Article
Optics
Francisco M. Munoz-Perez, Vicente Ferrando, Walter D. Furlan, Juan A. Monsoriu, J. Ricardo Arias-Gonzalez
Summary: Optical manipulation is an interdisciplinary field that involves manipulating particles at the micro and nanoscale. This article proposes a new trapping strategy using aperiodic kinoform diffractive lens based on the m-Bonacci sequence, which allows simultaneous trapping of particles in different focal planes. The extended manipulation capabilities enable dynamic three-dimensional all-optical lattices, which have various microscale and nanoscale applications.
Article
Physics, Applied
Nicolo Maccaferri, Paolo Vavassori, Denis Garoli
Summary: The combination of magneto-plasmonic nanopores and core-shell nanoparticles allows for longer acquisition times and the formation of a high-intensity electromagnetic field, enhancing the sensitivity of single-molecule detection in biosensors.
APPLIED PHYSICS LETTERS
(2021)
Article
Optics
Xingyi Li, Yuan Zhou, Suyang Ge, Guoxi Wang, Siqi Li, Zilei Liu, Xing Li, Wei Zhao, Baoli Yao, Wenfu Zhang
Summary: This article introduces a new type of on-chip optical tweezers that allow for diverse types of manipulation of micro-particles. By utilizing both the propagation phase and Pancharatnam-Berry phase, the researchers demonstrated spin-dependent trapping, moving, and circling of micro-particles and control of the spinning rotation using the spin angular momentum of the output beam.
Article
Multidisciplinary Sciences
Ane Kritzinger, Andrew Forbes, Patricia B. C. Forbes
Summary: In this study, micro-scaled polymer beads were functionalized with nano-scaled quantum dots to enable optical trapping and tweezing in an all-digital all-optical configuration, with in-situ fluorescence measurement. The chemistry required for this process, including deactivating the optical trapping environment and controlling size, adhesion, and agglomeration, is outlined. A novel holographic optical trapping set-up utilizing vectorially structured light is introduced, allowing for the delivery of tuneable forms of light and advancing the application of optics in chemistry.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Elham Babaei, Demelza Wright, Reuven Gordon
Summary: By combining fringe-field dielectrophoresis with nano aperture optical tweezers, single molecule analysis of proteins in an aqueous environment without modification is achieved. The trapping time for proteins is significantly faster when the counter electrode is positioned outside of the solution compared to the more common configuration inside the solution. These findings are a major advancement for the nanoaperture optical trapping technique for high-throughput protein analysis.
Article
Chemistry, Multidisciplinary
Daniel Saliba, Tuan Trinh, Christophe Lachance-Brais, Alexander L. Prinzen, Felix J. Rizzuto, Donatien de Rochambeau, Hanadi F. Sleiman
Summary: This research introduces a novel DNA nanotweezer that achieves simultaneous, asymmetric elongation of the molecular core through PCR, enabling the DNA tweezer to have a wider range of motion and the ability to respond to complex stimuli. The DNA nanotweezer can wrap around multiple streptavidin units, providing site-specific streptavidin recognition capability.
Article
Physics, Multidisciplinary
J. J. Hernandez-Sarria, Osvaldo N. Oliveira Jr, J. R. Mejia-Salazar
Summary: Researchers have designed an all-dielectric platform to optically trap small dielectric nanoparticles without heating the nanostructure in the infrared regime. By creating a strong electromagnetic hot spot, nanoparticles as small as 20 nm can be captured without heating.
PHYSICAL REVIEW LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Matthew Eliceiri, Costas P. Grigoropoulos
Summary: In this study, we have improved the maximum two-dimensional translation rate of optically tweezed silicon nanowires using a silicon film substrate and a specific laser wavelength. We have also reduced the power usage significantly. The mechanism for the enhanced tweezing effect was explained using finite difference time domain simulation, and the robust and deterministic placement of the nanowires on the film surface was demonstrated experimentally.
Article
Chemistry, Multidisciplinary
Theodoros D. Bouloumis, Domna G. Kotsifaki, Sile Nic Chormaic
Summary: By using proper nanocavity design and excitation, the self-induced back-action (SIBA) effect combined with Fano resonance has achieved stable trapping of 20 nm gold particles in metamaterial tweezers with low excitation intensity. Simulations reveal the existence of two groups of hotspots on the plasmonic array, which have tunable trap stiffnesses and can be used for sorting particles and biological molecules based on their characteristics.
Article
Biochemical Research Methods
Clementine Lipp, Kevin Uning, Jonathan Cottet, Daniel Migliozzi, Arnaud Bertsch, Philippe Renaud
Summary: A novel concept for controlled trapping and releasing of beads and cells in a PDMS microfluidic channel without obstacles present has been presented. The trapping principle relies on a two-level microfluidic configuration and pressure conditions are defined for each mode based on hydraulic-electrical circuit equivalence. Demonstrations show successful trapping of different materials with various working modes and pressure conditions.
Article
Physics, Applied
Domna G. Kotsifaki, Viet Giang Truong, Sile Nic Chormaic
Summary: This work demonstrates the sequential trapping of 20nm particles using metamaterial plasmonic optical tweezers, with the investigation of multiple trapping via trap stiffness measurements for various trapping configurations. The plasmonic configuration could be utilized as a light-driven nanoscale sorting device, offering an alternative method to trap multiple nanoparticles at distinct hotspots and control mass transport on the nanoscale.
APPLIED PHYSICS LETTERS
(2021)
Article
Chemistry, Physical
Wenshan Li, Frank Hennrich, Benjamin S. Flavel, Simone Dehm, Manfred Kappes, Ralph Krupke
Summary: Dielectrophoresis (DEP) describes the motion of suspended objects in an inhomogeneous electric field. Researchers have extensively studied DEP in aqueous and organic solutions, with recent applications focused on polymer-wrapped single-walled carbon nanotubes (SWCNTs) in organic solvents due to the availability of ultra-pure SWCNT content.
Article
Chemistry, Physical
Zhao Wang
Summary: This study used molecular dynamics simulations to investigate the physisorption behavior of hydrocarbon molecules on a covalent graphene-nanotube hybrid nanostructure. The results showed that the adsorbed molecules could diffuse into the nanotubes without external driving forces, due to variations in binding energy. Interestingly, the molecules remained trapped within the tubes even at room temperature, thanks to a gate effect observed at the neck region, overcoming the typical hindrance from concentration gradients. This passive mass transport and retention mechanism has implications for gas molecule storage and separation.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Multidisciplinary Sciences
Wei-Chen Lo, Ching-Hsiang Fan, Yi-Ju Ho, Chia-Wei Lin, Chih-Kuang Yeh
Summary: The AVT technique, inspired by tornadoes, successfully captures and increases the local concentration of MBs. This compact, easy-to-use, and biocompatible method enables systemic drug administration with extremely low doses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
O-Joun Lee, Hae Gyun Lim, K. Kirk Shung, Jin-Taek Kim, Hyung Ham Kim
Summary: This study aims to automatically measure the non-linear elastic moduli of live cells using conventional neural networks and multilayer perceptrons while maintaining the accuracy of manual methods. The proposed system applies pressure on cells, observes their physical changes, and utilizes machine learning models to infer their deformability. The experimental results demonstrate that the proposed system can distinguish invasive breast cancer cells from noninvasive ones.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Adam D. Carrithers, Martin J. Brown, Mohamed Z. Rashed, Sabina Islam, Orlin D. Velev, Stuart J. Williams
Review
Biochemical Research Methods
Mohamed Z. Rashed, Stuart J. Williams
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2020)
Article
Biophysics
Taylor J. Moehling, Dong Hoon Lee, Meghan E. Henderson, Mariah K. McDonald, Preston H. Tsang, Seba Kaakeh, Eugene S. Kim, Steven T. Wereley, Tamara L. Kinzer-Ursem, Katherine N. Clayton, Jacqueline C. Linnes
BIOSENSORS & BIOELECTRONICS
(2020)
Article
Mechanics
A. K. Nayak, A. Haque, B. Weigand, Steve Wereley
Article
Thermodynamics
Stuart J. Williams
Summary: This study investigates the use of heat and humidity for de-activating N95 masks, with food-warming cabinets potentially reaching suitable temperatures for this purpose. The experimental procedure could serve as a guide for characterizing similar food-warming cabinets.
JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME
(2021)
Article
Biophysics
Mohamed Z. Rashed, Jonathan A. Kopechek, Mariah C. Priddy, Krystal T. Hamorsky, Kenneth E. Palmer, Nikhil Mittal, Joseph Valdez, Joseph Flynn, Stuart J. Williams
Summary: The study demonstrates a rapid method for detecting COVID-19 antibodies using a commercially available impedance sensing platform. The platform successfully differentiated and detected positive clinical samples from negative controls, showing a strong correlation with standard ELISA test results. Detection occurs in less than five minutes, making it a promising tool for clinical settings.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Engineering, Electrical & Electronic
Choongbae Park, Steven T. Wereley
Summary: This paper presents a qualitative and quantitative analysis of rapid microvortex flow generation and manipulation induced by opto-electrohydrodynamic technique. A flow named twin opposing microvortex (TOMV) is generated by infrared laser light under non-uniform AC electric fields. It is found that the strength of the TOMV flow can be tuned by adjusting the AC voltage and frequency, with potential applications in in situ micropump and mixing.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2021)
Article
Chemistry, Physical
Md Mahmudur Rahman, Stuart J. Williams
Summary: This manuscript describes the potentially significant role of interfacial tension in viral infection, highlighting the impact of membrane tension changes on viral RNA transportation and the modulation of virus membrane interfacial tension by factors like temperature. The discussion is contextualized within recent SARS-CoV-2 studies, suggesting that membrane surface tension could be influenced by various atmospheric conditions, air conditioning systems, and mask usage.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Margaret R. Jett, Mohamed Z. Rashed, Susan P. Hendricks, Stuart J. Williams
Summary: This study used impedance spectroscopy measurements to extract the electrical properties of phytoplankton cells in suspension and successfully differentiated different algae species based on their specific membrane capacitance. There was no significant difference in the electrical properties between nitrogen-depleted and healthy control cultures of algae.
JOURNAL OF APPLIED PHYCOLOGY
(2021)
Article
Biochemical Research Methods
Kshitiz Gupta, Zhengwei Chen, Stuart J. Williams, Steven T. Wereley
Summary: This study investigates the behavior and properties of synthetic microparticles and biological cells using opto-electric heating and microfluidic techniques. It explores the real-time tuning of vortex characteristics in REP micro vortex and analyzes the process through experiments and computational modeling, while also discussing the limitations of using superposition in custom-shaped traps.
Article
Chemistry, Physical
Md Mahmudur Rahman, Stuart J. Williams
Summary: The study explores the collective behavior of colloidal particles in a non-equilibrium system, with a focus on the influence of external and interparticle forces, including hydrodynamic forces which are often overlooked. Experiment and simulation results show that the particles interact hydrodynamically in a rotating cylindrical cell, forming different structures and evolving based on gravity forces. The findings suggest that the rotation scheme plays a crucial role in determining the aggregation and motion of colloidal particles.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Public, Environmental & Occupational Health
Loic Anderegg, John Doyle, Margaret L. Gardel, Amit Gupta, Christian Hallas, Yuri Lensky, Nancy G. Love, Bronwyn A. Lucas, Edward Mazenc, Cole Meisenhelder, Ajay Pillarisetti, Daniel Ranard, Allison H. Squires, Jessica Vechakul, Nathaniel B. Vilas, Stuart Williams, Daniel Wilson, Tyler N. Chen
Summary: Humid heat is an effective method for decontamination of N95 respirators, with key parameters such as temperature, humidity, duration of exposure, and local microenvironment being crucial. Maintaining temperatures of 70-85 degrees C and relative humidity >50% for at least 30 min can effectively inactivate SARS-CoV-2 on N95 respirators while preserving fit and filtration efficiency, for three to five cycles. Dry heat is significantly less effective in viral inactivation.
Article
Chemistry, Analytical
Stuart J. Williams, Joseph D. Schneider, Benjamin C. King, Nicolas G. Green
Summary: The electric curtain is a platform for lifting and transporting charged particles in air. This study focuses on observations of simultaneous dielectrophoretic and electrostatic forces, which are less investigated at lower voltages. The electric curtain, consisting of interdigitated electrodes coated with polypropylene, generates an electric field below the Paschen limit. Results show that soda lime glass beads experience oscillatory rolling via dielectrophoretic forces and rapid projectile repulsion consistent with electrostatic phenomena. Additionally, simulations demonstrate that particles in close proximity to the curtain's surface produce a local field enhancement. These findings have implications for advanced applications involving triggered responses of particles.
Article
Cardiac & Cardiovascular Systems
Landon H. Tompkins, Barry N. Gellman, Steven R. Prina, Gino F. Morello, Thomas Roussel, Jonathan A. Kopechek, Stuart J. Williams, Priscilla C. Petit, Mark S. Slaughter, Steven C. Koenig, Kurt A. Dasse
Summary: This study aims to develop a dedicated mechanical circulatory support system for pediatric patients with heart failure. Numerical predictions and computational fluid dynamics simulations were used to investigate the hydrodynamic performance and mechanical properties of the latest device design (Version 3). The results show improved performance and mechanical properties compared to the previous design, indicating potential for better circulatory support.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2022)
Article
Engineering, Multidisciplinary
Dong Hoon Lee, Emilee A. Madsen, Jacqueline C. Linnes, Steven T. Wereley
Summary: Real-time viscosity measurement techniques are used to analyze the transition of hydrogels from liquid to gel state. The techniques involve passive rheometry with the addition of tracer particles to measure changes in viscosity by measuring diffusion coefficient. Particle diffusometry (PD) quantifies Brownian motion of sub-micron sized fluorescent particles by computing diffusion coefficients via statistical averaging. In this study, a method is demonstrated to study changes in diffusion coefficient over time using PD for a temporally and spatially resolved rheometry measurement technique. The refined PD algorithm is used to simulate viscosity changes during gelation, and the technique is applied to visualize temporal and spatial gradients of diffusion coefficient during hydrogel formation experiments. This work establishes the groundwork for quantifying changes in Brownian motion over time.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2023)
