Article
Medicine, General & Internal
Federica Lovisa, Anna Garbin, Sara Crotti, Piero Di Battista, Ilaria Gallingani, Carlotta Caterina Damanti, Anna Tosato, Elisa Carraro, Marta Pillon, Erfan Mafakheri, Filippo Romanato, Enrico Gaffo, Alessandra Biffi, Stefania Bortoluzzi, Marco Agostini, Lara Mussolin
Summary: This study identified 50 proteins significantly overrepresented in S-EVs of pediatric ALCL patients compared to healthy donors, indicating potential diagnostic and prognostic parameters for ALCL. The enrichment analysis revealed connections with cellular components, molecular functions, and biological processes related to S-EV origin and vesicular trafficking. Additionally, a topological enrichment analysis highlighted an increase in proteins of the PI3K/AKT pathway in ALCL S-EVs, suggesting a potential role in tumorigenesis.
Article
Oncology
Mai Hashimoto, Noriyuki Uesugi, Mitsumasa Osakabe, Naoki Yanagawa, Koki Otsuka, Yoshiki Kajiwara, Hideki Ueno, Akira Sasaki, Tamotsu Sugai
Summary: In this study, immunohistochemical techniques were used to evaluate biological markers expressed in cancer cells and cancer-associated fibroblasts in colorectal cancer (CRC). The high expression of TNC was identified as a prognostic marker for stages II and III CRC, suggesting that a specific subgroup defined by multiple markers can be used for prediction of CRC outcome.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Andrew M. Donson, Kelsey C. Bertrand, Kent A. Riemondy, Dexiang Gao, Yonghua Zhuang, Bridget Sanford, Gregory A. Norris, Rebecca J. Chapman, Rui Fu, Nicholas Willard, Andrea M. Griesinger, Graziella Ribeiro de Sousa, Vladimir Amani, Enrique Grimaldo, Todd C. Hankinson, Ffyona Booker, Martin Sill, Richard G. Grundy, Kristian W. Pajtler, David W. Ellison, Nicholas K. Foreman, Timothy A. Ritzmann
Summary: The study focuses on the biology of recurrent PFA and reveals that chromosomal changes at recurrence are associated with poor prognosis. The genetic evolution of neoplastic cells leads to cellular heterogeneity in PFAs.
Review
Medicine, General & Internal
Francesco Fabozzi, Silvia Ceccanti, Antonella Cacchione, Giovanna Stefania Colafati, Andrea Carai, Alessandro Crocoli, Angela Mastronuzzi, Denis A. Cozzi
Summary: Primary central nervous system tumors, specifically ependymomas, are the most common solid tumors in childhood, but occurrence outside the CNS is extremely rare. This study presents two cases of extra-CNS myxopapillary ependymomas originating in the sacrococcygeal region, highlighting the challenges in diagnosis, treatment, and follow-up of this rare disease.
Article
Immunology
Ismail Hendaoui, Ahlem Lahmar, Luca Campo, Sihem Mebarki, Sandrine Bichet, Daniel Hess, Martin Degen, Nidhameddine Kchir, Leila Charrada-Ben Farhat, Rania Hefaiedh, Christian Ruiz, Luigi M. Terracciano, Richard P. Tucker, Lotfi Hendaoui, Ruth Chiquet-Ehrismann
Summary: The study found that tenascin-C and tenascin-W were expressed in all biliary tract tumors, with tenascin-W not detected in normal hepatobiliary tissue. Additionally, the formation and organization of tenascin-W required co-culture of Huh-28 cells with bone marrow-derived stromal cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Noor Jailkhani, Karl R. Clauser, Howard H. Mak, Steffen Rickelt, Chenxi Tian, Charles A. Whittaker, Kenneth K. Tanabe, Stephen R. Purdy, Steven A. Carr, Richard O. Hynes
Summary: Metastases, which are difficult to detect and treat, are the leading cause of cancer-related deaths. There is a clinical need for therapies specifically targeting metastases. This study focuses on developing nanobodies against extracellular matrix (ECM) proteins expressed in human metastases as potential vehicles for targeted delivery of imaging and therapeutic agents. By using phage-display libraries and proteomics, the researchers identified a conserved set of ECM proteins that are abundantly expressed in metastases from TNBC and colorectal cancer. They successfully isolated nanobodies against one of these proteins, tenascin-C (TNC), and demonstrated their specificity in binding TNBC tumors and metastases. The study suggests that generic nanobodies against tumors and metastases have great potential as cancer-agnostic tools for delivering therapeutics to the tumor microenvironment.
Article
Multidisciplinary Sciences
Soundara Viveka Thangaraj, Vidyarani Shyamsundar, Arvind Krishnamurthy, Vijayalakshmi Ramshankar
Summary: Oral Tongue Squamous Cell Carcinoma (OTSCC) is a distinct sub-group of head and neck cancers characterized by its aggressive nature and high incidence of recurrence and metastasis. Transcriptome analysis of OTSCC patients identified key genes and deregulated pathways, leading to the validation of a panel of valuable prognostic markers that can be clinically useful in identifying poor prognosis and occult node metastasis in OTSCC patients. Up-regulation of certain genes was associated with treatment failure in early stages, while other genes were significantly correlated with occult node positivity, indicating their potential as indicators of poor prognosis.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Blanca Molins, Marc Figueras-Roca, Oliver Valero, Victor Llorenc, Sara Romero-Vazquez, Oriol Sibila, Alfredo Adan, Carolina Garcia-Vidal, Alex Soriano
Summary: In COVID-19 patients, monomeric CRP levels are associated with disease severity, and levels higher than 4000 ng/mL independently predict disease severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medical Laboratory Technology
Sing Kong Ho, Hsin-Bang Leu, Chau-Chung Wu, Hung- Yeh, Wei-Hsian Yin, Tsung-Hsien Lin, Kuan-Cheng Chang, Ji-Hung Wang, Wei-Kung Tseng, Jaw-Wen Chen, Yen-Wen Wu
Summary: Tenascin-C was found to be an independent predictor of total cardiovascular events, all-cause death, AMI, and heart failure hospitalization in patients with stable coronary heart disease.
CLINICA CHIMICA ACTA
(2022)
Article
Cell Biology
Juliane Bauch, Andreas Faissner
Summary: Oligodendrocytes play an important role in myelination in the central nervous system. The glycoproteins tenascin-C (Tnc) and tenascin-R (Tnr) regulate the differentiation and regeneration of oligodendrocytes, affecting the formation and thickness of myelin sheaths. Results from experiments using Tnc and Tnr knockout mice show increased number of myelin sheaths and thickness in the absence of these proteins.
Article
Biology
Chi-Keung Cheng, Yuk-Lin Yung, Hoi-Yun Chan, Kam-Tong Leung, Kathy Y. Y. Chan, Alex W. K. Leung, Frankie W. T. Cheng, Chi-Kong Li, Thomas S. K. Wan, Xi Luo, Herbert-Augustus Pitts, Joyce S. S. Cheung, Natalie P. H. Chan, Margaret H. L. Ng
Summary: A genomic analysis of pediatric acute myeloid leukemia patients reveals extensive gene fusion events and mutations, providing new insights into the genetic complexities of this cancer. The study highlights the importance of understanding the genetic basis of pediatric AML for improving prognostic classification and treatment options.
COMMUNICATIONS BIOLOGY
(2023)
Article
Physiology
Sandrine Gremlich, Tiziana P. Cremona, Eveline Yao, Farah Chabenet, Kleanthis Fytianos, Matthias Roth-Kleiner, Johannes C. Schittny
Summary: In 18-month-old TNC-deficient mice, exaggerated features of normal structural lung aging were observed, including increased lung volume, proliferation, and collagen content, while respiratory physiological parameters were similar to wild-type. TNC may play a significant role in lung aging processes.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Jan Styczynski, Artur Slomka, Monika Lecka, Katarzyna Albrecht, Michal Romiszewski, Monika Pogorzala, Malgorzata Kubicka, Beata Kurylo-Rafinska, Barbara Tejza, Grazyna Gadomska, Ewelina Kolanska-Dams, Malgorzata Michalska, Ewa Zekanowska
Summary: This study analyzed the prognostic impact of 12 serum iron metabolism parameters in children after intensive chemotherapy for acute leukemias (AL) or undergoing hematopoietic cell transplantation (HCT). High levels of ferritin and low levels of soluble hemojuvelin (sHJV) were found to have an adverse prognostic impact on overall survival (OS) and event-free survival (EFS) in children after HCT. The results were confirmed when combined with AL patients after intensive chemotherapy.
Review
Medicine, General & Internal
Sutapa Ray, Nagendra K. Chaturvedi, Kishor K. Bhakat, Angie Rizzino, Sidharth Mahapatra
Summary: Medulloblastoma is the most common malignant central nervous system tumor in pediatric patients. Tumors can be divided into average and high-risk status based on age, metastasis at diagnosis, and extent of surgical resection. High-throughput screening has allowed for the identification of four primary subgroups, each with further subdivisions based on cytogenetic and epigenetic events. Exploiting these genetic aberrations may lead to novel targeted therapeutics.
Article
Cell Biology
Cornelius Mueller-Buehl, Jacqueline Reinhard, Lars Roll, Verian Bader, Konstanze F. Winklhofer, Andreas Faissner
Summary: This study investigated the relationship between fast-spiking parvalbumin interneurons, perineuronal nets (PNNs), and synaptic distribution in the mature cortical inhibitory circuits. The results suggest that the specialized extracellular matrix structure plays a crucial role in regulating the interaction between these factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Clinical Neurology
Johannes Herta, Fabian Winter, Ekaterina Pataraia, Martha Feucht, Thomas Czech, Barbara Porsche, Ulrike Leiss, Irene Slavc, Andreas Peyrl, Gregor Kasprian, Karl Roessler, Christian Dorfer
Summary: This study evaluated the feasibility and safety of awake brain surgery and intraoperative language mapping in children and adolescents with structural epilepsies, finding that ABS is a valuable technique in selected pediatric patients.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2022)
Article
Clinical Neurology
Philip Pruckner, Karl-Heinz Nenning, Florian Ph S. Fischmeister, Mehmet-Salih Yildirim, Michelle Schwarz, Andreas Reitner, Susanne Aull-Watschinger, Johannes Koren, Christoph Baumgartner, Daniela Prayer, Karl Roessler, Christian Dorfer, Thomas Czech, Ekaterina Pataraia, Gregor Kasprian, Silvia Bonelli
Summary: In this study, a multimodal imaging approach was used to assess visual outcomes after epilepsy surgery. The study found that visual field deficits (VFDs) were more severe after anterior temporal lobectomy (ATL) compared to transsylvian selective amygdalohippocampectomy (tsSAHE). Volumetric optic radiation tractography damage could reliably predict the occurrence and extent of VFDs. Fixel-based analysis revealed a widespread decline in fiber cross-section within the ATL group.
Article
Genetics & Heredity
Johannes Gojo, Mimi Kjaersgaard, Barbara Zezschwitz, David Capper, Anna Tietze, Marcel Kool, Christine Haberler, Barry Pizer, Katja Hoff
Summary: The introduction of molecular methods has had a significant impact on paediatric neurooncology, leading to the identification of novel tumour types in rare CNS tumours. The rarity and novelty of these tumour types result in diagnostic and therapeutic challenges, but comprehensive molecular diagnostics and joint international efforts are encouraged to overcome these challenges and optimize patient management.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2023)
Letter
Clinical Neurology
Sibylle Madlener, Julia Furtner, Natalia Stepien, Daniel Senfter, Lisa Mayr, Maximilian Zeyda, Leon Gramss, Barbara Aistleitner, Sabine Spiegl-Kreinecker, Elisa Rivelles, Christian Dorfer, Karl Roessler, Thomas Czech, Amedeo A. Azizi, Andreas Peyrl, Daniela Loetsch-Gojo, Leonhard Muellauer, Christine Haberler, Irene Slavc, Johannes Gojo
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Cora Hedrich, Johannes Gojo, Amedeo Azizi, Andreas Peyrl, Irene Slavc, Fabian Winter, Thomas Czech, Christian Dorfer
Summary: This study analyzed the experience of using an external ventricular drain (EVD) for the perioperative treatment of hydrocephalus in pediatric posterior fossa tumors. The results showed that EVD was safe and effective.
CHILDS NERVOUS SYSTEM
(2023)
Article
Oncology
Natalia Stepien, Daniel Senfter, Julia Furtner, Christine Haberler, Christian Dorfer, Thomas Czech, Daniela Loetsch-Gojo, Lisa Mayr, Cora Hedrich, Alicia Baumgartner, Maria Aliotti-Lippolis, Hannah Schned, Johannes Holler, Katharina Bruckner, Irene Slavc, Amedeo A. Azizi, Andreas Peyrl, Leonhard Muellauer, Sibylle Madlener, Johannes Gojo
Summary: In this study, the researchers investigated the use of ddPCR as a highly sensitive method for detecting MYC amplification in the bodily fluids of group 3 MB patients. They found that ddPCR showed a sensitivity of 90% and a specificity of 100% in detecting MYC amplification in the CSF. These results suggest that liquid biopsy has the potential to improve diagnosis, disease staging, and monitoring in MB patients.
Article
Clinical Neurology
Farjad Khalaveh, Irene Steiner, Andrea Reinprecht, Thomas Czech, Gregor Kasprian, Karl Roessler, Christian Dorfer
Summary: This study presents the experience with an individualized surgical approach for treating Chiari malformation type 1. Based on neurological symptoms, the existence and extent of a syrinx, and the degree of tonsillar descent, four types of approaches were performed on a case-by-case basis in 81 patients. The results showed that the least invasive approach necessary to achieve clinical improvement should be selected, as the complication rate increased with the invasiveness of the approach. The severity of the tonsillar descent, basilar invagination, and current CM1 scores could be used to aid in the approach selection.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Oncology
Olga Ciobanu-Caraus, Thomas Czech, Andreas Peyrl, Christine Haberler, Gregor Kasprian, Julia Furtner, Marcel Kool, Martin Sill, Josa M. Frischer, Anna Cho, Irene Slavc, Karl Roessler, Johannes Gojo, Christian Dorfer
Summary: This study investigated the correlation between intraoperative observation of the site of origin and molecular subtypes of medulloblastoma (MB). The results showed that intraoperative observation had limited predictive value for determining the molecular subtype. Therefore, maximal safe resection should remain the aim of surgery.
Article
Multidisciplinary Sciences
Mario Mischkulnig, Benjamin Hopp, Lisa I. Wadiura, Farjad Khalaveh, Barbara Kiesel, Karl Roessler, Georg Widhalm, Christian Dorfer
Summary: A retrospective analysis was conducted at the Medical University of Vienna to evaluate the impact of the COVID-19 pandemic on the treatment of high-grade glioma patients. Patients treated during the pandemic had significantly shorter time intervals to surgery compared to the control group. Although patients treated during COVID-19 had slightly larger preoperative tumor volumes, overall patient survival was comparable between the two groups.
Article
Clinical Neurology
Johannes Herta, Theresa Bettina Loidl, Tobias Schmied, Matthias Tomschik, Farjad Khalaveh, Wei-Te Wang, Christian Dorfer
Summary: This study compared the effectiveness of percutaneous balloon compression (PBC) and radiofrequency thermocoagulation (RFTC) for treating trigeminal neuralgia. The results showed no significant difference between the two methods in terms of initial pain relief and recurrence-free survival. Factors such as multiple sclerosis and higher preoperative pain intensity increased the risk of not achieving pain relief. Although PBC had longer recurrence-free survival time, the difference was not statistically significant. The complication rate was similar between the two procedures. Further prospective comparative trials are needed.
ACTA NEUROCHIRURGICA
(2023)
Article
Biochemistry & Molecular Biology
Lisa Milchram, Ronald Kulovics, Markus Sonntagbauer, Silvia Schoenthaler, Klemens Vierlinger, Christian Dorfer, Charles Cameron, Okay Saydam, Andreas Weinhaeusel
Summary: Studies on tumor-associated antigens in brain tumors are limited. Antibody profiling revealed differences in antigen expression between preoperative and postoperative glioblastoma and meningioma patients, as well as characteristic signaling pathways associated with these antigens. The findings from this study provide new insights into molecular pathology and may have implications for the development of new treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Farjad Khalaveh, Mario Mischkulnig, Vitalij Zeiser, Matthias G. Vossen, Andrea Reinprecht, Christian Dorfer, Karl Roessler, Johannes Herta
Summary: This study demonstrates that CSF parameters collected from the EVD collection bag can be reliably assessed, reducing manipulation at the proximal port and minimizing the risk of infection.
Meeting Abstract
Oncology
Lisa Mayr, Maria Trissal, Kallen Schwark, Jenna Labelle, Seongbae Kong, Andrew Groves, Jeffrey Supko, Olivia Hack, Joana Marques, Eshini Panditharatna, Frank Dubois, Noah Greenwald, Pratiti Bandopadhayay, Keith Ligon, Julia Furtner-Srajer, Liesa Weiler-Wichtl, Ulrike Leiss, Verena Rosenmayr, Sibylle Madlener, Natalia Stepien, Daniela Lotsch-Gojo, Christian Dorfer, Karin Dieckmann, Amedeo Azizi, Armin Guntner, Hana Palova, Ondrej Slaby, Petra Pokorna, Rameen Beroukhim, Christof Kramm, David T. Jones, Jaroslav Sterba, Leonhard Mullauer, Christine Haberler, Nisha Perez, Sean Kim, Anthony Hsieh, Sasa Dimitrijevic, Mary Skrypek, Nina Martinez, Daniel Bowers, Mariella Filbin, Johannes Gojo, Carl Koschmann
Meeting Abstract
Clinical Neurology
P. Pruckner, K. -H. Nenning, S. M. Yildirim, M. Schwarz, J. Koren, C. Baumgartner, A. Reitner, E. Pataraia, K. Rossler, C. Dorfer, G. Kasprian, S. Bonelli