Article
Biochemistry & Molecular Biology
Grzegorz K. Jakubiak, Kamila Osadnik, Mateusz Lejawa, Tadeusz Osadnik, Marcin Golawski, Piotr Lewandowski, Natalia Pawlas
Summary: Metabolic syndrome is the coexistence of factors that increase the risk for type 2 diabetes and cardiovascular disease, and it is associated with oxidative stress. Among the components of metabolic syndrome, obesity and insulin resistance show the strongest association with oxidative stress.
Review
Biochemistry & Molecular Biology
Sepiso K. Masenga, Lombe S. Kabwe, Martin Chakulya, Annet Kirabo
Summary: Metabolic syndrome is a collection of conditions that increase the risk of type 2 diabetes mellitus and cardiovascular diseases. Obesity is closely linked to metabolic syndrome, as it promotes inflammation and oxidative stress, which are precursors of complications relating to metabolic syndrome components such as insulin resistance, hypertension, and hyperlipidemia. While oxidative stress and chronic inflammation are known to play a significant role in the development of metabolic syndrome, there has been limited research on the mechanisms underlying the contribution of oxidative stress. This review highlights the mechanisms by which reactive oxygen species contribute to mitochondrial dysfunction, protein damage, lipid peroxidation, and impaired antioxidant function in metabolic syndrome. Biomarkers of oxidative stress can be utilized for disease diagnosis and severity evaluation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Vincenza Frisardi, Carmela Matrone, Maria Elisabeth Street
Summary: Metabolic syndrome is influenced by genetic, environmental, and lifestyle factors, with defects in the autophagy machinery playing a role in its dysfunction; there is a mutual regulation between autophagy and MetS, with the HMGB1 protein playing a key role in this interaction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michelle Berenice Vega Joubert, Valentina Degrave, Paola Ingaramo, Maria Eugenia Oliva, Maria Eugenia D'Alessandro
Summary: This study analyzed the effects of different diets on liver inflammation and endothelial dysfunction, and demonstrated that chia seed can be an effective therapeutic strategy for improving these conditions.
Review
Biochemistry & Molecular Biology
Luca Rinaldi, Pia Clara Pafundi, Raffaele Galiero, Alfredo Caturano, Maria Vittoria Morone, Chiara Silvestri, Mauro Giordano, Teresa Salvatore, Ferdinando Carlo Sasso
Summary: Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) share similar features, with insulin resistance being a key factor. Lifestyle changes can improve symptoms, and there is a correlation between diabetes and multiorgan damage.
Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Francis Feldman, Mireille Koudoufio, Ramy El-Jalbout, Mathilde Foisy Sauve, Lena Ahmarani, Alain Theophile Sane, Nour-El-Houda Ould-Chikh, Thierry N'Timbane, Natalie Patey, Yves Desjardins, Alain Stintzi, Schohraya Spahis, Emile Levy
Summary: The study investigates the efficacy of cranberry proanthocyanidins (PACs) in improving metabolic syndrome (MetS) and liver complications. The results show that PACs can alleviate obesity, insulin resistance, and hyperlipidemia, and reduce oxidative stress and inflammation. Additionally, PACs improve fatty liver disease and inhibit liver gluconeogenesis.
Article
Nutrition & Dietetics
Adela Kabelova, Hana Malinska, Irena Markova, Olena Oliyarnyk, Blanka Chylikova, Ondrej Seda
Summary: Ellagic acid, a natural substance found in fruits and nuts, has beneficial effects on metabolic syndrome by lowering oxidative stress levels and improving characteristics of brown adipose tissue.
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Rocco Barazzoni, Gianluca Gortan Cappellari, Michela Zanetti, Katherine A. Klaus, Annamaria Semolic, Matthew L. Johnson, K. Sreekumaran Nair
Summary: Moderate caloric restriction can improve insulin sensitivity in obese individuals, potentially due to increased levels of unacylated ghrelin (UnAG). The study found that caloric restriction led to an increase in UnAG levels and was positively associated with improvements in insulin sensitivity.
CLINICAL NUTRITION
(2021)
Review
Pediatrics
Dario Iafusco, Roberto Franceschi, Alice Maguolo, Salvatore Guercio Nuzio, Antonino Crino, Maurizio Delvecchio, Lorenzo Iughetti, Claudio Maffeis, Valeria Calcaterra, Melania Manco
Summary: Type 2 diabetes develops within the context of metabolic syndrome and is influenced by a continuum of risk factors, including visceral obesity, high blood pressure, abnormal blood lipids, and impaired glucose control. This condition places a significant burden on beta-cell function during puberty, leading to irreversible deterioration and the onset of diabetes. This review aims to identify age-specific risk factors for type 2 diabetes in youth, summarize screening and diagnostic criteria, and explore potential treatment options. Visceral obesity and disrupted lipid metabolism are key factors in disease development. Genetic susceptibility to impaired beta-cell function in the presence of obesity and insulin resistance explains why some obese adolescents develop diabetes at a young age while others do not. Lifestyle interventions focusing on a healthy diet and physical activity remain the primary treatment approach for youth with type 2 diabetes. However, pharmacological management using common drugs, such as dipeptidyl peptidase-4 inhibitors and sodium-dependent glucose transport inhibitors, as well as new weight-reducing medications, like glucagon-like peptide 1 receptor agonists, could revolutionize the management of this disease. These medications have the potential to not only treat diabetes but also alleviate the burden of metabolic abnormalities associated with the syndrome and lead to significant weight loss.
Article
Biochemistry & Molecular Biology
Susana Rovira-Llopis, Ruben Diaz-Rua, Carmen Grau-del Valle, Francesca Iannantuoni, Zaida Abad-Jimenez, Neus Bosch-Sierra, Joaquin Panadero-Romero, Victor M. Victor, Milagros Rocha, Carlos Morillas, Celia Banuls
Summary: This study found significant differences in miRNA expression between metabolically healthy and unhealthy obese individuals, with some miRNAs associated with insulin resistance and lipid metabolism pathways, suggesting a potential role for miRNAs in metabolically healthy obesity.
Article
Biochemistry & Molecular Biology
Amanda J. Croft, Conagh Kelly, Dongqing Chen, Tatt Jhong Haw, Aaron L. Sverdlov, Doan T. M. Ngo
Summary: Obesity is associated with various metabolic disorders and cardiovascular diseases, causing increased hospitalizations, morbidity, and mortality. Dysfunction of adipose tissue due to chronic nutrient stress can lead to oxidative stress, mitochondrial dysfunction, inflammation, hypoxia, and insulin resistance. This study aimed to reduce adipose tissue oxidative stress by overexpressing the antioxidant mitochondrial catalase (mCAT) in adipose tissue to improve systemic metabolic function. The results showed that the AdipoQ-mCAT mice were protected from further metabolic impairment under obesogenic dietary conditions compared to obese wild-type mice, highlighting the critical role of physiological H2O2 signaling in metabolism and adipose tissue function.
Review
Nutrition & Dietetics
Hiroki Nishikawa, Akira Asai, Shinya Fukunishi, Shuhei Nishiguchi, Kazuhide Higuchi
Summary: Skeletal muscle plays a crucial role in insulin-induced glucose metabolism, with muscle loss and intramuscular fat accumulation closely linked. Skeletal muscle loss and fat accumulation are associated with various pathologies through factors such as oxidative stress, inflammatory cytokines, mitochondrial dysfunction, insulin resistance, and inactivity. The relationship between Metabolic Syndrome (Met-S) and sarcopenia is attracting attention, with persistent inflammation, fat deposition, and insulin resistance thought to play important roles in their association.
Review
Endocrinology & Metabolism
Somaya Albhaisi, Arun J. Sanyal
Summary: NAFLD has become a leading cause of chronic liver disease globally, closely linked to metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease. Metabolic inflexibility is considered a key factor in the progression of NAFLD to NASH and cirrhosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Zahra Fakhroueian, Sadegh Rajabi, Niloufar Salehi, Mostafa Rezaei Tavirani, Shokoofe Noori, Mitra Nourbakhsh
Summary: The effects of three synthesized ZnO nanofluids on breast cancer stem-like cells were evaluated in this study. The results showed that ZnO nanofluids could decrease the expression of stemness markers, induce apoptosis, and suppress JAK/STAT activity. ZnO-148 exhibited the most effective activity.
Article
Biochemistry & Molecular Biology
Sahar Yarahmadi, Navid Farahmandian, Reza Fadaei, Mehdi Koushki, Elham Bahreini, Saeed Karima, Sepideh Barzin Tond, Azadeh Rezaei, Mitra Nourbakhsh, Soudabeh Fallah
Summary: The study investigated the effects of resveratrol, atorvastatin, and their combination on gene expression in the cholesterol metabolic pathway in fatty liver. The results showed that resveratrol and atorvastatin reduced fat accumulation in the liver and improved blood lipid profiles compared to the control group. The combination therapy had significant effects on the expression of genes related to cholesterol metabolism and miR33.
DNA AND CELL BIOLOGY
(2023)
Article
Cell Biology
Mitra Nourbakhsh, Shokoofe Noori, Zahra Aminzade, Maryam Bayanati, Mehrdad Alemi, Afshin Zarghi
Summary: This study investigated the effects of a novel chalcone derivative MPP in combination with curcumin on the inflammatory pathways in breast and ovarian cancer cells. The results showed that MPP inhibited NF-κB activity, reduced the expression of inflammatory genes, and decreased the levels of proinflammatory cytokines and nitric oxide. These effects were enhanced when MPP was combined with curcumin.
MEDIATORS OF INFLAMMATION
(2023)
Article
Endocrinology & Metabolism
N. Heydari, R. Sharifi, M. Nourbakhsh, P. Golpour
Summary: This study aimed to investigate the expression of lncRNAs TUG1, MALAT1, and MEG3 in patients with type 2 diabetes and their association with biochemical and ER stress parameters. The results showed that the expression of TUG1, MEG3, ATF4, and CHOP genes was significantly increased in patients with diabetes. The expression levels of TUG1 and MEG3 were positively correlated with glycemic control indices and markers of ER stress, suggesting their potential as markers for identifying ER stress in hyperglycemia.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Cell Biology
Reza Ataei Kachouei, Alireza Doagoo, Maral Jalilzadeh, Seyyed Hossein Khatami, Shima Rajaei, Ali Jahanbazi Jahan-Abad, Farzaneh Salmani, Roya Pakrad, Somayeh Mahmoodi Baram, Mitra Nourbakhsh, Mohammad-Amin Abdollahifar, Hojjat Allah Abbaszadeh, Shokoofeh Noori, Mitra Rezaei, Meisam Mahdavi, Mohammad Reza Shahmohammadi, Saeed Karima
Summary: This study investigates the potential of Acetyl-11-keto-beta-boswellic acid (AKBA), an anti-inflammatory compound from Boswellia species, in preventing and treating non-alcoholic fatty liver disease (NAFLD). The results demonstrate that AKBA improves NAFLD-related serum parameters and inflammatory markers, preserves lipid metabolism, improves hepatic steatosis, and suppresses liver inflammation, thus preventing the progression of NAFLD.
Article
Medical Laboratory Technology
Nariman Moradi, Reza Fadaei, Maryam Roozbehkia, Mitra Nourbakhsh, Mona Nourbakhsh, Maryam Razzaghy-Azar, Bagher Larijani
Summary: This study investigated the associations of two newly discovered adipokines, Metrnl and asprosin, with obesity in children and adolescents. The results showed that Metrnl levels were lower in obese children, while asprosin levels were higher. These adipokines were correlated with obesity-related parameters such as BMI and insulin levels. Therefore, Metrnl and asprosin are potential therapeutic targets for obesity and its associated metabolic imbalances.
LABORATORY MEDICINE
(2023)
Article
Neurosciences
Niloufar Salehi, Mitra Nourbakhsh, Shokoofe Noori, Hossein Rezaeizadeh, Afshin Zarghi
Summary: This study investigates the ameliorating effect of Tehranolide (TEH) and Artemisinin (ART) on experimental autoimmune encephalomyelitis (EAE), a commonly used animal model for multiple sclerosis (MS). Both TEH and ART significantly alleviate EAE signs, with TEH showing greater potency. By modulating the expression of genes related to inflammation and myelination, TEH has the potential to be evaluated as an intervention for MS management.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Havva Afshari, Shokoofe Noori, Mitra Nourbakhsh, Azam Daraei, Mahsa Azami Movahed, Afshin Zarghi
Summary: This study aimed to synthesize a novel imidazo[1,2-a]pyridine derivative (MIA) and evaluate its anti-inflammatory activity and effects on NF-κB and STAT3 pathways in MDA-MB-231 and SKOV3 cell lines. The results showed that MIA exerted its anti-inflammatory activity by suppressing NF-κB and STAT3 signaling pathways, and curcumin enhanced all the anti-inflammatory effects of MIA.
Article
Integrative & Complementary Medicine
Alemeh Taheri, Samira Ezzati Mobaser, Pegah Golpour, Mona Nourbakhsh, Masoumeh Tavakoli-Yaraki, Sahar Yarahmadi, Mitra Nourbakhsh
Summary: In this study, the anti-fibrotic effects of hesperetin were investigated by targeting ECM components and matrix metalloproteinase enzymes. The results showed that hesperetin significantly reduced the production of markers of adipose tissue fibrosis and may be considered a potential compound for the treatment of obesity-associated fibrosis.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Genetics & Heredity
Mohammad Borji, Nikta Dadkhah Nikroo, Zeynab Yousefi, Mona Nourbakhsh, Zohreh Abdolvahabi, Mitra Nourbakhsh, Bagher Larijani, Maryam Razzaghy-Azar
Summary: The gene expression of CHREBP is elevated in individuals with obesity and metabolic syndrome, and it is associated with various metabolic and liver-related parameters.
Meeting Abstract
Endocrinology & Metabolism
Mitra Nourbakhsh, Mona Nourbakhsh, Pegah Golpour, Hosein Momeni, Maryam Razzaghy Azar
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Meeting Abstract
Endocrinology & Metabolism
Mona Nourbakhsh, Nastaran Ramezani, Mitra Nourbakhsh, Maryam Razzaghy Azar
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Article
Integrative & Complementary Medicine
Shokoofe Noori, Mitra Nourbakhsh, Hossein Imani, Niloofar Deravi, Niloufar Salehi, Zohreh Abdolvahabi
Summary: This study investigated the potential of using a combination of naringenin and CPT to modulate the immune response and inhibit tumor growth. The results showed promising effects of this combination in regulating immune response and inhibiting tumor growth, possibly through the JAK2/STAT3 signaling pathway.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
