Eosinophilic bioactivities in severe asthma

Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia

(2016) Steven G. Smith et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

(2016) Dean D. Metcalfe et al.   World Allergy Organization Journal

Pathobiology of Severe Asthma

(2015) Humberto E. Trejo Bittar et al.   Annual Review of Pathology-Mechanisms of Disease

Novel Targeted Therapies for Eosinophil-Associated Diseases and Allergy

(2015) Susanne Radonjic-Hoesli et al.   Annual Review of Pharmacology and Toxicology

Novel Therapies for Eosinophilic Disorders

(2015) Bruce S. Bochner   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Correlation between CCL26 production by human bronchial epithelial cells and airway eosinophils: Involvement in patients with severe eosinophilic asthma

(2015) Marie-Chantal Larose et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma phenotypes and the use of biologic medications in asthma and allergic disease: The next steps toward personalized care

(2015) Merritt L. Fajt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Toxicity of Eosinophil MBP Is Repressed by Intracellular Crystallization and Promoted by Extracellular Aggregation

(2015) Alice Soragni et al.   MOLECULAR CELL

Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials

(2015) Mario Castro et al.   Lancet Respiratory Medicine

High blood eosinophil count is associated with more frequent asthma attacks in asthma patients

(2014) Trung N. Tran et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Activation states of blood eosinophils in asthma

(2014) M. W. Johansson   CLINICAL AND EXPERIMENTAL ALLERGY

The eosinophil surface receptor epidermal growth factor–like module containing mucin-like hormone receptor 1 (EMR1): A novel therapeutic target for eosinophilic disorders

(2014) Fanny Legrand et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes

(2014) Katherine J. Baines et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophil Granule Proteins: Form and Function

(2014) K. Ravi Acharya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Innate Antifungal Immunity of Human Eosinophils Mediated by a  2 Integrin, CD11b

(2014) J. Yoon et al.   JOURNAL OF IMMUNOLOGY

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

(2014) Elisabeth H. Bel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Asthma biomarkers: what constitutes a ‘gold standard’?

(2014) Joseph R Arron et al.   THORAX

Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study

(2014) Mario Castro et al.   Lancet Respiratory Medicine

Eosinophil Cytokines, Chemokines, and Growth Factors: Emerging Roles in Immunity

(2014) Francis Davoine et al.   Frontiers in Immunology

High Blood Eosinophil Count Is a Risk Factor for Future Asthma Exacerbations in Adult Persistent Asthma

(2014) Robert S. Zeiger et al.   Journal of Allergy and Clinical Immunology-In Practice

αMβ2Integrin–Mediated Adhesion and Motility of IL-5–Stimulated Eosinophils on Periostin

(2013) Mats W. Johansson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

(2013) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

(2013) Wendy C. Moore et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Targeting eosinophils in allergy, inflammation and beyond

(2013) Patricia C. Fulkerson et al.   NATURE REVIEWS DRUG DISCOVERY

Distribution of sputum cellular phenotype in a large asthma cohort: predicting factors for eosinophilic vs neutrophilic inflammation

(2013) Florence N Schleich et al.   BMC Pulmonary Medicine

Biomarkers of eosinophil involvement in allergic and eosinophilic diseases: Review of phenotypic and serum markers including a novel assay to quantify levels of soluble Siglec-8

(2012) Ho Jeong Na et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

(2012) Ian D Pavord et al.   LANCET

Counterpoint: Is Measuring Sputum Eosinophils Useful in the Management of Severe Asthma? No, Not for the Vast Majority of Patients

(2011) Stephen P. Peters   CHEST

Glycomic analysis of human mast cells, eosinophils and basophils

(2011) S. J. North et al.   GLYCOBIOLOGY

Eosinophil extracellular DNA traps in skin diseases

(2011) Dagmar Simon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways

(2011) Ryszard Dworski et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples

(2011) Katherine J. Baines et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophil Granule Protein Localization in Eosinophilic Endomyocardial Disease

(2011) Benjamin L. Wright et al.   NEW ENGLAND JOURNAL OF MEDICINE

Eosinophils in health and disease: the LIAR hypothesis

(2010) J. J. Lee et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Human airway smooth muscle promotes eosinophil differentiation

(2009) A. I. Fanat et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE