Article
Engineering, Biomedical
Su -Wen Zhu, Mengjie Ye, Xianbin Ma, Zhi-Zhong Wu, Shu-Cheng Wan, Shao-Chen Yang, Hao Li, Zhigang Xu, Zhi-Jun Sun
Summary: In this study, pH-responsive nanomicelles (PDO NPs) were designed by loading a small molecular pro-drug synthesized by the Src inhibitor dasatinib and the chemotherapy drug oxaliplatin into the amphiphilic block copolymer iPDPA to enhance the immunological effects of chemotherapy for HNSCC. These nanomicelles can efficiently accumulate in tumor cells and achieve pH-responsive drug release. The PDO NPs can induce pyroptosis of tumor cells and potentiate antitumor immunity in subcutaneous and syngenetic orthotopic HNSCC mouse models, presenting a promising strategy to enhance immunochemotherapy for HNSCC.
ACTA BIOMATERIALIA
(2022)
Review
Cell Biology
Qiao Xu, Lan He, Shubing Zhang, Xiaotang Di, Hao Jiang
Summary: OTUD3 is a deubiquitinating enzyme involved in the regulation of various physiological processes such as immunity and inflammation. It is aberrantly expressed in tumors and can have tumor-promoting or anti-tumor effects on cancer cell proliferation, metastasis, and metabolism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Medicine, General & Internal
Yasuhiro Maruoka, Hiroaki Wakiyama, Peter L. Choyke, Hisataka Kobayashi
Summary: Near-infrared photoimmunotherapy (NIR-PIT) is a highly-selective cancer treatment using a photoabsorbing dye, currently undergoing global phase III clinical trials and conditionally approved in Japan. In addition to rapid, selective cancer cell death, it also stimulates anti-tumour immunity and may have improved results in combination with immune-checkpoint inhibitors.
Review
Oncology
Augusto Bleve, Francesca Maria Consonni, Chiara Porta, Valentina Garlatti, Antonio Sica
Summary: Immunotherapy has made significant progress in the treatment of cancer, but the presence of myeloid cells in the tumor microenvironment can greatly impact treatment response. Current strategies targeting TAMs and MDSCs are showing promising results in pre-clinical and clinical studies. Variability in immune profile within the tumor microenvironment, largely influenced by the frequency and phenotypic heterogeneity of infiltrating myeloid cells, can contribute to the variability in treatment response.
Review
Immunology
Jin Kyung Seok, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee
Summary: Inflammation is a host protection mechanism that can eliminate invasive pathogens from the body, but chronic inflammation may lead to various inflammatory and autoimmune diseases. Recent studies have shown the significant contribution of the NLRP3 inflammasome to the pathology of various inflammatory diseases. Understanding the activation regulation of NLRP3 inflammasome by multiple signaling pathways, post-translational modifications, and cellular organelles is crucial for the development of therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaopeng Peng, Ziwen Yu, Goverdhan Surineni, Bulian Deng, Meizhu Zhang, Chuan Li, Zhiqiang Sun, Wanyi Pan, Yao Liu, Shenglan Liu, Bin Yu, Jianjun Chen
Summary: In this study, a series of novel HDAC6 inhibitors containing polycyclic aromatic rings were discovered and evaluated for their pharmacological activities. Compound 10c showed high inhibitory activity against HDAC6 and selectivity over HDAC3. It also exhibited decent antiproliferative activity against cancer cell lines and demonstrated potential as an anti-cancer agent. Furthermore, the combination of 10c with a PD-L1 inhibitor showed promising results in reducing tumor burden and enhancing the anti-tumor immune response.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Jeffrey Duncan-Lowey, Emerson Crabill, Abigail Jarret, Shawna C. O. Reed, Craig R. Roy
Summary: Eukaryotes have cytosolic surveillance systems to detect invading microorganisms and initiate immune responses. Host-adapted pathogens have evolved strategies to modulate these surveillance systems, which allow them to spread and persist in the host. Coxiella burnetii inhibits type I interferon production by blocking RIG-I signaling through its Dot/Icm system.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Yujin Hong, Seong-Ok Lee, Changhoon Oh, Kwonyoon Kang, Jeongmin Ryoo, Dongyoung Kim, Kwangseog Ahn
Summary: This study reveals that ubiquitination and deubiquitination play critical roles in controlling AIM2 inflammasome activation. In resting state, AIM2 is ubiquitinated and degraded to prevent autoinflammation, while upon DNA stimulation, USP21-mediated deubiquitination increases AIM2 stability and assembly of the inflammasome. Fine-tuning of AIM2 by the ubiquitin system is essential for regulating AIM2 inflammasome activation.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Oncology
Shannon Lange, Laurens G. L. Sand, Matthew Bell, Sagar L. Patil, Deanna Langfitt, Stephen Gottschalk
Summary: We designed a chimeric cytokine receptor (GM18) that links CAR T-cell activation to MyD88 signaling. GM18 endows CAR T cells with sustained effector function in the setting of chronic antigen exposure, resulting in potent antitumor activity in preclinical solid tumor models.
Review
Cell Biology
Lin Fu, Kun Lu, Qian Jiao, Xi Chen, Fengju Jia
Summary: OTUD5 is a cysteine protease belonging to the OTU family, which functions as a deubiquitinase. It plays a crucial role in the deubiquitination of key proteins in various cellular signaling pathways, contributing to normal human development and physiological functions. Dysregulation of OTUD5 can result in physiological dysfunctions, including immunity and DNA damage repair, as well as the development of tumors, inflammatory diseases, and genetic disorders. Therefore, understanding and controlling the activity and expression of OTUD5 is of great significance for disease research and therapeutic interventions.
Article
Immunology
Hong-Yan Chen, Rong-Chun Tang, Jia-Wei Liang, Weijia Zhao, Shuang-Shuang Yu, Rui Xu, Ao Zhang, Shijin Geng, Xiu-Yuan Sun, Qing Ge, Jun Zhang
Summary: In this study, a novel negative regulator of the immune system, USP47, was discovered. By removing K63-linked polyubiquitin chains from TRAF3 and TRAF6, USP47 inhibits type I IFN signaling, leading to reduced antiviral immune responses.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Harshani S. Gurusingha Arachchige, Poornima D. H. Herath Mudiyanselage, Garrett C. VanHecke, Kush Patel, Hassan A. Cheaito, Q. Ping Dou, Young-Hoon Ahn
Summary: A study discovered tiaprofenic acid (TA) as a potential binder with ubiquitin carboxyl-terminal hydrolase L5 (UCHL5), leading to the design and synthesis of a TA derivative TAB2 as an inhibitor of UCHL5.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Review
Immunology
Sophie Janssens, Sofie Rennen, Patrizia Agostinis
Summary: Dendritic cells play a crucial role in the cancer immunity cycle by interacting with malignant cells undergoing immunogenic cell death, leading to DC maturation and activation of antitumor immunity. This process relies on the perception and decoding of danger signals released during immunogenic cell death.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Jin Hwa Cho, Kidae Kim, Sung Ah Kim, Sungryul Park, Bi-Oh Park, Jong-Hwan Kim, Seon-Young Kim, Min Jee Kwon, Myeong Hoon Han, Sung Bae Lee, Byoung Chul Park, Sung Goo Park, Jeong-Hoon Kim, Sunhong Kim
Summary: OTUD5 has been identified as a novel positive regulator of the mTOR complex signaling pathways, playing a role in stabilizing specific proteins to degrade the inhibitory protein DEPTOR of mTOR, affecting physiological phenotypes such as cell size and autophagy. Our results suggest a positive feedback loop between OTUD5 and the mTOR signaling pathway.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Health Care Sciences & Services
Mingxuan Liu, Yilin Ning, Salinelat Teixayavong, Mayli Mertens, Jie Xu, Daniel Shu Wei Ting, Lionel Tim-Ee Cheng, Jasmine Chiat Ling Ong, Zhen Ling Teo, Ting Fang Tan, Narrendar Ravichandran, Fei Wang, Leo Anthony Celi, Marcus Eng Hock Ong, Nan Liu
Summary: Artificial intelligence has shown its ability to extract insights from data, but ensuring fairness in high-stakes fields such as healthcare remains a concern. The notion of fairness in clinical contexts requires careful examination and alignment with ethical considerations. A multidisciplinary approach involving AI researchers, clinicians, and ethicists is necessary to bridge the gap between technical developments and clinical needs.
NPJ DIGITAL MEDICINE
(2023)
Article
Dermatology
Fanfan Zeng, Huoying Chen, Lan Chen, Jie Mao, Shaozhe Cai, Yifan Xiao, Jun Li, Junyu Shi, Bin Li, Yong Xu, Zheng Tan, Feili Gong, Bing Li, Youcun Qian, Lingli Dong, Fang Zheng
Summary: The autocrine circuit of IL-33 in keratinocytes promotes the progression of psoriatic skin inflammation, making IL-33 a potential therapeutic target for psoriasis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Biaolong Deng, Weiqi Zhang, Yicheng Zhu, Yangyang Li, Dan Li, Bin Li
Summary: Regulatory T (Treg) cells play a critical role in maintaining immune homeostasis and their dysfunction in aged patients may contribute to age-related diseases. Immune therapies targeting Treg cells show promising results in treating cancers and autoimmune diseases. Understanding Treg cell function better may help in developing new immune therapies against aging.
Article
Immunology
Youxiang Zhang, De-Hui Xiong, Yangyang Li, Guina Xu, Baoxin Zhang, Yang Liu, Shan Zhang, Qing Huang, Simin Chen, Fansheng Zeng, Jingyi Guo, Bin Li, Zhiqiang Qin, Zuping Zhang
Summary: The study showed that USP21 plays a crucial role in regulating immune interactions between Schistosoma and its host, with potential implications for treating hepatic fibrosis in patients with schistosomiasis. This was evidenced by changes in Th1 and Th17 responses amplified by Tregs and reduced levels of liver immunopathology in USP21 knockout mice.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Review
Immunology
Youkun Qian, Yicheng Zhu, Yangyang Li, Bin Li
Summary: This article discusses the importance of lung resident memory T cells in secondary immune responses and how they help enhance immunity against SARS-CoV-2. Studies show that these cells can rapidly respond to reinfection, limit tumor growth, but may also lead to pathologic immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ying Lu, Yangyang Li, Qi Liu, Na Tian, Peng Du, Fangming Zhu, Yichao Han, Xinnan Liu, Xisheng Liu, Xiao Peng, Xiaoxia Wang, Yuchen Wu, Lingfeng Tong, Yakui Li, Yemin Zhu, Lifang Wu, Ping Zhang, Ye Xu, Hanbei Chen, Bin Li, Xuemei Tong
Summary: In colorectal cancer, intratumoral regulatory T cells (Tregs) exhibit low activity of the MondoA-thioredoxin-interacting protein (TXNIP) axis and increased glucose uptake. While MondoA-deficient Tregs promoted Th1 responses in a subcutaneous colorectal cancer model, Treg-specific MondoA knockout mice were more susceptible to colorectal cancer induction.
Article
Cell Biology
Xisheng Liu, Xiaole Meng, Xiao Peng, Qianlan Yao, Fangming Zhu, Zhongyi Ding, Hongze Sun, Xueni Liu, Dan Li, Ying Lu, Huamei Tang, Bin Li, Zhihai Peng
Summary: The global downregulation of miRNA expression, potentially due to defects in miRNA processing machinery, is a hallmark of human cancer. In colorectal cancer (CRC), downregulation of the key regulator of miRNA processing, Argonaute 2 (AGO2), has been found to promote epithelial-mesenchymal transition (EMT) and indicate poor prognosis. Knockdown of AGO2 in CRC cells enhanced migration, invasion, and metastasis, while integrated analyses revealed neuropilin 1 (NRP1) as a new substrate of AGO2 via miR-185-3p. Therapeutically targeting the AGO2/miR-185-3p/NRP1 axis may offer a potential treatment approach for CRC.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Yikong Lin, Di Zhang, Yangyang Li, Yunyun Li, Bin Li, Meirong Du
Summary: This study revealed a crucial role of NR2F2 in regulating maternal-fetal immune tolerance through promoting Th2 differentiation of decidual CD4(+)T cells, with decreased NR2F2 expression associated with unexplained recurrent spontaneous abortion. The interaction between GATA-3 and NR2F2 was confirmed, suggesting GATA-3 may play an important role in the immunoregulatory process mediated by NR2F2, providing a potential biomarker for prediction and prevention of clinical unexplained RSA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mengdi Yang, Qianru Huang, Changcan Li, Zhiyuan Jiang, Jing Sun, Zhiyu Wang, Rui Liang, Dan Li, Bin Li, Hui Zhao
Summary: TOX is a novel tumor suppressor in colorectal cancer (CRC) that is associated with tumor stage and overall survival, suppressing mTOR signaling pathway and affecting cell proliferation, migration, invasion, and epithelial-mesenchymal transition. High expression of TOX is related to tumor stability, immune score, stromal score, and microsatellite instability in CRC, highlighting its therapeutic potential in combination with mTOR inhibitor or PD1 inhibitor in CRC treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Weiqi Zhang, Xu Liu, Yicheng Zhu, Xinnan Liu, Yunting Gu, Xueyu Dai, Bin Li
Summary: Regulatory T (Treg) cells and T helper type 17 (Th17) cells play crucial roles in immune responses, antagonizing each other in immune disorders. Restoring Th17/Treg balance by modifying the enzymatic activities of ROR gamma t and FOXP3 binding partners may be therapeutically applied to treat severe immune disorders.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Heng Xu, Zhu Zhu, Jian Hu, Jiawei Sun, Yan Wo, Xianshu Wang, Hongzhi Zou, Bin Li, Yixin Zhang
Summary: This study found that downregulation of cytotoxic CD8(+) T cells is a specific signature of keloids. Additionally, the upregulation of the NKG2A/CD94 complex and high levels of soluble human leukocyte antigen-E (sHLA-E) were associated with keloid formation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Zoology
Lei Bao, Xiao-Chen Bo, Huai-Wen Cao, Chen Qian, Zeng Wang, Bin Li
Summary: Chimeric antigen receptor T cells (CAR-T cells) are engineered T cells used in the treatment of various diseases, including autoimmune diseases. Regulatory T cells (Treg) have gained attention for their potential application in CAR-T therapy.
ZOOLOGICAL RESEARCH
(2022)
Review
Immunology
Yimeng Yu, Hongyu Bai, Fenglin Wu, Jieqiong Chen, Bin Li, Yangyang Li
Summary: This review focuses on the tissue adaptation of adipose tissue-resident regulatory T cells (AT Treg cells) and their response to various environmental signals. The transcriptional cascades triggered by these signals ultimately establish unique transcriptional modules in adipose tissue Treg cell subsets.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Yi Lu, Yi Wang, Yang Wang, Yu Wu, Yazhuo Huang, Xingtong Liu, Shuo Zhang, Sisi Zhong, Yinwei Li, Bin Li, Jing Sun, Sijie Fang, Huifang Zhou
Summary: This study investigated the immunophenotypes of orbital-infiltrating macrophages and their modulatory effects on orbital fibroblasts (OFs) in Graves' orbitopathy (GO). The results showed the presence of different immunophenotypes of macrophages in GO orbital connective tissues and their promotion effects on OFs through the IL-6/sIL-6R signaling pathway. These findings provide molecular rationale for the potential therapeutic use of blocking sIL-6R in GO.
Article
Cell Biology
Chenbo Ding, Zhibin Yu, Esen Sefik, Jing Zhou, Eleanna Kaffe, Gaoyang Wang, Bin Li, Richard A. Flavell, Weiguo Hu, Youqiong Ye, Hua-Bing Li
Summary: This study identified a T-reg-specific long noncoding RNA called Altre, which plays a role in regulating the mitochondrial function of T-reg cells in the liver of old mice by binding to Yin Yang 1. Deletion of Altre accelerates aging-associated liver pathogenesis.
Letter
Biochemistry & Molecular Biology
Yahui Liu, Juan Du, Xinnan Liu, Lingbiao Wang, Yichao Han, Chunrong Huang, Rui Liang, Fang Zheng, Guochao Shi, Bin Li
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
