due to their ecological relevance and the advancement of new technologies. Homing flights and reproduction show great potential for pesticide risk assessment, with the importance of translating relevant endpoints into regulatory test methods highlighted for future research and improved ecological relevance through comparative studies.
Article
Environmental Sciences
Jiahua Guo, Shan Liu, Li Zhou, Bo Cheng, Qi Li
Summary: In the last two decades, there has been an increase in the number of detected activated pharmaceutical ingredients (APIs) in the natural environment globally, leading to the need for prioritizing and ranking APIs of high concern. A new method was developed in this study to estimate the priority of APIs by using the number of products per API on the market multiplied by its daily dose, along with hazard assessment and risk scoring. This approach could potentially be applied in countries/regions where information on API usage is limited or non-existent.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Environmental Sciences
Urszula Klekotka, Diana Rogacz, Izabela Szymanek, Julita Malejko, Piotr Rychter, Beata Kalska-Szostko
Summary: The aim of this study is to assess the ecotoxicity of magnetite iron oxide-based nanoparticles on terrestrial and aquatic organisms. By evaluating various organisms, it was found that these nanoparticles are harmful to organisms from different trophic levels. Physical and chemical characterization of the nanoparticles was also performed.
Review
Biochemistry & Molecular Biology
Chisato Kataoka, Shosaku Kashiwada
Summary: Exposure of aquatic organisms to immunotoxic pollutants may lead to changes in the immune system and health issues, even posing a threat to populations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Maria Antonopoulou, Margarita Dormousoglou, Alexandra Spyrou, Alexandra Aikaterini Dimitroulia, Dimitris Vlastos
Summary: This study investigated the toxic potential of the antidepressant Paroxetine (PRX) on aquatic organisms and human lymphocytes. The results showed that PRX caused toxic effects on aquatic organisms and induced cytotoxic and genotoxic effects in human lymphocytes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biotechnology & Applied Microbiology
Samantha Goodman, Grace Chappell, Kathryn Z. Guyton, Igor P. Pogribny, Ivan Rusyn
Summary: This study systematically reviewed the epigenetic alterations induced by occupational and environmental human carcinogens. The evidence of epigenetic effects varied across different agents, with DNA methylation being the most studied area and histone modifications/chromatin state alterations being less investigated. Future studies should consider comprehensive study designs and investigate the persistence of effects following cessation of exposure.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2022)
Review
Environmental Sciences
S. Thanigaivel, Saranya Vinayagam, Lalitha Gnanasekaran, R. Suresh, Matias Soto-Moscoso, Wei-Hsin Chen
Summary: Emerging pollutants, including nanomaterials and microplastics, pose risks to aquatic ecosystems and human health. Microalgae-based mitigation techniques have shown promise in addressing these pollutants.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Carlie A. LaLone, Donovan J. Blatz, Marissa A. Jensen, Sara M. F. Vliet, Sally Mayasich, Kali Z. Mattingly, Thomas R. Transue, Wilson Melendez, Audrey Wilkinson, Cody W. Simmons, Carla Ng, Chengxin Zhang, Yang Zhang
Summary: Computational screening using molecular modeling approaches is widely used in drug discovery. This study aimed to develop an analysis pipeline for cross-species extrapolation in chemical safety evaluation. The SeqAPASS tool and ITASSER-generated protein models were used for sequence and structural comparisons, providing evidence of conservation for toxicity extrapolation. The pipeline facilitates rapid and efficient toxicological assessments among species with limited or no existing toxicity data.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Environmental Sciences
Yaping Cai, Jianming Lin, Sylvia Gimeno, Frederic Begnaud, Bernd Nowack
Summary: This study aimed to estimate the environmental concentrations of fragrance encapsulates in freshwater, sediment, and soil for 34 selected countries. The results showed that the fragrance encapsulates had no observable effects in ecotoxicological tests. Further research is needed to investigate their distribution and impact on the environment.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Laura-Jayne. A. Ellis, Stephen Kissane, Iseult Lynch
Summary: This study highlights the importance of environmental nano-biological interactions on model species and their progeny for nanomaterial risk assessment. It shows how maternal exposure to silver and titanium dioxide NMs affects the biological traits of offspring across multiple generations, with different levels of exposure leading to varying outcomes in terms of growth, reproduction, and survival. The research also reveals transgenerational responses to NM exposure concentrations, providing valuable insights for environmental risk assessments and predicting impacts on ecological systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Yidan Shang, Jingliang Dong, Fajiang He, Kiao Inthavong, Lin Tian, Jiyuan Tu
Summary: Inhaled particulate matter is associated with nasal diseases. This study numerically investigated microparticle transport and deposition in human and monkey nasal cavities. Differences in deposition patterns were observed due to variations in nostril direction and nasal valve width.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Environmental
Mark Honti, Stefan Hahn, Dieter Hennecke, Thomas Junker, Prasit Shrestha, Kathrin Fenner
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2016)
Article
Engineering, Environmental
Prasit Shrestha, Thomas Junker, Kathrin Fenner, Stefan Hahn, Mark Honti, Rani Bakkour, Cecilia Diaz, Dieter Hennecke
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2016)
Article
Medicine, Legal
Martin May, Wiebke Drost, Sabine Germer, Tanja Juffernholz, Stefan Hahn
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2016)
Article
Public, Environmental & Occupational Health
Katharina Bluemlein, Manfred Elend, Tim Meijster, Alison Margary, Rosalie Tibaldi, Stefan Hahn, Susanne Hesse
ANNALS OF WORK EXPOSURES AND HEALTH
(2018)
Article
Environmental Sciences
Stefan Hahn, Klaus Schneider, Stefan Gartiser, Wolfgang Heger, Inge Mangelsdorf
ENVIRONMENTAL HEALTH
(2010)
Review
Environmental Sciences
Stefan Hahn, Jessica Meyer, Michael Roitzsch, Christiaan Delmaar, Wolfgang Koch, Janine Schwarz, Astrid Heiland, Thomas Schendel, Christian Jung, Urs Schlueter
Summary: Spray applications are efficient for distributing substances uniformly on surfaces, but there are challenges in modeling exposure. Systematic evaluation and inter-model harmonization are recommended to improve predictions and consider variation in spray equipment.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Environmental Sciences
Urs Schlueter, Jessica Meyer, Andreas Ahrens, Francesca Borghi, Frederic Clerc, Christiaan Delmaar, Antonio Di Guardo, Tatsiana Dudzina, Peter Fantke, Wouter Fransman, Stefan Hahn, Henri Heussen, Christian Jung, Joonas Koivisto, Dorothea Koppisch, Alicia Paini, Nenad Savic, Andrea Spinazze, Maryam Zare Jeddi, Natalie von Goetz
Summary: Exposure models are crucial in exposure science, and the European Exposure Science Strategy has identified exposure modelling as a priority area. The European Chapter of the International Society of Exposure Science (ISES Europe) formed a working group to assess the state of exposure modelling in Europe and develop a strategic plan for improvement. The plan includes actions such as collecting available models, publishing a living document, and developing a best-practices handbook.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Article
Environmental Sciences
Monika Nendza, Stefan Hahn, Michael Klein, Ursula Klaschka, Silke Gabbert
Summary: Replacing hazardous chemicals with safer alternatives is crucial for a toxic-free environment. SCoRA proposes a concern-based scoring scheme for a flexible and transparent assessment of the impact potential of chemical alternatives, considering ecotoxicity, human health effects, and exposure-related information.
ENVIRONMENTAL SCIENCES EUROPE
(2023)
Article
Environmental Sciences
Stefan Hahn, Dieter Hennecke
Summary: This article focuses on the fate of natural polymers in the environment and their implications for assessing the persistence of synthetic polymers. The degradation of natural polymers varies depending on their structure and properties, with chemical and enzymatic hydrolysis being the most important processes. Therefore, when assessing the persistence of synthetic polymers, meaningful endpoints and polymer-specific criteria should be established.
ENVIRONMENTAL SCIENCES EUROPE
(2023)
Article
Public, Environmental & Occupational Health
Katharina Schwarz, Katharina Bluemlein, Thomas Goeen, Stefan Hahn, Ralph Hebisch, Wolfgang Koch, Ulrich Poppek, Anja Schaeferhenrich, Urs Schlueter, Monika Krug
Summary: The application of biocidal products by foam as an alternative to droplet spraying has inhalation exposure to aerosols as a concern. The study quantified the formation of inhalable aerosols during foaming and measured the aerosol release fractions of the active substance. The results showed that the aerosol release fractions varied and could be correlated to the process and foam parameters.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Anja Schaeferhenrich, Katharina Bluemlein, Wolfgang Koch, Stefan Hahn, Katharina Schwarz, Ulrich Poppek, Ralph Hebisch, Urs Schlueter, Monika Krug, Thomas Goeen
Summary: This study provides comparative exposure data for foam and spray applications of biocidal products in occupational settings, showing that potential dermal exposure is higher than inhalation exposure. While foam application reduces inhalation exposure, it does not significantly affect potential dermal exposure.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Roland Scholz, Stefan Hahn, Annette Bitsch
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2014)
Meeting Abstract
Pharmacology & Pharmacy
Kristin Krome, Stefan Hahn, Susanne Schwonbeck, Gustav Koennecker, Oliver Licht
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2014)
Article
Environmental Sciences
K Michel, C Brinkmann, S Hahn, W Dott, A Eisentraeger
ENVIRONMENTAL TOXICOLOGY
(2004)