Journal
ACTA PHARMACEUTICA SINICA B
Volume 6, Issue 6, Pages 564-567Publisher
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2016.05.009
Keywords
Lespecleza cuneata; Phenylpropanoid glycosides; Extraction and isolation; Hepatoprotective activity; Cuneataside E; Cuneataside F
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Funding
- National Mega-project for Innovative Drugs [2012ZX09301002-002]
- National Natural Science Foundation of China [81560632, 81202546]
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Two new phenylpropanoid glycosides named cuneataside E (1) and cuneataside F (2), were isolated from the aerial parts of Lespedeza cuneata (Dum. Cours.) G. Don, whose structures were E and Z isomer, respectively. Their structures were elucidated on the basis of comprehensive spectroscopic analysis (UV, IR, HR-ESI-MS, 1D and 2D NMR). In in vitro bioassays at 10 mu mol/L, compound 1 showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HeG2 cells. (C) 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND
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