Intracerebral Distribution of the Oncometabolite d-2-Hydroxyglutarate in Mice Bearing Mutant Isocitrate Dehydrogenase Brain Tumors: Implications for Tumorigenesis

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Hypoxia Induces Production of L-2-Hydroxyglutarate

(2015) Andrew M. Intlekofer et al.   Cell Metabolism

Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

(2015) William M. Oldham et al.   Cell Metabolism

New Developments in the Pathogenesis and Therapeutic Targeting of the IDH1 Mutation in Glioma

(2015) Lilia Dimitrov et al.   International Journal of Medical Sciences

The Notch Ligand DLL4 Defines a Capability of Human Dendritic Cells in Regulating Th1 and Th17 Differentiation

(2015) Lijun Meng et al.   JOURNAL OF IMMUNOLOGY

Global Profiling of Metabolic Adaptation to Hypoxic Stress in Human Glioblastoma Cells

(2015) Paulina Kucharzewska et al.   PLoS One

Clinical development of cancer therapeutics that target metabolism

(2015) B.F. Clem et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

T cell metabolic fitness in antitumor immunity

(2015) Peter J. Siska et al.   TRENDS IN IMMUNOLOGY

Intratumor Heterogeneity and Its Impact on Drug Distribution and Sensitivity

(2014) I Fuso Nerini et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

Oncometabolites: linking altered metabolism with cancer

(2013) Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family

(2013) Ana M. Pajor   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

2-Hydroxyglutarate is not a metabolite; D-2-hydroxyglutarate and L-2-hydroxyglutarate are!

(2013) E. A. Struys   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Garbage Truck of the Brain

(2013) M. Nedergaard   SCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D13C magnetic resonance spectroscopic imaging

(2012) Ilwoo Park et al.   MAGNETIC RESONANCE IN MEDICINE

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo

(2012) Janeta Popovici-Muller et al.   ACS Medicinal Chemistry Letters

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Isocitrate dehydrogenase mutations in gliomas

(2011) Changcun Guo et al.   CURRENT OPINION IN NEUROLOGY

Isocitrate dehydrogenase mutations in diffuse gliomas: clinical and aetiological implications

(2011) R. Gupta et al.   JOURNAL OF CLINICAL PATHOLOGY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunohistochemical localization of caspase-3, caspase-9 and Bax in U87 glioblastoma xenografts

(2008) Otilia Zarnescu et al.   JOURNAL OF MOLECULAR HISTOLOGY

Organic anion transporters OAT1 and OAT4 mediate the high affinity transport of glutarate derivatives accumulating in patients with glutaric acidurias

(2008) Yohannes Hagos et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE