Journal
REACTION CHEMISTRY & ENGINEERING
Volume 1, Issue 1, Pages 96-100Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5re00083a
Keywords
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Funding
- AstraZeneca
- EPSRC DTG
- University of Leeds
- EPSRC [EP/K039202/1] Funding Source: UKRI
- Austrian Science Fund (FWF) [J 3449] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [1603652, EP/K039202/1, 1232745] Funding Source: researchfish
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An automated continuous reactor for the synthesis of organic compounds, which uses online mass spectrometry (MS) for reaction monitoring and product quantification, is presented. Quantitative and rapid MS monitoring was developed and calibrated using HPLC. The amidation of methyl nicotinate with aqueous MeNH2 was optimised using design of experiments and a self-optimisation algorithm approach to produce > 93% yield.
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