Article
Neurosciences
Maria Isabel Carrasco-Campos, Cristina Perez-Ramirez, Elena Macias-Cortes, Elena Puerta-Garcia, Antonio Sanchez-Pozo, Carmen Arnal-Garcia, Francisco Javier Barrero-Hernandez, Miguel Angel Calleja-Hernandez, Alberto Jimenez-Morales, Marisa Canadas-Garre
Summary: This study found that gene polymorphisms in TNFRSF10A-rs20576 and CTSS-rs1136774 have an impact on the response to IFN-beta after 24 months of treatment, while the variations in CBLB (rs12487066), OAS1 (rs10774671) or GRIA3 (rs12557782) genes do not affect individual response to IFN-beta.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Luis F. Gonzalez, Eric Acuna, Gabriel Arellano, Paola Morales, Paula Sotomayor, Felipe Oyarzun-Ampuero, Rodrigo Naves
Summary: A new delivery system of IFN-β nanoparticles via intranasal administration was developed to improve clinical symptoms and control neuroinflammation in an experimental model of multiple sclerosis, showing potential effectiveness, non-invasiveness, and cost-effectiveness as a therapy for MS.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Multidisciplinary Sciences
Marcello Moccia, Giuseppina Affinito, Antonio Capacchione, Roberta Lanzillo, Antonio Carotenuto, Emma Montella, Maria Triassi, Vincenzo Brescia Morra, Raffaele Palladino
Summary: This study demonstrates the feasibility of merging clinical registry and routinely-collected healthcare data for future multiple sclerosis research, and confirms the important role of interferon beta formulations in managing MS with positive clinical outcomes. Differences between interferon beta formulations are primarily driven by adherence and healthcare resource utilization.
Review
Immunology
Giulia Frazzei, Ronald F. van Vollenhoven, Brigit A. de Jong, Sarah E. Siegelaar, Dirkjan van Schaardenburg
Summary: The preclinical phase of autoimmune disorders is characterized by an initial asymptomatic phase followed by nonspecific signs and symptoms. The phenotype of autoimmune diseases depends on involved organs, genetic susceptibility, and pathophysiological processes. There are similarities between different autoimmune diseases, such as regional variations in prevalence, female preponderance, genetic risk factors at the HLA level, overlapping cytokine profiles, and lifestyle risk factors. These diseases have a lengthy prodromal phase with a gradually evolving interaction between genetic profile and environment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Alexandre Xavier, Maria Pia Campagna, Vicki E. E. Maltby, Trevor Kilpatrick, Bruce V. V. Taylor, Helmut Butzkueven, Anne-Louise Ponsonby, Rodney J. J. Scott, Vilija G. G. Jokubaitis, Rodney A. A. Lea, Jeannette Lechner-Scott
Summary: This study shows that IFN beta treatment modifies the methylation profile of interferon response genes in MS patients, and a methylation treatment score (MTS) was constructed to accurately distinguish between treated and untreated patients. The study also found that IFN beta treatment recruits the endogenous anti-viral molecular machinery and affects the methylation levels of dendritic cells and regulatory CD4+ T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Shay Menascu, Roy Aloni, Mark Dolev, David Magalashvili, Keren Gutman, Sapir Dreyer-Alster, Franck Tarpin-Bernard, Ran Achiron, Gil Harari, Anat Achiron
Summary: The study found that MS patients who received 6-month cognitive game training showed significant improvement in executive function and information processing speed. Compared to the control group, the training group had a significantly higher percentage of patients who maintained stability or improved in cognitive domains.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Article
Biology
Cristina-Florentina Plesa, Diana Maria Chitimus, Carmen Adella Sirbu, Monica Marilena Tantu, Minerva Claudia Ghinescu, Daniela Anghel, Florentina Ionita-Radu
Summary: This case study describes a particular association between the remission phase of multiple sclerosis and the violent onset of interferon-induced thrombotic thrombocytopenic purpura.
Article
Immunology
Pablo Aliaga-Gaspar, Isaac Hurtado-Guerrero, Nicolas Lundahl Ciano-Petersen, Patricia Urbaneja, Isabel Brichette-Mieg, Virginia Reyes, Jose Luis Rodriguez-Bada, Roberto Alvarez-Lafuente, Rafael Arroyo, Ester Quintana, Lluis Ramio-Torrenta, Ana Alonso, Laura Leyva, Oscar Fernandez, Begona Oliver-Martos
Summary: IFN-beta treatment induces sIFNAR2 production in RRMS, with higher levels associated with a reduction in therapeutic response. In the short-term, some patients showed increased sIFNAR2 expression after IFN-beta stimulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Javier Marin-Prida, Nancy Pavon-Fuentes, Nielsen Lagumersindez-Denis, Hanlet Camacho-Rodriguez, Ana Margarita Garcia-Soca, Rocio De La Caridad Sarduy-Chavez, Erica Leandro Marciano Vieira, Juliana Carvalho-Tavares, Viviana Falcon-Cama, Julio Raul Fernandez-Masso, Ignacio Hernandez-Gonzalez, Gillian Martinez-Donato, Gerardo Guillen-Nieto, Eduardo Penton-Arias, Mauro Martins Teixeira, Giselle Penton-Rol
Summary: In this study, the potential benefits and mechanisms of action of Phycocyanobilin (PCB) in combating chronic experimental autoimmune encephalomyelitis (EAE), a nonclinical model of multiple sclerosis (MS), were evaluated. The study found that PCB can improve neurological symptoms, reduce inflammatory cytokine levels, and regulate relevant genes at the genetic level. In addition, PCB can reduce demyelination, decrease neuronal damage, and promote the generation of oligodendrocyte precursor cells. The combination of PCB with Interferon-beta (IFN-beta) showed better therapeutic effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Gloria Tucci, Cristina Garufi, Ilenia Pacella, Marta Zagaglioni, Alessandra Pinzon Grimaldos, Fulvia Ceccarelli, Fabrizio Conti, Francesca Romana Spinelli, Silvia Piconese
Summary: This study verifies the effects of Baricitinib on STAT phosphorylation in monocytes of rheumatoid arthritis (RA) patients and suggests that monocyte frequency and STAT1 phosphorylation could serve as early markers of response to Baricitinib therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Shahram Seyfi, Kayvan Latifi, Parviz Amri Male, Mahmoud Sadeghi Haddad Zavareh, Khadijeh Ezoji, Mousa Mohammadnia-Afrozi
Summary: This study retrospectively evaluated the clinical treatment outcomes of COVID-19 inpatients who received IFN-beta 1-a and IFN-beta 1-b. The results showed no significant difference between the two groups in terms of shortening disease time, clinical improvements, and other outcomes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Gianmarco Bellucci, Angela Albanese, Caterina Rizzi, Virginia Rinaldi, Marco Salvetti, Giovanni Ristori
Summary: Interferon-beta (IFN-beta) for Multiple Sclerosis (MS) is celebrating its 30th anniversary. The COVID-19 pandemic has reignited interest in the biology of interferon in health and disease, expanding its potential applications beyond neuroinflammation. The antiviral properties of IFN-beta align with the viral etiology hypothesis of MS, particularly in relation to the Epstein-Barr Virus. Furthermore, IFNs play a crucial role in the acute phase of SARS-CoV-2 infection, and IFN-beta has shown protective effects against SARS-CoV-2 in individuals with MS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ide Smets, Teresa Prezzemolo, Maya Imbrechts, Klara Mallants, Tania Mitera, Stephanie Humblet-Baron, Benedicte Dubois, Patrick Matthys, Adrian Liston, An Goris
Summary: The study indicates that both fingolimod and interferon-beta induce BAFF protein and mRNA expression, leading to a shift in the B cell pool towards a regulatory phenotype. Specifically, BAFF protein correlated with an increase in transitional B cells, decrease in switched B cells, and reduction in B cell-surface BAFF-R expression. However, BAFF does not directly influence the expression of immunoregulatory cytokines IL-10 and IL-35.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Runzhi Huang, Minghao Jin, Yifan Liu, Yuwei Lu, Mengyi Zhang, Penghui Yan, Shuyuan Xian, Siqiao Wang, Hao Zhang, Xinkun Zhang, Shaofeng Chen, Bingnan Lu, Yiting Yang, Zongqiang Huang, Xin Liu, Shizhao Ji
Summary: This study used bibliometric analysis to examine the global scientific production and distribution of fibroblast studies related to rheumatoid diseases (RDs). The analysis identified three important research directions: activation of different subsets of fibroblasts, regulation of fibroblast function, and in vitro validation of existing discoveries.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Jin Hyung Jung, Kyung Do Han, Young Bok Lee, Yong Gyu Park
Summary: The study found that there is an association between Behcet's disease and multiple sclerosis and rheumatoid arthritis, with patients with Behcet's disease having significantly higher odds of developing multiple sclerosis and rheumatoid arthritis compared to the control group.
