Article
Gastroenterology & Hepatology
Prashant Singh, Eric J. Alm, John M. Kelley, Vivian Cheng, Mark Smith, Zain Kassam, Judy Nee, Johanna Iturrino, Anthony Lembo
Summary: Fecal microbiota transplantation is an effective strategy to correct microbial dysbiosis in diarrhea-predominant irritable bowel syndrome. For patients with IBS-D, FMT with antibiotic pretreatment significantly reduces bacterial engraftment.
Review
Food Science & Technology
Sevda Zoghi, Amin Abbasi, Fatemah Sadeghpour Heravi, Mohammad Hossein Somi, Zeinab Nikniaz, Seyed Yaghoub Moaddab, Hamed Ebrahimzadeh Leylabadlo
Summary: This article discusses the association between the development of celiac disease and gut microbiota, the effects of infectious agents, especially the recent Covid-19 infection in celiac disease patients, and the efficacy of potential therapeutic approaches. Scientific literature suggests that microbiome-based therapy can improve the symptoms and quality of life of celiac disease patients, but the full potential of microbiota-based techniques requires further research.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Multidisciplinary Sciences
Jennifer T. Wolstenholme, Justin M. Saunders, Maren Smith, Jason D. Kang, Phillip B. Hylemon, Javier Gonzalez-Maeso, Andrew Fagan, Derrick Zhao, Masoumeh Sikaroodi, Jeremy Herzog, Amirhossein Shamsaddini, Marcela Pena-Rodriguez, Lianyong Su, Yun-Ling Tai, Jing Zheng, Po-Cheng Cheng, R. Balfour Sartor, Patrick M. Gillevet, Huiping Zhou, Jasmohan S. Bajaj
Summary: The study found that alcohol acceptance, intake, and preference decreased in mice colonized with post-fecal transplant stool. Microbial taxa associated with post-fecal transplant humans were also linked to lower alcohol consumption in mice. These findings suggest that targeting the gut microbiota and the microbial-intestinal interface may be a potential therapeutic approach to reduce alcohol consumption in humans.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Tejinder Pal Singh, Saurabh Kadyan, Harisha Devi, Gwoncheol Park, Ravinder Nagpal
Summary: The gut plays a significant role in regulating the physiology of various organs in the body, including the liver. The communication between the gut and liver is bidirectional, with gut-derived products being transported to the liver through the portal vein, triggering responses from the liver. Maintaining a healthy gut microbiome is crucial for the homeostasis of the gut-liver axis, while disturbances in this axis can lead to liver disorders. This article discusses the functional characteristics of a healthy gut-liver axis and explores the role of gut dysbiosis in liver diseases, as well as potential therapeutic approaches.
Article
Critical Care Medicine
Booker T. Davis, Zhangying Chen, Mecca B. A. R. Islam, Madeline E. Timken, Daniele Procissi, Steven J. Schwulst
Summary: Traumatic brain injury (TBI) can lead to dysbiosis of the gut microbiota, while fecal microbiota transfer (FMT) can restore the microbial community structure. In a mouse study, TBI mice treated with FMT showed improved neurocognitive and anatomical deficits. These findings suggest that restoring pre-injury gut microbial community structure may be an effective therapeutic intervention after TBI.
Review
Microbiology
Xianzhuo Zhang, Xufei Luo, Liang Tian, Ping Yue, Mengyao Li, Kefeng Liu, Daoming Zhu, Chongfei Huang, Qianling Shi, Liping Yang, Zhili Xia, Jinyu Zhao, Zelong Ma, Jianlong Li, Joseph W. Leung, Yanyan Lin, Jinqiu Yuan, Wenbo Meng, Xun Li, Yaolong Chen
Summary: This study summarized the associations between gut microbiome dysbiosis and various diseases, and conducted an umbrella review to determine the efficacy and safety of fecal microbiota transplantation (FMT) in treating these diseases. The research found that FMT was effective for recurrent Clostridium difficile infection (rCDI) with a high cure rate, and had moderate to high quality evidence for ulcerative colitis and Crohn's disease, but low to very low quality evidence for other diseases.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Immunology
Zhijie Huang, Yisheng Huang, Jun Chen, Zhengming Tang, Yuanxin Chen, Hongyu Liu, Mingshu Huang, Ling Qing, Li Li, Qin Wang, Bo Jia
Summary: Severe burn can lead to serious complications globally, with changes in the gut microbiome playing a significant role in pathogenesis. Dysbiosis and damage to the intestinal mucosal barrier post-burn can lead to bacterial translocation and subsequent complications. Modulating the microbiota composition may improve intestinal diseases and provide new directions for post-burn treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Dulce M. Minaya, Noah L. Weinstein, Krzysztof Czaja
Summary: This study successfully implemented cecal fistula implantation using 3D printing technology, providing an effective method for long-term and minimally invasive access to the gut microbiome. The fistula implantation had no significant impact on food intake, body weight, fat mass, or microglia activation, but temporarily reduced gut microbial diversity.
Article
Gastroenterology & Hepatology
Barbara Olendzki, Vanni Bucci, Caitlin Cawley, Rene Maserati, Margaret McManus, Effie Olednzki, Camilla Madziar, David Chiang, Doyle Ward, Randall Pellish, Christine Foley, Shakti Bhattarai, Beth A. McCormick, Ana Maldonado-Contreras
Summary: This study aims to investigate the impact of specific foods on the intestinal microbiome in patients with IBD and explore the interactions between diet and immunity to provide personalized nutrition guidance for IBD patients with dysbiosis-related conditions.
Review
Nutrition & Dietetics
Eleuterio A. Sanchez Romero, Erika Melendez Oliva, Jose Luis Alonso Perez, Sebastian Martin Perez, Silvia Turroni, Lorenzo Marchese, Jorge Hugo Villafane
Summary: This study aimed to review the association between gut microbiome and pain in OA patients and found only three out of 2084 studies supported a relationship, but the results were not conclusive. It also highlighted the lack of high-quality studies and significant technique disparities, making it impossible to draw firm conclusions on the topic.
Article
Critical Care Medicine
Booker T. Davis, Zhangying Chen, Mecca B. A. R. Islam, Madeline E. Timken, Daniele Procissi, Steven J. Schwulst
Summary: This study found that fecal microbiota transplantation can reduce ventriculomegaly, preserve white matter connectivity, and reduce inflammation after traumatic brain injury (TBI).
Review
Gastroenterology & Hepatology
Blaine Caslin, Kailey Mohler, Shreya Thiagarajan, Esther Melamed
Summary: Alcohol may have complex effects on autoimmune diseases, with potential pro-inflammatory and anti-inflammatory properties. These effects may be related to factors such as the dose, duration, type, cultural background, and sex of alcohol consumption.
Article
Critical Care Medicine
Jaeyun Sung, Sanu S. Rajendraprasad, Kemuel L. Philbrick, Brent A. Bauer, Ognjen Gajic, Aditya Shah, Krzysztof Laudanski, Johan S. Bakken, Joseph Skalski, Lioudmila V. Karnatovskaia
Summary: With a large number of cells and genes, the human gut microbiome is crucial for health and disease. Modern living disrupts the balance between the host and its microbiome, leading to adverse impacts on critical illness and patient outcomes. Restoring the gut microbiome shows promise for preventing and treating critical illnesses.
JOURNAL OF CRITICAL CARE
(2024)
Article
Microbiology
Bassam Abomoelak, Veronica Pemberton, Chirajyoti Deb, Stephani Campion, Michelle Vinson, Jennifer Mauck, Joseph Manipadam, Sailendharan Sudakaran, Samit Patel, Miguel Saps, Hesham A. El Enshasy, Theodoros Varzakas, Devendra Mehta
Summary: This prospective longitudinal study revealed distinct differences in gut microbiome between pediatric patients with functional abdominal pain disorders (FAPDs) and healthy controls, with variations observed not only in bacterial populations but also in diversity levels. The severity of symptoms in patients was found to be correlated with the gut microbiome, highlighting a potential relationship between the two. Additionally, the Faecalibacterium/Bacteroides ratio may serve as a promising diagnostic biomarker for FAPDs.
Review
Immunology
Ikram Hussain, Gabriel Liu Yuan Cher, Muhammad Abbas Abid, Muhammad Bilal Abid
Summary: COVID-19, caused by SARS-CoV-2, has led to a global crisis with potential multi-organ dysfunction. Alterations in the gut microbiome may be related to disease progression by causing intestinal permeability and exacerbating inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
